Wnk2 (WNK lysine deficient protein kinase 2) - Rat Genome Database

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Gene: Wnk2 (WNK lysine deficient protein kinase 2) Chinchilla lanigera
Analyze
Symbol: Wnk2
Name: WNK lysine deficient protein kinase 2
RGD ID: 8808089
Description: INVOLVED IN monoatomic ion homeostasis (ortholog); negative regulation of cell population proliferation (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); ASSOCIATED WITH genetic disease (ortholog); transient cerebral ischemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase WNK2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555154,729,347 - 4,852,920 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555154,730,647 - 4,852,920 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wnk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555154,729,347 - 4,852,920 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555154,730,647 - 4,852,920 (-)NCBIChiLan1.0ChiLan1.0
WNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38993,184,139 - 93,320,569 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl993,184,122 - 93,320,572 (+)EnsemblGRCh38hg38GRCh38
GRCh37995,946,421 - 96,082,851 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36994,987,033 - 95,122,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 34993,026,766 - 93,162,409NCBI
Celera966,388,916 - 66,525,074 (+)NCBICelera
Cytogenetic Map9q22.31NCBI
HuRef965,623,639 - 65,760,276 (+)NCBIHuRef
CHM1_1996,093,815 - 96,229,891 (+)NCBICHM1_1
T2T-CHM13v2.09105,350,754 - 105,487,952 (+)NCBIT2T-CHM13v2.0
Wnk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391349,189,778 - 49,302,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1349,189,779 - 49,301,490 (-)EnsemblGRCm39 Ensembl
GRCm381349,036,302 - 49,148,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1349,036,303 - 49,148,014 (-)EnsemblGRCm38mm10GRCm38
MGSCv371349,131,671 - 49,243,383 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361349,048,239 - 49,160,516 (-)NCBIMGSCv36mm8
Celera1350,126,696 - 50,238,177 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1325.07NCBI
Wnk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81715,709,648 - 15,818,874 (+)NCBIGRCr8
mRatBN7.21715,503,672 - 15,612,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1715,390,684 - 15,499,052 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01716,995,723 - 17,104,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,317,444 - 15,425,805 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01715,923,508 - 16,032,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1715,924,048 - 16,032,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01717,986,985 - 18,095,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41721,461,980 - 21,600,361 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11721,462,134 - 21,600,354 (+)NCBI
Celera1715,234,024 - 15,342,287 (+)NCBICelera
Cytogenetic Map17p14NCBI
WNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21146,102,884 - 46,243,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1946,109,305 - 46,246,187 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0964,307,620 - 64,444,141 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1992,372,410 - 92,506,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl992,372,410 - 92,507,916 (+)Ensemblpanpan1.1panPan2
WNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1198,433,897 - 98,533,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl198,454,799 - 98,493,085 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha198,827,313 - 98,927,715 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0199,049,650 - 99,150,488 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl199,049,659 - 99,151,162 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1198,663,461 - 98,763,845 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0198,398,830 - 98,499,197 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0199,154,381 - 99,254,788 (-)NCBIUU_Cfam_GSD_1.0
Wnk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049448,321,159 - 8,440,700 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364872,537,630 - 2,657,173 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364872,537,630 - 2,657,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl342,711,444 - 42,834,753 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1342,711,388 - 42,837,650 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2344,130,013 - 44,136,442 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112103,574,377 - 103,713,502 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12103,592,147 - 103,713,321 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603891,848,638 - 92,010,722 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248683,261,766 - 3,387,585 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248683,261,569 - 3,388,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000001784   ⟹   ENSCLAP00000001741
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555154,729,347 - 4,852,920 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001785   ⟹   ENSCLAP00000001742
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555154,729,347 - 4,852,920 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001786   ⟹   ENSCLAP00000001743
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555154,730,828 - 4,852,914 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001787   ⟹   ENSCLAP00000001744
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555154,730,828 - 4,852,914 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001788   ⟹   ENSCLAP00000001745
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555154,732,151 - 4,852,920 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001789   ⟹   ENSCLAP00000001746
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555154,732,437 - 4,852,914 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001790   ⟹   ENSCLAP00000001747
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555154,733,186 - 4,852,914 (-)Ensembl
RefSeq Acc Id: XM_013506886   ⟹   XP_013362340
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555154,730,647 - 4,852,920 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013362340 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000001741
  ENSCLAP00000001741.1
  ENSCLAP00000001742.1
  ENSCLAP00000001743.1
  ENSCLAP00000001744.1
  ENSCLAP00000001745.1
  ENSCLAP00000001746.1
  ENSCLAP00000001747.1
Reference Protein Sequences
RefSeq Acc Id: XP_013362340   ⟸   XM_013506886
- UniProtKB: A0A8C2UK37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000001746   ⟸   ENSCLAT00000001789
RefSeq Acc Id: ENSCLAP00000001745   ⟸   ENSCLAT00000001788
RefSeq Acc Id: ENSCLAP00000001742   ⟸   ENSCLAT00000001785
RefSeq Acc Id: ENSCLAP00000001741   ⟸   ENSCLAT00000001784
RefSeq Acc Id: ENSCLAP00000001744   ⟸   ENSCLAT00000001787
RefSeq Acc Id: ENSCLAP00000001743   ⟸   ENSCLAT00000001786
RefSeq Acc Id: ENSCLAP00000001747   ⟸   ENSCLAT00000001790
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001301 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000001784 ENTREZGENE
  ENSCLAT00000001784.1 UniProtKB/TrEMBL
  ENSCLAT00000001785.1 UniProtKB/TrEMBL
  ENSCLAT00000001786.1 UniProtKB/TrEMBL
  ENSCLAT00000001787.1 UniProtKB/TrEMBL
  ENSCLAT00000001788.1 UniProtKB/TrEMBL
  ENSCLAT00000001789.1 UniProtKB/TrEMBL
  ENSCLAT00000001790.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Wnk2 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE WNK2 UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2UJ99_CHILA UniProtKB/TrEMBL
  A0A8C2UJA0_CHILA UniProtKB/TrEMBL
  A0A8C2UK37 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UM20_CHILA UniProtKB/TrEMBL
  A0A8C2UMU9_CHILA UniProtKB/TrEMBL
  A0A8C2UP60_CHILA UniProtKB/TrEMBL
  A0A8C2UQ64_CHILA UniProtKB/TrEMBL