Symbol:
Mid2
Name:
midline 2
RGD ID:
1565674
Description:
Predicted to enable several functions, including microtubule binding activity; protein homodimerization activity; and transcription coactivator activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of viral transcription; and positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytoplasm. Predicted to colocalize with microtubule. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 101. Orthologous to human MID2 (midline 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; amphetamine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC363502; midline-2; probable E3 ubiquitin-protein ligase MID2; RGD1565674; similar to Trim1 alpha
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
MID2 (midline 2) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):
Mid2 (midline 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Mid2 (midline 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
MID2 (midline 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
MID2 (midline 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Mid2 (midline 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
MID2 (midline 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
MID2 (midline 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Mid2 (midline 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
MID1 (midline 1) HGNC
OrthoDB
Alliance orthologs 3
Mus musculus (house mouse):
Mid2 (midline 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
MID2 (midline 2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
mid2 (midline 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 X 109,143,057 - 109,245,257 (+) NCBI GRCr8 mRatBN7.2 X 104,354,692 - 104,456,757 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl X 104,355,316 - 104,453,473 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx X 106,484,643 - 106,582,790 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 X 109,983,989 - 110,082,138 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 X 107,531,877 - 107,629,899 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 X 112,019,897 - 112,121,980 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 112,020,646 - 112,121,943 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 52,479,569 - 52,581,663 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 128,496,689 - 128,595,233 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 3 43,484,990 - 43,583,167 (-) NCBI Celera Cytogenetic Map X q33 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Mid2 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 X 109,143,057 - 109,245,257 (+) NCBI GRCr8 mRatBN7.2 X 104,354,692 - 104,456,757 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl X 104,355,316 - 104,453,473 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx X 106,484,643 - 106,582,790 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 X 109,983,989 - 110,082,138 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 X 107,531,877 - 107,629,899 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 X 112,019,897 - 112,121,980 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 112,020,646 - 112,121,943 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 52,479,569 - 52,581,663 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 128,496,689 - 128,595,233 (+) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 Celera 3 43,484,990 - 43,583,167 (-) NCBI Celera Cytogenetic Map X q33 NCBI
MID2 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 X 107,825,735 - 107,931,637 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl X 107,825,755 - 107,931,637 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 X 107,068,965 - 107,174,867 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 X 106,956,116 - 107,057,077 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Celera X 107,540,045 - 107,645,826 (+) NCBI Celera Cytogenetic Map X q22.3 NCBI HuRef X 96,692,632 - 96,797,758 (+) NCBI HuRef CHM1_1 X 106,979,937 - 107,085,716 (+) NCBI CHM1_1 T2T-CHM13v2.0 X 106,262,471 - 106,368,728 (+) NCBI T2T-CHM13v2.0
Mid2 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 X 139,565,326 - 139,668,464 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl X 139,565,348 - 139,668,464 (+) Ensembl GRCm39 Ensembl GRCm38 X 140,664,304 - 140,767,715 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl X 140,664,599 - 140,767,715 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 X 137,212,567 - 137,302,254 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 X 136,011,320 - 136,114,080 (+) NCBI MGSCv36 mm8 Celera X 123,937,263 - 124,027,053 (+) NCBI Celera Cytogenetic Map X F1 NCBI cM Map X 61.35 NCBI
Mid2 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955490 7,973,211 - 8,088,427 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955490 7,977,771 - 8,168,912 (-) NCBI ChiLan1.0 ChiLan1.0
MID2 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 X 107,301,285 - 107,405,554 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 X 107,304,702 - 107,413,484 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 X 96,917,731 - 97,026,545 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 X 107,290,776 - 107,393,162 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl X 107,290,776 - 107,393,162 (+) Ensembl panpan1.1 panPan2
MID2 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 X 81,267,037 - 81,467,613 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl X 81,296,249 - 81,463,210 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha X 67,387,281 - 67,588,271 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 X 82,914,364 - 83,116,618 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl X 82,942,999 - 83,112,209 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 X 80,374,592 - 80,575,813 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 X 82,086,451 - 82,288,627 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 X 81,878,438 - 82,081,198 (+) NCBI UU_Cfam_GSD_1.0
Mid2 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 X 80,731,399 - 80,828,234 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936499 6,829,729 - 6,926,571 (-) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936499 6,833,328 - 6,926,531 (-) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
MID2 Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl X 88,294,067 - 88,393,742 (+) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 X 88,294,032 - 88,394,885 (+) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 X 102,730,773 - 102,831,117 (+) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
MID2 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 X 95,664,705 - 95,760,256 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl X 95,665,380 - 95,764,762 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666065 20,771,575 - 20,871,556 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Mid2
.
Predicted Target Of
Count of predictions: 35 Count of miRNA genes: 29 Interacting mature miRNAs: 33 Transcripts: ENSRNOT00000020145 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
1598872 Memor14 Memory QTL 14 4.5 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) X 93956491 138956491 Rat 1598856 Memor1 Memory QTL 1 1.9 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) X 103312877 148312877 Rat 1598809 Memor15 Memory QTL 15 4.4 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) X 103312877 148312877 Rat 738025 Stresp3 Stress response QTL 3 4.61 0.0066 stress-related behavior trait (VT:0010451) defensive burying - approach X 100567703 150256146 Rat 61430 Cia18 Collagen induced arthritis QTL 18 3.1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) X 14843113 120568734 Rat 61431 Cia19 Collagen induced arthritis QTL 19 4.4 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) X 65612192 120568734 Rat 738035 Stresp1 Stress response QTL 1 4.96 0.000011 stress-related behavior trait (VT:0010451) defensive burying - coping X 41304447 112935181 Rat 724551 Glom1 Glomerulus QTL 1 2.8 0.0004 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002) X 75294106 120294106 Rat 1598837 Memor13 Memory QTL 13 3.2 exploratory behavior trait (VT:0010471) difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678) X 41052407 146860749 Rat
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000079841 ⟹ ENSRNOP00000069903
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl X 104,355,316 - 104,453,473 (+) Ensembl Rnor_6.0 Ensembl X 112,020,646 - 112,121,943 (+) Ensembl
RefSeq Acc Id:
NM_001191889 ⟹ NP_001178818
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 109,143,820 - 109,241,973 (+) NCBI mRatBN7.2 X 104,355,316 - 104,453,473 (+) NCBI Rnor_6.0 X 112,020,565 - 112,118,696 (+) NCBI Rnor_5.0 3 52,479,569 - 52,581,663 (-) NCBI Celera 3 43,484,990 - 43,583,167 (-) NCBI
Sequence:
CAGCGGAGAAGGCGGGCGGCGGCCTAGAGTGGTGGTGGCGGCGGCGGCGGCAGCGACAGCGGCCCGGGAGCTTGCGCGGGAGCCCGAGCCAGCTTGCTGTGGAGGCCAGCGAGCGCACGGCGCTTCCC
hide sequence
RefSeq Acc Id:
XM_006234247 ⟹ XP_006234309
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 109,143,416 - 109,245,257 (+) NCBI mRatBN7.2 X 104,354,900 - 104,456,757 (+) NCBI Rnor_6.0 X 112,020,142 - 112,121,980 (+) NCBI Rnor_5.0 3 52,479,569 - 52,581,663 (-) NCBI
Sequence:
TGCTCAGGTTTCTCCGGTCACTCCTGCCAGGGGGAGAAAACATGTAAGCGCGCCTCCAGAGGAGGGGCACGGGGAGCTGGGAGTGGCGGGGGCGGCGGAAGGTGAGCCTAGGAAGGTGGCCCAGCGCC
hide sequence
RefSeq Acc Id:
XM_006234248 ⟹ XP_006234310
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 109,143,173 - 109,245,257 (+) NCBI mRatBN7.2 X 104,354,692 - 104,456,757 (+) NCBI Rnor_6.0 X 112,019,897 - 112,121,980 (+) NCBI Rnor_5.0 3 52,479,569 - 52,581,663 (-) NCBI
Sequence:
AAGAGTTTGGCCACAGTCTTCCTTCTGTACTTCACACATACCACCCGCTCGCTTGTAGACGCGCAAACACACACACACACACACACACACACACACACACATACACACACACACACACGCCTGTTCAG
hide sequence
RefSeq Acc Id:
XM_063280153 ⟹ XP_063136223
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 X 109,143,057 - 109,245,257 (+) NCBI
RefSeq Acc Id:
NP_001178818 ⟸ NM_001191889
- UniProtKB:
A0A0G2JWJ3 (UniProtKB/TrEMBL)
- Sequence:
MGESPASAVLNASAGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRP
hide sequence
RefSeq Acc Id:
XP_006234310 ⟸ XM_006234248
- Peptide Label:
isoform X3
- Sequence:
METLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPGSAMSSERIACQFCEQDPPR
hide sequence
RefSeq Acc Id:
XP_006234309 ⟸ XM_006234247
- Peptide Label:
isoform X1
- Sequence:
MGESPASAVLNASAGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRP
hide sequence
Ensembl Acc Id:
ENSRNOP00000069903 ⟸ ENSRNOT00000079841
RefSeq Acc Id:
XP_063136223 ⟸ XM_063280153
- Peptide Label:
isoform X2
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2008-04-30
Mid2
midline 2
Mid2_predicted
midline 2 (predicted)
'predicted' is removed
2292626 APPROVED
2006-03-30
Mid2_predicted
midline 2 (predicted)
RGD1565674_predicted
similar to Trim1 alpha (predicted)
Symbol and Name updated
1299863 APPROVED
2006-03-07
RGD1565674_predicted
similar to Trim1 alpha (predicted)
LOC363502
similar to Trim1 alpha
Symbol and Name status set to approved
1299863 APPROVED
2006-02-09
LOC363502
similar to Trim1 alpha
Symbol and Name status set to provisional
70820 PROVISIONAL
