Thoc2 (THO complex subunit 2) - Rat Genome Database

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Gene: Thoc2 (THO complex subunit 2) Rattus norvegicus
Analyze
Symbol: Thoc2
Name: THO complex subunit 2
RGD ID: 1561623
Description: Predicted to enable mRNA binding activity. Involved in negative regulation of neuron projection development. Predicted to be located in chromosome, telomeric region; cytoplasm; and nucleus. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in X-linked intellectual disability-short stature-overweight syndrome. Orthologous to human THOC2 (THO complex subunit 2); PARTICIPATES IN NXF1-NXT1 export pathway; RNA transport pathway; spliceosome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313308; RGD1561623; similar to THO complex 2; THO complex 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X125,500,549 - 125,615,139 (-)NCBIGRCr8
mRatBN7.2X120,634,966 - 120,749,569 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX120,634,968 - 120,749,513 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX122,744,669 - 122,859,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X126,266,121 - 126,380,689 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X123,861,559 - 123,976,122 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X128,153,824 - 128,268,327 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX128,161,895 - 128,268,322 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X128,246,548 - 128,361,045 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,196,205 - 3,310,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX119,751,149 - 119,864,843 (-)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows
Object Symbol
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Original Reference(s)
Thoc2Ratautistic disorder  ISOTHOC2 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Thoc2Ratautosomal hemophilia A  ISOTHOC2 (Homo sapiens)8554872ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA AClinVarPMID:31690835
Thoc2Ratfactor VIII deficiency  ISOTHOC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Factor 8 deficiency and congenitalClinVarPMID:31690835
Thoc2Ratgenetic disease  ISOTHOC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Thoc2Ratimmunodeficiency 127  ISOTHOC2 (Homo sapiens)8554872ClinVar Annotator: match by term: IMMUNODEFICIENCY 127ClinVarPMID:34976470 and PMID:37945483
Thoc2Ratintellectual disability  ISOTHOC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868
Thoc2RatNeurodevelopmental Disorders  ISOTHOC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868
Thoc2Ratsyndromic X-linked intellectual disability Lubs type  ISOTHOC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
Thoc2RatX Chromosome, Trisomy Xq25  ISOTHOC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Xq25 duplication syndromeClinVar 
Thoc2RatX-linked intellectual disability-short stature-overweight syndrome  ISOTHOC2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:1605217 more ...
Thoc2RatX-linked lymphoproliferative syndrome 2  ISOTHOC2 (Homo sapiens)8554872ClinVar Annotator: match by term: Lymphoproliferative syndrome 2 and X-linkedClinVarPMID:17080092 more ...
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Original Reference(s)
Thoc2RatX-linked intellectual disability-short stature-overweight syndrome  ISSThoc2 (Mus musculus)13592920OMIM:300957MouseDO 

1 to 20 of 89 rows

  
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Original Reference(s)
Thoc2Rat(-)-epigallocatechin 3-gallate multiple interactionsISOTHOC2 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of THOC2 mRNACTDPMID:22079256
Thoc2Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of THOC2 mRNACTDPMID:32145629
Thoc2Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOTHOC2 (Homo sapiens)64804642 more ...CTDPMID:31675489
Thoc2Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOThoc2 (Mus musculus)64804642 more ...CTDPMID:31388691
Thoc2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOThoc2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of THOC2 mRNACTDPMID:26377647
Thoc2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of THOC2 mRNACTDPMID:33387578
Thoc2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of THOC2 mRNACTDPMID:34747641
Thoc2Rat2-methylcholine affects expressionISOTHOC2 (Homo sapiens)6480464beta-methylcholine affects the expression of THOC2 mRNACTDPMID:21179406
Thoc2Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOTHOC2 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of THOC2 proteinCTDPMID:31675489
Thoc2Rat3,4-methylenedioxymethamphetamine decreases expressionEXP 6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of THOC2 mRNACTDPMID:30071829
Thoc2Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOTHOC2 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of THOC2 mRNACTDPMID:28628672
Thoc2Ratacrolein multiple interactionsISOTHOC2 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of THOC2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of THOC2 mRNACTDPMID:32699268
Thoc2Rataflatoxin B1 increases expressionISOThoc2 (Mus musculus)6480464Aflatoxin B1 results in increased expression of THOC2 mRNACTDPMID:19770486
Thoc2RatAflatoxin B2 alpha increases methylationISOTHOC2 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of THOC2 intronCTDPMID:30157460
Thoc2Ratalpha-pinene multiple interactionsISOTHOC2 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of THOC2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of THOC2 mRNACTDPMID:32699268
Thoc2Rataristolochic acid A decreases expressionISOTHOC2 (Homo sapiens)6480464aristolochic acid I results in decreased expression of THOC2 mRNACTDPMID:33212167
Thoc2RatAroclor 1254 decreases expressionISOThoc2 (Mus musculus)6480464Chlorodiphenyl (54% Chlorine) results in decreased expression of THOC2 mRNACTDPMID:23650126
Thoc2Ratatrazine increases expressionISOTHOC2 (Homo sapiens)6480464Atrazine results in increased expression of THOC2 mRNACTDPMID:22378314
Thoc2Ratbenzo[a]pyrene affects methylationISOTHOC2 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of THOC2 promoterCTDPMID:27901495
Thoc2Ratbeta-lapachone decreases expressionISOTHOC2 (Homo sapiens)6480464beta-lapachone results in decreased expression of THOC2 mRNACTDPMID:38218311

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Biological Process
1 to 20 of 23 rows

  
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Original Reference(s)
Thoc2Ratblastocyst development acts_upstream_of_or_withinIEAUniProtKB:B1AZI6 and ensembl:ENSMUSP000000446771600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2Ratblastocyst development acts_upstream_of_or_withinISOThoc2 (Mus musculus)1624291 PMID:24315442RGDPMID:24315442
Thoc2Ratcell morphogenesis acts_upstream_of_or_withinISOThoc2 (Mus musculus)1624291 PMID:24315442RGDPMID:24315442
Thoc2Ratcell morphogenesis acts_upstream_of_or_withinIEAUniProtKB:B1AZI6 and ensembl:ENSMUSP000000446771600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2Ratgeneration of neurons involved_inISOTHOC2 (Homo sapiens)1624291 PMID:26166480RGDPMID:26166480
Thoc2Ratgeneration of neurons involved_inIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2RatmRNA export from nucleus involved_inISOTHOC2 (Homo sapiens)1624291 PMID:17190602RGDPMID:17190602
Thoc2RatmRNA export from nucleus involved_inIEAInterPro:IPR0400071600115GO_REF:0000002InterProGO_REF:0000002
Thoc2RatmRNA export from nucleus involved_inIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2RatmRNA export from nucleus involved_inIBAFB:FBgn0031390 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Thoc2RatmRNA processing involved_inIEAInterPro:IPR0400071600115GO_REF:0000002InterProGO_REF:0000002
Thoc2RatmRNA transport involved_inIEAUniProtKB-KW:KW-05091600115GO_REF:0000043UniProtGO_REF:0000043
Thoc2Ratnegative regulation of neuron projection development  IMP 10413914 RGD 
Thoc2Ratneuron development involved_inISOTHOC2 (Homo sapiens)1624291 PMID:26166480RGDPMID:26166480
Thoc2Ratneuron development involved_inIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2Ratpoly(A)+ mRNA export from nucleus involved_inISOTHOC2 (Homo sapiens)1624291 PMID:22928037RGDPMID:22928037
Thoc2Ratpoly(A)+ mRNA export from nucleus involved_inIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2Ratregulation of gene expression acts_upstream_of_or_withinISOThoc2 (Mus musculus)1624291 PMID:24315442RGDPMID:24315442
Thoc2Ratregulation of gene expression acts_upstream_of_or_withinIEAUniProtKB:B1AZI6 and ensembl:ENSMUSP000000446771600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2Ratregulation of mRNA export from nucleus acts_upstream_of_or_withinISOThoc2 (Mus musculus)1624291 PMID:24315442RGDPMID:24315442
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Cellular Component
1 to 19 of 19 rows

  
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Original Reference(s)
Thoc2Ratchromosome, telomeric region located_inISOTHOC2 (Homo sapiens)1624291 PMID:24270157RGDPMID:24270157
Thoc2Ratchromosome, telomeric region located_inIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2Ratcytoplasm located_inISOTHOC2 (Homo sapiens)1624291 PMID:29851191RGDPMID:29851191
Thoc2Ratcytoplasm located_inIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Thoc2Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Thoc2Ratnucleus located_inIEAUniProtKB:B1AZI6 and ensembl:ENSMUSP000000446771600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2Ratnucleus located_inIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Thoc2Ratnucleus located_inISOThoc2 (Mus musculus)1624291 PMID:24315442RGDPMID:24315442
Thoc2Ratnucleus located_inISOTHOC2 (Homo sapiens)1624291 PMID:29851191RGDPMID:29851191
Thoc2RatTHO complex part_ofISOTHOC2 (Homo sapiens)1624291 PMID:15998806RGDPMID:15998806
Thoc2RatTHO complex part_ofIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2RatTHO complex part_ofIEAInterPro:IPR0400071600115GO_REF:0000002InterProGO_REF:0000002
Thoc2RatTHO complex part of transcription export complex part_ofISOTHOC2 (Homo sapiens)1624291 PMID:15998806RGDPMID:15998806
Thoc2RatTHO complex part of transcription export complex part_ofIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
Thoc2RatTHO complex part of transcription export complex part_ofIBAPANTHER:PTN000492184 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Thoc2Rattranscription export complex part_ofISOTHOC2 (Homo sapiens)1624291 PMID:15833825 and PMID:15998806RGDPMID:15833825 and PMID:15998806
Thoc2Rattranscription export complex part_ofIEAUniProtKB:Q8NI27 and ensembl:ENSP000002458381600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function

  

RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
Thoc2RatNXF1-NXT1 export pathway  ISOTHOC2 (Homo sapiens)9743960 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Reference
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Original Reference(s)
Thoc2RatRNA transport pathway  IEA 6907045 KEGGrno:03013
Thoc2Ratspliceosome pathway   IEA 6907045 KEGGrno:03040

#
Reference Title
Reference Citation
1. A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia. Di Gregorio E, etal., J Med Genet. 2013 Aug;50(8):543-51. doi: 10.1136/jmedgenet-2013-101542. Epub 2013 Jun 7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. mRNA export and the TREX complex. Katahira J Biochim Biophys Acta. 2012 Jun;1819(6):507-13. doi: 10.1016/j.bbagrm.2011.12.001. Epub 2011 Dec 8.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
PMID:15632090   PMID:15833825   PMID:15998806   PMID:17190602   PMID:18974867   PMID:22928037   PMID:24270157   PMID:24315442   PMID:26166480   PMID:31505169  



Thoc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X125,500,549 - 125,615,139 (-)NCBIGRCr8
mRatBN7.2X120,634,966 - 120,749,569 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX120,634,968 - 120,749,513 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX122,744,669 - 122,859,251 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X126,266,121 - 126,380,689 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X123,861,559 - 123,976,122 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X128,153,824 - 128,268,327 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX128,161,895 - 128,268,322 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X128,246,548 - 128,361,045 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X3,196,205 - 3,310,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX119,751,149 - 119,864,843 (-)NCBICelera
Cytogenetic MapXq35NCBI
THOC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X123,600,569 - 123,733,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX123,600,561 - 123,733,056 (-)EnsemblGRCh38hg38GRCh38
GRCh37X122,734,420 - 122,866,902 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X122,562,093 - 122,694,585 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X122,470,306 - 122,556,221NCBI
CeleraX123,120,365 - 123,252,932 (-)NCBICelera
Cytogenetic MapXq25NCBI
HuRefX112,121,467 - 112,254,690 (-)NCBIHuRef
CHM1_1X122,645,586 - 122,778,089 (-)NCBICHM1_1
T2T-CHM13v2.0X121,911,026 - 122,043,503 (-)NCBIT2T-CHM13v2.0
Thoc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X40,883,869 - 41,000,878 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX40,883,868 - 41,009,551 (-)EnsemblGRCm39 Ensembl
GRCm38X41,794,992 - 41,911,937 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX41,794,991 - 41,920,674 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X39,148,171 - 39,265,078 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X38,039,624 - 38,156,528 (-)NCBIMGSCv36mm8
CeleraX29,379,665 - 29,496,534 (-)NCBICelera
Cytogenetic MapXA4NCBI
cM MapX23.19NCBI
Thoc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547311,029,714 - 11,144,880 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547311,029,860 - 11,143,493 (+)NCBIChiLan1.0ChiLan1.0
THOC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X123,073,019 - 123,205,906 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X123,077,008 - 123,209,505 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X112,797,077 - 112,929,918 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X122,979,547 - 123,110,897 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX122,979,547 - 123,110,897 (-)Ensemblpanpan1.1panPan2
THOC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X95,087,209 - 95,217,450 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX95,095,711 - 95,199,747 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX81,155,235 - 81,285,078 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X96,857,397 - 96,987,320 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX96,865,923 - 96,970,059 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X94,303,965 - 94,433,814 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X96,060,074 - 96,189,923 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X95,849,520 - 95,979,385 (-)NCBIUU_Cfam_GSD_1.0
Thoc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X94,015,239 - 94,132,114 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364796,855,411 - 6,972,256 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364796,855,405 - 6,972,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
THOC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX101,171,362 - 101,284,551 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X101,170,969 - 101,284,623 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X115,935,230 - 116,048,832 (-)NCBISscrofa10.2Sscrofa10.2susScr3
THOC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606536,312,625 - 36,442,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Thoc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247972,299,694 - 2,411,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Thoc2
153 total Variants

Predicted Target Of
Summary Value
Count of predictions:1063
Count of miRNA genes:346
Interacting mature miRNAs:472
Transcripts:ENSRNOT00000009755
Prediction methods:Microtar, Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

BE103656  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X120,674,843 - 120,675,033 (+)MAPPERmRatBN7.2
Rnor_6.0X128,193,647 - 128,193,836NCBIRnor6.0
Rnor_5.0X128,286,371 - 128,286,560UniSTSRnor5.0
RGSC_v3.4X3,270,684 - 3,270,873UniSTSRGSC3.4
CeleraX119,790,325 - 119,790,514UniSTS
RH 3.4 Map5717.1UniSTS
Cytogenetic MapXq11UniSTS
UniSTS:238018  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X120,636,361 - 120,636,680 (+)MAPPERmRatBN7.2
Rnor_6.0X128,155,220 - 128,155,538NCBIRnor6.0
Rnor_5.0X128,247,944 - 128,248,262UniSTSRnor5.0
RGSC_v3.4X3,309,037 - 3,309,355UniSTSRGSC3.4
CeleraX119,752,543 - 119,752,861UniSTS
Cytogenetic MapXq11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000009755   ⟹   ENSRNOP00000009755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX120,643,457 - 120,749,513 (-)Ensembl
Rnor_6.0 EnsemblX128,161,895 - 128,268,285 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081880   ⟹   ENSRNOP00000074749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX120,634,968 - 120,749,513 (-)Ensembl
Rnor_6.0 EnsemblX128,162,119 - 128,268,322 (-)Ensembl
RefSeq Acc Id: NM_001191756   ⟹   NP_001178685
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X125,500,549 - 125,615,087 (-)NCBI
mRatBN7.2X120,634,966 - 120,749,513 (-)NCBI
Rnor_6.0X128,153,826 - 128,268,315 (-)NCBI
Rnor_5.0X128,246,548 - 128,361,045 (-)NCBI
CeleraX119,751,149 - 119,864,843 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257504   ⟹   XP_006257566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X125,500,549 - 125,615,139 (-)NCBI
mRatBN7.2X120,634,966 - 120,749,569 (-)NCBI
Rnor_6.0X128,153,824 - 128,268,327 (-)NCBI
Rnor_5.0X128,246,548 - 128,361,045 (-)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_001178685 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257566 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10880 (Get FASTA)   NCBI Sequence Viewer  
  EDM10881 (Get FASTA)   NCBI Sequence Viewer  
  EDM10882 (Get FASTA)   NCBI Sequence Viewer  
  EDM10883 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009755.7
  ENSRNOP00000074749
  ENSRNOP00000074749.2
  ENSRNOP00000102762
1 to 10 of 10 rows
RefSeq Acc Id: NP_001178685   ⟸   NM_001191756
- UniProtKB: F1M0V4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257566   ⟸   XM_006257504
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K8V3 (UniProtKB/TrEMBL),   F1M0V4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074749   ⟸   ENSRNOT00000081880
Ensembl Acc Id: ENSRNOP00000009755   ⟸   ENSRNOT00000009755
THO complex subunit 2 N-terminal   THO complex subunitTHOC2 C-terminal   THO complex subunitTHOC2 N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8V3-F1-model_v2 AlphaFold A0A0G2K8V3 1-1613 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13702002
Promoter ID:EPDNEW_R12525
Type:multiple initiation site
Name:Thoc2_1
Description:THO complex 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X128,268,309 - 128,268,369EPDNEW


1 to 20 of 20 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-1235 BioCyc
Ensembl Genes ENSRNOG00000007315 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009755.8 UniProtKB/TrEMBL
  ENSRNOT00000081880 ENTREZGENE
  ENSRNOT00000081880.2 UniProtKB/TrEMBL
  ENSRNOT00000163986 ENTREZGENE
InterPro Tho2 UniProtKB/TrEMBL
  THO_THOC2_C UniProtKB/TrEMBL
  THO_THOC2_N UniProtKB/TrEMBL
  THOC2_N UniProtKB/TrEMBL
NCBI Gene 313308 ENTREZGENE
PANTHER PTHR21597 UniProtKB/TrEMBL
  THO COMPLEX SUBUNIT 2 UniProtKB/TrEMBL
Pfam Tho2 UniProtKB/TrEMBL
  Thoc2 UniProtKB/TrEMBL
  THOC2_N UniProtKB/TrEMBL
PhenoGen Thoc2 PhenoGen
RatGTEx ENSRNOG00000007315 RatGTEx
UniProt A0A0G2K8V3 ENTREZGENE, UniProtKB/TrEMBL
  F1M0V4 ENTREZGENE, UniProtKB/TrEMBL
1 to 20 of 20 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-09-30 Thoc2  THO complex subunit 2  Thoc2  THO complex 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Thoc2  THO complex 2   Thoc2_predicted  THO complex 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Thoc2_predicted  THO complex 2 (predicted)  RGD1561623_predicted  similar to THO complex 2 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1561623_predicted  similar to THO complex 2 (predicted)  LOC313308  similar to THO complex 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313308  similar to THO complex 2      Symbol and Name status set to provisional 70820 PROVISIONAL