Mavs (mitochondrial antiviral signaling protein) - Rat Genome Database

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Gene: Mavs (mitochondrial antiviral signaling protein) Rattus norvegicus
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Symbol: Mavs
Name: mitochondrial antiviral signaling protein
RGD ID: 1359371
Description: Predicted to enable several functions, including CARD domain binding activity; RIG-I binding activity; and molecular condensate scaffold activity. Predicted to be involved in several processes, including positive regulation of cytokine production; regulation of DNA-templated transcription; and regulation of defense response. Predicted to act upstream of or within RIG-I signaling pathway and positive regulation of type I interferon production. Predicted to be located in mitochondrion and peroxisomal membrane. Predicted to be active in mitochondrial outer membrane. Orthologous to human MAVS (mitochondrial antiviral signaling protein); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS-1; MGC93707; mitochondrial antiviral-signaling protein; similar to RIKEN cDNA D430028G21; virus-induced signaling adapter; virus-induced signaling adaptor; virus-induced-signaling adapter; Visa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,904,673 - 138,919,129 (+)NCBIGRCr8
mRatBN7.23118,451,650 - 118,466,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,451,743 - 118,466,094 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3122,346,068 - 122,360,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,945,435 - 130,959,618 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,602,173 - 128,616,342 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,776,147 - 123,790,572 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,776,181 - 123,790,567 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03130,273,531 - 130,287,792 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,938,433 - 118,953,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,844,005 - 118,858,653 (+)NCBI
Celera3117,259,863 - 117,274,017 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Original Reference(s)
MavsRatinfluenza treatmentISOMavs (Mus musculus)40902992 RGD 
MavsRatinfluenza A disease_progressionISOMavs (Mus musculus)40903047 RGD 
MavsRatMetapneumovirus infections severityISOMavs (Mus musculus)40903044 RGD 
MavsRatplague susceptibilityISOMavs (Mus musculus)40903046 RGD 
MavsRatRotavirus Infections severityISOMavs (Mus musculus)40903048 RGD 
MavsRatvaccinia treatmentISOMavs (Mus musculus)40903043 RGD 
MavsRatWest Nile fever severityISOMavs (Mus musculus)40903045 RGD 
Object Symbol
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Original Reference(s)
MavsRatHuntington's disease-like 1  ISOMAVS (Homo sapiens)8554872ClinVar Annotator: match by term: Huntington disease-like 1ClinVarPMID:28492532
MavsRatInosine Triphosphatase Deficiency  ISOMAVS (Homo sapiens)8554872ClinVar Annotator: match by term: Inosine triphosphatase deficiencyClinVarPMID:26224535 more ...
MavsRatpantothenate kinase-associated neurodegeneration  ISOMAVS (Homo sapiens)8554872ClinVar Annotator: match by term: Pigmentary pallidal degenerationClinVarPMID:25741868 and PMID:28492532

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Original Reference(s)
MavsRat(1->4)-beta-D-glucan multiple interactionsISOMavs (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of MAVS mRNACTDPMID:36331819
MavsRat1,2-dimethylhydrazine multiple interactionsISOMavs (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MAVS mRNACTDPMID:22206623
MavsRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of MAVS mRNACTDPMID:18465118
MavsRat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:32119087
MavsRat4,4'-sulfonyldiphenol decreases methylationISOMavs (Mus musculus)6480464bisphenol S results in decreased methylation of MAVS exonCTDPMID:33297965
MavsRat4,4'-sulfonyldiphenol increases expressionISOMAVS (Homo sapiens)6480464bisphenol S results in increased expression of MAVS proteinCTDPMID:34186270
MavsRat4,4'-sulfonyldiphenol affects expressionISOMAVS (Homo sapiens)6480464bisphenol S affects the expression of MAVS proteinCTDPMID:31945527
MavsRat4,4'-sulfonyldiphenol increases expressionISOMavs (Mus musculus)6480464bisphenol S results in increased expression of MAVS mRNACTDPMID:39298647
MavsRat5-aza-2'-deoxycytidine increases expressionISOMavs (Mus musculus)6480464Decitabine results in increased expression of MAVS mRNACTDPMID:27923600
MavsRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of MAVS mRNACTDPMID:30047161
MavsRatacetamide decreases expressionEXP 6480464acetamide results in decreased expression of MAVS mRNACTDPMID:31881176
MavsRatacrylamide decreases expressionISOMAVS (Homo sapiens)6480464Acrylamide results in decreased expression of MAVS mRNACTDPMID:32763439
MavsRataflatoxin B1 decreases expressionISOMavs (Mus musculus)6480464Aflatoxin B1 results in decreased expression of MAVS mRNACTDPMID:19770486
MavsRatarsane affects methylationISOMAVS (Homo sapiens)6480464Arsenic affects the methylation of MAVS geneCTDPMID:25304211
MavsRatarsenic atom affects methylationISOMAVS (Homo sapiens)6480464Arsenic affects the methylation of MAVS geneCTDPMID:25304211
MavsRatarsenite(3-) multiple interactionsISOMAVS (Homo sapiens)6480464arsenite inhibits the reaction [G3BP1 protein binds to MAVS mRNA]CTDPMID:32406909
MavsRatbeauvericin increases expressionISOMAVS (Homo sapiens)6480464beauvericin results in increased expression of MAVS mRNACTDPMID:29203277
MavsRatbenzo[a]pyrene decreases expressionISOMavs (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of MAVS mRNACTDPMID:19770486
MavsRatbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of MAVS mRNACTDPMID:25181051
MavsRatbisphenol A multiple interactionsISOMAVS (Homo sapiens)6480464[[ginger extract results in increased abundance of Oils and Volatile] which co-treated with bisphenol A] affects the expression of MAVS proteinCTDPMID:33376534

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Biological Process
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Original Reference(s)
MavsRatactivation of innate immune response involved_inISSUniProtKB:Q7Z4341600115GO_REF:0000024UniProtGO_REF:0000024
MavsRatactivation of innate immune response involved_inISOMAVS (Homo sapiens)1624291 PMID:20628368RGDPMID:20628368
MavsRatantiviral innate immune response involved_inISOMAVS (Homo sapiens)1624291 PMID:27992402RGDPMID:27992402
MavsRatcellular response to exogenous dsRNA involved_inISSUniProtKB:Q7Z4341600115GO_REF:0000024UniProtGO_REF:0000024
MavsRatcellular response to exogenous dsRNA involved_inISOMAVS (Homo sapiens)1624291 PMID:16127453 and PMID:21957149RGDPMID:16127453 and PMID:21957149
MavsRatcytoplasmic pattern recognition receptor signaling pathway involved_inISOMAVS (Homo sapiens)1624291 PMID:16125763 and PMID:20451243RGDPMID:16125763 and PMID:20451243
MavsRatdefense response to bacterium involved_inISSUniProtKB:Q7Z4341600115GO_REF:0000024UniProtGO_REF:0000024
MavsRatdefense response to bacterium involved_inISOMAVS (Homo sapiens)1624291 PMID:19631370RGDPMID:19631370
MavsRatdefense response to virus involved_inIEAUniProtKB-KW:KW-00511600115GO_REF:0000043UniProtGO_REF:0000043
MavsRatimmune system process involved_inIEAARBA:ARBA000277991600115GO_REF:0000117UniProtGO_REF:0000117
MavsRatimmune system process involved_inIEAUniProtKB-KW:KW-03911600115GO_REF:0000043UniProtGO_REF:0000043
MavsRatinnate immune response involved_inISSUniProtKB:Q7Z4341600115GO_REF:0000024UniProtGO_REF:0000024
MavsRatinnate immune response involved_inISOMAVS (Homo sapiens)1624291 PMID:18818105 more ...RGDPMID:18818105 more ...
MavsRatinnate immune response involved_inIEAUniProtKB-KW:KW-03991600115GO_REF:0000043UniProtGO_REF:0000043
MavsRatinnate immune response acts_upstream_of_positive_effectISOMAVS (Homo sapiens)1624291 PMID:23951545RGDPMID:23951545
MavsRatintracellular signal transduction involved_inISOMAVS (Homo sapiens)1624291 PMID:16127453RGDPMID:16127453
MavsRatnegative regulation of viral genome replication involved_inISOMAVS (Homo sapiens)1624291 PMID:20451243RGDPMID:20451243
MavsRatnegative regulation of viral genome replication involved_inISOMavs (Mus musculus)1624291 PMID:20451243RGDPMID:20451243
MavsRatpositive regulation of canonical NF-kappaB signal transduction involved_inISOMAVS (Homo sapiens)1624291 PMID:16127453RGDPMID:16127453
MavsRatpositive regulation of chemokine (C-C motif) ligand 5 production involved_inISOMAVS (Homo sapiens)1624291 PMID:16127453RGDPMID:16127453
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Cellular Component
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Original Reference(s)
MavsRatcytoplasm located_inISOMAVS (Sus scrofa)1624291 PMID:24380861RGDPMID:24380861
MavsRatcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
MavsRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
MavsRatmitochondrial membrane located_inISOMAVS (Homo sapiens)1624291 PMID:20451243RGDPMID:20451243
MavsRatmitochondrial membrane is_active_inISOMAVS (Homo sapiens) and UniProtKB:Q7Z434-11624291 PMID:20451243RGDPMID:20451243
MavsRatmitochondrial membrane located_inISOMAVS (Sus scrofa)1624291 PMID:18586328RGDPMID:18586328
MavsRatmitochondrial outer membrane located_inISOMAVS (Homo sapiens)1624291 PMID:18818105RGDPMID:18818105
MavsRatmitochondrial outer membrane located_inIEAUniProtKB-SubCell:SL-01721600115GO_REF:0000044UniProtGO_REF:0000044
MavsRatmitochondrial outer membrane located_inIEAUniProtKB-KW:KW-10001600115GO_REF:0000043UniProtGO_REF:0000043
MavsRatmitochondrial outer membrane is_active_inISOMAVS (Homo sapiens)1624291 PMID:16127453 and PMID:26314863RGDPMID:16127453 and PMID:26314863
MavsRatmitochondrion located_inISOMAVS (Homo sapiens)1624291 PMID:20628368 and PMID:23582325RGDPMID:20628368 and PMID:23582325
MavsRatmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
MavsRatmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
MavsRatmitochondrion located_inISOMavs (Mus musculus)1624291 PMID:20451243 more ...RGDPMID:20451243 more ...
MavsRatmitochondrion located_inISSUniProtKB:Q7Z4341600115GO_REF:0000024UniProtGO_REF:0000024
MavsRatmitochondrion located_inISOMAVS (Homo sapiens) more ...1624291 RGDGO_REF:0000052
MavsRatmitochondrion is_active_inISOMAVS (Homo sapiens)1624291 PMID:16127453 more ...RGDPMID:16127453 more ...
MavsRatperoxisomal membrane located_inISOMAVS (Homo sapiens)1624291 PMID:20451243RGDPMID:20451243
MavsRatperoxisome located_inISOMavs (Mus musculus)1624291 PMID:20451243 and PMID:22745163RGDPMID:20451243 and PMID:22745163
MavsRatperoxisome located_inIEAUniProtKB-KW:KW-05761600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
MavsRatCARD domain binding enablesISOMAVS (Homo sapiens)1624291UniProtKB:O95786 more ...RGDPMID:16127453
MavsRatDNA-binding transcription factor binding enablesISOMAVS (Homo sapiens)1624291UniProtKB:Q14653 and PMID:18818105RGDPMID:18818105
MavsRatidentical protein binding enablesISOMAVS (Homo sapiens)1624291 PMID:16127453 and PMID:26803627RGDPMID:16127453 and PMID:26803627
MavsRatmolecular adaptor activity enablesISOMAVS (Homo sapiens)1624291 PMID:16858409RGDPMID:16858409
MavsRatmolecular condensate scaffold activity enablesISOMAVS (Homo sapiens)1624291 PMID:27992402RGDPMID:27992402
MavsRatprotein binding enablesISOMavs (Mus musculus)1624291UniProtKB:Q3UDK1 more ...RGDPMID:16858409 more ...
MavsRatprotein binding enablesISOMAVS (Homo sapiens)1624291UniProtKB:A2T3M4 more ...RGDPMID:16127453 more ...
MavsRatprotein binding enablesISOMAVS (Homo sapiens) and UniProtKB:Q7Z434-11624291UniProtKB:O95786-1 more ...RGDPMID:16585524 more ...
MavsRatprotein binding enablesISOMAVS (Homo sapiens) and UniProtKB:Q7Z434-11624291UniProtKB:Q86WV6 more ...RGDPMID:17460044 more ...
MavsRatprotein kinase binding enablesISOMAVS (Homo sapiens)1624291UniProtKB:Q13546 and PMID:16127453RGDPMID:16127453
MavsRatprotein serine/threonine kinase binding enablesISOMAVS (Homo sapiens)1624291UniProtKB:Q9UHD2 and PMID:18818105RGDPMID:18818105
MavsRatprotein-macromolecule adaptor activity enablesISOMAVS (Homo sapiens)1624291 PMID:16858409RGDPMID:16858409
MavsRatsignaling adaptor activity enablesISOMavs (Mus musculus)1624291 PMID:20451243 and PMID:23582325RGDPMID:20451243 and PMID:23582325
MavsRatsignaling adaptor activity enablesISOMAVS (Homo sapiens)1624291 PMID:18818105 more ...RGDPMID:18818105 more ...
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Imported Annotations - KEGG (archival)

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Original Reference(s)
MavsRathepatitis C pathway  IEA 6907045 KEGGrno:05160
MavsRatinfluenza A pathway  IEA 6907045 KEGGrno:05164
MavsRatmeasles pathway  IEA 6907045 KEGGrno:05162
MavsRatRetinoic acid-inducible gene (RIG) I-like receptor signaling pathway  IEA 6907045 KEGGrno:04622

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#
Reference Title
Reference Citation
1. Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection. Da Costa A, etal., Sci Rep. 2017 Jan 17;7:40720. doi: 10.1038/srep40720.
2. Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus. Deng J, etal., J Gen Virol. 2015 Aug;96(8):2104-2113. doi: 10.1099/vir.0.000178. Epub 2015 May 7.
3. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Ding S, etal., Elife. 2018 Nov 21;7. pii: 39494. doi: 10.7554/eLife.39494.
4. Transcriptomic response to Yersinia pestis: RIG-I like receptor signaling response is detrimental to the host against plague. Du Z, etal., J Genet Genomics. 2014 Jul 20;41(7):379-96. doi: 10.1016/j.jgg.2014.05.006. Epub 2014 Jun 3.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Constitutively Active MAVS Inhibits HIV-1 Replication via Type I Interferon Secretion and Induction of HIV-1 Restriction Factors. Gupta S, etal., PLoS One. 2016 Feb 5;11(2):e0148929. doi: 10.1371/journal.pone.0148929. eCollection 2016.
7. RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection. Kandasamy M, etal., PLoS Pathog. 2016 Jul 20;12(7):e1005754. doi: 10.1371/journal.ppat.1005754. eCollection 2016 Jul.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses. Song N, etal., Cell Rep. 2019 Aug 27;28(9):2386-2396.e5. doi: 10.1016/j.celrep.2019.07.085.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Xu LG, etal., Mol Cell 2005 Sep 16;19(6):727-40.
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PMID:12761501   PMID:15489334   PMID:16127453   PMID:16641100   PMID:18586328   PMID:18614015   PMID:18780793   PMID:18818105   PMID:19609254   PMID:19631370   PMID:20451243   PMID:21703541  
PMID:21957149   PMID:22745163  



Mavs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,904,673 - 138,919,129 (+)NCBIGRCr8
mRatBN7.23118,451,650 - 118,466,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,451,743 - 118,466,094 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3122,346,068 - 122,360,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,945,435 - 130,959,618 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,602,173 - 128,616,342 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,776,147 - 123,790,572 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,776,181 - 123,790,567 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03130,273,531 - 130,287,792 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,938,433 - 118,953,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,844,005 - 118,858,653 (+)NCBI
Celera3117,259,863 - 117,274,017 (+)NCBICelera
Cytogenetic Map3q36NCBI
MAVS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,846,834 - 3,876,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,846,799 - 3,876,123 (+)EnsemblGRCh38hg38GRCh38
GRCh37203,827,481 - 3,856,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,775,484 - 3,795,973 (+)NCBINCBI36Build 36hg18NCBI36
Celera203,889,325 - 3,918,630 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,776,247 - 3,805,626 (+)NCBIHuRef
CHM1_1203,827,384 - 3,856,773 (+)NCBICHM1_1
T2T-CHM13v2.0203,877,778 - 3,907,055 (+)NCBIT2T-CHM13v2.0
Mavs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,075,445 - 131,089,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,075,983 - 131,089,945 (+)EnsemblGRCm39 Ensembl
GRCm382131,234,063 - 131,248,025 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,234,063 - 131,248,025 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,059,874 - 131,073,761 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,925,579 - 130,939,466 (+)NCBIMGSCv36mm8
Celera2132,460,494 - 132,474,382 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.3NCBI
Mavs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,695,438 - 14,703,672 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,691,918 - 14,704,782 (+)NCBIChiLan1.0ChiLan1.0
MAVS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,806,483 - 4,834,798 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,885,044 - 3,903,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,659,558 - 3,702,397 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,659,559 - 3,701,089 (+)Ensemblpanpan1.1panPan2
MAVS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,510,209 - 17,529,286 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,512,761 - 17,523,807 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,342,451 - 17,353,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02417,930,606 - 17,947,974 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,930,603 - 17,942,617 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12417,526,451 - 17,537,501 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,637,457 - 17,648,500 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,965,346 - 17,976,396 (-)NCBIUU_Cfam_GSD_1.0
Mavs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,413,582 - 166,427,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,842,160 - 14,859,202 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648514,842,778 - 14,859,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAVS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,850,900 - 31,869,188 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11731,850,646 - 31,869,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,193,888 - 36,210,273 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAVS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,534,433 - 34,555,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,541,229 - 34,552,823 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660719,898,086 - 9,918,187 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mavs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,939,040 - 4,954,058 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,936,556 - 4,951,081 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Mavs
35 total Variants

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:115
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000034146
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 31 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat

1 to 10 of 31 rows
AI502240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,465,695 - 118,465,911 (+)MAPPERmRatBN7.2
Rnor_6.03123,790,174 - 123,790,389NCBIRnor6.0
Rnor_5.03130,287,394 - 130,287,609UniSTSRnor5.0
RGSC_v3.43118,952,687 - 118,952,902UniSTSRGSC3.4
Celera3117,273,623 - 117,273,838UniSTS
RH 3.4 Map31012.9UniSTS
Cytogenetic Map3q36UniSTS
RH139303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,452,224 - 118,452,348 (+)MAPPERmRatBN7.2
Rnor_6.03123,776,692 - 123,776,815NCBIRnor6.0
Rnor_5.03130,274,059 - 130,274,182UniSTSRnor5.0
RGSC_v3.43118,938,870 - 118,938,993UniSTSRGSC3.4
Celera3117,260,300 - 117,260,423UniSTS
RH 3.4 Map31016.3UniSTS
Cytogenetic Map3q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 21 of 21 rows
RefSeq Transcripts NM_001005556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENSRNOT00000034146   ⟹   ENSRNOP00000033476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3118,458,647 - 118,466,094 (+)Ensembl
Rnor_6.0 Ensembl3123,776,255 - 123,790,567 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090764   ⟹   ENSRNOP00000073053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3118,451,743 - 118,466,094 (+)Ensembl
Rnor_6.0 Ensembl3123,776,181 - 123,789,637 (+)Ensembl
RefSeq Acc Id: NM_001005556   ⟹   NP_001005556
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,812 - 138,919,125 (+)NCBI
mRatBN7.23118,451,788 - 118,466,090 (+)NCBI
Rnor_6.03123,776,255 - 123,790,568 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
RGSC_v3.43118,938,433 - 118,953,081 (+)RGD
Celera3117,259,863 - 117,274,017 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235034   ⟹   XP_006235096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,674 - 138,919,129 (+)NCBI
mRatBN7.23118,451,650 - 118,466,094 (+)NCBI
Rnor_6.03123,776,147 - 123,790,572 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235035   ⟹   XP_006235097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,736 - 138,919,129 (+)NCBI
mRatBN7.23118,451,733 - 118,466,094 (+)NCBI
Rnor_6.03123,776,173 - 123,790,572 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235036   ⟹   XP_006235098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,743 - 138,919,129 (+)NCBI
mRatBN7.23118,451,754 - 118,466,094 (+)NCBI
Rnor_6.03123,776,172 - 123,790,572 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235037   ⟹   XP_006235099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,812 - 138,919,129 (+)NCBI
mRatBN7.23118,451,733 - 118,466,094 (+)NCBI
Rnor_6.03123,776,174 - 123,790,572 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105011   ⟹   XP_038960939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,790 - 138,919,129 (+)NCBI
mRatBN7.23118,451,727 - 118,466,094 (+)NCBI
RefSeq Acc Id: XM_063283774   ⟹   XP_063139844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,906,047 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283775   ⟹   XP_063139845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,731 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283776   ⟹   XP_063139846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,788 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283778   ⟹   XP_063139848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,796 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283779   ⟹   XP_063139849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,787 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283780   ⟹   XP_063139850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,906,044 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283781   ⟹   XP_063139851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,673 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283782   ⟹   XP_063139852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,906,043 - 138,916,715 (+)NCBI
1 to 5 of 16 rows
1 to 5 of 16 rows
RefSeq Acc Id: NP_001005556   ⟸   NM_001005556
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235096   ⟸   XM_006235034
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235099   ⟸   XM_006235037
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006235098   ⟸   XM_006235036
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235097   ⟸   XM_006235035
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
- Sequence:
CARD   Caspase recruitment

Name Modeler Protein Id AA Range Protein Structure
AF-Q66HG9-F1-model_v2 AlphaFold Q66HG9 1-507 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692453
Promoter ID:EPDNEW_R2973
Type:initiation region
Name:Mavs_1
Description:mitochondrial antiviral signaling protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,776,210 - 123,776,270EPDNEW


1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-47818 BioCyc
Ensembl Genes ENSRNOG00000025295 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090764 ENTREZGENE
  ENSRNOT00000090764.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106026 IMAGE-MGC_LOAD
InterPro CARD_dom UniProtKB/Swiss-Prot
  CARD_IPS1 UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  MAVS UniProtKB/Swiss-Prot
KEGG Report rno:311430 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93707 IMAGE-MGC_LOAD
NCBI Gene 311430 ENTREZGENE
PANTHER DUF3504 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  PTHR21446:SF6 UniProtKB/Swiss-Prot
Pfam CARD_2 UniProtKB/Swiss-Prot
PhenoGen Mavs PhenoGen
RatGTEx ENSRNOG00000025295 RatGTEx
UniProt A0A8L2QH64 ENTREZGENE, UniProtKB/TrEMBL
  A6HQD4 ENTREZGENE, UniProtKB/TrEMBL
  MAVS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Mavs  mitochondrial antiviral signaling protein  Visa  virus-induced signaling adapter  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Visa  virus-induced signaling adapter  MGC93707  similar to RIKEN cDNA D430028G21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 MGC93707  similar to RIKEN cDNA D430028G21      Symbol and Name status set to provisional 70820 PROVISIONAL