Ccdc6 (coiled-coil domain containing 6) - Rat Genome Database

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Gene: Ccdc6 (coiled-coil domain containing 6) Rattus norvegicus
Analyze
Symbol: Ccdc6
Name: coiled-coil domain containing 6
RGD ID: 1587433
Description: Predicted to enable identical protein binding activity. Predicted to be located in cytosol. Orthologous to human CCDC6 (coiled-coil domain containing 6); PARTICIPATES IN thyroid cancer pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coiled-coil domain-containing protein 6; LOC691155; similar to coiled-coil domain containing 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82018,431,243 - 18,527,227 (-)NCBIGRCr8
mRatBN7.22018,432,177 - 18,528,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2018,433,695 - 18,528,658 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02019,729,005 - 19,825,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2019,732,894 - 19,825,150 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02021,865,813 - 21,961,494 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42019,160,547 - 19,253,922 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2019,819,225 - 19,915,464 (-)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccdc6Ratautosomal dominant intellectual developmental disorder 70  ISOCCDC6 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual developmental disorder and autosomal dominant 70ClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccdc6RatAlzheimer's disease  ISOCCDC6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:33589840
Ccdc6Ratpapillary thyroid carcinoma  ISOCCDC6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28030816

1 to 20 of 88 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccdc6Rat(+)-catechin multiple interactionsISOCCDC6 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CCDC6 mRNACTDPMID:24763279
Ccdc6Rat1,1-dichloroethene decreases expressionISOCcdc6 (Mus musculus)6480464vinylidene chloride results in decreased expression of CCDC6 mRNACTDPMID:26682919
Ccdc6Rat1,2-dimethylhydrazine multiple interactionsISOCcdc6 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of CCDC6 mRNACTDPMID:22206623
Ccdc6Rat17beta-estradiol increases expressionISOCcdc6 (Mus musculus)6480464Estradiol results in increased expression of CCDC6 mRNACTDPMID:39298647
Ccdc6Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOCcdc6 (Mus musculus)64804642 more ...CTDPMID:31388691
Ccdc6Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOCCDC6 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of CCDC6 mRNACTDPMID:17517823
Ccdc6Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Ccdc6Rat2-methylcholine affects expressionISOCCDC6 (Homo sapiens)6480464beta-methylcholine affects the expression of CCDC6 mRNACTDPMID:21179406
Ccdc6Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of CCDC6 proteinCTDPMID:34915118
Ccdc6Rat3-methylcholanthrene multiple interactionsISOCCDC6 (Homo sapiens)6480464Methylcholanthrene promotes the reaction [AHR protein binds to CCDC6 promoter]CTDPMID:20348232
Ccdc6Rat4,4'-sulfonyldiphenol increases expressionISOCCDC6 (Homo sapiens)6480464bisphenol S results in increased expression of CCDC6 proteinCTDPMID:34186270
Ccdc6Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of CCDC6 mRNACTDPMID:24780913
Ccdc6Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of CCDC6 mRNACTDPMID:30047161
Ccdc6Ratactinomycin D multiple interactionsISOCCDC6 (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of CCDC6 proteinCTDPMID:38460933
Ccdc6Rataflatoxin B1 decreases methylationISOCCDC6 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of CCDC6 geneCTDPMID:27153756
Ccdc6Ratall-trans-retinoic acid increases expressionEXP 6480464Tretinoin results in increased expression of CCDC6 mRNACTDPMID:20488242
Ccdc6Ratall-trans-retinoic acid decreases expressionISOCCDC6 (Homo sapiens)6480464Tretinoin results in decreased expression of CCDC6 mRNACTDPMID:33167477
Ccdc6Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of CCDC6 mRNACTDPMID:30047161
Ccdc6Ratamphetamine decreases expressionEXP 6480464Amphetamine results in decreased expression of CCDC6 mRNACTDPMID:30779732
Ccdc6Rataristolochic acid A decreases expressionISOCCDC6 (Homo sapiens)6480464aristolochic acid I results in decreased expression of CCDC6 mRNACTDPMID:33212167

1 to 20 of 88 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccdc6Ratbiological_process  ND 159840703/2007: no relevant rat dataRGD 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccdc6Ratcytosol located_inIEAUniProtKB:Q16204 and ensembl:ENSP000002631021600115GO_REF:0000107EnsemblGO_REF:0000107
Ccdc6Ratcytosol located_inISOCCDC6 (Homo sapiens)1624291 RGDGO_REF:0000052

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccdc6Ratidentical protein binding enablesISOCCDC6 (Homo sapiens)1624291UniProtKB:Q16204 and PMID:32296183RGDPMID:32296183
Ccdc6Ratidentical protein binding enablesIEAUniProtKB:Q16204 and ensembl:ENSP000002631021600115GO_REF:0000107EnsemblGO_REF:0000107
Ccdc6Ratprotein binding enablesISOCCDC6 (Homo sapiens)1624291UniProtKB:O60504 more ...RGDPMID:23108047 more ...

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ccdc6Ratthyroid cancer pathway  IEA 6907045 KEGGrno:05216

#
Reference Title
Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
PMID:37934513  



Ccdc6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82018,431,243 - 18,527,227 (-)NCBIGRCr8
mRatBN7.22018,432,177 - 18,528,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2018,433,695 - 18,528,658 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02019,729,005 - 19,825,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2019,732,894 - 19,825,150 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02021,865,813 - 21,961,494 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42019,160,547 - 19,253,922 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2019,819,225 - 19,915,464 (-)NCBICelera
Cytogenetic Map20p11NCBI
CCDC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381059,788,747 - 59,906,556 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1059,788,747 - 59,906,556 (-)EnsemblGRCh38hg38GRCh38
GRCh371061,548,505 - 61,666,314 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361061,218,527 - 61,336,824 (-)NCBINCBI36Build 36hg18NCBI36
Build 341061,218,527 - 61,336,314NCBI
Celera1054,814,284 - 54,932,343 (-)NCBICelera
Cytogenetic Map10q21.2NCBI
HuRef1055,536,106 - 55,653,768 (-)NCBIHuRef
CHM1_11061,830,646 - 61,948,180 (-)NCBICHM1_1
T2T-CHM13v2.01060,642,477 - 60,761,263 (-)NCBIT2T-CHM13v2.0
Ccdc6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391069,932,709 - 70,029,030 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1069,932,951 - 70,029,030 (+)EnsemblGRCm39 Ensembl
GRCm381070,096,878 - 70,193,200 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1070,097,121 - 70,193,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv371069,559,869 - 69,655,948 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361069,492,478 - 69,588,557 (+)NCBIMGSCv36mm8
Celera1071,188,144 - 71,284,304 (+)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.68NCBI
Ccdc6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542513,344,926 - 13,444,802 (-)NCBIChiLan1.0ChiLan1.0
CCDC6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2872,000,268 - 72,118,624 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11072,005,589 - 72,123,475 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01056,322,619 - 56,440,410 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11058,537,553 - 58,655,454 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1058,537,553 - 58,655,454 (-)Ensemblpanpan1.1panPan2
CCDC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1411,966,366 - 12,077,797 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl411,970,097 - 12,077,484 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha412,163,831 - 12,275,285 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0412,228,962 - 12,340,439 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl412,232,696 - 12,340,130 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1412,209,626 - 12,317,324 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0412,324,478 - 12,435,855 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0412,635,446 - 12,747,202 (-)NCBIUU_Cfam_GSD_1.0
Ccdc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721369,006,842 - 69,119,891 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366143,092,882 - 3,394,303 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366143,093,083 - 3,206,147 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1463,175,655 - 63,299,373 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11463,175,650 - 63,300,025 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21468,150,467 - 68,274,633 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCDC6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1971,382,842 - 71,501,589 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl971,383,032 - 71,497,403 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604832,267,861 - 32,386,892 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccdc6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247913,718,961 - 3,820,089 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247913,719,006 - 3,822,985 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ccdc6
700 total Variants

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:31
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000032159
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat

1 to 10 of 22 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


RefSeq Transcripts NM_001427373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000032159   ⟹   ENSRNOP00000033185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2018,433,695 - 18,528,658 (-)Ensembl
Rnor_6.0 Ensembl2019,732,894 - 19,825,150 (-)Ensembl
RefSeq Acc Id: NM_001427373   ⟹   NP_001414302
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82018,431,243 - 18,527,227 (-)NCBI
Protein RefSeqs NP_001414302 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000033185
  ENSRNOP00000033185.6
Ensembl Acc Id: ENSRNOP00000033185   ⟸   ENSRNOT00000032159
RefSeq Acc Id: NP_001414302   ⟸   NM_001427373
- UniProtKB: D4AEK9 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-D4AEK9-F1-model_v2 AlphaFold D4AEK9 1-470 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701560
Promoter ID:EPDNEW_R12080
Type:initiation region
Name:Ccdc6_1
Description:coiled-coil domain containing 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02019,825,220 - 19,825,280EPDNEW


1 to 12 of 12 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-3979 BioCyc
Ensembl Genes ENSRNOG00000024019 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032159 ENTREZGENE
  ENSRNOT00000032159.7 UniProtKB/TrEMBL
InterPro DUF2046 UniProtKB/TrEMBL
NCBI Gene 691155 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING PROTEIN 6 UniProtKB/TrEMBL
  DUF2046 UniProtKB/TrEMBL
Pfam DUF2046 UniProtKB/TrEMBL
PhenoGen Ccdc6 PhenoGen
RatGTEx ENSRNOG00000024019 RatGTEx
UniProt D4AEK9 ENTREZGENE, UniProtKB/TrEMBL
1 to 12 of 12 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Ccdc6  coiled-coil domain containing 6  LOC687820  similar to coiled-coil domain containing 6  Data merged from RGD:1596283 1643240 APPROVED
2008-03-06 Ccdc6  coiled-coil domain containing 6  LOC691155  similar to coiled-coil domain containing 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687820  similar to coiled-coil domain containing 6      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC691155  similar to coiled-coil domain containing 6      Symbol and Name status set to provisional 70820 PROVISIONAL