Wnk2 (WNK lysine deficient protein kinase 2) - Rat Genome Database

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Gene: Wnk2 (WNK lysine deficient protein kinase 2) Rattus norvegicus
Analyze
Symbol: Wnk2
Name: WNK lysine deficient protein kinase 2
RGD ID: 1307284
Description: Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein autophosphorylation; regulation of metal ion transport; and regulation of signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Biomarker of transient cerebral ischemia. Orthologous to human WNK2 (WNK lysine deficient protein kinase 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kinase deficient protein; LOC306811; RGD1307284; serine/threonine-protein kinase WNK2; similar to protein kinase, lysine deficient 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81715,709,648 - 15,818,874 (+)NCBIGRCr8
mRatBN7.21715,503,672 - 15,612,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1715,390,684 - 15,499,052 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01716,995,723 - 17,104,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,317,444 - 15,425,805 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01715,923,508 - 16,032,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1715,924,048 - 16,032,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01717,986,985 - 18,095,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41721,461,980 - 21,600,361 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11721,462,134 - 21,600,354 (+)NCBI
Celera1715,234,024 - 15,342,287 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnk2Rattransient cerebral ischemia  IEP 14398833 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnk2Ratgenetic disease  ISOWNK2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnk2Rat1,2-dimethylhydrazine increases expressionISOWnk2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of WNK2 mRNACTDPMID:22206623
Wnk2Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of WNK2 mRNACTDPMID:26945725
Wnk2Rat17beta-estradiol increases expressionISOWNK2 (Homo sapiens)6480464Estradiol results in increased expression of WNK2 mRNACTDPMID:31614463
Wnk2Rat17beta-estradiol multiple interactionsISOWNK2 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of WNK2 mRNACTDPMID:30165855
Wnk2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOWnk2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of WNK2 mRNACTDPMID:21570461
Wnk2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of WNK2 mRNACTDPMID:33387578
Wnk2Rat4,4'-sulfonyldiphenol decreases methylationISOWnk2 (Mus musculus)6480464bisphenol S results in decreased methylation of WNK2 exonCTDPMID:33297965
Wnk2Rat4-hydroxyphenyl retinamide increases expressionISOWnk2 (Mus musculus)6480464Fenretinide results in increased expression of WNK2 mRNACTDPMID:28973697
Wnk2Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of WNK2 mRNACTDPMID:30047161
Wnk2Ratafimoxifene decreases expressionISOWnk2 (Mus musculus)6480464afimoxifene results in decreased expression of WNK2 mRNACTDPMID:26879975
Wnk2Rataflatoxin B1 decreases methylationISOWNK2 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of WNK2 intronCTDPMID:30157460
Wnk2RatAflatoxin B2 alpha increases methylationISOWNK2 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of WNK2 intronCTDPMID:30157460
Wnk2Rataldehydo-D-glucose multiple interactionsISOWnk2 (Mus musculus)6480464[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in decreased expression of WNK2 mRNACTDPMID:37567420
Wnk2Ratalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of WNK2 mRNACTDPMID:35163327
Wnk2Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of WNK2 mRNACTDPMID:30047161
Wnk2Ratarsenous acid increases expressionISOWNK2 (Homo sapiens)6480464Arsenic Trioxide results in increased expression of WNK2 mRNACTDPMID:19763917
Wnk2Ratbenzo[a]pyrene decreases methylationISOWnk2 (Mus musculus)6480464Benzo(a)pyrene results in decreased methylation of WNK2 intronCTDPMID:27901495
Wnk2Ratbenzo[a]pyrene increases methylationISOWNK2 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of WNK2 promoterCTDPMID:27901495
Wnk2Ratbenzo[a]pyrene affects methylationISOWNK2 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of WNK2 intronCTDPMID:30157460
Wnk2Ratbenzo[e]pyrene increases methylationISOWNK2 (Homo sapiens)6480464benzo(e)pyrene results in increased methylation of WNK2 intronCTDPMID:30157460

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Biological Process
1 to 12 of 12 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Wnk2Ratintracellular signal transduction involved_inIBAMGI:1917097 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnk2Ratmonoatomic ion homeostasis involved_inISOWNK2 (Homo sapiens)1624291 PMID:21733846RGDPMID:21733846
Wnk2Ratmonoatomic ion homeostasis involved_inIBAMGI:1917097 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnk2Ratnegative regulation of cell population proliferation involved_inISOWNK2 (Homo sapiens)1624291 PMID:17667937RGDPMID:17667937
Wnk2Ratnegative regulation of ERK1 and ERK2 cascade involved_inISOWNK2 (Homo sapiens)1624291 PMID:17667937RGDPMID:17667937
Wnk2Ratnegative regulation of sodium ion transport involved_inIBAPANTHER:PTN000357109 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnk2Ratpositive regulation of canonical Wnt signaling pathway involved_inISOWNK2 (Homo sapiens)1624291 PMID:23797875RGDPMID:23797875
Wnk2Ratpositive regulation of potassium ion import across plasma membrane involved_inIBAFB:FBgn0037098 and PANTHER:PTN0003571091600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnk2Ratpositive regulation of sodium ion transmembrane transporter activity involved_inISOWNK2 (Homo sapiens)1624291 PMID:21733846RGDPMID:21733846
Wnk2Ratprotein autophosphorylation involved_inISOWNK2 (Homo sapiens)1624291 PMID:17667937RGDPMID:17667937
Wnk2Ratprotein phosphorylation involved_inISOWNK2 (Homo sapiens)1624291 PMID:21733846RGDPMID:21733846
Wnk2Ratprotein phosphorylation involved_inISOWnk2 (Mus musculus)1624291 PMID:21733846RGDPMID:21733846
1 to 12 of 12 rows

Cellular Component

  
Object Symbol
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Term
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Reference
Notes
Source
Original Reference(s)
Wnk2Ratcytoplasm located_inISOWNK2 (Homo sapiens)1624291 PMID:17667937RGDPMID:17667937
Wnk2Ratcytoplasm is_active_inIBAFB:FBgn0027497 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnk2Ratcytosol located_inISOWNK2 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Wnk2Ratcytosol located_inIEAUniProtKB:E9PCD1 and ensembl:ENSP000004111811600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
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Original Reference(s)
Wnk2RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Wnk2RatATP binding enablesIEAInterPro:IPR000719 and InterPro:IPR0246781600115GO_REF:0000002InterProGO_REF:0000002
Wnk2Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Wnk2Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Wnk2Ratpotassium channel inhibitor activity enablesIBAPANTHER:PTN000357109 and Wnk1 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnk2Ratprotein binding enablesISOWNK2 (Homo sapiens)1624291UniProtKB:O95747 more ...RGDPMID:35044719 and PMID:35271311
Wnk2Ratprotein kinase activity enablesIEAInterPro:IPR000719 and InterPro:IPR0082711600115GO_REF:0000002InterProGO_REF:0000002
Wnk2Ratprotein serine/threonine kinase activity enablesIEAEC:2.7.11.11600115GO_REF:0000003UniProtGO_REF:0000003
Wnk2Ratprotein serine/threonine kinase activity enablesIEAInterPro:IPR0246781600115GO_REF:0000002InterProGO_REF:0000002
Wnk2Ratprotein serine/threonine kinase activity enablesIBAMGI:1917097 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Wnk2Ratprotein serine/threonine kinase activity enablesIEAUniProtKB-KW:KW-07231600115GO_REF:0000043UniProtGO_REF:0000043
Wnk2Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
1 to 12 of 12 rows


#
Reference Title
Reference Citation
1. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Bhuiyan MIH, etal., J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:17667937   PMID:21733846   PMID:23797875   PMID:34918065  



Wnk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81715,709,648 - 15,818,874 (+)NCBIGRCr8
mRatBN7.21715,503,672 - 15,612,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1715,390,684 - 15,499,052 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01716,995,723 - 17,104,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,317,444 - 15,425,805 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01715,923,508 - 16,032,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1715,924,048 - 16,032,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01717,986,985 - 18,095,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41721,461,980 - 21,600,361 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11721,462,134 - 21,600,354 (+)NCBI
Celera1715,234,024 - 15,342,287 (+)NCBICelera
Cytogenetic Map17p14NCBI
WNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38993,184,139 - 93,320,569 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl993,184,122 - 93,320,572 (+)EnsemblGRCh38hg38GRCh38
GRCh37995,946,421 - 96,082,851 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36994,987,033 - 95,122,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 34993,026,766 - 93,162,409NCBI
Celera966,388,916 - 66,525,074 (+)NCBICelera
Cytogenetic Map9q22.31NCBI
HuRef965,623,639 - 65,760,276 (+)NCBIHuRef
CHM1_1996,093,815 - 96,229,891 (+)NCBICHM1_1
T2T-CHM13v2.09105,350,754 - 105,487,952 (+)NCBIT2T-CHM13v2.0
Wnk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391349,189,778 - 49,302,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1349,189,779 - 49,301,490 (-)EnsemblGRCm39 Ensembl
GRCm381349,036,302 - 49,148,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1349,036,303 - 49,148,014 (-)EnsemblGRCm38mm10GRCm38
MGSCv371349,131,671 - 49,243,383 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361349,048,239 - 49,160,516 (-)NCBIMGSCv36mm8
Celera1350,126,696 - 50,238,177 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1325.07NCBI
Wnk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555154,729,347 - 4,852,920 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555154,730,647 - 4,852,920 (-)NCBIChiLan1.0ChiLan1.0
WNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21146,102,884 - 46,243,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1946,109,305 - 46,246,187 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0964,307,620 - 64,444,141 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1992,372,410 - 92,506,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl992,372,410 - 92,507,916 (+)Ensemblpanpan1.1panPan2
WNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1198,433,897 - 98,533,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl198,454,799 - 98,493,085 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha198,827,313 - 98,927,715 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0199,049,650 - 99,150,488 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl199,049,659 - 99,151,162 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1198,663,461 - 98,763,845 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0198,398,830 - 98,499,197 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0199,154,381 - 99,254,788 (-)NCBIUU_Cfam_GSD_1.0
Wnk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049448,321,159 - 8,440,700 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364872,537,630 - 2,657,173 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364872,537,630 - 2,657,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl342,711,444 - 42,834,753 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1342,711,388 - 42,837,650 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2344,130,013 - 44,136,442 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112103,574,377 - 103,713,502 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12103,592,147 - 103,713,321 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603891,848,638 - 92,010,722 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248683,261,766 - 3,387,585 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248683,261,569 - 3,388,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Wnk2
617 total Variants

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:104
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000050696
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat

1 to 10 of 34 rows
RH133678  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21715,512,886 - 15,513,069 (+)MAPPERmRatBN7.2
Rnor_6.01715,932,673 - 15,932,855NCBIRnor6.0
Rnor_5.01717,996,062 - 17,996,244UniSTSRnor5.0
RGSC_v3.41721,470,605 - 21,470,787UniSTSRGSC3.4
Celera1715,242,648 - 15,242,830UniSTS
RH 3.4 Map17175.2UniSTS
Cytogenetic Map17p14UniSTS
RH134232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21715,610,923 - 15,611,115 (+)MAPPERmRatBN7.2
Rnor_6.01716,030,716 - 16,030,907NCBIRnor6.0
Rnor_5.01718,093,696 - 18,093,887UniSTSRnor5.0
RGSC_v3.41721,598,806 - 21,598,997UniSTSRGSC3.4
Celera1715,340,732 - 15,340,923UniSTS
RH 3.4 Map17176.4UniSTS
Cytogenetic Map17p14UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 88 87 56 25 56 6 212 97 93 42 60 31


1 to 30 of 34 rows
RefSeq Transcripts NM_001191556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 34 rows

Ensembl Acc Id: ENSRNOT00000050696   ⟹   ENSRNOP00000039118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
Rnor_6.0 Ensembl1715,924,048 - 16,032,271 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084304   ⟹   ENSRNOP00000075510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
Rnor_6.0 Ensembl1715,966,234 - 16,032,420 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094776   ⟹   ENSRNOP00000081251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109017   ⟹   ENSRNOP00000091659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,609,895 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115946   ⟹   ENSRNOP00000084430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117530   ⟹   ENSRNOP00000079712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,610,352 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117974   ⟹   ENSRNOP00000096453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
RefSeq Acc Id: NM_001191556   ⟹   NP_001178485
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,710,657 - 15,818,869 (+)NCBI
mRatBN7.21715,504,261 - 15,612,479 (+)NCBI
Rnor_6.01715,924,048 - 16,032,271 (+)NCBI
Rnor_5.01717,986,985 - 18,095,251 (+)NCBI
Celera1715,234,024 - 15,342,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253715   ⟹   XP_006253777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,652 - 15,818,874 (+)NCBI
mRatBN7.21715,503,672 - 15,611,154 (+)NCBI
Rnor_6.01715,923,508 - 16,029,687 (+)NCBI
Rnor_5.01717,986,985 - 18,095,251 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600515   ⟹   XP_017456004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,658 - 15,818,874 (+)NCBI
mRatBN7.21715,503,672 - 15,612,479 (+)NCBI
Rnor_6.01715,924,128 - 16,032,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600516   ⟹   XP_017456005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,655 - 15,817,544 (+)NCBI
mRatBN7.21715,503,672 - 15,611,154 (+)NCBI
Rnor_6.01715,924,128 - 16,030,946 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095658   ⟹   XP_038951586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,654 - 15,817,544 (+)NCBI
mRatBN7.21715,503,672 - 15,611,154 (+)NCBI
RefSeq Acc Id: XM_039095665   ⟹   XP_038951593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,655 - 15,818,874 (+)NCBI
mRatBN7.21715,503,672 - 15,612,479 (+)NCBI
RefSeq Acc Id: XM_063276355   ⟹   XP_063132425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,650 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276356   ⟹   XP_063132426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,650 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276357   ⟹   XP_063132427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,648 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276358   ⟹   XP_063132428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,649 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276359   ⟹   XP_063132429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,651 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276360   ⟹   XP_063132430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,656 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276361   ⟹   XP_063132431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,654 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276362   ⟹   XP_063132432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,650 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276363   ⟹   XP_063132433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,655 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276364   ⟹   XP_063132434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,653 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276365   ⟹   XP_063132435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,656 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276366   ⟹   XP_063132436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,655 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276367   ⟹   XP_063132437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,653 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276368   ⟹   XP_063132438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,712,626 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276369   ⟹   XP_063132439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,653 - 15,818,874 (+)NCBI
1 to 30 of 35 rows
Protein RefSeqs NP_001178485 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253777 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456004 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456005 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951586 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951593 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132425 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132426 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132427 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132428 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132429 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132430 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132431 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132432 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132433 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132434 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132435 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132436 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132437 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132438 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132439 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98130 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039118
  ENSRNOP00000039118.5
  ENSRNOP00000075510
  ENSRNOP00000075510.2
  ENSRNOP00000079712
  ENSRNOP00000079712.1
  ENSRNOP00000081251
  ENSRNOP00000081251.1
1 to 30 of 35 rows
1 to 5 of 28 rows
1 to 5 of 28 rows
RefSeq Acc Id: NP_001178485   ⟸   NM_001191556
- UniProtKB: D3ZMJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253777   ⟸   XM_006253715
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AC38 (UniProtKB/TrEMBL),   D3ZMJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456004   ⟸   XM_017600515
- Peptide Label: isoform X6
- UniProtKB: A0A0G2KAS8 (UniProtKB/TrEMBL),   D3ZMJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456005   ⟸   XM_017600516
- Peptide Label: isoform X7
- UniProtKB: D3ZMJ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075510   ⟸   ENSRNOT00000084304
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMJ7-F1-model_v2 AlphaFold D3ZMJ7 1-2063 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-9988 BioCyc
Ensembl Genes ENSRNOG00000016684 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050696 ENTREZGENE
  ENSRNOT00000050696.6 UniProtKB/TrEMBL
  ENSRNOT00000084304 ENTREZGENE
  ENSRNOT00000084304.2 UniProtKB/TrEMBL
  ENSRNOT00000094776 ENTREZGENE
  ENSRNOT00000094776.1 UniProtKB/TrEMBL
  ENSRNOT00000109017.1 UniProtKB/TrEMBL
  ENSRNOT00000115946 ENTREZGENE
  ENSRNOT00000115946.1 UniProtKB/TrEMBL
  ENSRNOT00000117530 ENTREZGENE
  ENSRNOT00000117530.1 UniProtKB/TrEMBL
  ENSRNOT00000117974 ENTREZGENE
  ENSRNOT00000117974.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
  WNK_Ser-Thr_kinase UniProtKB/TrEMBL
NCBI Gene 306811 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Wnk2 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016684 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2KAS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZP34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZXV8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AC38 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APM9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMJ7 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Wnk2  WNK lysine deficient protein kinase 2  RGD1307284  similar to protein kinase, lysine deficient 1; kinase deficient protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1307284  similar to protein kinase, lysine deficient 1; kinase deficient protein   RGD1307284_predicted  similar to protein kinase, lysine deficient 1; kinase deficient protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1307284_predicted  similar to protein kinase, lysine deficient 1; kinase deficient protein (predicted)  LOC306811_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306811_predicted  similar to protein kinase, lysine deficient 1; kinase deficient protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL