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Gene: Hist1h2af (histone cluster 1 H2A family member F) Rattus norvegicus

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Symbol:

Hist1h2af

Name:

histone cluster 1 H2A family member F

RGD ID:

1564767

Description:

Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation and negative regulation of cell population proliferation. Predicted to be part of CENP-A containing nucleosome. Predicted to be active in nucleus. Orthologous to human H2AC8 (H2A clustered histone 8); PARTICIPATES IN systemic lupus erythematosus pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

histone cluster 1, H2af; Histone H2a; LOC498753; RGD1564767

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	H2AC8 (H2A clustered histone 8)	HGNC	OMA, Panther, Treefam
Mus musculus (house mouse):	H2ac13 (H2A clustered histone 13)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100980195 (histone H2A type 1-B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	H2AC4 (H2A clustered histone 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	H2AC4 (H2A clustered histone 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103222003 (histone H2A type 1-B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	H2AC15 (H2A clustered histone 15)	HGNC	HomoloGene
Homo sapiens (human):	H2AC1 (H2A clustered histone 1)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	H2ac23 (H2A clustered histone 23)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Mus musculus (house mouse):	H2ac22 (H2A clustered histone 22)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Mus musculus (house mouse):	H2ac8 (H2A clustered histone 8)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Mus musculus (house mouse):	H2ac13 (H2A clustered histone 13)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Homo sapiens (human):	H2AC8 (H2A clustered histone 8)	Alliance	DIOPT (HGNC\|OMA\|PANTHER)
Mus musculus (house mouse):	H2ac10 (H2A clustered histone 10)	Alliance	DIOPT (OMA\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	H2ac4 (H2A clustered histone 4)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Mus musculus (house mouse):	H2ac11 (H2A clustered histone 11)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Mus musculus (house mouse):	H2ac7 (H2A clustered histone 7)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Mus musculus (house mouse):	H2ac6 (H2A clustered histone 6)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Mus musculus (house mouse):	H2ac24 (H2A clustered histone 24)	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Danio rerio (zebrafish):	si:ch211-113a14.25	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-113a14.25	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-261m9.11	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-113a14.19	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HTA1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG31618	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33808	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33814	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33817	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33820	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33823	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33826	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33829	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33832	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33835	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33838	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33841	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33844	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33847	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33850	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33853	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33856	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33859	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33862	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	His2A:CG33865	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-12	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-16	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-19	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-21	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-30	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-33	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-35	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-43	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-47	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-51	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-53	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-57	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-61	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-65	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-68	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	his-7	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HTA2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	41,807,261 - 41,807,653 (-)	NCBI		GRCr8
mRatBN7.2	17	41,379,404 - 41,379,796 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	41,379,404 - 41,379,796 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	41,453,432 - 41,453,824 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	43,057,478 - 43,057,870 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	41,336,134 - 41,336,526 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	43,627,237 - 43,627,629 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	43,627,237 - 43,627,629 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	45,481,622 - 45,482,014 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	48,513,674 - 48,514,066 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	41,010,602 - 41,010,994 (-)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hist1h2af	Rat	juvenile rheumatoid arthritis		ISO	H2AC8 (Homo sapiens)	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19565504

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hist1h2af	Rat	(-)-demecolcine	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Demecolcine results in increased expression of H2AC8 mRNA	CTD	PMID:23649840
Hist1h2af	Rat	1,2-dimethylhydrazine	increases expression	ISO	H2ac13 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in increased expression of HIST1H2AF mRNA	CTD	PMID:22206623
Hist1h2af	Rat	17beta-estradiol	affects expression	ISO	H2AC8 (Homo sapiens)	6480464	Estradiol affects the expression of H2AC8 mRNA	CTD	PMID:22574217
Hist1h2af	Rat	17beta-estradiol	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Estradiol results in increased expression of H2AC8 mRNA	CTD	PMID:20106945 and PMID:21632981
Hist1h2af	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Tetrachlorodibenzodioxin results in increased expression of H2AC8 mRNA	CTD	PMID:20106945 and PMID:21632981
Hist1h2af	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	EXP		6480464	Tetrachlorodibenzodioxin results in increased expression of HIST1H2AF mRNA	CTD	PMID:33387578
Hist1h2af	Rat	2-hydroxypropanoic acid	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Lactic Acid results in increased expression of H2AC8 mRNA	CTD	PMID:30851411
Hist1h2af	Rat	2-palmitoylglycerol	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	2-palmitoylglycerol results in increased expression of H2AC8 mRNA	CTD	PMID:37199045
Hist1h2af	Rat	4,4'-sulfonyldiphenol	multiple interactions	ISO	H2ac13 (Mus musculus)	6480464	[bisphenol S co-treated with LIF protein] affects the expression of H2AC13 mRNA more ...	CTD	PMID:30951980
Hist1h2af	Rat	4,4'-sulfonyldiphenol	affects expression	ISO	H2ac13 (Mus musculus)	6480464	bisphenol S affects the expression of H2AC13 mRNA	CTD	PMID:30951980
Hist1h2af	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	H2ac13 (Mus musculus)	6480464	bisphenol S results in increased expression of HIST1H2AF mRNA	CTD	PMID:30951980
Hist1h2af	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of HIST1H2AF mRNA	CTD	PMID:24780913
Hist1h2af	Rat	aflatoxin B1	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Aflatoxin B1 results in increased expression of H2AC8 mRNA	CTD	PMID:27153756
Hist1h2af	Rat	all-trans-retinoic acid	multiple interactions	ISO	H2ac13 (Mus musculus)	6480464	[bisphenol A co-treated with Tretinoin] affects the expression of H2AC13 mRNA more ...	CTD	PMID:30951980
Hist1h2af	Rat	benzo[a]pyrene	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Benzo(a)pyrene results in increased expression of H2AC8 mRNA	CTD	PMID:20064835 more ...
Hist1h2af	Rat	benzo[a]pyrene diol epoxide I	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	7 more ...	CTD	PMID:20382639
Hist1h2af	Rat	berberine	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	Berberine results in decreased expression of H2AC8 mRNA	CTD	PMID:27311644
Hist1h2af	Rat	bisphenol A	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	bisphenol A results in decreased expression of H2AC8 mRNA	CTD	PMID:29275510
Hist1h2af	Rat	bisphenol A	affects expression	ISO	H2ac13 (Mus musculus)	6480464	bisphenol A affects the expression of H2AC13 mRNA	CTD	PMID:30951980 and PMID:36347119
Hist1h2af	Rat	bisphenol A	multiple interactions	ISO	H2ac13 (Mus musculus)	6480464	[bisphenol A co-treated with LIF protein] results in decreased expression of HIST1H2AF mRNA more ...	CTD	PMID:30951980
Hist1h2af	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of HIST1H2AF mRNA	CTD	PMID:34947998
Hist1h2af	Rat	bisphenol F	multiple interactions	ISO	H2ac13 (Mus musculus)	6480464	[bisphenol F co-treated with LIF protein] affects the expression of H2AC13 mRNA more ...	CTD	PMID:30951980
Hist1h2af	Rat	bisphenol F	affects expression	ISO	H2ac13 (Mus musculus)	6480464	bisphenol F affects the expression of H2AC13 mRNA	CTD	PMID:30951980
Hist1h2af	Rat	cadmium atom	multiple interactions	ISO	H2AC8 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of H2AC8 mRNA	CTD	PMID:35301059
Hist1h2af	Rat	cadmium dichloride	multiple interactions	ISO	H2AC8 (Homo sapiens)	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of H2AC8 mRNA	CTD	PMID:35301059
Hist1h2af	Rat	chromium(6+)	affects expression	ISO	H2ac13 (Mus musculus)	6480464	chromium hexavalent ion affects the expression of H2AC13 mRNA	CTD	PMID:28472532
Hist1h2af	Rat	cisplatin	increases expression	EXP		6480464	Cisplatin results in increased expression of HIST1H2AF protein	CTD	PMID:22023808
Hist1h2af	Rat	cobalt dichloride	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	cobaltous chloride results in decreased expression of H2AC8 mRNA	CTD	PMID:19320972
Hist1h2af	Rat	copper(II) sulfate	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Copper Sulfate results in increased expression of H2AC8 mRNA	CTD	PMID:19549813
Hist1h2af	Rat	coumestrol	multiple interactions	ISO	H2AC8 (Homo sapiens)	6480464	[Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of H2AC8 mRNA	CTD	PMID:19167446
Hist1h2af	Rat	coumestrol	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	Coumestrol results in decreased expression of H2AC8 mRNA	CTD	PMID:19167446
Hist1h2af	Rat	Cuprizon	increases expression	EXP		6480464	Cuprizone results in increased expression of HIST1H2AF mRNA	CTD	PMID:26577399
Hist1h2af	Rat	cyclosporin A	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	Cyclosporine results in decreased expression of H2AC8 mRNA	CTD	PMID:27989131
Hist1h2af	Rat	cyclosporin A	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Cyclosporine results in increased expression of H2AC8 mRNA	CTD	PMID:20106945
Hist1h2af	Rat	deguelin	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	deguelin results in increased expression of H2AC8 mRNA	CTD	PMID:33512557
Hist1h2af	Rat	dichloroacetic acid	increases expression	ISO	H2ac13 (Mus musculus)	6480464	Dichloroacetic Acid results in increased expression of H2AC13 mRNA	CTD	PMID:28962523
Hist1h2af	Rat	dimethylarsinous acid	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	dimethylarsinous acid results in increased expression of H2AC8 mRNA	CTD	PMID:23876855
Hist1h2af	Rat	dioxygen	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	Oxygen deficiency results in decreased expression of H2AC8 mRNA	CTD	PMID:26516004
Hist1h2af	Rat	doxorubicin	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Doxorubicin results in increased expression of H2AC8 mRNA	CTD	PMID:29803840
Hist1h2af	Rat	Enterolactone	multiple interactions	ISO	H2AC8 (Homo sapiens)	6480464	[Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of H2AC8 mRNA	CTD	PMID:19167446
Hist1h2af	Rat	fenpyroximate	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	fenpyroximate results in increased expression of H2AC8 mRNA	CTD	PMID:33512557
Hist1h2af	Rat	formaldehyde	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Formaldehyde results in increased expression of H2AC8 mRNA	CTD	PMID:20655997
Hist1h2af	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of HIST1H2AF mRNA	CTD	PMID:33387578
Hist1h2af	Rat	hydrogen peroxide	affects expression	ISO	H2AC8 (Homo sapiens)	6480464	Hydrogen Peroxide affects the expression of H2AC8 mRNA	CTD	PMID:20044591
Hist1h2af	Rat	iron dichloride	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	ferrous chloride results in increased expression of H2AC8 mRNA	CTD	PMID:35984750
Hist1h2af	Rat	isotretinoin	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	Isotretinoin results in decreased expression of H2AC8 mRNA	CTD	PMID:20436886
Hist1h2af	Rat	Licochalcone B	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	licochalcone B results in increased expression of H2AC8 mRNA	CTD	PMID:33647349
Hist1h2af	Rat	lidocaine	increases expression	EXP		6480464	Lidocaine results in increased expression of HIST1H2AF mRNA	CTD	PMID:35283115
Hist1h2af	Rat	menadione	affects expression	ISO	H2AC8 (Homo sapiens)	6480464	Vitamin K 3 affects the expression of H2AC8 mRNA	CTD	PMID:20044591
Hist1h2af	Rat	methyl methanesulfonate	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Methyl Methanesulfonate results in increased expression of H2AC8 mRNA	CTD	PMID:23649840
Hist1h2af	Rat	methylisothiazolinone	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	2-methyl-4-isothiazolin-3-one results in decreased expression of H2AC8 mRNA	CTD	PMID:31629900
Hist1h2af	Rat	methylseleninic acid	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	methylselenic acid results in decreased expression of H2AC8 mRNA	CTD	PMID:18548127
Hist1h2af	Rat	N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal	multiple interactions	ISO	H2ac13 (Mus musculus)	6480464	[MYBPC3 protein affects the susceptibility to benzyloxycarbonylleucyl-leucyl-leucine aldehyde] which results in decreased expression of H2AC13 mRNA	CTD	PMID:25566086
Hist1h2af	Rat	N-Nitrosopyrrolidine	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	N-Nitrosopyrrolidine results in decreased expression of H2AC8 mRNA	CTD	PMID:32234424
Hist1h2af	Rat	paracetamol	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Acetaminophen results in increased expression of H2AC8 mRNA	CTD	PMID:29067470
Hist1h2af	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of HIST1H2AF mRNA	CTD	PMID:33387578
Hist1h2af	Rat	phenformin	decreases expression	EXP		6480464	Phenformin results in decreased expression of HIST1H2AF mRNA	CTD	PMID:31324951
Hist1h2af	Rat	phenobarbital	affects expression	ISO	H2ac13 (Mus musculus)	6480464	Phenobarbital affects the expression of H2AC8 mRNA	CTD	PMID:23091169
Hist1h2af	Rat	pirinixic acid	decreases expression	ISO	H2ac13 (Mus musculus)	6480464	pirinixic acid results in decreased expression of H2AC8 mRNA	CTD	PMID:17426115
Hist1h2af	Rat	potassium dichromate	increases expression	ISO	H2ac13 (Mus musculus)	6480464	Potassium Dichromate results in increased expression of H2AC8 mRNA	CTD	PMID:23608068
Hist1h2af	Rat	pyrimidifen	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	pyrimidifen results in increased expression of H2AC8 mRNA	CTD	PMID:33512557
Hist1h2af	Rat	quercetin	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Quercetin results in increased expression of H2AC8 mRNA	CTD	PMID:21632981
Hist1h2af	Rat	quercetin	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	Quercetin results in decreased expression of H2AC8 protein	CTD	PMID:19207037
Hist1h2af	Rat	rac-lactic acid	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Lactic Acid results in increased expression of H2AC8 mRNA	CTD	PMID:30851411
Hist1h2af	Rat	rotenone	decreases expression	EXP		6480464	Rotenone results in decreased expression of HIST1H2AF mRNA	CTD	PMID:28374803
Hist1h2af	Rat	rotenone	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Rotenone results in increased expression of H2AC8 mRNA	CTD	PMID:33512557
Hist1h2af	Rat	silicon dioxide	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Silicon Dioxide analog results in increased expression of H2AC8 mRNA and Silicon Dioxide results in increased expression of H2AC8 mRNA	CTD	PMID:23806026 and PMID:25351596
Hist1h2af	Rat	sodium arsenite	decreases expression	ISO	H2AC8 (Homo sapiens)	6480464	sodium arsenite results in decreased expression of H2AC8 mRNA	CTD	PMID:24516582
Hist1h2af	Rat	sodium arsenite	decreases expression	ISO	H2ac13 (Mus musculus)	6480464	sodium arsenite results in decreased expression of H2AC8 mRNA	CTD	PMID:37682722
Hist1h2af	Rat	sodium dodecyl sulfate	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Sodium Dodecyl Sulfate results in increased expression of H2AC8 mRNA	CTD	PMID:31734321
Hist1h2af	Rat	tebufenpyrad	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	4-chloro-N-((4-(1 and 1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of H2AC8 mRNA	CTD	PMID:33512557
Hist1h2af	Rat	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of HIST1H2AF mRNA	CTD	PMID:33387578
Hist1h2af	Rat	thiram	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Thiram results in increased expression of H2AC8 mRNA	CTD	PMID:38568856
Hist1h2af	Rat	titanium dioxide	increases expression	ISO	H2ac13 (Mus musculus)	6480464	titanium dioxide results in increased expression of H2AC13 mRNA	CTD	PMID:23557971
Hist1h2af	Rat	trimellitic anhydride	increases expression	ISO	H2ac13 (Mus musculus)	6480464	trimellitic anhydride results in increased expression of H2AC13 mRNA and trimellitic anhydride results in increased expression of H2AC8 mRNA	CTD	PMID:19042947
Hist1h2af	Rat	trovafloxacin	decreases expression	ISO	H2ac13 (Mus musculus)	6480464	trovafloxacin results in decreased expression of H2AC8 mRNA	CTD	PMID:35537566
Hist1h2af	Rat	valproic acid	increases expression	ISO	H2AC8 (Homo sapiens)	6480464	Valproic Acid results in increased expression of H2AC8 mRNA	CTD	PMID:28001369
Hist1h2af	Rat	vinclozolin	decreases expression	EXP		6480464	vinclozolin results in decreased expression of HIST1H2AF mRNA	CTD	PMID:23034163 and PMID:23555832

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hist1h2af	Rat	heterochromatin formation	involved_in	IBA	PANTHER:PTN000604564 and SGD:S000005372	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Hist1h2af	Rat	negative regulation of cell population proliferation	involved_in	ISO	H2AC8 (Homo sapiens)	1624291	PMID:23956221	RGD	PMID:23956221

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hist1h2af	Rat	CENP-A containing nucleosome	part_of	ISO	H2AC8 (Homo sapiens)	1624291	PMID:21743476	RGD	PMID:21743476
Hist1h2af	Rat	chromosome	located_in	IEA	UniProtKB-KW:KW-0158	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Hist1h2af	Rat	chromosome	located_in	IEA	UniProtKB-SubCell:SL-0468	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Hist1h2af	Rat	nucleosome	part_of	ISO	H2AC8 (Homo sapiens)	1624291	PMID:20498094 more ...	RGD	PMID:20498094 more ...
Hist1h2af	Rat	nucleosome	part_of	IBA	FB:FBgn0001197 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Hist1h2af	Rat	nucleosome	part_of	IEA	InterPro:IPR002119	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Hist1h2af	Rat	nucleosome	part_of	IEA	UniProtKB-KW:KW-0544	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Hist1h2af	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Hist1h2af	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Hist1h2af	Rat	nucleus	located_in	ISO	H2AC8 (Homo sapiens)	1624291	PMID:16319397 and PMID:16457589	RGD	PMID:16319397 and PMID:16457589
Hist1h2af	Rat	nucleus	is_active_in	IBA	FB:FBgn0001196 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hist1h2af	Rat	DNA binding	enables	IEA	UniProtKB-KW:KW-0238	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Hist1h2af	Rat	DNA binding	enables	IEA	InterPro:IPR002119 and InterPro:IPR007125	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Hist1h2af	Rat	protein binding	enables	ISO	H2AC8 (Homo sapiens)	1624291	UniProtKB:P06899 more ...	RGD	PMID:20498094 more ...
Hist1h2af	Rat	protein heterodimerization activity	enables	IEA	InterPro:IPR009072	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Hist1h2af	Rat	structural constituent of chromatin	enables	IBA	PANTHER:PTN000604564 more ...	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Hist1h2af	Rat	structural constituent of chromatin	enables	IEA	InterPro:IPR002119	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Hist1h2af	Rat	systemic lupus erythematosus pathway		IEA		6907045		KEGG	rno:05322

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:16319397	PMID:16457589	PMID:23956221	PMID:37175793

Hist1h2af
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	41,807,261 - 41,807,653 (-)	NCBI		GRCr8
mRatBN7.2	17	41,379,404 - 41,379,796 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	41,379,404 - 41,379,796 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	41,453,432 - 41,453,824 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	43,057,478 - 43,057,870 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	41,336,134 - 41,336,526 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	43,627,237 - 43,627,629 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	43,627,237 - 43,627,629 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	45,481,622 - 45,482,014 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	48,513,674 - 48,514,066 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	17	41,010,602 - 41,010,994 (-)	NCBI		Celera
Cytogenetic Map	17	p11	NCBI

H2AC8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	26,216,921 - 26,217,437 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	26,216,921 - 26,218,515 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	26,217,149 - 26,217,665 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	26,325,127 - 26,325,690 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	26,325,126 - 26,325,690	NCBI
Celera	6	27,446,451 - 27,447,014 (+)	NCBI		Celera
Cytogenetic Map	6	p22.2	NCBI
HuRef	6	26,160,148 - 26,160,711 (+)	NCBI		HuRef
CHM1_1	6	26,219,309 - 26,219,872 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	26,085,398 - 26,085,914 (+)	NCBI		T2T-CHM13v2.0

H2ac13
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	21,900,582 - 21,901,029 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	21,900,592 - 21,900,984 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	21,716,412 - 21,716,859 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	21,716,422 - 21,716,814 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	21,808,291 - 21,808,683 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	21,723,887 - 21,724,279 (+)	NCBI		MGSCv36	mm8
Celera	13	21,991,890 - 21,992,282 (+)	NCBI		Celera
Cytogenetic Map	13	A3.1	NCBI
cM Map	13	7.93	NCBI

LOC100980195
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	40,864,363 - 40,864,867 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	36,865,767 - 36,867,625 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	26,051,779 - 26,052,699 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	26,711,828 - 26,712,774 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	26,711,993 - 26,712,385 (+)	Ensembl	panpan1.1		panPan2

H2AC4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	35	23,990,768 - 23,991,294 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	35	23,869,214 - 23,869,723 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	35	24,105,768 - 24,106,277 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	35	24,105,845 - 24,106,237 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	35	23,922,062 - 23,922,567 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	35	23,973,137 - 23,973,646 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	35	25,405,752 - 25,406,261 (-)	NCBI		UU_Cfam_GSD_1.0

H2AC4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	20,729,997 - 20,730,389 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	20,729,940 - 20,730,466 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LOC103222003
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	46,034,332 - 46,034,877 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	46,222,435 - 46,222,824 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	26,153,483 - 26,154,036 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants in Hist1h2af
1 total Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain	Variant Page
17	45481794	45481795	T	C	snv	IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU)	View more Information

Predicted Target Of

	Summary Value
Count of predictions:	19
Count of miRNA genes:	19
Interacting mature miRNAs:	19
Transcripts:	ENSRNOT00000022965
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631497	Bp98	Blood pressure QTL 98	3.66		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	41354651	60463643	Rat
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	69599340	Rat
1358295	Aocep1	Aortic cell protein QTL 1	6.1	7e-07	thoracic aorta cellular protein amount (VT:0010598)	aortic cell percentage	17	40990005	85990005	Rat
1354640	Scl32	Serum cholesterol level QTL 32	5.4		blood HDL cholesterol amount (VT:0000184)	blood high density lipoprotein cholesterol level (CMO:0000052)	17	15781592	60781592	Rat
152023626	Bp403	Blood pressure QTL 403	3.86		arterial blood pressure trait (VT:2000000)		17	23930421	79524188	Rat
2301412	Kidm40	Kidney mass QTL 40		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	37479847	82479847	Rat
9590107	Sffal7	Serum free fatty acids level QTL 7	4.81	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	17	28409147	73409147	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	27389946	53481766	Rat
70157	Niddm32	Non-insulin dependent diabetes mellitus QTL 32	4.34		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	22454924	50909196	Rat
724549	Niddm56	Non-insulin dependent diabetes mellitus QTL 56		0.03	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	17	31990784	76990784	Rat
1354651	Lmblg2	Limb length QTL 2	6		tibia length (VT:0004357)	tibia length (CMO:0000450)	17	4299130	69599340	Rat
1598871	Memor5	Memory QTL 5	5.3		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	17	40540041	80387013	Rat
1354628	Stl13	Serum triglyceride level QTL 13	3.8		blood triglyceride amount (VT:0002644)	blood triglyceride level (CMO:0000118)	17	21293039	60781592	Rat
1581512	Cm55	Cardiac mass QTL 55	2.8	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	27027949	56836890	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4528038	49528038	Rat
1354630	Cm34	Cardiac mass QTL 34	8.7		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	17	4299130	69599340	Rat
61394	Bp8	Blood pressure QTL 8	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	23080567	59555013	Rat
1559055	Bp278	Blood pressure QTL 278		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	68653184	Rat
10450503	Bp386	Blood pressure QTL 386		0.28	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	31368391	62109574	Rat
152025238	Slep14	Serum leptin concentration QTL 14	4.62		blood leptin amount (VT:0005667)		17	24184890	79524188	Rat
1354638	Insul1	Insulin level QTL 1	4.8		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	17	4299130	69599340	Rat
2313854	Bp343	Blood pressure QTL 343	3.9		life span trait (VT:0005372)	age at time of death (CMO:0001193)	17	31990784	50909196	Rat
2317054	Aia12	Adjuvant induced arthritis QTL 12	4.24		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	17	38281509	83281509	Rat
1331765	Hrtrt15	Heart rate QTL 15	4.094		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	17	15330613	55836425	Rat
8552928	Pigfal9	Plasma insulin-like growth factor 1 level QTL 9	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	17	28409147	73409147	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	34550843	73951021	Rat
2317060	Aia26	Adjuvant induced arthritis QTL 26	3.22		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	17	38281509	83281509	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4528038	49528038	Rat
12903980	Cm120	Cardiac mass QTL 120		0.002	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	17	23653184	68653184	Rat
12903981	Am17	Aortic mass QTL 17		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	17	23653184	68653184	Rat
4889955	Bss93	Bone structure and strength QTL 93	4.4		tibia size trait (VT:0100001)	tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)	17	27027949	60463643	Rat
2303561	Bw91	Body weight QTL 91	2		body mass (VT:0001259)	body weight (CMO:0000012)	17	8868462	53868462	Rat
12903982	Kidm70	Kidney mass QTL 70		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	17	23653184	70974005	Rat
12903978	Cm118	Cardiac mass QTL 118		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	17	23653184	68653184	Rat
2324621	Coatc5	Coat color QTL 5			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	17	31368391	73951021	Rat
12903979	Cm119	Cardiac mass QTL 119		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	17	23653184	68653184	Rat
1354619	Bp242	Blood pressure QTL 242	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	24599340	69599340	Rat
1354596	Bw32	Body weight QTL 32	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	17	4299130	60781592	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	69599340	Rat
152023740	Bp406	Blood pressure QTL 406	6.06		arterial blood pressure trait (VT:2000000)		17	23930421	79524188	Rat
1354663	Bvd5	Brain ventricular dilatation QTL 5	3.51	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	17	31990784	81292925	Rat
7488966	Bp370	Blood pressure QTL 370		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	23653184	57246843	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	60781592	Rat
152023737	Bp405	Blood pressure QTL 405	5.06		arterial blood pressure trait (VT:2000000)			23930421	79524188	Rat
1354659	Scl68	Serum cholesterol level QTL 68	3.9		blood VLDL cholesterol amount (VT:0005144)	blood very low density lipoprotein cholesterol level (CMO:0000648)	17	15781592	60781592	Rat
152023736	Bp404	Blood pressure QTL 404	3.78		arterial blood pressure trait (VT:2000000)		17	23930421	79524188	Rat
724528	Uae4	Urinary albumin excretion QTL 4	4.9	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	17	35837085	69599340	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	8	46	108	87	86	55	25	55	6	205	90	88	44	59	31


RefSeq Transcripts	NM_001024282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC130391	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U95113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022965 ⟹ ENSRNOP00000022965

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	17	41,379,404 - 41,379,796 (-)	Ensembl
Rnor_6.0 Ensembl	17	43,627,237 - 43,627,629 (-)	Ensembl

RefSeq Acc Id:

NM_001024282 ⟹ NP_001019453

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	41,807,261 - 41,807,653 (-)	NCBI
mRatBN7.2	17	41,379,404 - 41,379,796 (-)	NCBI
Rnor_6.0	17	43,627,237 - 43,627,629 (-)	NCBI
Rnor_5.0	17	45,481,622 - 45,482,014 (-)	NCBI
RGSC_v3.4	17	48,513,674 - 48,514,066 (+)	RGD
Celera	17	41,010,602 - 41,010,994 (-)	RGD

Sequence:

show sequence

ATGTCTGGACGCGGCAAGCAGGGCGGCAAGGCTCGGGCTAAGGCCAAGACCCGCTCCTCCCGGGCCGGCCTGCAGTTCCCCGTGGGCCGCGTGCACCGTCTGCTTTACAAGGGCAACTACTCGGAGAG
GGTGGGCGCCAGCGCCCCGGTGTACTTGGCGGCTGTGCTGGAGTACCTGACGGCCGAGATCCTGGAGCTGGCGGGCAACGCGGCGAGGGACAACAAAAAGACACGCATCATCCCGCGCCACCTACAGC
TGGCCATTCGCAACGATGAGGAGCTCAACAAGCTGCTGGGCCGTGTGACCATCGCGCAGGGCGGCGTCCTGCCCAACATCCAGGCAGTGCTGCTGCCCAAAAAGACCGAGAGCCACCACAAGTCCAAG
GGGAAATAG

hide sequence


Protein RefSeqs	NP_001019453	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB53641	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001019453 ⟸ NM_001024282
- UniProtKB:	Q64598 (UniProtKB/Swiss-Prot), Q6I8Q6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLYKGNYSERVGASAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKSK GK hide sequence

Ensembl Acc Id:

ENSRNOP00000022965 ⟸ ENSRNOT00000022965

Protein Domains

Histone H2A C-terminal Histone H2A/H2B/H3

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6I8Q6-F1-model_v2	AlphaFold	Q6I8Q6	1-130	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13700455

Promoter ID:

EPDNEW_R10979

Type:

multiple initiation site

Name:

Hist1h2af_1

Description:

histone cluster 1 H2A family member F

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	17	43,627,642 - 43,627,702	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-9383	BioCyc
Ensembl Genes	ENSRNOG00000022146	Ensembl
Gene3D-CATH	Histone, subunit A	UniProtKB/Swiss-Prot
InterPro	Histone-fold	UniProtKB/Swiss-Prot
	Histone_H2A	UniProtKB/Swiss-Prot
	Histone_H2A/H2B/H3	UniProtKB/Swiss-Prot
	Histone_H2A_C	UniProtKB/Swiss-Prot
	Histone_H2A_CS	UniProtKB/Swiss-Prot
NCBI Gene	498753	ENTREZGENE
PANTHER	HISTONE H2A	UniProtKB/Swiss-Prot
Pfam	Histone	UniProtKB/Swiss-Prot
	Histone_H2A_C	UniProtKB/Swiss-Prot
PhenoGen	Hist1h2af	PhenoGen
PRINTS	HISTONEH2A	UniProtKB/Swiss-Prot
PROSITE	HISTONE_H2A	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000022146	RatGTEx
SMART	H2A	UniProtKB/Swiss-Prot
Superfamily-SCOP	Histone-fold	UniProtKB/Swiss-Prot
UniProt	H2A1F_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6I8Q6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-05-23	Hist1h2af	histone cluster 1 H2A family member F	Hist1h2af	histone cluster 1, H2af	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1564767	Histone H2a	RGD1564767_predicted	Histone H2a (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-07	RGD1564767_predicted	Histone H2a (predicted)	LOC498753	Histone H2a	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498753	Histone H2a			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)