Ikbke (inhibitor of nuclear factor kappa B kinase subunit epsilon) - Rat Genome Database

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Gene: Ikbke (inhibitor of nuclear factor kappa B kinase subunit epsilon) Rattus norvegicus
Analyze
Symbol: Ikbke
Name: inhibitor of nuclear factor kappa B kinase subunit epsilon
RGD ID: 1308352
Description: Predicted to enable several functions, including IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including interleukin-17-mediated signaling pathway; positive regulation of gene expression; and positive regulation of innate immune response. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; LOC363984
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,264,404 - 45,290,737 (-)NCBIGRCr8
mRatBN7.21342,712,154 - 42,738,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,712,159 - 42,737,143 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,320,191 - 45,345,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,608,323 - 46,633,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,872,035 - 43,897,029 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,031,325 - 48,056,394 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,031,410 - 48,056,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,107,093 - 53,132,162 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,197,625 - 44,222,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11344,211,668 - 44,233,796 (-)NCBI
Celera1343,057,856 - 43,082,833 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
amlexanox  (ISO)
andrographolide  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
brilliant green  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroethene  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
crystal violet  (ISO)
cyproconazole  (ISO)
daunorubicin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diclofenac  (ISO)
diethyl maleate  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
lipopolysaccharide  (ISO)
melphalan  (ISO)
motexafin gadolinium  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sucrose  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
triadimefon  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc acetate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
mitochondrial membrane  (ISO)
nucleus  (ISO)
PML body  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10421793   PMID:10882136   PMID:12477932   PMID:12761501   PMID:16876765   PMID:20188669   PMID:23741427   PMID:24380861   PMID:24882218   PMID:27129230   PMID:30794866   PMID:34933200  


Genomics

Comparative Map Data
Ikbke
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,264,404 - 45,290,737 (-)NCBIGRCr8
mRatBN7.21342,712,154 - 42,738,470 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,712,159 - 42,737,143 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,320,191 - 45,345,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,608,323 - 46,633,354 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,872,035 - 43,897,029 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,031,325 - 48,056,394 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,031,410 - 48,056,394 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,107,093 - 53,132,162 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,197,625 - 44,222,609 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11344,211,668 - 44,233,796 (-)NCBI
Celera1343,057,856 - 43,082,833 (-)NCBICelera
Cytogenetic Map13q13NCBI
IKBKE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,470,476 - 206,496,889 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,470,476 - 206,496,889 (+)EnsemblGRCh38hg38GRCh38
GRCh371206,643,819 - 206,670,222 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,710,419 - 204,736,845 (+)NCBINCBI36Build 36hg18NCBI36
Build 341203,032,190 - 203,058,617NCBI
Celera1179,895,028 - 179,921,668 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,341,834 - 177,368,529 (+)NCBIHuRef
CHM1_11207,915,782 - 207,942,429 (+)NCBICHM1_1
T2T-CHM13v2.01205,734,655 - 205,761,052 (+)NCBIT2T-CHM13v2.0
Ikbke
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,182,337 - 131,207,339 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,182,080 - 131,207,344 (-)EnsemblGRCm39 Ensembl
GRCm381131,254,600 - 131,279,601 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,254,343 - 131,279,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,151,179 - 133,176,140 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,082,148 - 133,107,109 (-)NCBIMGSCv36mm8
Celera1133,876,834 - 133,902,322 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.93NCBI
Ikbke
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,056,014 - 42,077,701 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,056,014 - 42,077,701 (+)NCBIChiLan1.0ChiLan1.0
IKBKE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,881,624 - 42,909,446 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,847,151 - 42,873,352 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,070,565 - 182,096,797 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,351,807 - 186,377,970 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,351,807 - 186,377,971 (+)Ensemblpanpan1.1panPan2
IKBKE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,747,303 - 2,772,574 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl382,747,297 - 2,772,587 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,839,619 - 2,864,841 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,744,869 - 2,770,037 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,744,859 - 2,770,035 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,738,094 - 2,763,301 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0383,131,469 - 3,156,703 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,331,693 - 3,356,866 (+)NCBIUU_Cfam_GSD_1.0
Ikbke
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,825,925 - 68,851,246 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365576,066,207 - 6,090,767 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IKBKE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,123,265 - 67,147,989 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,123,055 - 67,147,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,367,929 - 73,388,131 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IKBKE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,865,720 - 22,892,346 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,865,734 - 22,891,920 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,564,077 - 23,591,390 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ikbke
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,913,742 - 4,933,267 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,913,734 - 4,934,096 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ikbke
102 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:471
Count of miRNA genes:229
Interacting mature miRNAs:266
Transcripts:ENSRNOT00000038151
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
RH130591  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,712,185 - 42,712,379 (+)MAPPERmRatBN7.2
Rnor_6.01348,031,437 - 48,031,630NCBIRnor6.0
Rnor_5.01353,107,205 - 53,107,398UniSTSRnor5.0
RGSC_v3.41344,197,652 - 44,197,845UniSTSRGSC3.4
Celera1343,057,883 - 43,058,076UniSTS
RH 3.4 Map13110.6UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000038151   ⟹   ENSRNOP00000030127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,712,159 - 42,737,143 (-)Ensembl
Rnor_6.0 Ensembl1348,031,410 - 48,056,394 (-)Ensembl
RefSeq Acc Id: NM_001108854   ⟹   NP_001102324
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,264,412 - 45,289,396 (-)NCBI
mRatBN7.21342,712,159 - 42,737,143 (-)NCBI
Rnor_6.01348,031,410 - 48,056,394 (-)NCBI
Rnor_5.01353,107,093 - 53,132,162 (-)NCBI
RGSC_v3.41344,197,625 - 44,222,609 (-)RGD
Celera1343,057,856 - 43,082,833 (-)RGD
Sequence:
RefSeq Acc Id: XM_017598875   ⟹   XP_017454364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,264,404 - 45,290,031 (-)NCBI
mRatBN7.21342,712,154 - 42,737,765 (-)NCBI
Rnor_6.01348,031,325 - 48,056,378 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090949   ⟹   XP_038946877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,264,404 - 45,290,737 (-)NCBI
mRatBN7.21342,712,154 - 42,738,470 (-)NCBI
RefSeq Acc Id: XM_039090950   ⟹   XP_038946878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,264,404 - 45,283,851 (-)NCBI
mRatBN7.21342,712,154 - 42,731,598 (-)NCBI
RefSeq Acc Id: XM_063272513   ⟹   XP_063128583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,277,588 - 45,290,028 (-)NCBI
RefSeq Acc Id: XR_005492260
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,264,404 - 45,290,021 (-)NCBI
mRatBN7.21342,712,159 - 42,737,755 (-)NCBI
RefSeq Acc Id: XR_005492261
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,275,785 - 45,290,028 (-)NCBI
mRatBN7.21342,723,532 - 42,737,762 (-)NCBI
RefSeq Acc Id: XR_005492262
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,280,166 - 45,290,014 (-)NCBI
mRatBN7.21342,727,913 - 42,737,746 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102324 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454364 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946877 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946878 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128583 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM09830 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030127.3
RefSeq Acc Id: NP_001102324   ⟸   NM_001108854
- UniProtKB: D4A5E7 (UniProtKB/TrEMBL),   A6IC17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454364   ⟸   XM_017598875
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000030127   ⟸   ENSRNOT00000038151
RefSeq Acc Id: XP_038946877   ⟸   XM_039090949
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946878   ⟸   XM_039090950
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063128583   ⟸   XM_063272513
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5E7-F1-model_v2 AlphaFold D4A5E7 1-717 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698795
Promoter ID:EPDNEW_R9320
Type:multiple initiation site
Name:Ikbke_1
Description:inhibitor of nuclear factor kappa B kinase subunit epsilon
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01348,056,350 - 48,056,410EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308352 AgrOrtholog
BioCyc Gene G2FUF-18353 BioCyc
Ensembl Genes ENSRNOG00000025100 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038151.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.420 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IKK UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/TrEMBL
KEGG Report rno:363984 UniProtKB/TrEMBL
NCBI Gene 363984 ENTREZGENE
PANTHER IKB KINASE UniProtKB/TrEMBL
  INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  TBK1_CCD1 UniProtKB/TrEMBL
  TBK1_ULD UniProtKB/TrEMBL
PhenoGen Ikbke PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025100 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A6IC17 ENTREZGENE, UniProtKB/TrEMBL
  D4A5E7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-01 Ikbke  inhibitor of nuclear factor kappa B kinase subunit epsilon  Ikbke  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Ikbke  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon  Ikbke  inhibitor of kappaB kinase epsilon   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ikbke  inhibitor of kappaB kinase epsilon   Ikbke_predicted  inhibitor of kappaB kinase epsilon (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ikbke_predicted  inhibitor of kappaB kinase epsilon (predicted)      Symbol and Name status set to approved 70820 APPROVED