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Gene: Pi4kb (phosphatidylinositol 4-kinase beta) Rattus norvegicus

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Symbol:

Pi4kb

Name:

phosphatidylinositol 4-kinase beta

RGD ID:

621214

Description:

Enables 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in inner ear development; phosphatidylinositol phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within lysosome organization. Predicted to be located in Golgi membrane. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 87. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta); PARTICIPATES IN inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

catalytic phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta; phosphatidylinositol 4-kinase, catalytic, beta polypeptide; PI4K-beta; PI4Kbeta; Pik4cb; ptdIns 4-kinase beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PI4KB (phosphatidylinositol 4-kinase beta)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pi4kb (phosphatidylinositol 4-kinase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pi4kb (phosphatidylinositol 4-kinase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PI4KB (phosphatidylinositol 4-kinase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PI4KB (phosphatidylinositol 4-kinase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pi4kb (phosphatidylinositol 4-kinase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PI4KB (phosphatidylinositol 4-kinase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PI4KB (phosphatidylinositol 4-kinase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pi4kb (phosphatidylinositol 4-kinase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PI4KB (phosphatidylinositol 4-kinase beta)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pi4kb (phosphatidylinositol 4-kinase beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pi4kb (phosphatidylinositol 4-kinase, catalytic, beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PIK1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	fwd	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pifk-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pi4kb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	185,229,392 - 185,261,697 (+)	NCBI		GRCr8
mRatBN7.2	2	182,540,377 - 182,572,684 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	182,540,567 - 182,588,488 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	190,205,165 - 190,237,217 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	188,000,894 - 188,032,951 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	182,837,647 - 182,869,695 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	196,139,724 - 196,172,055 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	196,139,755 - 196,171,713 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	215,634,003 - 215,666,743 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	189,874,613 - 189,906,640 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	189,834,020 - 189,866,048 (+)	NCBI
Celera	2	175,082,416 - 175,114,456 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pi4kb	Rat	autosomal dominant nonsyndromic deafness 87		ISO	PI4KB (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:33358777
Pi4kb	Rat	Dravet syndrome		ISO	PI4KB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Severe myoclonic epilepsy in infancy	ClinVar	PMID:28492532
Pi4kb	Rat	gastrointestinal stromal tumor		ISO	PI4KB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Gastrointestinal stromal tumor	ClinVar	PMID:28492532
Pi4kb	Rat	immunodeficiency 42		ISO	PI4KB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency	ClinVar	PMID:28492532
Pi4kb	Rat	MHC class II deficiency		ISO	PI4KB (Homo sapiens)	8554872	ClinVar Annotator: match by term: MHC class II deficiency	ClinVar	PMID:28492532
Pi4kb	Rat	parathyroid carcinoma		ISO	PI4KB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Parathyroid carcinoma	ClinVar	PMID:28492532
Pi4kb	Rat	severe congenital neutropenia 3		ISO	PI4KB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Kostmann syndrome	ClinVar	PMID:28492532
Pi4kb	Rat	severe congenital neutropenia 5		ISO	PI4KB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Congenital neutropenia-myelofibrosis-nephromegaly syndrome	ClinVar	PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pi4kb	Rat	Coronavirus infectious disease		ISO	PI4KB (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:22253445
Pi4kb	Rat	severe acute respiratory syndrome		ISO	PI4KB (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:22253445

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pi4kb	Rat	autosomal dominant nonsyndromic deafness 87		ISO	PI4KB (Homo sapiens)	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pi4kb	Rat	(+)-catechin	multiple interactions	ISO	PI4KB (Homo sapiens)	6480464	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PI4KB mRNA	CTD	PMID:24763279
Pi4kb	Rat	17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of PI4KB mRNA	CTD	PMID:20068009
Pi4kb	Rat	17beta-estradiol	increases expression	ISO	Pi4kb (Mus musculus)	6480464	Estradiol results in increased expression of PI4KB mRNA	CTD	PMID:39298647
Pi4kb	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Pi4kb (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of PI4KB mRNA	CTD	PMID:21570461
Pi4kb	Rat	2,4-dinitrotoluene	affects expression	EXP		6480464	2 and 4-dinitrotoluene affects the expression of PI4KB mRNA	CTD	PMID:21346803
Pi4kb	Rat	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	ISO	PI4KB (Homo sapiens)	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PI4KB mRNA	CTD	PMID:28628672
Pi4kb	Rat	4,4'-sulfonyldiphenol	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of PI4KB mRNA	CTD	PMID:36041667
Pi4kb	Rat	5-fluorouracil	multiple interactions	ISO	PI4KB (Homo sapiens)	6480464	TP53 protein affects the reaction [Fluorouracil results in decreased expression of PI4KB mRNA]	CTD	PMID:15016801
Pi4kb	Rat	6-propyl-2-thiouracil	decreases expression	EXP		6480464	Propylthiouracil results in decreased expression of PI4KB mRNA	CTD	PMID:30047161
Pi4kb	Rat	acetylsalicylic acid	decreases expression	ISO	PI4KB (Homo sapiens)	6480464	Aspirin results in decreased expression of PI4KB mRNA	CTD	PMID:15928584
Pi4kb	Rat	all-trans-retinoic acid	increases expression	ISO	PI4KB (Homo sapiens)	6480464	Tretinoin results in increased expression of PI4KB mRNA	CTD	PMID:33167477
Pi4kb	Rat	amitrole	decreases expression	EXP		6480464	Amitrole results in decreased expression of PI4KB mRNA	CTD	PMID:30047161
Pi4kb	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of PI4KB mRNA	CTD	PMID:16483693
Pi4kb	Rat	arsenite(3-)	decreases expression	ISO	Pi4kb (Mus musculus)	6480464	arsenite results in decreased expression of PI4KB protein	CTD	PMID:37955338
Pi4kb	Rat	Benzo[k]fluoranthene	increases expression	ISO	Pi4kb (Mus musculus)	6480464	benzo(k)fluoranthene results in increased expression of PI4KB mRNA	CTD	PMID:26377693
Pi4kb	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	Pi4kb (Mus musculus)	6480464	Diethylhexyl Phthalate results in increased expression of PI4KB mRNA	CTD	PMID:34319233
Pi4kb	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of PI4KB mRNA	CTD	PMID:25181051 and PMID:30816183
Pi4kb	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of PI4KB mRNA	CTD	PMID:36041667
Pi4kb	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of PI4KB gene	CTD	PMID:28505145
Pi4kb	Rat	bisphenol A	multiple interactions	ISO	PI4KB (Homo sapiens)	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PI4KB mRNA	CTD	PMID:28628672
Pi4kb	Rat	bisphenol F	multiple interactions	EXP		6480464	[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of PI4KB mRNA	CTD	PMID:36041667
Pi4kb	Rat	bortezomib	decreases expression	ISO	PI4KB (Homo sapiens)	6480464	Bortezomib results in decreased expression of PI4KB mRNA	CTD	PMID:20977926
Pi4kb	Rat	caffeine	affects phosphorylation	ISO	PI4KB (Homo sapiens)	6480464	Caffeine affects the phosphorylation of PI4KB protein	CTD	PMID:35688186
Pi4kb	Rat	cisplatin	increases expression	ISO	PI4KB (Homo sapiens)	6480464	Cisplatin results in increased expression of PI4KB mRNA	CTD	PMID:27392435
Pi4kb	Rat	coumarin	increases phosphorylation	ISO	PI4KB (Homo sapiens)	6480464	coumarin results in increased phosphorylation of PI4KB protein	CTD	PMID:35688186
Pi4kb	Rat	deoxynivalenol	affects phosphorylation	ISO	Pi4kb (Mus musculus)	6480464	deoxynivalenol affects the phosphorylation of PI4KB protein	CTD	PMID:23811945
Pi4kb	Rat	dexamethasone	multiple interactions	ISO	PI4KB (Homo sapiens)	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PI4KB mRNA	CTD	PMID:28628672
Pi4kb	Rat	dioxygen	multiple interactions	ISO	Pi4kb (Mus musculus)	6480464	[sulforaphane affects the susceptibility to Oxygen] which affects the expression of PI4KB mRNA	CTD	PMID:30529165
Pi4kb	Rat	doxorubicin	decreases expression	ISO	PI4KB (Homo sapiens)	6480464	Doxorubicin results in decreased expression of PI4KB mRNA	CTD	PMID:29803840
Pi4kb	Rat	endosulfan	decreases expression	EXP		6480464	Endosulfan results in decreased expression of PI4KB mRNA	CTD	PMID:29391264
Pi4kb	Rat	enzyme inhibitor	multiple interactions	ISO	PI4KB (Homo sapiens)	6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PI4KB protein	CTD	PMID:23301498
Pi4kb	Rat	ethanol	decreases expression	EXP		6480464	Ethanol results in decreased expression of PI4KB mRNA	CTD	PMID:17920746
Pi4kb	Rat	flavonoids	increases expression	EXP		6480464	Flavonoids results in increased expression of PI4KB mRNA	CTD	PMID:18035473
Pi4kb	Rat	folic acid	decreases expression	ISO	Pi4kb (Mus musculus)	6480464	Folic Acid results in decreased expression of PI4KB mRNA	CTD	PMID:25629700
Pi4kb	Rat	FR900359	affects phosphorylation	ISO	PI4KB (Homo sapiens)	6480464	FR900359 affects the phosphorylation of PI4KB protein	CTD	PMID:37730182
Pi4kb	Rat	genistein	multiple interactions	EXP		6480464	[Genistein co-treated with Methoxychlor] results in increased expression of PI4KB mRNA	CTD	PMID:21782745
Pi4kb	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of PI4KB mRNA	CTD	PMID:22061828
Pi4kb	Rat	indometacin	multiple interactions	ISO	PI4KB (Homo sapiens)	6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PI4KB mRNA	CTD	PMID:28628672
Pi4kb	Rat	lead(0)	affects splicing	ISO	PI4KB (Homo sapiens)	6480464	Lead affects the splicing of PI4KB mRNA	CTD	PMID:28903495
Pi4kb	Rat	leflunomide	decreases expression	ISO	PI4KB (Homo sapiens)	6480464	leflunomide results in decreased expression of PI4KB mRNA	CTD	PMID:28988120
Pi4kb	Rat	methimazole	decreases expression	EXP		6480464	Methimazole results in decreased expression of PI4KB mRNA	CTD	PMID:30047161
Pi4kb	Rat	methoxychlor	multiple interactions	EXP		6480464	[Genistein co-treated with Methoxychlor] results in increased expression of PI4KB mRNA	CTD	PMID:21782745
Pi4kb	Rat	methoxychlor	increases expression	EXP		6480464	Methoxychlor results in increased expression of PI4KB mRNA	CTD	PMID:21782745
Pi4kb	Rat	nitrates	multiple interactions	ISO	Pi4kb (Mus musculus)	6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of PI4KB mRNA	CTD	PMID:35964746
Pi4kb	Rat	paracetamol	increases expression	ISO	PI4KB (Homo sapiens)	6480464	Acetaminophen results in increased expression of PI4KB mRNA	CTD	PMID:22230336
Pi4kb	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of PI4KB mRNA	CTD	PMID:33387578
Pi4kb	Rat	perfluorohexanesulfonic acid	decreases expression	ISO	Pi4kb (Mus musculus)	6480464	perfluorohexanesulfonic acid results in decreased expression of PI4KB mRNA	CTD	PMID:37995155
Pi4kb	Rat	perfluorooctanoic acid	increases expression	EXP		6480464	perfluorooctanoic acid results in increased expression of PI4KB mRNA	CTD	PMID:19162173
Pi4kb	Rat	phenobarbital	increases expression	ISO	Pi4kb (Mus musculus)	6480464	Phenobarbital results in increased expression of PI4KB mRNA	CTD	PMID:19270015
Pi4kb	Rat	pirinixic acid	multiple interactions	ISO	PI4KB (Homo sapiens)	6480464	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PI4KB mRNA	CTD	PMID:19710929
Pi4kb	Rat	sulfadimethoxine	decreases expression	EXP		6480464	Sulfadimethoxine results in decreased expression of PI4KB mRNA	CTD	PMID:30047161
Pi4kb	Rat	sulforaphane	multiple interactions	ISO	Pi4kb (Mus musculus)	6480464	[sulforaphane affects the susceptibility to Oxygen] which affects the expression of PI4KB mRNA	CTD	PMID:30529165
Pi4kb	Rat	tetracycline	increases expression	ISO	Pi4kb (Mus musculus)	6480464	Tetracycline results in increased expression of PI4KB mRNA	CTD	PMID:16917069
Pi4kb	Rat	Tributyltin oxide	decreases phosphorylation	ISO	Pi4kb (Mus musculus)	6480464	bis(tri-n-butyltin)oxide results in decreased phosphorylation of PI4KB protein	CTD	PMID:22174045
Pi4kb	Rat	triphenyl phosphate	affects expression	ISO	PI4KB (Homo sapiens)	6480464	triphenyl phosphate affects the expression of PI4KB mRNA	CTD	PMID:37042841
Pi4kb	Rat	vitamin E	increases expression	ISO	PI4KB (Homo sapiens)	6480464	Vitamin E results in increased expression of PI4KB mRNA	CTD	PMID:19244175

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pi4kb	Rat	inner ear development	involved_in	ISS	UniProtKB:Q9UBF8	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Pi4kb	Rat	inner ear development	involved_in	IBA	PANTHER:PTN002559530 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pi4kb	Rat	inner ear development	involved_in	ISO	PI4KB (Homo sapiens)	1624291	PMID:33358777	RGD	PMID:33358777
Pi4kb	Rat	inner ear development	involved_in	IEA	UniProtKB:Q9UBF8 and ensembl:ENSP00000357867	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pi4kb	Rat	lipid metabolic process	involved_in	IEA	UniProtKB-KW:KW-0443	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pi4kb	Rat	lysosome organization	acts_upstream_of_or_within	ISO	PI4KB (Homo sapiens)	1624291	PMID:25365221	RGD	PMID:25365221
Pi4kb	Rat	lysosome organization	acts_upstream_of_or_within	IEA	UniProtKB:Q9UBF8 and ensembl:ENSP00000357867	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pi4kb	Rat	phosphatidylinositol phosphate biosynthetic process	involved_in	IBA	CGD:CAL0000195103 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pi4kb	Rat	phosphatidylinositol phosphate biosynthetic process	involved_in	IEA	InterPro:IPR015433	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Pi4kb	Rat	phosphatidylinositol-mediated signaling	involved_in	IBA	PANTHER:PTN000005673 and dictyBase:DDB_G0278727	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pi4kb	Rat	cytoplasm	is_active_in	IBA	FB:FBgn0004373 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pi4kb	Rat	endomembrane system	located_in	IEA	UniProtKB-SubCell:SL-0147	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Pi4kb	Rat	endoplasmic reticulum	located_in	IEA	UniProtKB-KW:KW-0256	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pi4kb	Rat	Golgi apparatus	located_in	ISO	PI4KB (Homo sapiens)	1624291	PMID:25365221	RGD	PMID:25365221
Pi4kb	Rat	Golgi apparatus	located_in	IEA	UniProtKB-KW:KW-0333	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pi4kb	Rat	Golgi apparatus	located_in	IEA	UniProtKB:Q9UBF8 and ensembl:ENSP00000357867	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pi4kb	Rat	Golgi apparatus	located_in	IEA	UniProtKB-SubCell:SL-0132	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Pi4kb	Rat	Golgi membrane	located_in	ISO	PI4KB (Homo sapiens)	1624291	PMID:27009356	RGD	PMID:27009356
Pi4kb	Rat	Golgi membrane	located_in	IEA	UniProtKB-SubCell:SL-0134	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Pi4kb	Rat	Golgi membrane	located_in	IEA	UniProtKB:Q9UBF8 and ensembl:ENSP00000357867	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pi4kb	Rat	membrane	is_active_in	IBA	CGD:CAL0000198621 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pi4kb	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pi4kb	Rat	mitochondrial outer membrane	located_in	IEA	UniProtKB-SubCell:SL-0172	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Pi4kb	Rat	mitochondrial outer membrane	located_in	IEA	UniProtKB-KW:KW-1000	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pi4kb	Rat	mitochondrion	located_in	IEA	UniProtKB-KW:KW-0496	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pi4kb	Rat	rough endoplasmic reticulum membrane	located_in	IEA	UniProtKB-SubCell:SL-0237	1600115	GO_REF:0000044	UniProt	GO_REF:0000044

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pi4kb	Rat	1-phosphatidylinositol 4-kinase activity		IDA		633727		RGD
Pi4kb	Rat	1-phosphatidylinositol 4-kinase activity		TAS		625563		RGD
Pi4kb	Rat	1-phosphatidylinositol 4-kinase activity	enables	IEA	EC:2.7.1.67	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Pi4kb	Rat	1-phosphatidylinositol 4-kinase activity	enables	IEA	RHEA:19877	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Pi4kb	Rat	1-phosphatidylinositol 4-kinase activity	enables	ISO	PI4KB (Homo sapiens)	1624291	PMID:11277933 and PMID:27009356	RGD	PMID:11277933 and PMID:27009356
Pi4kb	Rat	1-phosphatidylinositol 4-kinase activity	enables	IEA	UniProtKB:Q9UBF8 and ensembl:ENSP00000357867	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pi4kb	Rat	1-phosphatidylinositol 4-kinase activity	enables	IBA	PANTHER:PTN000005893 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Pi4kb	Rat	14-3-3 protein binding	enables	ISS	UniProtKB:Q9UBF8	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Pi4kb	Rat	14-3-3 protein binding	enables	ISO	PI4KB (Homo sapiens)	1624291	PMID:23572552	RGD	PMID:23572552
Pi4kb	Rat	14-3-3 protein binding	enables	IEA	UniProtKB:Q9UBF8 and ensembl:ENSP00000357867	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Pi4kb	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pi4kb	Rat	kinase activity	enables	IEA	InterPro:IPR018936	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Pi4kb	Rat	kinase activity	enables	IEA	UniProtKB-KW:KW-0418	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pi4kb	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Pi4kb	Rat	phosphatidylinositol kinase activity	enables	IEA	ARBA:ARBA00033494	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Pi4kb	Rat	protein binding		IPI	Ncs1 (Rattus norvegicus)	7241276		RGD
Pi4kb	Rat	protein binding	enables	ISO	PI4KB (Homo sapiens)	1624291	UniProtKB:P03300-PRO_0000424692 more ...	RGD	PMID:16912074 more ...
Pi4kb	Rat	protein binding	enables	ISO	PI4KB (Homo sapiens) and UniProtKB:Q9UBF8-2	1624291	UniProtKB:P62491 and PMID:24876499	RGD	PMID:24876499
Pi4kb	Rat	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Pi4kb	Rat	inositol phosphate metabolic pathway		IEA		6907045		KEGG	rno:00562
Pi4kb	Rat	phosphatidylinositol 3-kinase signaling pathway		IEA		6907045		KEGG	rno:04070

BioCyc Pathways

D-myo-inositol (1,4,5)-trisphosphate biosynthesis	3-phosphoinositide biosynthesis

#	Reference Title	Reference Citation
1.	Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease.	Cuozzo FP, etal., Biochim Biophys Acta 2002 May 21;1587(1):99-106.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase.	Nakagawa T, etal., Biochem J 1996 Dec 1;320 ( Pt 2):643-9.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.	Taverna E, etal., J Cell Sci. 2002 Oct 15;115(Pt 20):3909-22.

PMID:14607934	PMID:14607979	PMID:16638749	PMID:17088255	PMID:18474610	PMID:23572552	PMID:23899475	PMID:27009356

Pi4kb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	185,229,392 - 185,261,697 (+)	NCBI		GRCr8
mRatBN7.2	2	182,540,377 - 182,572,684 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	182,540,567 - 182,588,488 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	190,205,165 - 190,237,217 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	188,000,894 - 188,032,951 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	182,837,647 - 182,869,695 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	196,139,724 - 196,172,055 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	196,139,755 - 196,171,713 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	215,634,003 - 215,666,743 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	189,874,613 - 189,906,640 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	189,834,020 - 189,866,048 (+)	NCBI
Celera	2	175,082,416 - 175,114,456 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

PI4KB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	151,291,797 - 151,327,715 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	151,291,797 - 151,327,715 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	151,264,273 - 151,300,191 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	149,531,037 - 149,565,348 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	148,077,485 - 148,111,797	NCBI
Celera	1	124,379,704 - 124,414,015 (-)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	122,642,216 - 122,678,133 (-)	NCBI		HuRef
CHM1_1	1	152,660,019 - 152,695,935 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	150,415,490 - 150,452,405 (-)	NCBI		T2T-CHM13v2.0

Pi4kb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	94,882,042 - 94,914,248 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	94,882,042 - 94,914,154 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	94,974,731 - 95,006,937 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	94,974,731 - 95,006,843 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	94,778,653 - 94,810,765 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	95,060,140 - 95,091,993 (+)	NCBI		MGSCv36	mm8
Celera	3	96,405,996 - 96,438,094 (+)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	40.74	NCBI

Pi4kb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955588	648,180 - 679,374 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955588	648,180 - 679,374 (-)	NCBI	ChiLan1.0	ChiLan1.0

PI4KB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	98,492,576 - 98,528,619 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	98,243,803 - 98,279,850 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	126,653,794 - 126,689,690 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	130,300,844 - 130,336,320 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	130,300,844 - 130,336,311 (-)	Ensembl	panpan1.1		panPan2

PI4KB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	60,359,545 - 60,386,093 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	60,360,236 - 60,384,778 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	59,803,028 - 59,830,272 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	61,375,750 - 61,403,019 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	61,375,754 - 61,402,452 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	60,203,634 - 60,230,882 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	60,289,810 - 60,317,042 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	61,018,193 - 61,044,694 (-)	NCBI		UU_Cfam_GSD_1.0

Pi4kb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	22,465,447 - 22,493,491 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	1,495,833 - 1,523,276 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	1,495,833 - 1,523,307 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PI4KB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	97,918,245 - 97,949,931 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	97,918,234 - 97,949,929 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	107,119,069 - 107,150,710 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PI4KB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	12,358,758 - 12,395,372 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	12,358,762 - 12,394,661 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	11,933,446 - 11,970,304 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pi4kb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	18,532,986 - 18,564,492 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	18,533,603 - 18,564,160 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Pi4kb
100 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	54
Count of miRNA genes:	39
Interacting mature miRNAs:	52
Transcripts:	ENSRNOT00000040501
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	114837527	211674221	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	136445150	202447032	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	122609194	206936711	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	114837675	212549332	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	152413072	185122374	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	78665619	219826953	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	143657411	190602963	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	152413072	185122374	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	152413072	185122374	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	157142209	202446871	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	152413072	185122374	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	169745596	214745596	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	135552573	202446871	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168354880	185122374	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	157142078	211086598	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	114837527	185876470	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56043031	202447032	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	152413072	185122374	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	136916935	189599348	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	157142078	192625452	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150540301	202447032	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118275	202447032	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	136916935	213594495	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	76539322	202447032	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150341684	202446871	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	168594495	213594495	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	141596551	202447032	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	112456140	212696837	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150341585	189039377	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	143157029	210020885	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	133914684	202447032	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	144599348	189599348	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	112456140	212696837	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	150540301	202447032	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147798556	192798556	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	172710921	184114403	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	162765032	207765032	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166539266	211539266	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	160564068	205564068	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	74786664	206665859	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	143657569	184114274	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
2293084	Iddm26	Insulin dependent diabetes mellitus QTL 26	2.9		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	174930955	213594495	Rat

RH128413

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,572,291 - 182,572,511 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,171,665 - 196,171,884	NCBI	Rnor6.0
Rnor_5.0	2	215,666,351 - 215,666,570	UniSTS	Rnor5.0
RGSC_v3.4	2	189,906,523 - 189,906,742	UniSTS	RGSC3.4
Celera	2	175,114,339 - 175,114,558	UniSTS
RH 3.4 Map	2	1212.8	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH142980

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,569,398 - 182,569,609 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,168,772 - 196,168,982	NCBI	Rnor6.0
Rnor_5.0	2	215,663,458 - 215,663,668	UniSTS	Rnor5.0
RGSC_v3.4	2	189,903,630 - 189,903,840	UniSTS	RGSC3.4
Celera	2	175,111,446 - 175,111,656	UniSTS
RH 3.4 Map	2	1196.1	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH144445

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,540,402 - 182,540,529 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,139,781 - 196,139,907	NCBI	Rnor6.0
Rnor_5.0	2	215,634,467 - 215,634,593	UniSTS	Rnor5.0
RGSC_v3.4	2	189,874,639 - 189,874,765	UniSTS	RGSC3.4
Celera	2	175,082,442 - 175,082,568	UniSTS
RH 3.4 Map	2	1199.1	UniSTS
Cytogenetic Map	2	q34	UniSTS

MARC_27466-27467:1034353260:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	185,250,181 - 185,251,044 (+)	Marker Load Pipeline
mRatBN7.2	2	182,561,171 - 182,562,034 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,160,545 - 196,161,407	NCBI	Rnor6.0
Rnor_5.0	2	215,655,231 - 215,656,093	UniSTS	Rnor5.0
RGSC_v3.4	2	189,895,403 - 189,896,265	UniSTS	RGSC3.4
Celera	2	175,103,220 - 175,104,082	UniSTS
Cytogenetic Map	2	q34	UniSTS

D3Umi7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,549,029 - 182,549,846 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,148,406 - 196,149,222	NCBI	Rnor6.0
Rnor_5.0	2	215,643,092 - 215,643,908	UniSTS	Rnor5.0
RGSC_v3.4	2	189,883,264 - 189,884,080	UniSTS	RGSC3.4
Celera	2	175,091,071 - 175,091,887	UniSTS
Cytogenetic Map	2	q34	UniSTS

REN33561

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,571,864 - 182,572,134 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,171,238 - 196,171,507	NCBI	Rnor6.0
Rnor_5.0	2	215,665,924 - 215,666,193	UniSTS	Rnor5.0
RGSC_v3.4	2	189,906,096 - 189,906,365	UniSTS	RGSC3.4
Celera	2	175,113,912 - 175,114,181	UniSTS
Cytogenetic Map	2	q34	UniSTS

REN33651

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	182,549,344 - 182,549,598 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	196,148,721 - 196,148,974	NCBI	Rnor6.0
Rnor_5.0	2	215,643,407 - 215,643,660	UniSTS	Rnor5.0
RGSC_v3.4	2	189,883,579 - 189,883,832	UniSTS	RGSC3.4
Celera	2	175,091,386 - 175,091,639	UniSTS
Cytogenetic Map	2	q34	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_031083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761332	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103232	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282633	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_591217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC130969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY724527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D84667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000040501 ⟹ ENSRNOP00000039342

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,548,848 - 182,588,488 (+)	Ensembl
Rnor_6.0 Ensembl	2	196,139,755 - 196,171,713 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080966 ⟹ ENSRNOP00000070653

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,540,567 - 182,572,680 (+)	Ensembl
Rnor_6.0 Ensembl	2	196,145,384 - 196,171,573 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103639 ⟹ ENSRNOP00000082231

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,540,572 - 182,588,488 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112486 ⟹ ENSRNOP00000095998

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,544,007 - 182,588,488 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112810 ⟹ ENSRNOP00000093461

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,540,572 - 182,588,488 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118319 ⟹ ENSRNOP00000089657

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	182,540,572 - 182,572,680 (+)	Ensembl

RefSeq Acc Id:

NM_031083 ⟹ NP_112345

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,229,392 - 185,261,419 (+)	NCBI
mRatBN7.2	2	182,540,377 - 182,572,409 (+)	NCBI
Rnor_6.0	2	196,139,755 - 196,171,782 (+)	NCBI
Rnor_5.0	2	215,634,003 - 215,666,743 (+)	NCBI
RGSC_v3.4	2	189,874,613 - 189,906,640 (+)	RGD
Celera	2	175,082,416 - 175,114,456 (+)	RGD

Sequence:

show sequence

TTACTATGGCATCGGTAGTGTCCTGACAGTTCGGAAAGCAGGAAAGCAAGCGCCGAGAAGAAAGGCTCGGGCCCAGCGGACTCTTACATCGCAACCCATCAAGGAATTGTTATTTTGGGTCCTGCAAG
TGGGGTCCGGTCCAACTTGAGGTAGCGTGAAGGCCCCTTCAGGCGGCGCCGCGGGCAGCCCCGCAGCCGGGGCCTGGTGCAGCCGCCGCGGCCGCTGTCAGGGAAGCGCAGGCGGCCAATGGAACCCG
GGAGCGGCCGCTGCTGCTGAGGCGGCGGTGTCGGCAGTCCGACCCCGACCGCCTGCACCCCCTCCGCGAGGGTCCCCCGGAGCTTGGAAGCTCGAAGTCTGGCTGTAGCCATGGGAGACATGGTAGTG
GAGCCTGCCACCCTGAAGCCAACTTCTGAGCCTACTCCTAGCCCATCAGGGAATAACGGGGGCTCCCTACTAAGCGTCATCACGGAGGGGGTCGGGGAACTGTCAGTGATTGACCCTGAGGTGGCCCA
GAAGGCCTGCCAGGAGGTACTGGAGAAAGTCAAGCTTTTGCATGGAGGTGTAGCCATCTCTAGCAAAGGCAGCCCACTGGAGTTGGTTAATGGGGATGGTGTGGACAATGAGATCCGTTGCCTAGATG
ATCCACCTACCGAGATCAGGGAGGAAGAAGATGAGATGGAGCCTGGTGTGGTCTCTGGCACAGCCAAAGGAACAAGAAGAAGACGACAGAACAACTCAGCCAAACAGTCTTGGCTCCTGAGGCTGTTT
GAATCAAAACTATTTGACATCTCTATGGCCATTTCATACTTGTATAACTCCAAGGAGCCGGGAGTGCAAGCCTACATTGGCAACCGGCTCTTCTGCTTTCGCAATGAGGATGTGGACTTCTATTTGCC
CCAGTTGCTTAACATGTATATCCATATGGATGAGGATGTGGGTGATGCCATTAAACCCTACATAGTCCACCGTTGTCGCCAGAGCATCAACTTTTCCCTCCAGTGTGCCCTGTTGCTTGGGGCCTACT
CTTCAGACATGCACATTTCCACTCAACGACACTCCCGAGGGACCAAGTTACGGAAGCTAATCCTCTCAGATGAGCTGAAGCCAGCTCACCGAAAGAGGGAGCTGCCAACTTTAAGCCCAGCCCCTGAC
ACAGGACTGTCTCCCTCTAAAAGGACTCACCAGCGCTCTAAGTCAGATGCCACGGCCAGCATAAGTCTCAGCAGCAACCTGAAACGAACAGCCAGCAACCCTAAAGTGGAGAATGAGGATGAGGAGCT
CTCCTCCAGCACCGAGAGTATTGATAATTCATTCAGTTCCCCTGTCCGGCTGGCCCCTGAGCGAGAATTCATCAAGTCCTTGATGGCAATCGGCAAACGGCTGGCCACGCTCCCCACTAAAGAGCAAA
AAACACAAAGGCTGATCTCAGAACTTTCCCTGCTCAACCATAAGCTCCCTGCCCGAGTCTGGCTGCCCACAGCTGGCTTTGACCACCACGTGGTCCGTGTGCCCCACACACAAGCTGTTGTCCTCAAT
TCCAAGGATAAGGCTCCCTACCTGATCTATGTGGAAGTTCTTGAATGTGAAAACTTCGACACAACTAATGTTCCTGCCCGGATTCCTGAAAACCGAATTCGGAGTACGAGGTCTGTGGAGAACCTGCC
GGAATGTGGTATCACTCACGAGCAGCGGGCTGGCAGCTTCAGCACTGTGCCCAATTATGACAATGACGATGAAGCCTGGTCGGTGGATGACATAGGCGAGCTGCAGGTGGAGCTCCCAGAAGTGCACA
CCAACAGCTGTGACAACATCTCTCAGTTCTCGGTGGACAGCATCACCAGCCAGGAGAGCAAGGAGCCTGTGTTCATTGCGGCAGGGGACATCAGACGGCGCCTTTCAGAACAGCTGGCTCACACTCCC
ACAGCCTTCAAACGAGACCCTGAAGACCCTTCTGCAGTCGCCCTCAAAGAGCCCTGGCAGGAGAAAGTGCGGAGGATCAGAGAAGGTTCCCCGTATGGCCATCTTCCCAATTGGCGACTCCTTTCAGT
CATTGTCAAGTGTGGAGATGACCTTCGCCAGGAGCTGCTGGCTTTCCAGGTGTTGAAACAACTGCAGTCCATTTGGGAACAGGAGCGAGTGCCTCTTTGGATCAAGCCATATAAGATTCTTGTGATTT
CAGCTGACAGTGGCATGATTGAACCAGTAGTCAACGCTGTGTCCATCCACCAGGTGAAGAAACAGTCACAGCTCTCCTTGCTCGATTACTTCCTGCAGGAGCATGGCAGTTACACCACTGAGGCATTC
CTCAGTGCCCAGCGCAATTTTGTGCAAAGTTGTGCTGGCTACTGCTTGGTCTGCTACCTATTACAAGTCAAGGACAGGCACAATGGGAACATCCTTCTGGACGCAGAAGGTCACATCATCCACATCGA
CTTTGGCTTCATCCTTTCCAGCTCACCCCGAAACCTGGGCTTCGAGACGTCAGCCTTTAAGCTGACCACAGAATTTGTGGATGTAATGGGCGGCCTGAACGGTGATATGTTCAACTACTATAAGATGC
TCATGCTGCAAGGGCTGATCGCTGCTCGCAAACACATGGACAAGGTGGTACAGATTGTGGAGATCATGCAGCAAGGTTCTCAGCTTCCTTGCTTCCATGGCTCCAGCACCATTCGCAACCTCAAAGAG
AGGTTCCACATGAGCATGACTGAGGAGCAGCTGCAGCTGCTGGTGGAGCAGATGGTGGACGGCAGCATGAGGTCCATCACCACCAAACTCTACGATGGCTTCCAGTACCTCACCAATGGCATCATGTG
ACACCACTTTCAGGCCCAGAAGTGGTGGGATTGAAGGCACCCTCCTTAGGAGGACCCTTGCCTAAGAAAACCTAAATCACAAAATCCCACCTACCTAACCACCTACCCAAGGGAAATGGAAGGCAAAA
AACACAAAGGATCATGTGGTAACCATGAGAGCTGGCCAAAGGGTAGGAGAGCCAACCATGGGGTCCAGACTTGCTGGGGCTTCCCCACCTCTTGCTGTGTCAGTATTGCCACCTGACAGATCCCAGGA
CTCACTGCCCTCCAGAGAACAGAGATGATGAACATGAGGAGGACTGGAACCTTCTTCCCCTCGGGGATCTCATCTTTTACTATCCCTGGGTCCCAGCAAGATGGGAGGAGTGGGTTCTTGGTACTTAG
GACTT

hide sequence

RefSeq Acc Id:

XM_008761333 ⟹ XP_008759555

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,229,591 - 185,261,697 (+)	NCBI
mRatBN7.2	2	182,540,576 - 182,572,684 (+)	NCBI
Rnor_6.0	2	196,139,724 - 196,172,055 (+)	NCBI

Sequence:

show sequence

GGCATGACTCGGGCAGCTCACCCGACTCAGATTACTATGGCATCGGTAGTGTCCTGACAGTTCG
GAAAGCAGGAAAGCAAGCGCCGAGAAGAAAGGCTCGGGCCCAGCGGACTCTTACATCGCAACCCATCAAGGAATTGTTATTTTGGGTCCTGCAAGTGGGGTCCGGTCCAACTTGAGGTAGCGTGAAGG
CCCCTTCAGGCGGCGCCGCGGGCAGCCCCGCAGCCGGGGCCTGGTGCAGCCGCCGCGGCCGCTGTCAGGGAAGCGCAGGCGGCCAATGGAACCCGGGAGCGGCCGCTGCTGCTGAGGCGGCGGTGTCG
GCAGTCCGACCCCGACCGCCTGCACCCCCTCCGCGAGGGTCCCCCGGAGGATGGTGCTCAAGCCACCAAACTTGCACACACGGCAAGTGCTCCTACCCACTGAGCCTCCCTCACCTGTCCTATGCCCA
GCTTTCTGCACCTGTTGATGTCATCTGGTTTCTCGAACAGCTTGGAAGCTCGAAGTCTGGCTGTAGCCATGGGAGACATGGTAGTGGAGCCTGCCACCCTGAAGCCAACTTCTGAGCCTACTCCTAGC
CCATCAGGGAATAACGGGGGCTCCCTACTAAGCGTCATCACGGAGGGGGTCGGGGAACTGTCAGTGATTGACCCTGAGGTGGCCCAGAAGGCCTGCCAGGAGGTACTGGAGAAAGTCAAGCTTTTGCA
TGGAGGTGTAGCCATCTCTAGCAAAGGCAGCCCACTGGAGTTGGTTAATGGGGATGGTGTGGACAATGAGATCCGTTGCCTAGATGATCCACCTACCGAGATCAGGGAGGAAGAAGATGAGATGGAGC
CTGGTGTGGTCTCTGGCACAGCCAAAGGAACAAGAAGAAGACGACAGAACAACTCAGCCAAACAGTCTTGGCTCCTGAGGCTGTTTGAATCAAAACTATTTGACATCTCTATGGCCATTTCATACTTG
TATAACTCCAAGGAGCCGGGAGTGCAAGCCTACATTGGCAACCGGCTCTTCTGCTTTCGCAATGAGGATGTGGACTTCTATTTGCCCCAGTTGCTTAACATGTATATCCATATGGATGAGGATGTGGG
TGATGCCATTAAACCCTACATAGTCCACCGTTGTCGCCAGAGCATCAACTTTTCCCTCCAGTGTGCCCTGTTGCTTGGGGCCTACTCTTCAGACATGCACATTTCTACTCAACGACACTCCCGAGGGA
CCAAGTTACGGAAGCTAATCCTCTCAGATGAGCTGAAGCCAGCTCACCGAAAGAGGGAGCTGCCAACTTTAAGCCCAGCCCCTGACACAGGACTGTCTCCCTCTAAAAGGACTCACCAGCGCTCTAAG
TCAGATGCCACGGCCAGCATAAGTCTCAGCAGCAACCTGAAACGAACAGCCAGCAACCCTAAAGTGGAGAATGAGGATGAGGAGCTCTCCTCCAGCACCGAGAGTATTGATAATTCATTCAGTTCCCC
TGTCCGGCTGGCCCCTGAGCGAGAATTCATCAAGTCCTTGATGGCAATCGGCAAACGGCTGGCCACGCTCCCCACTAAAGAGCAAAAAACACAAAGGCTGATCTCAGAACTTTCCCTGCTCAACCATA
AGCTCCCTGCCCGAGTCTGGCTGCCCACAGCTGGCTTTGACCACCACGTGGTCCGTGTGCCCCACACACAAGCTGTTGTCCTCAATTCCAAGGATAAGGCTCCCTACCTGATCTATGTGGAAGTTCTT
GAATGTGAAAACTTCGACACAACTAATGTTCCTGCCCGGATTCCTGAAAACCGAATTCGGAGTACGAGGTCTGTGGAGAACCTGCCGGAATGTGGTATCACTCACGAGCAGCGGGCTGGCAGCTTCAG
CACTGTGCCCAATTATGACAATGACGATGAAGCCTGGTCGGTGGATGACATAGGCGAGCTGCAGGTGGAGCTCCCAGAAGTGCACACCAACAGCTGTGACAACATCTCTCAGTTCTCGGTGGACAGCA
TCACCAGCCAGGAGAGCAAGGAGCCTGTGTTCATTGCGGCAGGGGACATCAGACGGCGCCTTTCAGAACAGCTGGCTCACACTCCCACAGCCTTCAAACGAGACCCTGAAGACCCTTCTGCAGTCGCC
CTCAAAGAGCCCTGGCAGGAGAAAGTGCGGAGGATCAGAGAAGGTTCCCCGTATGGCCATCTTCCCAATTGGCGACTCCTTTCAGTCATTGTCAAGTGTGGAGATGACCTTCGCCAGGAGCTGCTGGC
TTTCCAGGTGTTGAAACAACTGCAGTCCATTTGGGAACAGGAGCGAGTGCCTCTTTGGATCAAGCCATATAAGATTCTTGTGATTTCAGCTGACAGTGGCATGATTGAACCAGTAGTCAACGCTGTGT
CCATCCACCAGGTGAAGAAACAGTCACAGCTCTCCTTGCTCGATTACTTCCTGCAGGAGCATGGCAGTTACACCACTGAGGCATTCCTCAGTGCCCAGCGCAATTTTGTGCAAAGTTGTGCTGGCTAC
TGCTTGGTCTGCTACCTATTACAAGTCAAGGACAGGCACAATGGGAACATCCTTCTGGACGCAGAAGGTCACATCATCCACATCGACTTTGGCTTCATCCTTTCCAGCTCACCCCGAAACCTGGGCTT
CGAGACGTCAGCCTTTAAGCTGACCACAGAATTTGTGGATGTAATGGGCGGCCTGAACGGTGATATGTTCAACTACTATAAGATGCTCATGCTGCAAGGGCTGATCGCTGCTCGCAAACACATGGACA
AGGTGGTACAGATTGTGGAGATCATGCAGCAAGGTTCTCAGCTTCCTTGCTTCCATGGCTCCAGCACCATTCGCAACCTCAAAGAGAGGTTCCACATGAGCATGACTGAGGAGCAGCTGCAGCTGCTG
GTGGAGCAGATGGTGGACGGCAGCATGAGGTCCATCACCACCAAACTCTACGATGGCTTCCAGTACCTCACCAATGGCATCATGTGACACCACTTTCAGGCCCAGAAGTGGTGGGATTGAAGGCACCC
TCCTTAGGAGGACCCTTGCCTAAGAAAACCTAAATCACAAAATCCCACCTACCTAACCACCTACCCAAGGGAAATGGAAGGCAAAAAACACAAAGGATCATGTGGTAACCATGAGAGCTGGCCAAAGG
GTAGGAGAGCCAACCATGGGGTCCAGACTTGCTGGGGCTTCCCCACCTCTTGCTGTGTCAGTATTGCCACCTGACAGATCCCAGGACTCACTGCCCTCCAGAGAACAGAGATGATGAACATGAGGAGG
ACTGGAACCTTCTTCCCCTCGGGGATCTCAGAGGTTTTCTACAAAACCATCTTTTACTTTCCCTGGGTCCCAGCAAGATGGGAGGAGTGGGTTCTTGGTACTTAGGACTTAATCCTATGTTTGGCCAT
GCTGCTGCCCAACTCTGTCCCCATCTGGGGGCTGACCCCTAGCCCACATTCCCGACAGGTGGGTCCTGCACTTGCTTAGGTTCCCCATCATGGGGGTAAGGAAGGGAACTGACACGATCCCTCTAATA
TATTGAGGGTATTGGCTTAGCCATGGGGAAATTTCTCACCCTGATCCTTTCCTCACACCCAGGGAAATAGCTCTCATTTTTTTTTTTTAATTTTTAATTTTTGTTTGAAATAAAGTCCTTAGTTAGC

hide sequence

RefSeq Acc Id:

XM_039103230 ⟹ XP_038959158

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,229,591 - 185,261,697 (+)	NCBI
mRatBN7.2	2	182,540,576 - 182,572,684 (+)	NCBI

RefSeq Acc Id:

XM_039103231 ⟹ XP_038959159

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,229,592 - 185,261,697 (+)	NCBI
mRatBN7.2	2	182,540,576 - 182,572,684 (+)	NCBI

RefSeq Acc Id:

XM_039103232 ⟹ XP_038959160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,229,592 - 185,261,697 (+)	NCBI
mRatBN7.2	2	182,540,576 - 182,572,684 (+)	NCBI

RefSeq Acc Id:

XM_039103233 ⟹ XP_038959161

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,229,591 - 185,261,697 (+)	NCBI
mRatBN7.2	2	182,540,576 - 182,572,684 (+)	NCBI

RefSeq Acc Id:

XM_039103234 ⟹ XP_038959162

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,229,691 - 185,261,697 (+)	NCBI
mRatBN7.2	2	182,540,575 - 182,572,684 (+)	NCBI

RefSeq Acc Id:

XM_039103235 ⟹ XP_038959163

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,229,591 - 185,261,697 (+)	NCBI
mRatBN7.2	2	182,540,576 - 182,572,684 (+)	NCBI

RefSeq Acc Id:

XM_063282632 ⟹ XP_063138702

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,229,592 - 185,261,697 (+)	NCBI

RefSeq Acc Id:

XM_063282633 ⟹ XP_063138703

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	185,239,717 - 185,261,697 (+)	NCBI


Protein RefSeqs	NP_112345	(Get FASTA)	NCBI Sequence Viewer
	XP_008759555	(Get FASTA)	NCBI Sequence Viewer
	XP_038959158	(Get FASTA)	NCBI Sequence Viewer
	XP_038959159	(Get FASTA)	NCBI Sequence Viewer
	XP_038959160	(Get FASTA)	NCBI Sequence Viewer
	XP_038959161	(Get FASTA)	NCBI Sequence Viewer
	XP_038959162	(Get FASTA)	NCBI Sequence Viewer
	XP_038959163	(Get FASTA)	NCBI Sequence Viewer
	XP_063138702	(Get FASTA)	NCBI Sequence Viewer
	XP_063138703	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA18969	(Get FASTA)	NCBI Sequence Viewer
	EDL85763	(Get FASTA)	NCBI Sequence Viewer
	EDL85764	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000039342
	ENSRNOP00000082231
	ENSRNOP00000089657
	ENSRNOP00000093461
	ENSRNOP00000095998
GenBank Protein	O08561	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112345 ⟸ NM_031083

- UniProtKB:

O08561 (UniProtKB/Swiss-Prot), A6K2T7 (UniProtKB/TrEMBL), A0A8L2QJX4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQS
WLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPT
LSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHT
QAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSE
QLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGS
YTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSST
IRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM

hide sequence

RefSeq Acc Id:	XP_008759555 ⟸ XM_008761333
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I6ALD3 (UniProtKB/TrEMBL), A0A8L2QJX4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPSFLHLLMSSGFSNSLEARSLAVAMGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGE LSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCF RNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASN PKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRI RSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYG HLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILL DAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDG FQYLTNGIM hide sequence

Ensembl Acc Id:

ENSRNOP00000070653 ⟸ ENSRNOT00000080966

Ensembl Acc Id:

ENSRNOP00000039342 ⟸ ENSRNOT00000040501

RefSeq Acc Id:	XP_038959162 ⟸ XM_039103234
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I6AD21 (UniProtKB/TrEMBL), A0A0G2JYH1 (UniProtKB/TrEMBL)

Protein Domains

PI3K/PI4K catalytic PIK helical

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O08561-F1-model_v2	AlphaFold	O08561	1-816	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13691534

Promoter ID:

EPDNEW_R2059

Type:

initiation region

Name:

Pi4kb_1

Description:

phosphatidylinositol 4-kinase beta

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R2060

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	196,139,717 - 196,139,777	EPDNEW

RGD ID:

13691535

Promoter ID:

EPDNEW_R2060

Type:

initiation region

Name:

Pi4kb_2

Description:

phosphatidylinositol 4-kinase beta

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R2059

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	196,139,963 - 196,140,023	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-52130	BioCyc
BioCyc Pathway	PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis]	BioCyc
	PWY-6352 [3-phosphoinositide biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-6351	BioCyc
	PWY-6352	BioCyc
Ensembl Genes	ENSRNOG00000021024	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000040501	ENTREZGENE
	ENSRNOT00000103639	ENTREZGENE
	ENSRNOT00000112486	ENTREZGENE
	ENSRNOT00000112810	ENTREZGENE
	ENSRNOT00000118319	ENTREZGENE
Gene3D-CATH	1.10.1070.11	UniProtKB/Swiss-Prot
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4	UniProtKB/Swiss-Prot
InterPro	Kinase-like_dom	UniProtKB/Swiss-Prot
	PI3/4_kinase_cat	UniProtKB/Swiss-Prot
	PI3/4_kinase_cat_sf	UniProtKB/Swiss-Prot
	PI3/4_kinase_CS	UniProtKB/Swiss-Prot
	PI4KB-PIK1_PIK	UniProtKB/Swiss-Prot
	PI_Kinase	UniProtKB/Swiss-Prot
	PInositide-3_kin_accessory_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:81747	UniProtKB/Swiss-Prot
NCBI Gene	81747	ENTREZGENE
PANTHER	PHOSPHATIDYLINOSITOL 4-KINASE BETA	UniProtKB/Swiss-Prot
	PI_Kinase	UniProtKB/Swiss-Prot
Pfam	PI3_PI4_kinase	UniProtKB/Swiss-Prot
	PI4KB-PIK1_PIK	UniProtKB/Swiss-Prot
PhenoGen	Pi4kb	PhenoGen
PROSITE	PI3_4_KINASE_1	UniProtKB/Swiss-Prot
	PI3_4_KINASE_2	UniProtKB/Swiss-Prot
	PI3_4_KINASE_3	UniProtKB/Swiss-Prot
	PIK_HELICAL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000021024	RatGTEx
SMART	PI3Kc	UniProtKB/Swiss-Prot
Superfamily-SCOP	Kinase_like	UniProtKB/Swiss-Prot
UniProt	A0A0G2JYH1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZT79	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AD21	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ALD3	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ASK5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QJX4	ENTREZGENE, UniProtKB/TrEMBL
	A6K2T7	ENTREZGENE, UniProtKB/TrEMBL
	O08561	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-01	Pi4kb	phosphatidylinositol 4-kinase beta	Pi4kb	phosphatidylinositol 4-kinase, catalytic, beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-09	Pi4kb	phosphatidylinositol 4-kinase, catalytic, beta	Pi4kb	phosphatidylinositol 4-kinase, catalytic, beta polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-19	Pi4kb	phosphatidylinositol 4-kinase, catalytic, beta polypeptide	Pik4cb	phosphatidylinositol 4-kinase, catalytic, beta polypeptide	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Pik4cb	phosphatidylinositol 4-kinase, catalytic, beta polypeptide		phosphatidylinositol 4-kinase	Name updated	1299863	APPROVED
2002-08-07	Pik4cb	phosphatidylinositol 4-kinase			Symbol and Name status set to provisional	70820	PROVISIONAL

Note Type	Note	Reference
gene_cellular_localization	dispersed in the cytoplasm	633727
gene_expression	expressed ubiquitously; present throughout the grey matter of the brain; enriched in fetal brain	633727
gene_protein	816 amino acids; 91.6 kDa	633727

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways