RGD Reference Report - Transcriptomic response to Yersinia pestis: RIG-I like receptor signaling response is detrimental to the host against plague. - Rat Genome Database

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Transcriptomic response to Yersinia pestis: RIG-I like receptor signaling response is detrimental to the host against plague.

Authors: Du, Zongmin  Yang, Huiying  Tan, Yafang  Tian, Guang  Zhang, Qingwen  Cui, Yujun  Yanfeng Yan,   Wu, Xiaohong  Chen, Zuyun  Cao, Shiyang  Bi, Yujing  Han, Yanping  Wang, Xiaoyi  Song, Yajun  Yang, Ruifu 
Citation: Du Z, etal., J Genet Genomics. 2014 Jul 20;41(7):379-96. doi: 10.1016/j.jgg.2014.05.006. Epub 2014 Jun 3.
RGD ID: 40903046
Pubmed: PMID:25064677   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jgg.2014.05.006   (Journal Full-text)

Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection. In this study, RNA-sequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection. Over 6000 genes were differentially expressed over the 12 h infection. Kinetic responses of pathogen recognition receptor signaling pathways, apoptosis, antigen processing, and presentation pathway and coagulation system were analyzed in detail. Among them, RIG-I-like receptor (RLR) signaling pathway, which was established for antiviral defense, was significantly affected. Mice lacking MAVS, the adaptor of the RLR signaling pathway, were less sensitive to infection and exhibited lower IFN-β production, higher Th1-type cytokines IFN-γ and IL-12 production, and lower Th2-type cytokines IL-4 and IL-13 production in the serum compared with wild-type mice. Moreover, infection of pathogenic bacteria other than Y. pestis also altered the expression of the RLR pathway, suggesting that the response of RLR pathway to bacterial infection is a universal mechanism.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
plague susceptibilityISOMavs (Mus musculus)40903046; 40903046 RGD 
plague susceptibilityIMP 40903046 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mavs  (mitochondrial antiviral signaling protein)

Genes (Mus musculus)
Mavs  (mitochondrial antiviral signaling protein)

Genes (Homo sapiens)
MAVS  (mitochondrial antiviral signaling protein)


Additional Information