Prl7a4 (prolactin family 7, subfamily A, member 4) - Rat Genome Database

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Gene: Prl7a4 (prolactin family 7, subfamily A, member 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prl7a4
Name: prolactin family 7, subfamily A, member 4
RGD ID: 1359651
Description: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease and impulse control disorder. Orthologous to human PRL (prolactin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ghd8; growth hormone d8; LOC306929; prolactin-like protein-F beta
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81737,356,924 - 37,365,980 (+)NCBIGRCr8
mRatBN7.21737,148,524 - 37,157,580 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1737,148,520 - 37,157,579 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1737,010,503 - 37,019,560 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01738,614,511 - 38,623,568 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01736,957,652 - 36,966,709 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01739,095,463 - 39,104,519 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1739,095,459 - 39,104,519 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01740,954,519 - 40,963,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41743,724,864 - 43,734,392 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11743,727,703 - 43,737,233 (+)NCBI
Celera1736,656,274 - 36,665,329 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prl7a4Ratcell surface receptor signaling pathway involved_inIBAPANTHER:PTN000151829 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prl7a4Ratfemale pregnancy involved_inIBAMGI:894281 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prl7a4Ratmammary gland development involved_inIBAMGI:97762 and PANTHER:PTN0001518331600115GO_REF:0000033GO_CentralGO_REF:0000033
Prl7a4Ratpositive regulation of lactation involved_inIBAPANTHER:PTN000151833 and UniProtKB:P012391600115GO_REF:0000033GO_CentralGO_REF:0000033
Prl7a4Ratpositive regulation of receptor signaling pathway via JAK-STAT involved_inIBAMGI:97762 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prl7a4Ratresponse to nutrient levels involved_inIBAMGI:95707 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prl7a4Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Prl7a4Ratextracellular region located_inIEAInterPro:IPR001400 and InterPro:IPR0181161600115GO_REF:0000002InterProGO_REF:0000002
Prl7a4Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Prl7a4Ratextracellular space is_active_inIBAMGI:1341833 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Prl7a4Rathormone activity enablesIEAInterPro:IPR001400 and InterPro:IPR0181161600115GO_REF:0000002InterProGO_REF:0000002
Prl7a4Rathormone activity enablesIBAMGI:1341833 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Prl7a4Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Prl7a4Ratprolactin receptor binding enablesIBAPANTHER:PTN000151833 and Prl3d4 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:17095594   PMID:26697363   PMID:26862561  



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Variants in Prl7a4
35 total Variants

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:82
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000040600
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 43 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat

1 to 10 of 43 rows
AI179972  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map8542.6UniSTS
Cytogenetic Map17p11UniSTS




appendage
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
integumental system
mesenchyme
nervous system
reproductive system
respiratory system
1 12 2 3 2 2 1 3 11 17 1



Ensembl Acc Id: ENSRNOT00000040600   ⟹   ENSRNOP00000046132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,148,520 - 37,157,579 (+)Ensembl
Rnor_6.0 Ensembl1739,095,459 - 39,104,519 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098352   ⟹   ENSRNOP00000097233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1737,148,717 - 37,157,579 (+)Ensembl
RefSeq Acc Id: NM_001008341   ⟹   NP_001008342
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81737,356,924 - 37,365,980 (+)NCBI
mRatBN7.21737,148,524 - 37,157,580 (+)NCBI
Rnor_6.01739,095,463 - 39,104,519 (+)NCBI
Rnor_5.01740,954,519 - 40,963,575 (+)NCBI
RGSC_v3.41743,724,864 - 43,734,392 (+)RGD
Celera1736,656,274 - 36,665,329 (+)RGD
Sequence:
Protein RefSeqs NP_001008342 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV51823 (Get FASTA)   NCBI Sequence Viewer  
  CDW51448 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046132
  ENSRNOP00000046132.2
  ENSRNOP00000097233.1
RefSeq Acc Id: NP_001008342   ⟸   NM_001008341
- Peptide Label: precursor
- UniProtKB: E9PST6 (UniProtKB/TrEMBL),   Q5UFU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046132   ⟸   ENSRNOT00000040600
Ensembl Acc Id: ENSRNOP00000097233   ⟸   ENSRNOT00000098352

Name Modeler Protein Id AA Range Protein Structure
AF-E9PST6-F1-model_v2 AlphaFold E9PST6 1-250 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-9469 BioCyc
Ensembl Genes ENSRNOG00000029126 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040600 ENTREZGENE
  ENSRNOT00000040600.4 UniProtKB/TrEMBL
  ENSRNOT00000098352.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Somatotropin UniProtKB/TrEMBL
  Somatotropin_CS UniProtKB/TrEMBL
KEGG Report rno:306929 UniProtKB/TrEMBL
NCBI Gene 306929 ENTREZGENE
PANTHER PROLACTIN-7A1-RELATED UniProtKB/TrEMBL
  Somatotropin UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/TrEMBL
PhenoGen Prl7a4 PhenoGen
PROSITE SOMATOTROPIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029126 RatGTEx
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
UniProt A0A8I6AU34_RAT UniProtKB/TrEMBL
  E9PST6 ENTREZGENE, UniProtKB/TrEMBL
  Q5UFU0 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-07 Prl7a4  prolactin family 7, subfamily A, member 4  Prl7a4  prolactin family 7, subfamily a, member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-05-04 Prl7a4  prolactin family 7, subfamily a, member 4  LOC306929  prolactin-like protein-F beta  Symbol and Name updated 1624237 APPROVED
2005-07-29 LOC306929  prolactin-like protein-F beta      Symbol and Name status set to provisional 70820 PROVISIONAL