Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Epm2aip1 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:22079256 | Epm2aip1 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:22206623 | Epm2aip1 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of EPM2AIP1 mRNA | CTD | PMID:29097150 | Epm2aip1 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of EPM2AIP1 mRNA | CTD | PMID:32145629 | Epm2aip1 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Epm2aip1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EPM2AIP1 mRNA | CTD | PMID:19465110 more ... | Epm2aip1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:33387578 | Epm2aip1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EPM2AIP1 mRNA | CTD | PMID:32109520 | Epm2aip1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of EPM2AIP1 mRNA | CTD | PMID:21570461 | Epm2aip1 | Rat | 2,4,6-tribromophenol | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Epm2aip1 | Rat | 2-methylcholine | affects expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of EPM2AIP1 mRNA | CTD | PMID:21179406 | Epm2aip1 | Rat | 4,4'-sulfonyldiphenol | increases methylation | ISO | Epm2aip1 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of EPM2AIP1 exon | CTD | PMID:33297965 | Epm2aip1 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:30047161 | Epm2aip1 | Rat | aflatoxin B1 | decreases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:19770486 | Epm2aip1 | Rat | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:30047161 | Epm2aip1 | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:30779732 | Epm2aip1 | Rat | antirheumatic drug | increases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of EPM2AIP1 mRNA | CTD | PMID:24449571 | Epm2aip1 | Rat | aristolochic acid A | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:33212167 | Epm2aip1 | Rat | arsane | decreases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Arsenic results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:19654921 | Epm2aip1 | Rat | arsane | affects methylation | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of EPM2AIP1 gene | CTD | PMID:25304211 | Epm2aip1 | Rat | arsenic atom | decreases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Arsenic results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:19654921 | Epm2aip1 | Rat | arsenic atom | affects methylation | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of EPM2AIP1 gene | CTD | PMID:25304211 | Epm2aip1 | Rat | avobenzone | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | avobenzone results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:31016361 | Epm2aip1 | Rat | azoxystrobin | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:33854195 | Epm2aip1 | Rat | benzo[a]pyrene | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of EPM2AIP1 mRNA | CTD | PMID:22228805 | Epm2aip1 | Rat | benzo[a]pyrene | decreases methylation | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of EPM2AIP1 exon | CTD | PMID:27901495 | Epm2aip1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EPM2AIP1 mRNA | CTD | PMID:29097150 more ... | Epm2aip1 | Rat | bisphenol A | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of EPM2AIP1 protein | CTD | PMID:31675489 | Epm2aip1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of EPM2AIP1 mRNA | CTD | PMID:32145629 | Epm2aip1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:30816183 more ... | Epm2aip1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with tributyltin] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:31129395 | Epm2aip1 | Rat | bisphenol A | decreases methylation | ISO | Epm2aip1 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of EPM2AIP1 promoter | CTD | PMID:27312807 | Epm2aip1 | Rat | butanal | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:26079696 | Epm2aip1 | Rat | cadmium atom | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EPM2AIP1 mRNA | CTD | PMID:35301059 | Epm2aip1 | Rat | cadmium dichloride | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EPM2AIP1 mRNA | CTD | PMID:35301059 | Epm2aip1 | Rat | camptothecin | increases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Camptothecin results in increased expression of EPM2AIP1 mRNA | CTD | PMID:17374387 | Epm2aip1 | Rat | carbon nanotube | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | Epm2aip1 | Rat | CGP 52608 | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to EPM2AIP1 gene] | CTD | PMID:28238834 | Epm2aip1 | Rat | chlorpyrifos | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:33854195 | Epm2aip1 | Rat | ciguatoxin CTX1B | affects expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of EPM2AIP1 mRNA | CTD | PMID:18353800 | Epm2aip1 | Rat | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of EPM2AIP1 mRNA | CTD | PMID:24386269 | Epm2aip1 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of EPM2AIP1 mRNA | CTD | PMID:30556269 | Epm2aip1 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of EPM2AIP1 mRNA | CTD | PMID:30556269 | Epm2aip1 | Rat | copper(II) sulfate | increases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of EPM2AIP1 mRNA | CTD | PMID:19549813 | Epm2aip1 | Rat | crocidolite asbestos | decreases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:29279043 | Epm2aip1 | Rat | cyclosporin A | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Cyclosporine results in increased expression of EPM2AIP1 mRNA | CTD | PMID:19770486 | Epm2aip1 | Rat | cyclosporin A | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:25562108 | Epm2aip1 | Rat | daunorubicin | increases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Daunorubicin results in increased expression of EPM2AIP1 mRNA | CTD | PMID:17374387 | Epm2aip1 | Rat | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of EPM2AIP1 mRNA | CTD | PMID:23640034 | Epm2aip1 | Rat | decabromodiphenyl ether | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of EPM2AIP1 protein | CTD | PMID:31675489 | Epm2aip1 | Rat | Dibutyl phosphate | affects expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of EPM2AIP1 mRNA | CTD | PMID:37042841 | Epm2aip1 | Rat | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:21266533 | Epm2aip1 | Rat | dioxygen | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of EPM2AIP1 mRNA | CTD | PMID:24205000 | Epm2aip1 | Rat | dorsomorphin | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:27188386 | Epm2aip1 | Rat | ethanol | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:29432896 | Epm2aip1 | Rat | ethanol | affects splicing | ISO | Epm2aip1 (Mus musculus) | 6480464 | Ethanol affects the splicing of EPM2AIP1 mRNA | CTD | PMID:30319688 | Epm2aip1 | Rat | etoposide | increases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Etoposide results in increased expression of EPM2AIP1 mRNA | CTD | PMID:17374387 | Epm2aip1 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of EPM2AIP1 mRNA | CTD | PMID:24136188 | Epm2aip1 | Rat | folic acid | decreases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:25629700 | Epm2aip1 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:33387578 | Epm2aip1 | Rat | glyphosate | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:33854195 | Epm2aip1 | Rat | imidacloprid | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:33854195 | Epm2aip1 | Rat | leflunomide | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | leflunomide results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:28988120 | Epm2aip1 | Rat | maneb | multiple interactions | ISO | Epm2aip1 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:36117858 | Epm2aip1 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:30047161 | Epm2aip1 | Rat | methylmercury chloride | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:28001369 | Epm2aip1 | Rat | nickel sulfate | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | nickel sulfate results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:22714537 | Epm2aip1 | Rat | paracetamol | affects expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of EPM2AIP1 mRNA | CTD | PMID:17562736 | Epm2aip1 | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:33387578 | Epm2aip1 | Rat | paracetamol | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:21420995 | Epm2aip1 | Rat | paraquat | multiple interactions | ISO | Epm2aip1 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:36117858 | Epm2aip1 | Rat | pentanal | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | pentanal results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:26079696 | Epm2aip1 | Rat | perfluorooctane-1-sulfonic acid | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:27153767 | Epm2aip1 | Rat | phenobarbital | affects expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of EPM2AIP1 mRNA | CTD | PMID:19159669 | Epm2aip1 | Rat | phenobarbital | decreases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:23091169 | Epm2aip1 | Rat | potassium chromate | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:22079256 | Epm2aip1 | Rat | potassium chromate | increases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of EPM2AIP1 mRNA | CTD | PMID:22079256 | Epm2aip1 | Rat | potassium dichromate | increases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Potassium Dichromate results in increased expression of EPM2AIP1 protein | CTD | PMID:23718831 | Epm2aip1 | Rat | resveratrol | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:23557933 | Epm2aip1 | Rat | SB 431542 | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 and PMID:37664457 | Epm2aip1 | Rat | sodium arsenate | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of EPM2AIP1 mRNA | CTD | PMID:21795629 | Epm2aip1 | Rat | sodium fluoride | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of EPM2AIP1 protein | CTD | PMID:28918527 | Epm2aip1 | Rat | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:30047161 | Epm2aip1 | Rat | sunitinib | increases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of EPM2AIP1 mRNA | CTD | PMID:31533062 | Epm2aip1 | Rat | temozolomide | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:31758290 | Epm2aip1 | Rat | tetrachloromethane | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of EPM2AIP1 mRNA | CTD | PMID:17484886 | Epm2aip1 | Rat | tetraphene | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of EPM2AIP1 mRNA | CTD | PMID:26377693 | Epm2aip1 | Rat | thiabendazole | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:33854195 | Epm2aip1 | Rat | triadimefon | decreases expression | EXP | | 6480464 | triadimefon results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:30047161 | Epm2aip1 | Rat | tributylstannane | increases expression | EXP | | 6480464 | tributyltin results in increased expression of EPM2AIP1 mRNA | CTD | PMID:31129395 | Epm2aip1 | Rat | tributylstannane | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with tributyltin] results in increased expression of EPM2AIP1 mRNA | CTD | PMID:31129395 | Epm2aip1 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:33387578 | Epm2aip1 | Rat | triphenyl phosphate | affects expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of EPM2AIP1 mRNA | CTD | PMID:37042841 | Epm2aip1 | Rat | triptonide | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | triptonide results in increased expression of EPM2AIP1 mRNA | CTD | PMID:33045310 | Epm2aip1 | Rat | trovafloxacin | increases expression | ISO | Epm2aip1 (Mus musculus) | 6480464 | trovafloxacin results in increased expression of EPM2AIP1 mRNA | CTD | PMID:35537566 | Epm2aip1 | Rat | urethane | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:28818685 | Epm2aip1 | Rat | valproic acid | affects expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of EPM2AIP1 mRNA | CTD | PMID:25979313 | Epm2aip1 | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of EPM2AIP1 mRNA | CTD | PMID:29427782 | Epm2aip1 | Rat | valproic acid | multiple interactions | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:27188386 | Epm2aip1 | Rat | valproic acid | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:23179753 more ... | Epm2aip1 | Rat | vincristine | decreases expression | ISO | EPM2AIP1 (Homo sapiens) | 6480464 | Vincristine results in decreased expression of EPM2AIP1 mRNA | CTD | PMID:23649840 | |