MAVS (mitochondrial antiviral signaling protein) - Rat Genome Database

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Gene: MAVS (mitochondrial antiviral signaling protein) Pan paniscus
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Symbol: MAVS
Name: mitochondrial antiviral signaling protein
RGD ID: 11727106
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); protein serine/threonine kinase binding (ortholog); INVOLVED IN positive regulation of defense response to virus by host (ortholog); positive regulation of DNA-binding transcription factor activity (ortholog); positive regulation of interferon-alpha production (ortholog); ASSOCIATED WITH Huntington's disease-like 1 (ortholog); influenza (ortholog); influenza A (ortholog); FOUND IN mitochondrial membrane (ortholog); mitochondrial outer membrane (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,806,483 - 4,834,798 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,885,044 - 3,903,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,659,558 - 3,702,397 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,659,559 - 3,701,089 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (IEA)
antiviral innate immune response  (IEA)
cellular response to exogenous dsRNA  (IEA)
cytoplasmic pattern recognition receptor signaling pathway  (IEA)
defense response to bacterium  (IEA)
defense response to virus  (IEA)
immune system process  (IEA)
innate immune response  (IEA)
intracellular signal transduction  (IEA)
negative regulation of viral genome replication  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of chemokine (C-C motif) ligand 5 production  (IEA)
positive regulation of defense response to virus by host  (IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of interferon-alpha production  (IEA,ISO)
positive regulation of interferon-beta production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of IP-10 production  (IEA)
positive regulation of myeloid dendritic cell cytokine production  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (IEA)
positive regulation of protein import into nucleus  (IEA)
positive regulation of response to cytokine stimulus  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type I interferon production  (IEA,ISO)
positive regulation of type I interferon-mediated signaling pathway  (IEA)
protein localization to mitochondrion  (IEA)
regulation of peroxisome organization  (IEA)
RIG-I signaling pathway  (ISO)
signal transduction  (IEA)

Cellular Component

References

Genomics

Comparative Map Data
MAVS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,806,483 - 4,834,798 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,885,044 - 3,903,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,659,558 - 3,702,397 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,659,559 - 3,701,089 (+)Ensemblpanpan1.1panPan2
MAVS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,846,834 - 3,876,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,846,799 - 3,876,123 (+)EnsemblGRCh38hg38GRCh38
GRCh37203,827,481 - 3,856,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,775,484 - 3,795,973 (+)NCBINCBI36Build 36hg18NCBI36
Celera203,889,325 - 3,918,630 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,776,247 - 3,805,626 (+)NCBIHuRef
CHM1_1203,827,384 - 3,856,773 (+)NCBICHM1_1
T2T-CHM13v2.0203,877,778 - 3,907,055 (+)NCBIT2T-CHM13v2.0
Mavs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,075,445 - 131,089,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,075,983 - 131,089,945 (+)EnsemblGRCm39 Ensembl
GRCm382131,234,063 - 131,248,025 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,234,063 - 131,248,025 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,059,874 - 131,073,761 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,925,579 - 130,939,466 (+)NCBIMGSCv36mm8
Celera2132,460,494 - 132,474,382 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.3NCBI
Mavs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,904,673 - 138,919,129 (+)NCBIGRCr8
mRatBN7.23118,451,650 - 118,466,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,451,743 - 118,466,094 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3122,346,068 - 122,360,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,945,435 - 130,959,618 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,602,173 - 128,616,342 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,776,147 - 123,790,572 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,776,181 - 123,790,567 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03130,273,531 - 130,287,792 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,938,433 - 118,953,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,844,005 - 118,858,653 (+)NCBI
Celera3117,259,863 - 117,274,017 (+)NCBICelera
Cytogenetic Map3q36NCBI
Mavs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,695,438 - 14,703,672 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,691,918 - 14,704,782 (+)NCBIChiLan1.0ChiLan1.0
MAVS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,510,209 - 17,529,286 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,512,761 - 17,523,807 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,342,451 - 17,353,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02417,930,606 - 17,947,974 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,930,603 - 17,942,617 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12417,526,451 - 17,537,501 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,637,457 - 17,648,500 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,965,346 - 17,976,396 (-)NCBIUU_Cfam_GSD_1.0
Mavs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,413,582 - 166,427,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,842,160 - 14,859,202 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648514,842,778 - 14,859,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAVS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,850,900 - 31,869,188 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11731,850,646 - 31,869,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,193,888 - 36,210,273 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAVS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,534,433 - 34,555,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,541,229 - 34,552,823 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660719,898,086 - 9,918,187 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mavs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,939,040 - 4,954,058 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,936,556 - 4,951,081 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000029558   ⟹   ENSPPAP00000007316
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl203,659,559 - 3,701,089 (+)Ensembl
RefSeq Acc Id: XM_003821318   ⟹   XP_003821366
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBI
NHGRI_mPanPan1204,806,483 - 4,834,798 (+)NCBI
Mhudiblu_PPA_v0203,885,044 - 3,903,554 (+)NCBI
PanPan1.1203,685,510 - 3,701,089 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008974793   ⟹   XP_008973041
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,812,289 - 4,837,991 (+)NCBI
NHGRI_mPanPan1204,809,203 - 4,834,798 (+)NCBI
Mhudiblu_PPA_v0203,885,201 - 3,902,045 (+)NCBI
PanPan1.1203,685,652 - 3,701,088 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034947159   ⟹   XP_034803050
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBI
NHGRI_mPanPan1204,806,484 - 4,834,798 (+)NCBI
Mhudiblu_PPA_v0203,885,044 - 3,901,548 (+)NCBI
RefSeq Acc Id: XM_063601028   ⟹   XP_063457098
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,812,296 - 4,837,991 (+)NCBI
RefSeq Acc Id: XM_063601029   ⟹   XP_063457099
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,816,554 - 4,837,991 (+)NCBI
RefSeq Acc Id: XR_008622265
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,809,731 - 4,836,259 (+)NCBI
NHGRI_mPanPan1204,806,483 - 4,834,798 (+)NCBI
RefSeq Acc Id: XR_008622267
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBI
NHGRI_mPanPan1204,806,483 - 4,834,798 (+)NCBI
RefSeq Acc Id: XR_008622268
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBI
NHGRI_mPanPan1204,806,483 - 4,834,798 (+)NCBI
RefSeq Acc Id: XR_008622269
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBI
NHGRI_mPanPan1204,806,484 - 4,834,798 (+)NCBI
RefSeq Acc Id: XR_010110996
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003821366 (Get FASTA)   NCBI Sequence Viewer  
  XP_008973041 (Get FASTA)   NCBI Sequence Viewer  
  XP_034803050 (Get FASTA)   NCBI Sequence Viewer  
  XP_063457098 (Get FASTA)   NCBI Sequence Viewer  
  XP_063457099 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000007316.1
RefSeq Acc Id: XP_003821366   ⟸   XM_003821318
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZQS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008973041   ⟸   XM_008974793
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZQS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034803050   ⟸   XM_034947159
- Peptide Label: isoform X2
Ensembl Acc Id: ENSPPAP00000007316   ⟸   ENSPPAT00000029558
RefSeq Acc Id: XP_063457098   ⟸   XM_063601028
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063457099   ⟸   XM_063601029
- Peptide Label: isoform X3
Protein Domains
Caspase recruitment


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000026515 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000029558.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro CARD_dom UniProtKB/TrEMBL
  CARD_IPS1 UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  MAVS UniProtKB/TrEMBL
KEGG Report pps:100979730 UniProtKB/TrEMBL
NCBI Gene MAVS ENTREZGENE
PANTHER DUF3504 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR21446:SF6 UniProtKB/TrEMBL
Pfam CARD_2 UniProtKB/TrEMBL
UniProt A0A2R8ZQS6 ENTREZGENE, UniProtKB/TrEMBL