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Gene: Ift140 (intraflagellar transport 140) Rattus norvegicus

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Symbol:

Ift140

Name:

intraflagellar transport 140

RGD ID:

2318759

Description:

Predicted to be involved in intraciliary retrograde transport and regulation of cilium assembly. Predicted to act upstream of or within several processes, including cilium organization; embryonic organ development; and regionalization. Predicted to be located in several cellular components, including microtubule organizing center; nucleoplasm; and photoreceptor cell cilium. Predicted to be part of intraciliary transport particle A. Predicted to be active in axoneme and ciliary basal body. Human ortholog(s) of this gene implicated in retinitis pigmentosa and short-rib thoracic dysplasia 9 with or without polydactyly. Orthologous to human IFT140 (intraflagellar transport 140); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; endosulfan.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

intraflagellar transport protein 140 homolog; LOC100362124

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IFT140 (intraflagellar transport 140)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Ift140 (intraflagellar transport 140)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ift140 (intraflagellar transport 140)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IFT140 (intraflagellar transport 140)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IFT140 (intraflagellar transport 140)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ift140 (intraflagellar transport 140)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IFT140 (intraflagellar transport 140)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	IFT140 (intraflagellar transport 140)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ift140 (intraflagellar transport 140)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ift140 (intraflagellar transport 140)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	IFT140 (intraflagellar transport 140)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ift140 (intraflagellar transport 140 homolog (Chlamydomonas))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	che-11	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	rempA	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ift140	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Allele / Splice:

Ift140^em1Kyo

Genetic Models:

W-Ift140^em1Kyo

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	14,537,134 - 14,624,926 (+)	NCBI		GRCr8
mRatBN7.2	10	14,032,665 - 14,121,682 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	14,032,648 - 14,120,433 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	14,373,668 - 14,461,509 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	14,373,679 - 14,461,160 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	14,189,328 - 14,276,940 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	14,258,556 - 14,348,468 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	13,711,169 - 13,793,096 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift140	Rat	asphyxiating thoracic dystrophy		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Jeune thoracic dystrophy	ClinVar	PMID:16199547\|PMID:17576681\|PMID:22503633\|PMID:23418020\|PMID:24009529\|PMID:25741868\|PMID:26216056\|PMID:28288023\|PMID:28492532\|PMID:28559085\|PMID:28724397\|PMID:29068549\|PMID:29688594\|PMID:30773290\|PMID:31589614\|PMID:31964843\|PMID:32483926\|PMID:34429528\|PMID:34890546\|PMID:35140360\|PMID:9536098
Ift140	Rat	asphyxiating thoracic dystrophy 1		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Chondroectodermal dysplasia-like syndrome \| ClinVar Annotator: match by term: Short-rib more ...	ClinVar	PMID:17576681\|PMID:22503633\|PMID:23418020\|PMID:24009529\|PMID:25741868\|PMID:26216056\|PMID:28288023\|PMID:28492532\|PMID:28559085\|PMID:28724397\|PMID:29068549\|PMID:29688594\|PMID:30773290\|PMID:9536098
Ift140	Rat	autosomal dominant polycystic kidney disease		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Autosomal dominant polycystic kidney disease	ClinVar	PMID:16199547\|PMID:22282595\|PMID:22503633\|PMID:23418020\|PMID:24009529\|PMID:25741868\|PMID:26216056\|PMID:26968735\|PMID:28492532\|PMID:31589614\|PMID:31964843\|PMID:31980526\|PMID:32037395\|PMID:34890546\|PMID:35649421
Ift140	Rat	cystic kidney disease		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Renal cyst	ClinVar	PMID:16199547\|PMID:22282595\|PMID:22503633\|PMID:23418020\|PMID:24009529\|PMID:25741868\|PMID:26216056\|PMID:26968735\|PMID:28492532\|PMID:31589614\|PMID:31630094\|PMID:31736247\|PMID:31964843\|PMID:31980526\|PMID:32037395\|PMID:34890546\|PMID:34906470\|PMID:35649421
Ift140	Rat	epilepsy		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Epilepsy	ClinVar	PMID:28492532
Ift140	Rat	fundus dystrophy		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Retinal dystrophy	ClinVar	PMID:16199547\|PMID:17576681\|PMID:22282595\|PMID:22503633\|PMID:23418020\|PMID:24009529\|PMID:25741868\|PMID:26216056\|PMID:26497376\|PMID:26766544\|PMID:26968735\|PMID:28492532\|PMID:29068549\|PMID:29688594\|PMID:30479745\|PMID:30902645\|PMID:31213501\|PMID:31456290\|PMID:31589614\|PMID:31630094\|PMID:31736247\|PMID:3196484\|PMID:31964843\|PMID:31980526\|PMID:32007091\|PMID:32037395\|PMID:32483926\|PMID:32531858\|PMID:32901917\|PMID:33452237\|PMID:33946315\|PMID:34217267\|PMID:34596737\|PMID:34758253\|PMID:34890546\|PMID:35140360\|PMID:35649421\|PMID:36460718\|PMID:9536098
Ift140	Rat	genetic disease		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532\|PMID:32901917\|PMID:34217267
Ift140	Rat	Idiopathic Generalized Epilepsy		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Idiopathic generalized epilepsy	ClinVar	PMID:28492532
Ift140	Rat	kidney disease		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: renal disease	ClinVar	PMID:25741868\|PMID:32037395
Ift140	Rat	Leber congenital amaurosis		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Leber congenital amaurosis	ClinVar	PMID:25741868
Ift140	Rat	microcephaly		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Microcephaly	ClinVar	PMID:25741868\|PMID:28492532
Ift140	Rat	myoepithelioma		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Myoepithelial tumor	ClinVar
Ift140	Rat	nephronophthisis		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Nephronophthisis	ClinVar	PMID:17576681\|PMID:22503633\|PMID:25741868\|PMID:28288023\|PMID:28492532\|PMID:28559085\|PMID:28724397\|PMID:28844315\|PMID:29068549\|PMID:29688594\|PMID:29706353\|PMID:30773290\|PMID:9536098
Ift140	Rat	nephronophthisis 1		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: juvenile nephronophthisis	ClinVar	PMID:17576681\|PMID:22503633\|PMID:25741868\|PMID:28288023\|PMID:28492532\|PMID:28559085\|PMID:28724397\|PMID:29068549\|PMID:29688594\|PMID:30773290\|PMID:9536098
Ift140	Rat	optic atrophy		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Optic atrophy	ClinVar	PMID:25741868\|PMID:28492532
Ift140	Rat	polycystic kidney disease		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Polycystic kidney disease	ClinVar	PMID:16199547\|PMID:22282595\|PMID:22503633\|PMID:23418020\|PMID:24009529\|PMID:25741868\|PMID:26216056\|PMID:26968735\|PMID:28492532\|PMID:31589614\|PMID:31964843\|PMID:31980526\|PMID:32037395\|PMID:34890546\|PMID:35649421
Ift140	Rat	retinitis pigmentosa		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Retinitis pigmentosa	ClinVar	PMID:16199547\|PMID:22503633\|PMID:23418020\|PMID:24009529\|PMID:25741868\|PMID:26216056\|PMID:26497376\|PMID:26766544\|PMID:26968735\|PMID:28041643\|PMID:28492532\|PMID:28559085\|PMID:29068549\|PMID:29688594\|PMID:30479745\|PMID:31213501\|PMID:31456290\|PMID:31589614\|PMID:31630094\|PMID:31736247\|PMID:3196484\|PMID:31964843\|PMID:31980526\|PMID:32007091\|PMID:32483926\|PMID:32531858\|PMID:33452237\|PMID:34429528\|PMID:34596737\|PMID:34758253\|PMID:34890546\|PMID:34906470\|PMID:35140360\|PMID:36084042\|PMID:38219857
Ift140	Rat	retinitis pigmentosa 80		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Retinal ciliopathy due to mutation in the retinitis pigmentosa-1 gene more ...	ClinVar	PMID:16199547\|PMID:17576681\|PMID:22282595\|PMID:22503633\|PMID:23418020\|PMID:24009529\|PMID:24698627\|PMID:25741868\|PMID:26216056\|PMID:26359340\|PMID:26766544\|PMID:26968735\|PMID:28288023\|PMID:28492532\|PMID:28512305\|PMID:28559085\|PMID:28724397\|PMID:29068549\|PMID:29111861\|PMID:29688594\|PMID:30479745\|PMID:30773290\|PMID:31047384\|PMID:31054281\|PMID:31130284\|PMID:31213501\|PMID:31589614\|PMID:31630094\|PMID:31736247\|PMID:31964843\|PMID:31980526\|PMID:32007091\|PMID:32037395\|PMID:32531858\|PMID:32860008\|PMID:33452237\|PMID:34429528\|PMID:34596737\|PMID:34758253\|PMID:34890546\|PMID:34906470\|PMID:35649421\|PMID:36084042\|PMID:38219857\|PMID:9536098
Ift140	Rat	short-rib thoracic dysplasia 9 with or without polydactyly		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Saldino-Mainzer syndrome \| ClinVar Annotator: match by term: Short-rib thoracic more ...	ClinVar	PMID:16199547\|PMID:17576681\|PMID:19370764\|PMID:19561590\|PMID:20301784\|PMID:20354512\|PMID:22282595\|PMID:22503633\|PMID:23418020\|PMID:24009529\|PMID:24183451\|PMID:24698627\|PMID:25640679\|PMID:25741868\|PMID:26216056\|PMID:26359340\|PMID:26766544\|PMID:26968735\|PMID:27058611\|PMID:27874174\|PMID:28041643\|PMID:28288023\|PMID:28492532\|PMID:28512305\|PMID:28559085\|PMID:28724397\|PMID:28844315\|PMID:28991257\|PMID:29068549\|PMID:29111861\|PMID:29688594\|PMID:29706353\|PMID:29758562\|PMID:29801666\|PMID:30479745\|PMID:30773290\|PMID:30902645\|PMID:31047384\|PMID:31054281\|PMID:31130284\|PMID:31213501\|PMID:31456290\|PMID:31589614\|PMID:31630094\|PMID:31736247\|PMID:31964843\|PMID:31980526\|PMID:32007091\|PMID:32037395\|PMID:32483926\|PMID:32531858\|PMID:32860008\|PMID:32901917\|PMID:33452237\|PMID:33532864\|PMID:33576794\|PMID:33946315\|PMID:34217267\|PMID:34429528\|PMID:34596737\|PMID:34662339\|PMID:34758253\|PMID:34890546\|PMID:34906470\|PMID:35140360\|PMID:35649421\|PMID:36084042\|PMID:36460718\|PMID:38219857\|PMID:9536098
Ift140	Rat	tuberous sclerosis 2		ISO	RGD:1605413	8554872	ClinVar Annotator: match by term: Tuberous sclerosis 2	ClinVar	PMID:16114042\|PMID:17287951\|PMID:20498439\|PMID:28492532\|PMID:29932062

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift140	Rat	asphyxiating thoracic dystrophy		ISO	RGD:1605413	11554173	CTD Direct Evidence: marker/mechanism	CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift140	Rat	asphyxiating thoracic dystrophy 1		ISS	RGD:1553664	13592920	OMIM:208500	MouseDO
Ift140	Rat	short-rib thoracic dysplasia 9 with or without polydactyly		ISS	RGD:1553664	13592920	OMIM:266920	MouseDO

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift140	Rat	retinitis pigmentosa 80		ISO	RGD:1605413	7240710		OMIM
Ift140	Rat	short-rib thoracic dysplasia 9 with or without polydactyly		ISO	RGD:1605413	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift140	Rat	(+)-schisandrin B	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of IFT140 mRNA]	CTD	PMID:31150632
Ift140	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	RGD:1553664	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IFT140 mRNA	CTD	PMID:36331819
Ift140	Rat	17beta-estradiol	decreases expression	ISO	RGD:1605413	6480464	Estradiol results in decreased expression of IFT140 mRNA	CTD	PMID:31614463
Ift140	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1553664	6480464	Tetrachlorodibenzodioxin results in decreased expression of IFT140 mRNA	CTD	PMID:19770486
Ift140	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of IFT140 mRNA	CTD	PMID:33387578
Ift140	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1553664	6480464	Tetrachlorodibenzodioxin affects the expression of IFT140 mRNA	CTD	PMID:21570461
Ift140	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	RGD:1553664	6480464	bisphenol S results in decreased expression of IFT140 mRNA	CTD	PMID:39298647
Ift140	Rat	acrylamide	decreases expression	ISO	RGD:1605413	6480464	Acrylamide results in decreased expression of IFT140 mRNA	CTD	PMID:32763439
Ift140	Rat	aristolochic acid A	decreases expression	ISO	RGD:1605413	6480464	aristolochic acid I results in decreased expression of IFT140 mRNA	CTD	PMID:33212167
Ift140	Rat	arsane	affects methylation	ISO	RGD:1605413	6480464	Arsenic affects the methylation of IFT140 gene	CTD	PMID:25304211
Ift140	Rat	arsane	multiple interactions	ISO	RGD:1605413	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of IFT140 more ...	CTD	PMID:39836092
Ift140	Rat	arsenic atom	affects methylation	ISO	RGD:1605413	6480464	Arsenic affects the methylation of IFT140 gene	CTD	PMID:25304211
Ift140	Rat	arsenic atom	multiple interactions	ISO	RGD:1605413	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of IFT140 more ...	CTD	PMID:39836092
Ift140	Rat	arsenous acid	increases expression	ISO	RGD:1553664	6480464	Arsenic Trioxide results in increased expression of IFT140 mRNA	CTD	PMID:35676786
Ift140	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1553664	6480464	Benzo(a)pyrene results in decreased expression of IFT140 mRNA	CTD	PMID:22228805
Ift140	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1605413	6480464	Benzo(a)pyrene results in increased methylation of IFT140 5' UTR	CTD	PMID:27901495
Ift140	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1605413	6480464	Benzo(a)pyrene affects the methylation of IFT140 intron	CTD	PMID:30157460
Ift140	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1553664	6480464	Benzo(a)pyrene results in increased methylation of IFT140 intron	CTD	PMID:27901495
Ift140	Rat	benzo[e]pyrene	increases methylation	ISO	RGD:1605413	6480464	benzo(e)pyrene results in increased methylation of IFT140 intron	CTD	PMID:30157460
Ift140	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1605413	6480464	Diethylhexyl Phthalate results in decreased expression of IFT140 mRNA	CTD	PMID:31163220
Ift140	Rat	bis(2-ethylhexyl) phthalate	increases expression	ISO	RGD:1553664	6480464	Diethylhexyl Phthalate results in increased expression of IFT140 mRNA	CTD	PMID:34319233
Ift140	Rat	bisphenol A	decreases methylation	ISO	RGD:1605413	6480464	bisphenol A results in decreased methylation of IFT140 gene	CTD	PMID:31601247
Ift140	Rat	bisphenol A	multiple interactions	ISO	RGD:1605413	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of IFT140 gene	CTD	PMID:31601247
Ift140	Rat	bisphenol F	multiple interactions	ISO	RGD:1605413	6480464	[bisphenol F co-treated with Fulvestrant] results in increased methylation of IFT140 gene	CTD	PMID:31601247
Ift140	Rat	cadmium sulfate	multiple interactions	ISO	RGD:1553664	6480464	cadmium sulfate affects the reaction [MTF1 affects the expression of IFT140 mRNA]	CTD	PMID:16221973
Ift140	Rat	chlorpyrifos	decreases expression	ISO	RGD:1553664	6480464	Chlorpyrifos results in decreased expression of IFT140 mRNA	CTD	PMID:37019170
Ift140	Rat	clofibrate	decreases expression	ISO	RGD:1553664	6480464	Clofibrate results in decreased expression of IFT140 mRNA	CTD	PMID:23811191
Ift140	Rat	copper(II) sulfate	decreases expression	ISO	RGD:1605413	6480464	Copper Sulfate results in decreased expression of IFT140 mRNA	CTD	PMID:19549813
Ift140	Rat	cyclosporin A	decreases expression	ISO	RGD:1553664	6480464	Cyclosporine results in decreased expression of IFT140 mRNA	CTD	PMID:19770486
Ift140	Rat	DDE	decreases expression	ISO	RGD:1605413	6480464	Dichlorodiphenyl Dichloroethylene results in decreased expression of IFT140 mRNA	CTD	PMID:38568856
Ift140	Rat	diarsenic trioxide	increases expression	ISO	RGD:1553664	6480464	Arsenic Trioxide results in increased expression of IFT140 mRNA	CTD	PMID:35676786
Ift140	Rat	dicrotophos	increases expression	ISO	RGD:1605413	6480464	dicrotophos results in increased expression of IFT140 mRNA	CTD	PMID:28302478
Ift140	Rat	dorsomorphin	multiple interactions	ISO	RGD:1605413	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Ift140	Rat	endosulfan	decreases expression	EXP		6480464	Endosulfan results in decreased expression of IFT140 mRNA	CTD	PMID:29391264
Ift140	Rat	FR900359	decreases phosphorylation	ISO	RGD:1605413	6480464	FR900359 results in decreased phosphorylation of IFT140 protein	CTD	PMID:37730182
Ift140	Rat	fulvestrant	increases methylation	ISO	RGD:1605413	6480464	Fulvestrant results in increased methylation of IFT140 gene	CTD	PMID:31601247
Ift140	Rat	fulvestrant	multiple interactions	ISO	RGD:1605413	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of IFT140 gene; [bisphenol F co-treated more ...	CTD	PMID:31601247
Ift140	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of IFT140 mRNA	CTD	PMID:33387578
Ift140	Rat	methapyrilene	increases methylation	ISO	RGD:1605413	6480464	Methapyrilene results in increased methylation of IFT140 intron	CTD	PMID:30157460
Ift140	Rat	methylmercury chloride	decreases expression	ISO	RGD:1605413	6480464	methylmercuric chloride results in decreased expression of IFT140 mRNA	CTD	PMID:28001369
Ift140	Rat	okadaic acid	decreases expression	ISO	RGD:1605413	6480464	Okadaic Acid results in decreased expression of IFT140 mRNA	CTD	PMID:38832940
Ift140	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of IFT140 mRNA	CTD	PMID:33387578
Ift140	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1553664	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IFT140 mRNA	CTD	PMID:36331819
Ift140	Rat	phenylmercury acetate	decreases expression	ISO	RGD:1605413	6480464	Phenylmercuric Acetate results in decreased expression of IFT140 mRNA	CTD	PMID:26272509
Ift140	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:1605413	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Ift140	Rat	SB 431542	multiple interactions	ISO	RGD:1605413	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Ift140	Rat	silicon dioxide	decreases expression	ISO	RGD:1605413	6480464	Silicon Dioxide analog results in decreased expression of IFT140 mRNA	CTD	PMID:25895662
Ift140	Rat	silicon dioxide	decreases methylation	ISO	RGD:1605413	6480464	Silicon Dioxide results in decreased methylation of IFT140 gene	CTD	PMID:34973136
Ift140	Rat	sodium arsenite	multiple interactions	ISO	RGD:1605413	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of IFT140 more ...	CTD	PMID:25879800\|PMID:39836092
Ift140	Rat	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of IFT140 mRNA	CTD	PMID:31150632
Ift140	Rat	tetrachloromethane	multiple interactions	EXP		6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of IFT140 mRNA]	CTD	PMID:31150632
Ift140	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of IFT140 mRNA	CTD	PMID:34492290
Ift140	Rat	titanium dioxide	increases expression	ISO	RGD:1553664	6480464	titanium dioxide results in increased expression of IFT140 mRNA	CTD	PMID:29264374
Ift140	Rat	triphenyl phosphate	increases expression	EXP		6480464	triphenyl phosphate results in increased expression of IFT140 mRNA	CTD	PMID:30589522
Ift140	Rat	triptonide	increases expression	ISO	RGD:1553664	6480464	triptonide results in increased expression of IFT140 mRNA	CTD	PMID:33045310
Ift140	Rat	trovafloxacin	decreases expression	ISO	RGD:1553664	6480464	trovafloxacin results in decreased expression of IFT140 mRNA	CTD	PMID:35537566
Ift140	Rat	tungsten	decreases expression	ISO	RGD:1553664	6480464	Tungsten results in decreased expression of IFT140 mRNA	CTD	PMID:30912803
Ift140	Rat	urethane	decreases expression	ISO	RGD:1605413	6480464	Urethane results in decreased expression of IFT140 mRNA	CTD	PMID:28818685
Ift140	Rat	valproic acid	increases methylation	ISO	RGD:1605413	6480464	Valproic Acid results in increased methylation of IFT140 gene	CTD	PMID:29154799
Ift140	Rat	valproic acid	increases expression	ISO	RGD:1605413	6480464	Valproic Acid results in increased expression of IFT140 mRNA	CTD	PMID:37505509

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift140	Rat	cilium assembly	involved_in	ISO	RGD:1605413	1624291	PMID:28724397	RGD	PMID:28724397
Ift140	Rat	cilium assembly	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	cilium assembly	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:5311831 PMID:22282595	RGD	PMID:22282595
Ift140	Rat	cilium assembly	involved_in	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	cilium organization	involved_in	IEA	ARBA:ARBA00027540	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Ift140	Rat	determination of left/right symmetry	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	determination of left/right symmetry	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	PMID:25807483	RGD	PMID:25807483
Ift140	Rat	embryonic brain development	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	embryonic brain development	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:4458412 PMID:23469164	RGD	PMID:23469164
Ift140	Rat	embryonic camera-type eye development	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:4458412 PMID:23469164	RGD	PMID:23469164
Ift140	Rat	embryonic camera-type eye development	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	embryonic cranial skeleton morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	embryonic cranial skeleton morphogenesis	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:4458412 PMID:23469164	RGD	PMID:23469164
Ift140	Rat	embryonic digit morphogenesis	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:4458412 PMID:23469164	RGD	PMID:23469164
Ift140	Rat	embryonic digit morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	heart development	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	PMID:25807483	RGD	PMID:25807483
Ift140	Rat	heart development	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	intraciliary retrograde transport	involved_in	ISO	RGD:1605413	1624291	PMID:22503633	RGD	PMID:22503633
Ift140	Rat	intraciliary retrograde transport	involved_in	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	intraciliary retrograde transport	involved_in	IBA	FB:FBgn0260933\|MGI:2146906\|PANTHER:PTN000404361\|UniProtKB:Q96RY7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ift140	Rat	intraciliary retrograde transport	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	intraciliary retrograde transport	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:4458412 PMID:24009529	RGD	PMID:24009529
Ift140	Rat	intraciliary transport	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:5311828 PMID:24619649	RGD	PMID:24619649
Ift140	Rat	intraciliary transport	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	limb morphogenesis	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:4458412 PMID:24009529	RGD	PMID:24009529
Ift140	Rat	limb morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	neural tube patterning	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:4458412 PMID:24009529	RGD	PMID:24009529
Ift140	Rat	neural tube patterning	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	non-motile cilium assembly	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	non-motile cilium assembly	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:4458412 PMID:24009529	RGD	PMID:24009529
Ift140	Rat	photoreceptor cell outer segment organization	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	photoreceptor cell outer segment organization	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:5311828 PMID:24619649	RGD	PMID:24619649
Ift140	Rat	protein localization to cilium	involved_in	ISO	RGD:1605413	1624291	PMID:22503633	RGD	PMID:22503633
Ift140	Rat	protein localization to cilium	involved_in	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	protein localization to cilium	acts_upstream_of_or_within	ISO	RGD:1605413	1624291	PMID:20889716	RGD	PMID:20889716
Ift140	Rat	regulation of cilium assembly	involved_in	ISO	RGD:1605413	1624291	PMID:22503633	RGD	PMID:22503633
Ift140	Rat	regulation of cilium assembly	involved_in	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	regulation of smoothened signaling pathway	acts_upstream_of_or_within	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	regulation of smoothened signaling pathway	acts_upstream_of_or_within	ISO	RGD:1553664	1624291	MGI:4458412 PMID:24009529	RGD	PMID:24009529

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift140	Rat	axoneme	is_active_in	IBA	MGI:2146906\|PANTHER:PTN000404360\|UniProtKB:A0A644F0T7\|UniProtKB:A8BAF1\|UniProtKB:A8BJ87	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ift140	Rat	axoneme	located_in	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	axoneme	located_in	ISO	RGD:1553664	1624291	PMID:20368623, PMID:23418020	RGD	PMID:20368623\|PMID:23418020
Ift140	Rat	cell projection	located_in	IEA	UniProtKB-KW:KW-0966	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ift140	Rat	centriole	located_in	ISO	RGD:1553664	1624291	PMID:29487109	RGD	PMID:29487109
Ift140	Rat	centriole	located_in	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	centrosome	located_in	ISO	RGD:1605413	1624291	PMID:23418020	RGD	PMID:23418020
Ift140	Rat	centrosome	located_in	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	ciliary basal body	is_active_in	IBA	MGI:2146906\|PANTHER:PTN000404360\|UniProtKB:A0A644F0T7\|UniProtKB:A8BAF1\|UniProtKB:A8BJ87\|UniProtKB:Q96RY7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ift140	Rat	ciliary basal body	located_in	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	ciliary basal body	located_in	ISO	RGD:1605413\|UniProtKB:Q96RY7-1	1624291		RGD	GO_REF:0000052
Ift140	Rat	ciliary basal body	located_in	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	ciliary basal body	located_in	ISO	RGD:1605413	1624291	PMID:22503633	RGD	PMID:22503633
Ift140	Rat	ciliary basal body	located_in	ISO	RGD:1553664	1624291	PMID:23418020, PMID:23955340, PMID:24619649	RGD	PMID:23418020\|PMID:23955340\|PMID:24619649
Ift140	Rat	cilium	located_in	ISO	RGD:1605413	1624291	PMID:27932497	RGD	PMID:27932497
Ift140	Rat	cilium	located_in	IEA	UniProtKB-SubCell:SL-0066	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Ift140	Rat	cilium	located_in	IEA	ARBA:ARBA00028353	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Ift140	Rat	cilium	located_in	IEA	UniProtKB-KW:KW-0969	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Ift140	Rat	cilium	located_in	ISO	RGD:1553664	1624291	PMID:20368623, PMID:21209331, PMID:29487109	RGD	PMID:20368623\|PMID:21209331\|PMID:29487109
Ift140	Rat	cilium	located_in	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	cilium	located_in	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	cone photoreceptor outer segment	located_in	ISO	RGD:1553664	1624291	PMID:24619649	RGD	PMID:24619649
Ift140	Rat	cone photoreceptor outer segment	located_in	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	intraciliary transport particle	part_of	IEA	ARBA:ARBA00050083	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Ift140	Rat	intraciliary transport particle A	part_of	ISO	RGD:1605413	1624291	PMID:20889716, PMID:27173435, PMID:27932497	RGD	PMID:20889716\|PMID:27173435\|PMID:27932497
Ift140	Rat	intraciliary transport particle A	part_of	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	intraciliary transport particle A	part_of	ISO	RGD:1553664	1624291	PMID:20889716	RGD	PMID:20889716
Ift140	Rat	intraciliary transport particle A	part_of	IBA	MGI:2146906\|PANTHER:PTN000404361\|UniProtKB:Q96RY7	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ift140	Rat	intraciliary transport particle A	part_of	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	mitochondrion	located_in	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	mitochondrion	located_in	ISO	RGD:1605413\|UniProtKB:Q96RY7-1	1624291		RGD	GO_REF:0000052
Ift140	Rat	non-motile cilium	located_in	ISO	RGD:1553664	1624291	PMID:24009529	RGD	PMID:24009529
Ift140	Rat	non-motile cilium	located_in	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	nucleoplasm	located_in	IEA	UniProtKB:Q96RY7\|ensembl:ENSP00000406012	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ift140	Rat	nucleoplasm	located_in	ISO	RGD:1605413\|UniProtKB:Q96RY7-1	1624291		RGD	GO_REF:0000052
Ift140	Rat	photoreceptor connecting cilium	located_in	ISO	RGD:1553664	1624291	PMID:20368623, PMID:24619649	RGD	PMID:20368623\|PMID:24619649
Ift140	Rat	photoreceptor connecting cilium	located_in	IEA	UniProtKB:E9PY46\|ensembl:ENSMUSP00000024983	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ift140	Rat	protein binding	enables	ISO	RGD:1605413	1624291	UniProtKB:Q8NEZ3\|UniProtKB:Q9HBG6 PMID:27173435, PMID:27932497, PMID:29220510	RGD	PMID:27173435\|PMID:27932497\|PMID:29220510

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:20368623	PMID:20889716	PMID:21209331	PMID:22282595	PMID:22503633	PMID:23418020	PMID:23469164	PMID:23955340	PMID:24009529	PMID:24619649	PMID:25807483	PMID:27932497
PMID:28724397	PMID:29487109

Ift140
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	14,537,134 - 14,624,926 (+)	NCBI		GRCr8
mRatBN7.2	10	14,032,665 - 14,121,682 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	14,032,648 - 14,120,433 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	14,373,668 - 14,461,509 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	14,373,679 - 14,461,160 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	14,189,328 - 14,276,940 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	14,258,556 - 14,348,468 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	13,711,169 - 13,793,096 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

IFT140
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	1,510,427 - 1,612,072 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	1,510,427 - 1,612,072 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	1,560,428 - 1,662,073 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	1,500,431 - 1,597,299 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	1,772,703 - 1,874,383 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	1,486,013 - 1,587,550 (-)	NCBI		HuRef
CHM1_1	16	1,560,388 - 1,662,050 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	1,525,455 - 1,627,919 (-)	NCBI		T2T-CHM13v2.0

Ift140
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	25,235,056 - 25,318,461 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	25,235,059 - 25,318,469 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	25,016,083 - 25,099,499 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	25,016,085 - 25,099,495 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	25,153,031 - 25,236,444 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	24,744,323 - 24,827,086 (+)	NCBI		MGSCv36	mm8
Celera	17	25,543,013 - 25,624,378 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.53	NCBI

Ift140
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	15,630,501 - 15,718,484 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	15,625,429 - 15,719,006 (+)	NCBI	ChiLan1.0	ChiLan1.0

IFT140
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	1,772,348 - 1,877,046 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	5,560,156 - 5,659,086 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	130,150 - 232,369 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	1,566,309 - 1,662,833 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	1,566,824 - 1,658,884 (-)	Ensembl	panpan1.1		panPan2

IFT140
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	39,262,887 - 39,308,912 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	39,295,045 - 39,308,758 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	40,497,349 - 40,577,227 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	39,574,931 - 39,655,255 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	39,577,733 - 39,655,241 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	39,252,090 - 39,332,397 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	39,224,274 - 39,304,564 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	39,702,970 - 39,783,289 (+)	NCBI		UU_Cfam_GSD_1.0

Ift140
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	104,290,046 - 104,364,999 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936694	2,344,283 - 2,423,520 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936694	2,344,448 - 2,419,396 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IFT140
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	40,309,635 - 40,372,135 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	40,309,298 - 40,372,139 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,776,363 - 41,835,312 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IFT140
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	1,419,432 - 1,523,342 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	1,415,664 - 1,521,843 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	29,562,562 - 29,667,409 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ift140
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	621,203 - 711,493 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624913	616,283 - 712,040 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Ift140
282 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	107
Count of miRNA genes:	94
Interacting mature miRNAs:	99
Transcripts:	ENSRNOT00000022063
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
7387235	Uae41	Urinary albumin excretion QTL 41	5.26	0.1874	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	1	29497586	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat

RH127790

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	14,076,808 - 14,077,001 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	14,417,899 - 14,418,091	NCBI	Rnor6.0
Rnor_5.0	10	14,233,321 - 14,233,513	UniSTS	Rnor5.0
RGSC_v3.4	10	14,304,856 - 14,305,048	UniSTS	RGSC3.4
Celera	10	13,749,486 - 13,749,678	UniSTS
Cytogenetic Map	10	q12	UniSTS

RH133574

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	14,056,395 - 14,056,595 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	14,397,500 - 14,397,699	NCBI	Rnor6.0
Rnor_5.0	10	14,213,142 - 14,213,341	UniSTS	Rnor5.0
RGSC_v3.4	10	14,284,461 - 14,284,660	UniSTS	RGSC3.4
Celera	10	13,729,059 - 13,729,258	UniSTS
RH 3.4 Map	10	168.8	UniSTS

This gene Ift140 is modified in the following models/strains:

W-Ift140^em1Kyo

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31


RefSeq Transcripts	NM_001427126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006246055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022063 ⟹ ENSRNOP00000022063

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	14,032,648 - 14,120,433 (+)	Ensembl
Rnor_6.0 Ensembl	10	14,373,679 - 14,461,160 (+)	Ensembl

RefSeq Acc Id:

NM_001427126 ⟹ NP_001414055

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,537,466 - 14,624,926 (+)	NCBI

RefSeq Acc Id:

XM_039087092 ⟹ XP_038943020

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,537,134 - 14,624,926 (+)	NCBI
mRatBN7.2	10	14,032,668 - 14,121,682 (+)	NCBI

RefSeq Acc Id:

XM_039087093 ⟹ XP_038943021

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,537,165 - 14,624,926 (+)	NCBI
mRatBN7.2	10	14,032,668 - 14,121,682 (+)	NCBI

RefSeq Acc Id:

XM_039087096 ⟹ XP_038943024

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,571,927 - 14,624,926 (+)	NCBI
mRatBN7.2	10	14,067,416 - 14,121,682 (+)	NCBI

RefSeq Acc Id:

XM_039087097 ⟹ XP_038943025

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,537,134 - 14,606,569 (+)	NCBI
mRatBN7.2	10	14,032,665 - 14,092,962 (+)	NCBI

RefSeq Acc Id:

XM_063268240 ⟹ XP_063124310

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	14,537,165 - 14,624,926 (+)	NCBI


Protein RefSeqs	NP_001414055	(Get FASTA)	NCBI Sequence Viewer
	XP_038943020	(Get FASTA)	NCBI Sequence Viewer
	XP_038943021	(Get FASTA)	NCBI Sequence Viewer
	XP_038943024	(Get FASTA)	NCBI Sequence Viewer
	XP_038943025	(Get FASTA)	NCBI Sequence Viewer
	XP_063124310	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022063
	ENSRNOP00000022063.5
	ENSRNOP00000100739

Ensembl Acc Id:

ENSRNOP00000022063 ⟸ ENSRNOT00000022063

RefSeq Acc Id:	XP_038943025 ⟸ XM_039087097
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_038943020 ⟸ XM_039087092
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038943021 ⟸ XM_039087093
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038943024 ⟸ XM_039087096
- Peptide Label:	isoform X4

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LY69-F1-model_v2	AlphaFold	F1LY69	1-1463	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13697040

Promoter ID:

EPDNEW_R7563

Type:

single initiation site

Name:

Ift140_1

Description:

intraflagellar transport 140

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R7564

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	14,373,691 - 14,373,751	EPDNEW

RGD ID:

13697044

Promoter ID:

EPDNEW_R7564

Type:

initiation region

Name:

Ift140_2

Description:

intraflagellar transport 140

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R7563

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	14,373,994 - 14,374,054	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-25809	BioCyc
Ensembl Genes	ENSRNOG00000016545	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000022063	ENTREZGENE
	ENSRNOT00000022063.7	UniProtKB/TrEMBL
	ENSRNOT00000146112	ENTREZGENE
Gene3D-CATH	1.25.40.470	UniProtKB/TrEMBL
	2.130.10.10	UniProtKB/TrEMBL
InterPro	TPR-like_helical_dom	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	100362124	ENTREZGENE
PANTHER	IFT140/172-RELATED	UniProtKB/TrEMBL
	INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG	UniProtKB/TrEMBL
PhenoGen	Ift140	PhenoGen
RatGTEx	ENSRNOG00000016545	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	NHL repeat	UniProtKB/TrEMBL
	SSF48452	UniProtKB/TrEMBL
	WD40_like	UniProtKB/TrEMBL
UniProt	F1LY69	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-08-27	Ift140	intraflagellar transport 140	LOC100362124	intraflagellar transport 140	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-05	LOC100362124	intraflagellar transport 140			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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