Mrps6 (mitochondrial ribosomal protein S6) - Rat Genome Database

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Gene: Mrps6 (mitochondrial ribosomal protein S6) Rattus norvegicus
Analyze
Symbol: Mrps6
Name: mitochondrial ribosomal protein S6
RGD ID: 2322928
Description: Predicted to enable small ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial small ribosomal subunit. Orthologous to human MRPS6 (mitochondrial ribosomal protein S6); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 28S ribosomal protein S6, mitochondrial; LOC100360017; LOC288253; mitochondrial ribosomal protein S6-like; small ribosomal subunit protein bS6m
RGD Orthologs
Human
Mouse
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,778,667 - 44,834,420 (+)NCBIGRCr8
mRatBN7.21131,295,358 - 31,348,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,295,614 - 31,348,484 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01132,208,246 - 32,263,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,211,115 - 32,263,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,815,281 - 35,868,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,998,158 - 32,097,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,054,415 - 32,154,155 (+)NCBI
Celera1130,951,984 - 31,005,364 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
translation  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14651853   PMID:18614015   PMID:25838379  


Genomics

Comparative Map Data
Mrps6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,778,667 - 44,834,420 (+)NCBIGRCr8
mRatBN7.21131,295,358 - 31,348,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,295,614 - 31,348,484 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01132,208,246 - 32,263,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,211,115 - 32,263,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01135,815,281 - 35,868,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41131,998,158 - 32,097,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11132,054,415 - 32,154,155 (+)NCBI
Celera1130,951,984 - 31,005,364 (+)NCBICelera
Cytogenetic Map11q11NCBI
MRPS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,073,578 - 34,143,030 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2134,073,224 - 34,143,034 (+)EnsemblGRCh38hg38GRCh38
GRCh372135,445,878 - 35,515,330 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362134,367,693 - 34,437,200 (+)NCBINCBI36Build 36hg18NCBI36
Build 342134,367,692 - 34,437,198NCBI
Celera2120,645,386 - 20,714,895 (+)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2120,976,108 - 20,993,807 (+)NCBIHuRef
CHM1_12135,008,095 - 35,077,595 (+)NCBICHM1_1
T2T-CHM13v2.02132,455,648 - 32,525,106 (+)NCBIT2T-CHM13v2.0
Mrps6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391691,855,224 - 91,909,115 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1691,855,158 - 91,909,115 (+)EnsemblGRCm39 Ensembl
GRCm381692,058,336 - 92,112,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1692,058,270 - 92,112,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv371692,058,581 - 92,112,472 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361691,947,195 - 92,001,086 (+)NCBIMGSCv36mm8
Celera1693,184,244 - 93,196,878 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1653.44NCBI
Mrps6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497129,201,108 - 29,217,575 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365008,250,248 - 8,267,241 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365008,250,254 - 8,266,725 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRPS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113197,687,906 - 197,756,773 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,518,381 - 207,553,021 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRPS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1258,062,923 - 58,130,815 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl258,063,353 - 58,130,637 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666071565,893 - 633,757 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrps6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474522,231,776 - 22,304,147 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474522,231,789 - 22,304,147 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrps6
297 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:34
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000002752
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

Markers in Region
UniSTS:259143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,315,417 - 31,315,546 (+)MAPPERmRatBN7.2
Rnor_6.01132,230,937 - 32,231,065NCBIRnor6.0
Rnor_5.01135,835,850 - 35,835,978UniSTSRnor5.0
RGSC_v3.41132,064,846 - 32,064,974UniSTSRGSC3.4
Celera1130,972,261 - 30,972,389UniSTS
Cytogenetic Map11q11UniSTS
RH130175  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,324,153 - 31,324,348 (+)MAPPERmRatBN7.2
Rnor_6.01132,239,671 - 32,239,865NCBIRnor6.0
Rnor_5.01135,844,584 - 35,844,778UniSTSRnor5.0
RGSC_v3.41132,073,580 - 32,073,774UniSTSRGSC3.4
Celera1130,980,995 - 30,981,189UniSTS
RH 3.4 Map11217.2UniSTS
RH134101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,348,082 - 31,348,265 (+)MAPPERmRatBN7.2
Rnor_6.01132,263,600 - 32,263,782NCBIRnor6.0
Rnor_5.01135,868,513 - 35,868,695UniSTSRnor5.0
RGSC_v3.41132,097,514 - 32,097,696UniSTSRGSC3.4
Celera1131,004,965 - 31,005,147UniSTS
RH 3.4 Map11206.9UniSTS
BI279882  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,316,132 - 31,316,282 (+)MAPPERmRatBN7.2
Rnor_6.01132,231,652 - 32,231,801NCBIRnor6.0
Rnor_5.01135,836,565 - 35,836,714UniSTSRnor5.0
RGSC_v3.41132,065,561 - 32,065,710UniSTSRGSC3.4
Celera1130,972,976 - 30,973,125UniSTS
RH 3.4 Map11201.9UniSTS
Cytogenetic Map11q11UniSTS
AU049315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,255,527 - 31,255,793 (+)MAPPERmRatBN7.2
Rnor_6.01132,171,915 - 32,172,180NCBIRnor6.0
Rnor_5.01135,776,688 - 35,776,953UniSTSRnor5.0
RGSC_v3.41132,004,629 - 32,004,894UniSTSRGSC3.4


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 55 39 19 39 8 11 74 35 41 11 8
Low 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087452   ⟹   ENSRNOP00000071228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,295,614 - 31,348,484 (+)Ensembl
Rnor_6.0 Ensembl1132,211,115 - 32,263,899 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097460   ⟹   ENSRNOP00000083769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,336,417 - 31,348,484 (+)Ensembl
RefSeq Acc Id: XM_063270891   ⟹   XP_063126961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,778,667 - 44,834,420 (+)NCBI
Protein Sequences
Protein RefSeqs XP_063126961 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071228.1
  ENSRNOP00000083769.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000071228   ⟸   ENSRNOT00000087452
RefSeq Acc Id: ENSRNOP00000083769   ⟸   ENSRNOT00000097460
RefSeq Acc Id: XP_063126961   ⟸   XM_063270891

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M6D0-F1-model_v2 AlphaFold F1M6D0 1-125 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698072
Promoter ID:EPDNEW_R8589
Type:multiple initiation site
Name:Mrps6_1
Description:mitochondrial ribosomal protein S6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01132,211,133 - 32,211,193EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2322928 AgrOrtholog
BioCyc Gene G2FUF-21865 BioCyc
Ensembl Genes ENSRNOG00000059381 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087452.2 UniProtKB/TrEMBL
  ENSRNOT00000097460.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.60 UniProtKB/TrEMBL
InterPro Ribosomal_S6 UniProtKB/TrEMBL
  Ribosomal_S6_sf UniProtKB/TrEMBL
  Transl_elong_EF1B/ribosomal_S6 UniProtKB/TrEMBL
NCBI Gene 100360017 ENTREZGENE
PANTHER 28S RIBOSOMAL PROTEIN S6, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR21011 UniProtKB/TrEMBL
Pfam Ribosomal_S6 UniProtKB/TrEMBL
PhenoGen Mrps6 PhenoGen
RatGTEx ENSRNOG00000059381 RatGTEx
Superfamily-SCOP SSF54995 UniProtKB/TrEMBL
UniProt A0A8I5ZVY2_RAT UniProtKB/TrEMBL
  F1M6D0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 LOC100360017  mitochondrial ribosomal protein S6-like  Mrps6  mitochondrial ribosomal protein S6  Data merged from RGD:1304761 737654 APPROVED
2013-08-01 LOC100360017  mitochondrial ribosomal protein S6-like  LOC100360017  mitochondrial ribosomal protein S6-like  Type changed (type changed from [null] to [protein-coding]) 629549 APPROVED
2010-05-06 LOC100360017  mitochondrial ribosomal protein S6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Mrps6  mitochondrial ribosomal protein S6   Mrps6_predicted  mitochondrial ribosomal protein S6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mrps6_predicted  mitochondrial ribosomal protein S6 (predicted)      Symbol and Name status set to approved 70820 APPROVED