Phf21b (PHD finger protein 21B) - Rat Genome Database

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Gene: Phf21b (PHD finger protein 21B) Rattus norvegicus
Analyze
Symbol: Phf21b
Name: PHD finger protein 21B
RGD ID: 1308739
Description: Orthologous to human PHF21B (PHD finger protein 21B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamiprid; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC300117; RGD1308739; similar to hypothetical protein BC012187
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87117,793,643 - 117,864,141 (-)NCBIGRCr8
mRatBN7.27115,913,704 - 115,984,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7115,915,412 - 115,984,215 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7117,665,985 - 117,734,741 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07119,891,709 - 119,960,466 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07119,861,154 - 119,929,908 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07125,649,688 - 125,720,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7125,649,688 - 125,718,986 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07125,370,846 - 125,438,318 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47122,808,454 - 122,879,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17122,839,964 - 122,912,933 (-)NCBI
Celera7112,213,870 - 112,282,352 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf21bRatintellectual disability  ISORGD:13441838554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Phf21bRatPhelan-McDermid syndrome  ISORGD:13441838554872ClinVar Annotator: match by term: Phelan-McDermid syndromeClinVar 

1 to 20 of 38 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf21bRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PHF21B mRNACTDPMID:33387578
Phf21bRat4,4'-sulfonyldiphenol decreases expressionISORGD:15530536480464bisphenol S results in decreased expression of PHF21B mRNACTDPMID:30951980|PMID:39298647
Phf21bRat4,4'-sulfonyldiphenol affects methylationISORGD:15530536480464bisphenol S affects the methylation of PHF21B geneCTDPMID:31683443
Phf21bRat4,4'-sulfonyldiphenol increases methylationISORGD:13441836480464bisphenol S results in increased methylation of PHF21B geneCTDPMID:31601247
Phf21bRat4,4'-sulfonyldiphenol decreases methylationISORGD:15530536480464bisphenol S results in decreased methylation of PHF21B exonCTDPMID:33297965
Phf21bRatacetamiprid increases expressionEXP 6480464acetamiprid results in increased expression of PHF21B mRNACTDPMID:27782041
Phf21bRataflatoxin B1 increases methylationISORGD:13441836480464Aflatoxin B1 results in increased methylation of PHF21B intronCTDPMID:30157460
Phf21bRatAflatoxin B2 alpha affects methylationISORGD:13441836480464aflatoxin B2 affects the methylation of PHF21B intronCTDPMID:30157460
Phf21bRatbenzo[a]pyrene increases methylationISORGD:13441836480464Benzo(a)pyrene results in increased methylation of PHF21B promoterCTDPMID:27901495
Phf21bRatbenzo[e]pyrene decreases methylationISORGD:13441836480464benzo(e)pyrene results in decreased methylation of PHF21B intronCTDPMID:30157460
Phf21bRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of PHF21B mRNACTDPMID:25181051
Phf21bRatbisphenol A decreases expressionISORGD:15530536480464bisphenol A results in decreased expression of PHF21B mRNACTDPMID:32156529|PMID:38074096
Phf21bRatbisphenol A increases methylationISORGD:13441836480464bisphenol A results in increased methylation of PHF21B geneCTDPMID:31601247
Phf21bRatcisplatin multiple interactionsISORGD:13441836480464[Cisplatin co-treated with jinfukang] results in decreased expression of PHF21B mRNACTDPMID:27392435
Phf21bRatcisplatin decreases expressionISORGD:13441836480464Cisplatin results in decreased expression of PHF21B mRNACTDPMID:27392435
Phf21bRatdorsomorphin multiple interactionsISORGD:13441836480464[NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...CTDPMID:27188386
Phf21bRatendosulfan increases expressionEXP 6480464Endosulfan results in increased expression of PHF21B mRNACTDPMID:29391264
Phf21bRatfulvestrant increases methylationISORGD:13441836480464Fulvestrant results in increased methylation of PHF21B geneCTDPMID:31601247
Phf21bRatfuran increases methylationEXP 6480464furan results in increased methylation of PHF21B geneCTDPMID:27387713
Phf21bRatfuran decreases expressionEXP 6480464furan results in decreased expression of PHF21B mRNACTDPMID:27387713

1 to 20 of 38 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Phf21bRatprotein binding enablesISORGD:1344183|UniProtKB:Q96EK2-31624291UniProtKB:Q8N9N5-2|UniProtKB:Q9P2K3-2 PMID:26871637RGDPMID:26871637
Phf21bRatprotein binding enablesISORGD:13441831624291UniProtKB:Q12800 PMID:26871637RGDPMID:26871637


#
Reference Title
Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:15632090  



Phf21b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87117,793,643 - 117,864,141 (-)NCBIGRCr8
mRatBN7.27115,913,704 - 115,984,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7115,915,412 - 115,984,215 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7117,665,985 - 117,734,741 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07119,891,709 - 119,960,466 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07119,861,154 - 119,929,908 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07125,649,688 - 125,720,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7125,649,688 - 125,718,986 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07125,370,846 - 125,438,318 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47122,808,454 - 122,879,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17122,839,964 - 122,912,933 (-)NCBI
Celera7112,213,870 - 112,282,352 (-)NCBICelera
Cytogenetic Map7q34NCBI
PHF21B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382244,881,162 - 45,010,005 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2244,881,162 - 45,010,005 (-)EnsemblGRCh38hg38GRCh38
GRCh372245,277,042 - 45,405,886 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362243,655,706 - 43,784,245 (-)NCBINCBI36Build 36hg18NCBI36
Build 342243,597,578 - 43,726,118NCBI
Celera2229,188,973 - 29,317,403 (-)NCBICelera
Cytogenetic Map22q13.31NCBI
HuRef2228,224,326 - 28,376,232 (-)NCBIHuRef
CHM1_12245,235,760 - 45,364,535 (-)NCBICHM1_1
T2T-CHM13v2.02245,364,687 - 45,493,893 (-)NCBIT2T-CHM13v2.0
Phf21b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391584,669,577 - 84,740,330 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1584,669,582 - 84,740,250 (-)EnsemblGRCm39 Ensembl
GRCm381584,785,376 - 84,856,129 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1584,785,381 - 84,856,049 (-)EnsemblGRCm38mm10GRCm38
MGSCv371584,615,806 - 84,686,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361584,613,150 - 84,683,815 (-)NCBIMGSCv36mm8
Celera1586,917,054 - 86,987,956 (-)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.08NCBI
Phf21b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541329,442,357 - 29,507,060 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541329,442,357 - 29,507,060 (-)NCBIChiLan1.0ChiLan1.0
PHF21B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22354,714,505 - 54,845,937 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12257,406,964 - 57,540,892 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02225,773,965 - 25,907,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12243,959,758 - 44,006,406 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2243,959,758 - 44,088,445 (-)Ensemblpanpan1.1panPan2
PHF21B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11021,042,151 - 21,068,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1020,986,924 - 21,066,392 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1020,915,777 - 20,998,844 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01021,722,328 - 21,805,422 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1021,721,607 - 21,806,414 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11021,442,069 - 21,525,097 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01021,762,329 - 21,845,707 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01021,936,652 - 22,019,622 (+)NCBIUU_Cfam_GSD_1.0
Phf21b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049454,759,457 - 4,767,422 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367182,212,741 - 2,240,530 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHF21B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl54,291,396 - 4,386,247 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.154,290,962 - 4,387,112 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.251,661,338 - 1,697,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PHF21B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11927,353,586 - 27,501,080 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604597,845,948 - 97,977,833 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Phf21b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247524,544,003 - 4,605,501 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247524,543,998 - 4,605,501 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Phf21b
439 total Variants

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:70
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000017906
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 31 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat

1 to 10 of 31 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000017906   ⟹   ENSRNOP00000017906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7115,915,412 - 115,984,215 (-)Ensembl
Rnor_6.0 Ensembl7125,649,688 - 125,718,986 (+)Ensembl
RefSeq Acc Id: NM_001130680   ⟹   NP_001124152
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87117,795,348 - 117,864,141 (-)NCBI
mRatBN7.27115,915,412 - 115,984,215 (-)NCBI
Rnor_6.07125,649,688 - 125,718,986 (+)NCBI
Rnor_5.07125,370,846 - 125,438,318 (+)NCBI
RGSC_v3.47122,808,454 - 122,879,651 (-)RGD
Celera7112,213,870 - 112,282,352 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765685   ⟹   XP_008763907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87117,793,643 - 117,863,574 (-)NCBI
mRatBN7.27115,913,704 - 115,983,508 (-)NCBI
Rnor_6.07125,650,469 - 125,720,694 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078846   ⟹   XP_038934774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87117,797,309 - 117,863,571 (-)NCBI
mRatBN7.27115,917,399 - 115,983,506 (-)NCBI
Protein RefSeqs NP_001124152 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763907 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934774 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15598 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017906
  ENSRNOP00000017906.4
  ENSRNOP00000104335
RefSeq Acc Id: NP_001124152   ⟸   NM_001130680
- UniProtKB: D4A9U0 (UniProtKB/TrEMBL),   A6HTC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763907   ⟸   XM_008765685
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000017906   ⟸   ENSRNOT00000017906
RefSeq Acc Id: XP_038934774   ⟸   XM_039078846
- Peptide Label: isoform X2
PHD-type

Name Modeler Protein Id AA Range Protein Structure
AF-D4A9U0-F1-model_v2 AlphaFold D4A9U0 1-494 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-32569 BioCyc
Ensembl Genes ENSRNOG00000013067 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017906 ENTREZGENE
  ENSRNOT00000017906.7 UniProtKB/TrEMBL
  ENSRNOT00000129997 ENTREZGENE
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:300117 UniProtKB/TrEMBL
NCBI Gene 300117 ENTREZGENE
PANTHER PHD FINGER PROTEIN UniProtKB/TrEMBL
  PHD FINGER PROTEIN 21B UniProtKB/TrEMBL
Pfam PHD UniProtKB/TrEMBL
PhenoGen Phf21b PhenoGen
PROSITE ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013067 RatGTEx
SMART PHD UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
UniProt A6HTC4 ENTREZGENE, UniProtKB/TrEMBL
  D4A9U0 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Phf21b  PHD finger protein 21B   Phf21b_predicted  PHD finger protein 21B (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Phf21b_predicted  PHD finger protein 21B (predicted)  RGD1308739_predicted  similar to hypothetical protein BC012187 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308739_predicted  similar to hypothetical protein BC012187 (predicted)  LOC300117_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC300117_predicted  similar to hypothetical protein BC012187 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL