Symbol:
Foxa2
Name:
forkhead box A2
RGD ID:
2808
Description:
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SMAD binding activity. Involved in positive regulation of transcription by RNA polymerase II and response to insulin. Located in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human FOXA2 (forkhead box A2); PARTICIPATES IN forkhead class A signaling pathway; Hedgehog signaling pathway; maturity-onset diabetes of the young pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
forkhead box protein A2; hepatocyte nuclear factor 3 beta; hepatocyte nuclear factor 3, beta; hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; Hnf3b
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
FOXA2 (forkhead box A2) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Foxa2 (forkhead box A2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Foxa2 (forkhead box A2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
FOXA2 (forkhead box A2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
FOXA2 (forkhead box A2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Foxa2 (forkhead box A2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
FOXA2 (forkhead box A2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
FOXA2 (forkhead box A2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Foxa2 (forkhead box A2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Foxa2 (forkhead box A2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
FOXA2 (forkhead box A2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
foxa2 (forkhead box A2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
pha-4
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Drosophila melanogaster (fruit fly):
fkh
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
foxa2
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 3 155,923,305 - 155,927,508 (-) NCBI GRCr8 mRatBN7.2 3 135,470,123 - 135,474,326 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 3 135,470,131 - 135,474,326 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 3 139,406,140 - 139,410,336 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 3 147,990,259 - 147,994,455 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 3 145,698,089 - 145,702,294 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 3 142,383,084 - 142,387,493 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 142,383,278 - 142,387,481 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 148,793,310 - 148,797,690 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 136,739,009 - 136,743,204 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 3 136,644,581 - 136,648,777 (-) NCBI Celera 3 134,324,023 - 134,328,218 (-) NCBI Celera Cytogenetic Map 3 q41 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Foxa2 Rat (1->4)-beta-D-glucan multiple interactions ISO Foxa2 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of FOXA2 mRNA CTD PMID:36331819 Foxa2 Rat 1,2-dichloroethane increases expression ISO Foxa2 (Mus musculus) 6480464 ethylene dichloride results in increased expression of FOXA2 mRNA CTD PMID:28960355 Foxa2 Rat 1,2-dimethylhydrazine decreases expression EXP 6480464 1 and 2-Dimethylhydrazine results in decreased expression of FOXA2 mRNA CTD PMID:32387197 Foxa2 Rat 1,2-dimethylhydrazine decreases expression ISO Foxa2 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of FOXA2 mRNA CTD PMID:22206623 Foxa2 Rat 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of FOXA2 mRNA CTD PMID:25380136 Foxa2 Rat 17beta-estradiol increases expression ISO FOXA2 (Homo sapiens) 6480464 Estradiol results in increased expression of FOXA2 mRNA CTD PMID:23184660 Foxa2 Rat 17beta-estradiol increases expression ISO Foxa2 (Mus musculus) 6480464 Estradiol results in increased expression of FOXA2 mRNA CTD PMID:39298647 Foxa2 Rat 17beta-estradiol multiple interactions EXP 6480464 [Testosterone co-treated with Estradiol] results in decreased expression of FOXA2 mRNA CTD PMID:32741896 Foxa2 Rat 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of FOXA2 mRNA CTD PMID:32145629 Foxa2 Rat 17beta-estradiol multiple interactions ISO FOXA2 (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of FOXA2 mRNA CTD PMID:30165855 Foxa2 Rat 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO Foxa2 (Mus musculus) 6480464 FOXA2 protein inhibits the reaction [Dihydrotestosterone results in increased expression of LCN5 mRNA] CTD PMID:16740652 Foxa2 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Foxa2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of FOXA2 mRNA CTD PMID:21570461 and PMID:24058054 Foxa2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Foxa2 (Mus musculus) 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of FOXA2 mRNA CTD PMID:25975270 Foxa2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Foxa2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of FOXA2 mRNA CTD PMID:19933214 and PMID:25975270 Foxa2 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Foxa2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of FOXA2 mRNA CTD PMID:24052564 and PMID:37172768 Foxa2 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of FOXA2 mRNA CTD PMID:19490992 Foxa2 Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Foxa2 (Mus musculus) 6480464 2 more ... CTD PMID:38648751 Foxa2 Rat 2,4-dinitrotoluene affects expression EXP 6480464 2 and 4-dinitrotoluene affects the expression of FOXA2 mRNA CTD PMID:21346803 Foxa2 Rat 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 Foxa2 Rat 3,3',4,4',5-pentachlorobiphenyl affects expression ISO Foxa2 (Mus musculus) 6480464 3 more ... CTD PMID:37080397 Foxa2 Rat 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of FOXA2 mRNA CTD PMID:25380136 Foxa2 Rat 4,4'-diaminodiphenylmethane decreases expression ISO Foxa2 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of FOXA2 mRNA CTD PMID:18648102 Foxa2 Rat 4,4'-sulfonyldiphenol increases expression ISO Foxa2 (Mus musculus) 6480464 bisphenol S results in increased expression of FOXA2 mRNA CTD PMID:30951980 and PMID:33297965 Foxa2 Rat 4,4'-sulfonyldiphenol affects expression ISO Foxa2 (Mus musculus) 6480464 bisphenol S affects the expression of FOXA2 mRNA CTD PMID:39298647 Foxa2 Rat 4,4'-sulfonyldiphenol multiple interactions ISO Foxa2 (Mus musculus) 6480464 [bisphenol S co-treated with Tretinoin] results in decreased expression of FOXA2 mRNA CTD PMID:30951980 Foxa2 Rat 5-fluorouracil decreases expression ISO Foxa2 (Mus musculus) 6480464 Fluorouracil results in decreased expression of FOXA2 protein CTD PMID:21296659 Foxa2 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of FOXA2 mRNA CTD PMID:30047161 Foxa2 Rat 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:36863560 Foxa2 Rat acetaldehyde affects expression ISO Foxa2 (Mus musculus) 6480464 Acetaldehyde affects the expression of FOXA2 mRNA CTD PMID:22634333 Foxa2 Rat acetic acid affects expression ISO Foxa2 (Mus musculus) 6480464 Acetic Acid affects the expression of FOXA2 protein CTD PMID:21296659 Foxa2 Rat aflatoxin B1 decreases methylation ISO FOXA2 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of FOXA2 gene CTD PMID:27153756 Foxa2 Rat alachlor increases expression EXP 6480464 alachlor results in increased expression of FOXA2 mRNA CTD PMID:12419858 Foxa2 Rat aldehydo-D-glucose multiple interactions ISO Foxa2 (Mus musculus) 6480464 [Metformin co-treated with Glucose] affects the localization of FOXA2 protein CTD PMID:16489446 Foxa2 Rat all-trans-retinoic acid decreases expression ISO Foxa2 (Mus musculus) 6480464 Tretinoin results in decreased expression of FOXA2 mRNA CTD PMID:12834868 Foxa2 Rat all-trans-retinoic acid affects expression ISO FOXA2 (Homo sapiens) 6480464 Tretinoin affects the expression of FOXA2 mRNA and Tretinoin affects the expression of FOXA2 protein CTD PMID:31600526 Foxa2 Rat all-trans-retinoic acid multiple interactions ISO Foxa2 (Mus musculus) 6480464 [bisphenol S co-treated with Tretinoin] results in decreased expression of FOXA2 mRNA CTD PMID:30951980 Foxa2 Rat all-trans-retinoic acid increases expression ISO FOXA2 (Homo sapiens) 6480464 Tretinoin results in increased expression of FOXA2 mRNA CTD PMID:21934132 and PMID:34742744 Foxa2 Rat all-trans-retinol multiple interactions EXP 6480464 Vitamin A inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein] CTD PMID:16863852 Foxa2 Rat amitrole decreases expression EXP 6480464 Amitrole results in decreased expression of FOXA2 mRNA CTD PMID:30047161 Foxa2 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of FOXA2 mRNA CTD PMID:16483693 Foxa2 Rat arsane multiple interactions ISO Foxa2 (Mus musculus) 6480464 [sodium arsenite results in increased abundance of Arsenic] which affects the expression of FOXA2 mRNA more ... CTD PMID:36689145 Foxa2 Rat arsenic atom multiple interactions ISO Foxa2 (Mus musculus) 6480464 [sodium arsenite results in increased abundance of Arsenic] which affects the expression of FOXA2 mRNA more ... CTD PMID:36689145 Foxa2 Rat arsenite(3-) increases methylation ISO FOXA2 (Homo sapiens) 6480464 arsenite results in increased methylation of FOXA2 promoter CTD PMID:23974009 Foxa2 Rat Azoxymethane multiple interactions ISO Foxa2 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of FOXA2 mRNA CTD PMID:29950665 Foxa2 Rat baicalin decreases expression ISO FOXA2 (Homo sapiens) 6480464 baicalin results in decreased expression of FOXA2 mRNA and baicalin results in decreased expression of FOXA2 protein CTD PMID:32687838 Foxa2 Rat Benoxacor increases expression ISO Foxa2 (Mus musculus) 6480464 benoxacor results in increased expression of FOXA2 mRNA CTD PMID:34850242 Foxa2 Rat benzo[a]pyrene affects expression ISO FOXA2 (Homo sapiens) 6480464 Benzo(a)pyrene affects the expression of FOXA2 mRNA CTD PMID:21714911 Foxa2 Rat benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of FOXA2 mRNA CTD PMID:34283317 Foxa2 Rat benzo[a]pyrene affects methylation ISO FOXA2 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of FOXA2 promoter CTD PMID:27901495 Foxa2 Rat benzo[a]pyrene decreases methylation ISO FOXA2 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of FOXA2 5' UTR CTD PMID:27901495 Foxa2 Rat benzo[a]pyrene decreases expression ISO FOXA2 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of FOXA2 mRNA CTD PMID:26238291 more ... Foxa2 Rat bexarotene decreases expression EXP 6480464 bexarotene results in decreased expression of FOXA2 mRNA CTD PMID:16648578 Foxa2 Rat bis(2-chloroethyl) sulfide increases expression ISO Foxa2 (Mus musculus) 6480464 Mustard Gas results in increased expression of FOXA2 mRNA CTD PMID:15674843 Foxa2 Rat bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of FOXA2 protein CTD PMID:30597186 Foxa2 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of FOXA2 mRNA CTD PMID:25181051 Foxa2 Rat bisphenol A decreases expression ISO Foxa2 (Mus musculus) 6480464 bisphenol A results in decreased expression of FOXA2 mRNA CTD PMID:35479511 Foxa2 Rat bisphenol A increases expression ISO Foxa2 (Mus musculus) 6480464 bisphenol A results in increased expression of FOXA2 mRNA CTD PMID:30951980 and PMID:34585602 Foxa2 Rat bisphenol A affects methylation ISO Foxa2 (Mus musculus) 6480464 bisphenol A affects the methylation of FOXA2 promoter CTD PMID:27334623 Foxa2 Rat bisphenol A affects methylation EXP 6480464 bisphenol A affects the methylation of FOXA2 promoter CTD PMID:27415467 Foxa2 Rat bisphenol F increases expression ISO FOXA2 (Homo sapiens) 6480464 bisphenol F results in increased expression of FOXA2 mRNA CTD PMID:33476716 Foxa2 Rat bisphenol F increases expression ISO Foxa2 (Mus musculus) 6480464 bisphenol F results in increased expression of FOXA2 mRNA CTD PMID:30951980 Foxa2 Rat bromochloroacetic acid affects expression ISO Foxa2 (Mus musculus) 6480464 bromochloroacetic acid affects the expression of FOXA2 protein CTD PMID:21296659 Foxa2 Rat butan-1-ol multiple interactions ISO FOXA2 (Homo sapiens) 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of FOXA2 mRNA CTD PMID:29432896 Foxa2 Rat cadmium atom multiple interactions ISO FOXA2 (Homo sapiens) 6480464 UNC1999 inhibits the reaction [Cadmium results in decreased expression of FOXA2 mRNA] CTD PMID:36321828 Foxa2 Rat cadmium atom decreases expression ISO FOXA2 (Homo sapiens) 6480464 Cadmium results in decreased expression of FOXA2 mRNA CTD PMID:36321828 Foxa2 Rat cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of FOXA2 mRNA CTD PMID:19010381 Foxa2 Rat cadmium dichloride increases expression ISO FOXA2 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of FOXA2 mRNA CTD PMID:38568856 Foxa2 Rat caffeine decreases phosphorylation ISO FOXA2 (Homo sapiens) 6480464 Caffeine results in decreased phosphorylation of FOXA2 protein CTD PMID:35688186 Foxa2 Rat carbamazepine affects expression ISO FOXA2 (Homo sapiens) 6480464 Carbamazepine affects the expression of FOXA2 mRNA CTD PMID:25979313 Foxa2 Rat carbamazepine affects expression ISO Foxa2 (Mus musculus) 6480464 Carbamazepine affects the expression of FOXA2 mRNA CTD PMID:22634333 Foxa2 Rat carbendazim increases expression ISO Foxa2 (Mus musculus) 6480464 carbendazim results in increased expression of FOXA2 mRNA CTD PMID:26071454 Foxa2 Rat carbon nanotube decreases expression ISO Foxa2 (Mus musculus) 6480464 Nanotubes and Carbon analog results in decreased expression of FOXA2 mRNA CTD PMID:25554681 Foxa2 Rat CGP 52608 multiple interactions ISO FOXA2 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to FOXA2 gene] CTD PMID:28238834 Foxa2 Rat CHIR 99021 multiple interactions EXP 6480464 Chir 99021 inhibits the reaction [FOXA2 protein binds to GJA1 promoter] CTD PMID:34283317 Foxa2 Rat CHIR 99021 decreases expression EXP 6480464 Chir 99021 results in decreased expression of FOXA2 mRNA and Chir 99021 results in decreased expression of FOXA2 protein CTD PMID:34283317 Foxa2 Rat chlorpyrifos increases expression ISO Foxa2 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of FOXA2 mRNA CTD PMID:32715474 Foxa2 Rat choline multiple interactions ISO Foxa2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FOXA2 gene CTD PMID:20938992 Foxa2 Rat copper atom multiple interactions ISO FOXA2 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of FOXA2 mRNA CTD PMID:20971185 Foxa2 Rat copper(0) multiple interactions ISO FOXA2 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in decreased expression of FOXA2 mRNA CTD PMID:20971185 Foxa2 Rat curcumin decreases expression ISO Foxa2 (Mus musculus) 6480464 Curcumin results in decreased expression of FOXA2 mRNA CTD PMID:27237783 Foxa2 Rat cyclosporin A increases expression ISO Foxa2 (Mus musculus) 6480464 Cyclosporine results in increased expression of FOXA2 mRNA CTD PMID:19770486 Foxa2 Rat cyclosporin A decreases expression ISO FOXA2 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of FOXA2 mRNA CTD PMID:20106945 and PMID:25562108 Foxa2 Rat cylindrospermopsin increases expression ISO FOXA2 (Homo sapiens) 6480464 cylindrospermopsin results in increased expression of FOXA2 mRNA CTD PMID:24921660 Foxa2 Rat cylindrospermopsin decreases expression ISO FOXA2 (Homo sapiens) 6480464 cylindrospermopsin results in decreased expression of FOXA2 mRNA CTD PMID:30500929 Foxa2 Rat cypermethrin increases expression ISO Foxa2 (Mus musculus) 6480464 cypermethrin results in increased expression of FOXA2 mRNA CTD PMID:32214279 Foxa2 Rat cyproconazole increases expression ISO Foxa2 (Mus musculus) 6480464 cyproconazole results in increased expression of FOXA2 mRNA CTD PMID:22045034 Foxa2 Rat D-glucose multiple interactions ISO Foxa2 (Mus musculus) 6480464 [Metformin co-treated with Glucose] affects the localization of FOXA2 protein CTD PMID:16489446 Foxa2 Rat dexamethasone multiple interactions ISO Foxa2 (Mus musculus) 6480464 Dexamethasone affects the reaction [G6PC2 promoter SNP affects the reaction [FOXA2 protein binds to G6PC2 promoter]] CTD PMID:27653037 Foxa2 Rat dexamethasone decreases expression ISO FOXA2 (Homo sapiens) 6480464 Dexamethasone results in decreased expression of FOXA2 protein CTD PMID:34742744 Foxa2 Rat dextran sulfate multiple interactions ISO Foxa2 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of FOXA2 mRNA CTD PMID:29950665 Foxa2 Rat dibenz[a,h]anthracene increases expression ISO Foxa2 (Mus musculus) 6480464 1 more ... CTD PMID:26377693 Foxa2 Rat dimethyl sulfoxide decreases expression ISO FOXA2 (Homo sapiens) 6480464 Dimethyl Sulfoxide results in decreased expression of FOXA2 mRNA CTD PMID:22105179 Foxa2 Rat dorsomorphin multiple interactions ISO FOXA2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXA2 mRNA CTD PMID:27188386 Foxa2 Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of FOXA2 mRNA CTD PMID:29391264 Foxa2 Rat epoxiconazole decreases expression ISO Foxa2 (Mus musculus) 6480464 epoxiconazole results in decreased expression of FOXA2 mRNA CTD PMID:35436446 Foxa2 Rat estriol increases expression ISO FOXA2 (Homo sapiens) 6480464 Estriol results in increased expression of FOXA2 mRNA CTD PMID:23184660 Foxa2 Rat fentin chloride increases expression EXP 6480464 triphenyltin chloride results in increased expression of FOXA2 mRNA CTD PMID:37156404 Foxa2 Rat flusilazole affects expression ISO Foxa2 (Mus musculus) 6480464 flusilazole affects the expression of FOXA2 mRNA CTD PMID:22634333 Foxa2 Rat folic acid multiple interactions ISO Foxa2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FOXA2 gene CTD PMID:20938992 Foxa2 Rat folic acid decreases expression ISO Foxa2 (Mus musculus) 6480464 Folic Acid results in decreased expression of FOXA2 mRNA CTD PMID:25629700 Foxa2 Rat fumonisin B1 decreases expression ISO Foxa2 (Mus musculus) 6480464 fumonisin B1 results in decreased expression of FOXA2 mRNA CTD PMID:16221962 Foxa2 Rat gamma-aminobutyric acid decreases expression ISO Foxa2 (Mus musculus) 6480464 gamma-Aminobutyric Acid results in decreased expression of FOXA2 mRNA CTD PMID:32048404 Foxa2 Rat genistein increases expression ISO Foxa2 (Mus musculus) 6480464 Genistein results in increased expression of FOXA2 mRNA CTD PMID:21810550 Foxa2 Rat genistein affects expression ISO Foxa2 (Mus musculus) 6480464 Genistein affects the expression of FOXA2 mRNA and Genistein affects the expression of FOXA2 protein CTD PMID:32186404 Foxa2 Rat geraniol decreases expression ISO FOXA2 (Homo sapiens) 6480464 geraniol results in decreased expression of FOXA2 mRNA CTD PMID:27683099 Foxa2 Rat glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of FOXA2 mRNA CTD PMID:24136188 Foxa2 Rat glucose multiple interactions ISO Foxa2 (Mus musculus) 6480464 [Metformin co-treated with Glucose] affects the localization of FOXA2 protein CTD PMID:16489446 Foxa2 Rat glutathione multiple interactions ISO Foxa2 (Mus musculus) 6480464 Glutathione affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of FOXA2 mRNA] and Glutathione affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of FOXA2 protein] CTD PMID:36689145 Foxa2 Rat hexaconazole increases expression ISO Foxa2 (Mus musculus) 6480464 hexaconazole results in increased expression of FOXA2 mRNA CTD PMID:22045034 Foxa2 Rat ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of FOXA2 mRNA CTD PMID:37077353 Foxa2 Rat L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein] CTD PMID:16863852 Foxa2 Rat L-methionine multiple interactions ISO Foxa2 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FOXA2 gene CTD PMID:20938992 Foxa2 Rat lead nitrate multiple interactions ISO Foxa2 (Mus musculus) 6480464 lead nitrate affects the reaction [FOXA2 affects the expression of MT1 mRNA] and lead nitrate affects the reaction [FOXA2 affects the expression of MT2 mRNA] CTD PMID:11891201 Foxa2 Rat lead(0) decreases expression ISO FOXA2 (Homo sapiens) 6480464 Lead results in decreased expression of FOXA2 mRNA CTD PMID:37467947 Foxa2 Rat lipopolysaccharide decreases expression ISO Foxa2 (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of FOXA2 protein CTD PMID:16002565 Foxa2 Rat Mesaconitine increases expression EXP 6480464 mesaconitine results in increased expression of FOXA2 protein CTD PMID:37182599 Foxa2 Rat metformin multiple interactions ISO Foxa2 (Mus musculus) 6480464 [Metformin co-treated with Glucose] affects the localization of FOXA2 protein CTD PMID:16489446 Foxa2 Rat methimazole decreases expression EXP 6480464 Methimazole results in decreased expression of FOXA2 mRNA CTD PMID:30047161 Foxa2 Rat methylmercury chloride increases expression ISO FOXA2 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of FOXA2 mRNA CTD PMID:34328791 Foxa2 Rat N-methyl-N-nitrosourea decreases expression ISO FOXA2 (Homo sapiens) 6480464 Methylnitrosourea results in decreased expression of FOXA2 mRNA CTD PMID:27221058 Foxa2 Rat N-nitrosodimethylamine decreases expression EXP 6480464 Dimethylnitrosamine results in decreased expression of FOXA2 mRNA CTD PMID:25380136 Foxa2 Rat naphthalene increases expression ISO Foxa2 (Mus musculus) 6480464 naphthalene results in increased expression of FOXA2 protein CTD PMID:16239640 Foxa2 Rat nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of FOXA2 mRNA CTD PMID:24136188 Foxa2 Rat nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of FOXA2 mRNA and nitrofen results in decreased expression of FOXA2 protein CTD PMID:16863852 and PMID:31843527 Foxa2 Rat nitrofen multiple interactions ISO FOXA2 (Homo sapiens) 6480464 Vitamin E inhibits the reaction [nitrofen results in decreased expression of FOXA2 mRNA] CTD PMID:16490937 Foxa2 Rat nitrofen decreases expression ISO FOXA2 (Homo sapiens) 6480464 nitrofen results in decreased expression of FOXA2 mRNA CTD PMID:16490937 Foxa2 Rat nitrofen multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein] more ... CTD PMID:16863852 and PMID:31843527 Foxa2 Rat ozone multiple interactions ISO Foxa2 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of FOXA2 mRNA CTD PMID:34911549 Foxa2 Rat paracetamol affects expression ISO Foxa2 (Mus musculus) 6480464 Acetaminophen affects the expression of FOXA2 mRNA CTD PMID:15606129 and PMID:17562736 Foxa2 Rat paracetamol decreases expression ISO FOXA2 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of FOXA2 mRNA CTD PMID:21420995 and PMID:29067470 Foxa2 Rat perfluorooctane-1-sulfonic acid decreases expression ISO Foxa2 (Mus musculus) 6480464 perfluorooctane sulfonic acid results in decreased expression of FOXA2 mRNA CTD PMID:25510869 Foxa2 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Foxa2 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of FOXA2 mRNA CTD PMID:36331819 Foxa2 Rat phenformin decreases expression EXP 6480464 Phenformin results in decreased expression of FOXA2 mRNA CTD PMID:31324951 Foxa2 Rat phenobarbital affects expression ISO Foxa2 (Mus musculus) 6480464 Phenobarbital affects the expression of FOXA2 mRNA CTD PMID:23091169 Foxa2 Rat phenylmercury acetate increases expression ISO FOXA2 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of FOXA2 mRNA CTD PMID:26272509 Foxa2 Rat phenylmercury acetate multiple interactions ISO FOXA2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXA2 mRNA CTD PMID:27188386 Foxa2 Rat pirinixic acid multiple interactions ISO Foxa2 (Mus musculus) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FOXA2 mRNA CTD PMID:19710929 Foxa2 Rat pirinixic acid decreases expression ISO Foxa2 (Mus musculus) 6480464 pirinixic acid results in decreased expression of FOXA2 mRNA CTD PMID:18445702 Foxa2 Rat progesterone decreases expression ISO Foxa2 (Mus musculus) 6480464 Progesterone results in decreased expression of FOXA2 mRNA CTD PMID:22238285 Foxa2 Rat Ptaquiloside decreases expression ISO Foxa2 (Mus musculus) 6480464 ptaquiloside results in decreased expression of FOXA2 mRNA CTD PMID:23274088 Foxa2 Rat raloxifene increases expression ISO FOXA2 (Homo sapiens) 6480464 Raloxifene Hydrochloride results in increased expression of FOXA2 mRNA CTD PMID:23184660 Foxa2 Rat reactive oxygen species decreases expression ISO FOXA2 (Homo sapiens) 6480464 Reactive Oxygen Species results in decreased expression of FOXA2 mRNA CTD PMID:25800948 Foxa2 Rat resveratrol decreases expression ISO FOXA2 (Homo sapiens) 6480464 resveratrol results in decreased expression of FOXA2 mRNA CTD PMID:20878097 Foxa2 Rat resveratrol increases expression ISO FOXA2 (Homo sapiens) 6480464 resveratrol results in increased expression of FOXA2 mRNA CTD PMID:20878097 Foxa2 Rat rotenone increases expression EXP 6480464 Rotenone results in increased expression of FOXA2 mRNA CTD PMID:28374803 Foxa2 Rat SB 431542 multiple interactions ISO FOXA2 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FOXA2 mRNA CTD PMID:27188386 Foxa2 Rat silicon dioxide decreases expression ISO FOXA2 (Homo sapiens) 6480464 Silicon Dioxide analog results in decreased expression of FOXA2 mRNA CTD PMID:25895662 Foxa2 Rat silicon dioxide decreases expression ISO Foxa2 (Mus musculus) 6480464 Silicon Dioxide results in decreased expression of FOXA2 mRNA CTD PMID:23221170 Foxa2 Rat sodium arsenite multiple interactions ISO FOXA2 (Homo sapiens) 6480464 [sodium arsenite co-treated with monoisoamyl-2 and 3-dimercaptosuccinate] results in decreased expression of FOXA2 mRNA CTD PMID:19615344 Foxa2 Rat sodium arsenite decreases expression ISO Foxa2 (Mus musculus) 6480464 sodium arsenite results in decreased expression of FOXA2 mRNA CTD PMID:37682722 Foxa2 Rat sodium arsenite multiple interactions ISO Foxa2 (Mus musculus) 6480464 [sodium arsenite results in increased abundance of Arsenic] which affects the expression of FOXA2 mRNA more ... CTD PMID:36689145 Foxa2 Rat sodium arsenite decreases expression ISO FOXA2 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of FOXA2 mRNA CTD PMID:19615344 Foxa2 Rat sodium dodecyl sulfate increases expression ISO FOXA2 (Homo sapiens) 6480464 Sodium Dodecyl Sulfate results in increased expression of FOXA2 mRNA CTD PMID:31734321 Foxa2 Rat streptozocin multiple interactions EXP 6480464 copper bis(3 and 5-diisopropylsalicylate) inhibits the reaction [Streptozocin results in decreased expression of FOXA2] CTD PMID:23795780 Foxa2 Rat sulfadimethoxine decreases expression EXP 6480464 Sulfadimethoxine results in decreased expression of FOXA2 mRNA CTD PMID:30047161 Foxa2 Rat testosterone multiple interactions EXP 6480464 [Testosterone co-treated with Estradiol] results in decreased expression of FOXA2 mRNA CTD PMID:32741896 Foxa2 Rat tetraphene decreases expression ISO Foxa2 (Mus musculus) 6480464 benz(a)anthracene results in decreased expression of FOXA2 mRNA CTD PMID:26377693 Foxa2 Rat titanium dioxide multiple interactions ISO Foxa2 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of FOXA2 mRNA CTD PMID:29950665 Foxa2 Rat titanium dioxide decreases methylation ISO Foxa2 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of FOXA2 gene and titanium dioxide results in decreased methylation of FOXA2 promoter CTD PMID:35295148 Foxa2 Rat trichloroethene decreases expression ISO Foxa2 (Mus musculus) 6480464 Trichloroethylene results in decreased expression of FOXA2 mRNA CTD PMID:25549359 Foxa2 Rat triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of FOXA2 mRNA CTD PMID:30589522 Foxa2 Rat UNC1999 multiple interactions ISO FOXA2 (Homo sapiens) 6480464 UNC1999 inhibits the reaction [Cadmium results in decreased expression of FOXA2 mRNA] CTD PMID:36321828 Foxa2 Rat urethane decreases expression ISO FOXA2 (Homo sapiens) 6480464 Urethane results in decreased expression of FOXA2 mRNA CTD PMID:28818685 Foxa2 Rat valproic acid increases methylation ISO FOXA2 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of FOXA2 gene CTD PMID:29154799 Foxa2 Rat valproic acid decreases expression ISO Foxa2 (Mus musculus) 6480464 Valproic Acid results in decreased expression of FOXA2 mRNA CTD PMID:27237783 Foxa2 Rat valproic acid decreases expression ISO FOXA2 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of FOXA2 mRNA and Valproic Acid results in decreased expression of FOXA2 protein CTD PMID:23179753 more ... Foxa2 Rat valproic acid affects expression ISO FOXA2 (Homo sapiens) 6480464 Valproic Acid affects the expression of FOXA2 mRNA CTD PMID:25979313 Foxa2 Rat valproic acid increases expression ISO Foxa2 (Mus musculus) 6480464 Valproic Acid results in increased expression of FOXA2 mRNA CTD PMID:22045034 Foxa2 Rat vitamin D decreases expression ISO Foxa2 (Mus musculus) 6480464 Vitamin D deficiency results in decreased expression of FOXA2 mRNA CTD PMID:32330513 Foxa2 Rat vitamin E multiple interactions EXP 6480464 Vitamin E inhibits the reaction [nitrofen results in decreased expression of FOXA2 protein] CTD PMID:16863852 Foxa2 Rat vitamin E multiple interactions ISO FOXA2 (Homo sapiens) 6480464 Vitamin E inhibits the reaction [nitrofen results in decreased expression of FOXA2 mRNA] CTD PMID:16490937 Foxa2 Rat zinc atom increases degradation ISO FOXA2 (Homo sapiens) 6480464 Zinc deficiency results in increased degradation of FOXA2 protein CTD PMID:12107072 Foxa2 Rat zinc dichloride decreases expression ISO FOXA2 (Homo sapiens) 6480464 zinc chloride results in decreased expression of FOXA2 mRNA CTD PMID:21540303 Foxa2 Rat zinc(0) increases degradation ISO FOXA2 (Homo sapiens) 6480464 Zinc deficiency results in increased degradation of FOXA2 protein CTD PMID:12107072
Imported Annotations - KEGG (archival)
Imported Annotations - PID (archival)
(1->4)-beta-D-glucan (ISO) 1,2-dichloroethane (ISO) 1,2-dimethylhydrazine (EXP,ISO) 1-naphthyl isothiocyanate (EXP) 17beta-estradiol (EXP,ISO) 17beta-hydroxy-5alpha-androstan-3-one (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO) 2,4-dinitrotoluene (EXP) 3,3',4,4',5-pentachlorobiphenyl (EXP,ISO) 4,4'-diaminodiphenylmethane (EXP,ISO) 4,4'-sulfonyldiphenol (ISO) 5-fluorouracil (ISO) 6-propyl-2-thiouracil (EXP) 7,12-dimethyltetraphene (EXP) acetaldehyde (ISO) acetic acid (ISO) aflatoxin B1 (ISO) alachlor (EXP) aldehydo-D-glucose (ISO) all-trans-retinoic acid (ISO) all-trans-retinol (EXP) amitrole (EXP) ammonium chloride (EXP) arsane (ISO) arsenic atom (ISO) arsenite(3-) (ISO) Azoxymethane (ISO) baicalin (ISO) Benoxacor (ISO) benzo[a]pyrene (EXP,ISO) bexarotene (EXP) bis(2-chloroethyl) sulfide (ISO) bis(2-ethylhexyl) phthalate (EXP) bisphenol A (EXP,ISO) bisphenol F (ISO) bromochloroacetic acid (ISO) butan-1-ol (ISO) cadmium atom (ISO) cadmium dichloride (EXP,ISO) caffeine (ISO) carbamazepine (ISO) carbendazim (ISO) carbon nanotube (ISO) CGP 52608 (ISO) CHIR 99021 (EXP) chlorpyrifos (ISO) choline (ISO) copper atom (ISO) copper(0) (ISO) curcumin (ISO) cyclosporin A (ISO) cylindrospermopsin (ISO) cypermethrin (ISO) cyproconazole (ISO) D-glucose (ISO) dexamethasone (ISO) dextran sulfate (ISO) dibenz[a,h]anthracene (ISO) dimethyl sulfoxide (ISO) dorsomorphin (ISO) endosulfan (EXP) epoxiconazole (ISO) estriol (ISO) fentin chloride (EXP) flusilazole (ISO) folic acid (ISO) fumonisin B1 (ISO) gamma-aminobutyric acid (ISO) genistein (ISO) geraniol (ISO) glafenine (EXP) glucose (ISO) glutathione (ISO) hexaconazole (ISO) ketoconazole (EXP) L-ascorbic acid (EXP) L-methionine (ISO) lead nitrate (ISO) lead(0) (ISO) lipopolysaccharide (ISO) Mesaconitine (EXP) metformin (ISO) methimazole (EXP) methylmercury chloride (ISO) N-methyl-N-nitrosourea (ISO) N-nitrosodimethylamine (EXP) naphthalene (ISO) nefazodone (EXP) nitrofen (EXP,ISO) ozone (ISO) paracetamol (ISO) perfluorooctane-1-sulfonic acid (ISO) phenformin (EXP) phenobarbital (ISO) phenylmercury acetate (ISO) pirinixic acid (ISO) progesterone (ISO) Ptaquiloside (ISO) raloxifene (ISO) reactive oxygen species (ISO) resveratrol (ISO) rotenone (EXP) SB 431542 (ISO) silicon dioxide (ISO) sodium arsenite (ISO) sodium dodecyl sulfate (ISO) streptozocin (EXP) sulfadimethoxine (EXP) testosterone (EXP) tetraphene (ISO) titanium dioxide (ISO) trichloroethene (ISO) triphenyl phosphate (EXP) UNC1999 (ISO) urethane (ISO) valproic acid (ISO) vitamin D (ISO) vitamin E (EXP,ISO) zinc atom (ISO) zinc dichloride (ISO) zinc(0) (ISO)
Biological Process
adult locomotory behavior (ISO,ISS) anatomical structure formation involved in morphogenesis (ISO) anatomical structure morphogenesis (IBA,ISO) anterior/posterior pattern specification (ISO) cell development (ISO) cell differentiation (IBA) cell differentiation in hindbrain (ISO) cell fate specification (ISO,ISS) cellular response to cadmium ion (ISO) chromatin organization (IEA) connective tissue development (ISO) dopaminergic neuron differentiation (IEA,ISO,ISS) dorsal/ventral neural tube patterning (ISO) dorsal/ventral pattern formation (ISO) ectoderm formation (ISO) endocrine pancreas development (IEA,ISO) epithelial tube branching involved in lung morphogenesis (ISO) gene expression (ISO) glucose mediated signaling pathway (ISO) in utero embryonic development (ISO) lung development (ISO) lung epithelial cell differentiation (ISO) mesendoderm development (ISO) negative regulation of epithelial to mesenchymal transition (IEA,ISO) negative regulation of neuron differentiation (ISO) negative regulation of transcription by RNA polymerase II (IDA,ISO) neuron differentiation (ISO) neuron fate specification (ISO) Notch signaling pathway (ISO) pattern specification process (ISO) positive regulation of DNA-templated transcription (IEA,ISO,ISS) positive regulation of dopaminergic neuron differentiation (ISO) positive regulation of embryonic development (ISO,ISS) positive regulation of gastrulation (ISO,ISS) positive regulation of neuron differentiation (ISO) positive regulation of smoothened signaling pathway (ISO) positive regulation of transcription by RNA polymerase II (IDA,IEA,IMP,ISO) positive regulation of transcription by RNA polymerase III (ISO) primitive streak formation (ISO,ISS) regulation of blood coagulation (IEA,ISO) regulation of DNA-templated transcription (IDA,IEA,ISO) regulation of gene expression (ISO) regulation of insulin secretion involved in cellular response to glucose stimulus (ISO) regulation of lipid metabolic process (ISO) regulation of steroid metabolic process (ISO) regulation of transcription by RNA polymerase II (IBA,IEA,ISO) response to insulin (IEP) signal transduction involved in regulation of gene expression (ISO) smoothened signaling pathway (ISO) somite rostral/caudal axis specification (ISO) transcription by RNA polymerase II (ISO)
Molecular Function
chromatin binding (ISO) DNA binding (IEA,ISO) DNA-binding transcription activator activity, RNA polymerase II-specific (IDA,ISO) DNA-binding transcription factor activity (IDA,IEA,IMP,ISO) DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,ISO) DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO) double-stranded DNA binding (IDA,ISO) kinase binding (IPI) nucleic acid binding (ISO) protein binding (IPI,ISO) protein domain specific binding (IEA) RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IDA,ISO) RNA polymerase II-specific DNA-binding transcription factor binding (IPI) sequence-specific DNA binding (IDA,IEA,ISO) sequence-specific double-stranded DNA binding (IEA,ISO) SMAD binding (IDA) transcription cis-regulatory region binding (IEA,ISO) transcription corepressor activity (IDA)
1.
Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians.
Abderrahmani A, etal., Diabetes. 2000 Feb;49(2):306-8.
2.
Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivo.
Banks KE, etal., J Virol 2002 Dec;76(24):12974-80.
3.
Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells.
Boonsaen T, etal., Biochem J. 2007 Jul 15;405(2):359-67.
4.
Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors.
Foucher I, etal., Development. 2003 May;130(9):1867-76. doi: 10.1242/dev.00414.
5.
SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta.
Freitas HS, etal., Mol Cell Endocrinol. 2009 Jun 16;305(1-2):63-70. Epub 2009 Mar 4.
6.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.
Upstream region of rat serum albumin gene promoter contributes to promoter activity: presence of functional binding site for hepatocyte nuclear factor-3.
Hsiang CH, etal., Biochem J. 1999 Mar 1;338 ( Pt 2):241-9.
8.
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.
Lai E, etal., Genes Dev 1991 Mar;5(3):416-27.
9.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
10.
SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains.
Minoo P, etal., Nucleic Acids Res. 2008 Jan;36(1):179-88. Epub 2007 Nov 14.
11.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.
Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2.
Nock A, etal., J Biol Chem. 2009 Jul 24;284(30):19915-26. Epub 2009 May 28.
13.
Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression.
Park SH and Waxman DJ, J Biol Chem 2001 Nov 16;276(46):43031-9.
14.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
15.
PID Annotation Import Pipeline
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16.
GOA pipeline
RGD automated data pipeline
17.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
18.
Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.
Sund NJ, etal., Genes Dev. 2001 Jul 1;15(13):1706-15.
19.
Genetic variants of FOXA2: risk of type 2 diabetes and effect on metabolic traits in North Indians.
Tabassum R, etal., J Hum Genet. 2008;53(11-12):957-65. Epub 2008 Sep 17.
20.
Tentative Sequence Identification Numbers
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21.
Low levels of eosinophil cationic proteins in patients with asthma.
Venge P, etal., Lancet 1977 Aug 20;2(8034):373-5.
22.
Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release.
Wang H, etal., J Biol Chem. 2002 May 17;277(20):17564-70. Epub 2002 Mar 1.
23.
Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.
Wang JC, etal., J Biol Chem. 2000 Jun 16;275(24):18418-23.
24.
The ratio of FoxA1 to FoxA2 in lung adenocarcinoma is regulated by LncRNA HOTAIR and chromatin remodeling factor LSH.
Wang R, etal., Sci Rep. 2015 Dec 11;5:17826. doi: 10.1038/srep17826.
25.
Hepatocyte nuclear factor-4alpha interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression.
Wang Z and Burke PA, FEBS J. 2010 Oct;277(19):4066-75. doi: 10.1111/j.1742-4658.2010.07802.x. Epub 2010 Aug 23.
26.
Role of Foxa-2 in adipocyte metabolism and differentiation.
Wolfrum C, etal., J Clin Invest. 2003 Aug;112(3):345-56. Epub 2003 Jul 15.
27.
Identification of missense mutations in the hepatocyte nuclear factor-3beta gene in Japanese subjects with late-onset Type II diabetes mellitus.
Zhu Q, etal., Diabetologia. 2000 Sep;43(9):1197-200.
Foxa2 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 3 155,923,305 - 155,927,508 (-) NCBI GRCr8 mRatBN7.2 3 135,470,123 - 135,474,326 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 3 135,470,131 - 135,474,326 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 3 139,406,140 - 139,410,336 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 3 147,990,259 - 147,994,455 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 3 145,698,089 - 145,702,294 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 3 142,383,084 - 142,387,493 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 142,383,278 - 142,387,481 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 148,793,310 - 148,797,690 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 136,739,009 - 136,743,204 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 3 136,644,581 - 136,648,777 (-) NCBI Celera 3 134,324,023 - 134,328,218 (-) NCBI Celera Cytogenetic Map 3 q41 NCBI
FOXA2 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 20 22,580,998 - 22,585,490 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 20 22,580,998 - 22,585,455 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 20 22,561,636 - 22,566,128 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 20 22,509,823 - 22,514,102 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Celera 20 22,635,086 - 22,639,544 (-) NCBI Celera Cytogenetic Map 20 p11.21 NCBI HuRef 20 22,523,682 - 22,527,950 (-) NCBI HuRef CHM1_1 20 22,562,253 - 22,566,723 (-) NCBI CHM1_1 T2T-CHM13v2.0 20 22,640,367 - 22,644,859 (-) NCBI T2T-CHM13v2.0
Foxa2 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 2 147,884,797 - 147,888,889 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 2 147,884,797 - 147,888,889 (-) Ensembl GRCm39 Ensembl GRCm38 2 148,042,877 - 148,046,969 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 2 148,042,877 - 148,046,969 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 2 147,868,614 - 147,872,705 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 2 147,734,364 - 147,738,410 (-) NCBI MGSCv36 mm8 Celera 2 149,306,403 - 149,310,523 (-) NCBI Celera Cytogenetic Map 2 G3 NCBI cM Map 2 73.38 NCBI
Foxa2 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955415 29,982,940 - 29,986,255 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955415 29,982,940 - 29,987,093 (-) NCBI ChiLan1.0 ChiLan1.0
FOXA2 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 21 23,451,059 - 23,454,654 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 20 23,447,894 - 23,451,489 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 20 22,519,942 - 22,524,262 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 20 22,872,251 - 22,874,997 (-) NCBI panpan1.1 PanPan1.1 panPan2
FOXA2 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 24 1,010,370 - 1,013,791 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 24 1,010,651 - 1,013,072 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 24 1,034,459 - 1,038,788 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 24 1,413,104 - 1,417,432 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 24 1,414,234 - 1,417,447 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 24 1,010,961 - 1,015,301 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 24 1,114,770 - 1,118,263 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 24 1,388,439 - 1,392,767 (+) NCBI UU_Cfam_GSD_1.0
Foxa2 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024408640 149,544,748 - 149,549,068 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936620 2,966,341 - 2,969,349 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936620 2,966,341 - 2,969,349 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
FOXA2 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 17 29,997,401 - 30,001,707 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 17 29,997,397 - 30,001,704 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 17 34,053,453 - 34,057,746 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
FOXA2 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 2 51,577,127 - 51,585,168 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 2 51,577,833 - 51,580,297 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666078 6,377,377 - 6,381,582 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Foxa2
.
Predicted Target Of
Count of predictions: 72 Count of miRNA genes: 65 Interacting mature miRNAs: 70 Transcripts: ENSRNOT00000017742 Prediction methods: Miranda, Rnahybrid Result types: miRGate_prediction
2312673 Scl63 Serum cholesterol level QTL 63 0.001 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 3 98535255 168026850 Rat 1598877 Bp285 Blood pressure QTL 285 1.5 0.03 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 3 120538241 165538241 Rat 1578653 Vnigr3 Vascular neointimal growth QTL 3 3.1 artery morphology trait (VT:0002191) artery neointimal hyperplastic lesion area (CMO:0001414) 3 130656562 169034231 Rat 2302373 Gluco39 Glucose level QTL 39 5.01 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 3 98535386 161695835 Rat 70216 Cm14 Cardiac mass QTL 14 2.1 heart mass (VT:0007028) heart wet weight (CMO:0000069) 3 31172320 163586636 Rat 2292591 Esta4 Estrogen-induced thymic atrophy QTL 4 thymus mass (VT:0004954) thymus wet weight (CMO:0000855) 3 47233211 147415807 Rat 1581568 Rf53 Renal function QTL 53 urine total protein amount (VT:0000032) urine protein excretion rate to body weight ratio (CMO:0001099) 3 56395968 161299569 Rat 1578754 Stresp16 Stress response QTL 16 4 0.001 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) 3 112681431 157681431 Rat 1300173 Rf11 Renal function QTL 11 3.38 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 3 121056165 145956249 Rat 9589106 Insul23 Insulin level QTL 23 13.86 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 3 131635904 169034231 Rat 8694437 Bw167 Body weight QTL 167 22.46 0.001 retroperitoneal fat pad mass (VT:0010430) retroperitoneal fat pad weight to body weight ratio (CMO:0000635) 3 91797474 136797474 Rat 10755461 Coatc16 Coat color QTL 16 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) 3 122438700 167438700 Rat 8662816 Vetf4 Vascular elastic tissue fragility QTL 4 4 renal artery integrity trait (VT:0010642) number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563) 3 59242096 157323038 Rat 1559282 Emca5 Estrogen-induced mammary cancer QTL 5 3.9 mammary gland integrity trait (VT:0010552) percentage of study population developing mammary tumors during a period of time (CMO:0000948) 3 43827364 169034231 Rat 1354611 Despr2 Despair related QTL 2 3.03 0.0028 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) 3 97084464 142084464 Rat 2303620 Vencon4 Ventilatory control QTL 4 3.9 respiration trait (VT:0001943) tidal volume (CMO:0000222) 3 127162703 168026850 Rat 631841 Niddm39 Non-insulin dependent diabetes mellitus QTL 39 3.36 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 3 94856903 159898684 Rat 1576306 Schws3 Schwannoma susceptibility QTL 3 0.001 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 3 118839124 163839124 Rat 619618 Rf3 Renal disease susceptibility QTL 3 6.5 0.001 urine albumin amount (VT:0002871) urine albumin excretion rate to body weight ratio (CMO:0001270) 3 107693393 152693393 Rat 1300159 Kidm4 Kidney mass QTL 4 3.83 kidney mass (VT:0002707) right kidney wet weight to body weight ratio (CMO:0001953) 3 121056165 157309487 Rat 2301971 Cm71 Cardiac mass QTL 71 4.63 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) 3 41874578 155617519 Rat 2312659 Slep7 Serum leptin concentration QTL 7 0.001 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 3 98535255 168026850 Rat 631673 Iddm13 Insulin dependent diabetes mellitus QTL 13 1.3 0.663 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 3 130193298 161695983 Rat 2301970 Bw81 Body weight QTL 81 5.19 body mass (VT:0001259) body weight (CMO:0000012) 3 41874578 155617519 Rat 1581546 Pur13 Proteinuria QTL 13 2.93 0.0335 urine total protein amount (VT:0000032) urine protein excretion rate (CMO:0000759) 3 78196190 146592722 Rat 1578656 Vnigr2 Vascular neointimal growth QTL 2 4.2 artery morphology trait (VT:0002191) lesioned artery residual lumen area (CMO:0001417) 3 130656562 169034231 Rat 631541 Bp81 Blood pressure QTL 81 4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 3 124122556 169034231 Rat 2293087 Iddm27 Insulin dependent diabetes mellitus QTL 27 2.68 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 3 97551417 147415807 Rat 2312670 Bw94 Body weight QTL 94 0.01 inguinal fat pad mass (VT:0010424) inguinal fat pad weight to body weight ratio (CMO:0001253) 3 98535255 168026850 Rat 724532 Cm17 Cardiac mass QTL 17 2 heart mass (VT:0007028) calculated heart weight (CMO:0000073) 3 95735366 140735366 Rat
PMC86995P1
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 3 135,471,448 - 135,471,736 (-) MAPPER mRatBN7.2 Rnor_6.0 3 142,385,880 - 142,386,167 NCBI Rnor6.0 Rnor_5.0 3 148,796,077 - 148,796,364 UniSTS Rnor5.0 RGSC_v3.4 3 136,740,327 - 136,740,614 UniSTS RGSC3.4 Celera 3 134,325,341 - 134,325,628 UniSTS Cytogenetic Map 3 q41 UniSTS
Foxa2
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 3 135,471,443 - 135,471,646 (-) MAPPER mRatBN7.2 Rnor_6.0 3 142,385,970 - 142,386,172 NCBI Rnor6.0 Rnor_5.0 3 148,796,167 - 148,796,369 UniSTS Rnor5.0 RGSC_v3.4 3 136,740,322 - 136,740,524 UniSTS RGSC3.4 Celera 3 134,325,336 - 134,325,538 UniSTS Cytogenetic Map 3 q41 UniSTS
UniSTS:474762
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 3 135,471,091 - 135,471,539 (-) MAPPER mRatBN7.2 Rnor_6.0 3 142,386,077 - 142,386,524 NCBI Rnor6.0 Rnor_5.0 3 148,796,274 - 148,796,721 UniSTS Rnor5.0 RGSC_v3.4 3 136,739,970 - 136,740,417 UniSTS RGSC3.4 Celera 3 134,324,984 - 134,325,431 UniSTS Cytogenetic Map 3 q41 UniSTS
UniSTS:547510
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 3 135,471,502 - 135,471,639 (-) MAPPER mRatBN7.2 Rnor_6.0 3 142,385,977 - 142,386,113 NCBI Rnor6.0 Rnor_5.0 3 148,796,174 - 148,796,310 UniSTS Rnor5.0 Celera 3 134,325,395 - 134,325,531 UniSTS Cytogenetic Map 3 q41 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
2
12
74
82
86
59
17
59
6
129
41
59
18
58
27
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Ensembl Acc Id:
ENSRNOT00000017742 ⟹ ENSRNOP00000017742
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 3 135,470,131 - 135,474,326 (-) Ensembl Rnor_6.0 Ensembl 3 142,383,278 - 142,387,481 (+) Ensembl
RefSeq Acc Id:
NM_001399085 ⟹ NP_001386014
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 3 155,923,305 - 155,926,488 (-) NCBI mRatBN7.2 3 135,470,123 - 135,473,306 (-) NCBI
RefSeq Acc Id:
NM_012743 ⟹ NP_036875
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 3 155,923,307 - 155,927,508 (-) NCBI mRatBN7.2 3 135,470,125 - 135,474,326 (-) NCBI Rnor_6.0 3 142,383,290 - 142,387,485 (+) NCBI Rnor_5.0 3 148,793,310 - 148,797,690 (+) NCBI RGSC_v3.4 3 136,739,009 - 136,743,204 (-) RGD Celera 3 134,324,023 - 134,328,218 (-) RGD
Sequence:
TCTCCCGGGTATTGGCTGCAGCTAAGCGGGGCTTCCTGGGCCGACTGAGGTGGGTAGCCAGAAAAAGGCCTGAGGTGGCTGACAACCAGGGCGGCCAGACAACGCGAGTCCTGCGCGCCTTCTGAGGC
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RefSeq Acc Id:
NP_036875 ⟸ NM_012743
- Peptide Label:
isoform 2
- UniProtKB:
P32182 (UniProtKB/Swiss-Prot), G3V7Q2 (UniProtKB/TrEMBL), A6K7B1 (UniProtKB/TrEMBL)
- Sequence:
MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNASLGMNGMNTYMSMSAAAMGSGSGNMSAGSMNMSSYVGAGMSPSLAGMSPGAGAMAGMSGSAGAAGVAGMGPHLSPSLSPLGGQAAGAMGGLAPYA
hide sequence
Ensembl Acc Id:
ENSRNOP00000017742 ⟸ ENSRNOT00000017742
RefSeq Acc Id:
NP_001386014 ⟸ NM_001399085
- Peptide Label:
isoform 1
- UniProtKB:
P32182 (UniProtKB/Swiss-Prot)
RGD ID: 13692494 Promoter ID: EPDNEW_R3019 Type: multiple initiation site Name: Foxa2_1 Description: forkhead box A2 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 3 142,383,261 - 142,383,321 EPDNEW
BioCyc Gene G2FUF-47523 BioCyc
Ensembl Genes ENSRNOG00000013133 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017742 ENTREZGENE
ENSRNOT00000017742.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fork-head_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Fork_head_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Forkhead_box_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
FOX_domain-containing UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TF_fork_head_CS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TF_fork_head_CS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25099 UniProtKB/Swiss-Prot
NCBI Gene 25099 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
HEPATOCYTE NUCLEAR FACTOR 3-BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Forkhead UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Forkhead_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
HNF_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Foxa2 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FORK_HEAD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
FORK_HEAD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
FORK_HEAD_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013133 RatGTEx
SMART SM00339 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC209148
UniProt A6K7B1 ENTREZGENE, UniProtKB/TrEMBL
FOXA2_RAT UniProtKB/Swiss-Prot
G3V7Q2 ENTREZGENE, UniProtKB/TrEMBL
P32182 ENTREZGENE
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2004-09-10
Foxa2
forkhead box A2
Hnf3b
hepatocyte nuclear factor 3, beta
Symbol and Name updated
1299863 APPROVED
2002-11-06
Hnf3b
hepatocyte nuclear factor 3, beta
Hepatocyte nuclear factor 3 beta
Name updated
625702 APPROVED
2002-06-10
Hnf3b
Hepatocyte nuclear factor 3 beta
Symbol and Name status set to approved
70586 APPROVED
Note Type
Note
Reference
gene_process
modulates stimulation of male-specific liver Cyp2c11 expression by Stat5b
70587
gene_process
in combination with with other liver transcription factors, including Hnf1, Cebpa (C/EBP)and Hnf6, mediates liver-specific expression of hepatic Cyp genes.
70587
