Wnk2 (WNK lysine deficient protein kinase 2) - Rat Genome Database

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Gene: Wnk2 (WNK lysine deficient protein kinase 2) Rattus norvegicus
Analyze
Symbol: Wnk2
Name: WNK lysine deficient protein kinase 2
RGD ID: 1307284
Description: Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; regulation of metal ion transport; and regulation of signal transduction. Predicted to be active in cytosol. Biomarker of transient cerebral ischemia. Orthologous to human WNK2 (WNK lysine deficient protein kinase 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kinase deficient protein; LOC306811; RGD1307284; serine/threonine-protein kinase WNK2; similar to protein kinase, lysine deficient 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81715,709,648 - 15,818,874 (+)NCBIGRCr8
mRatBN7.21715,503,672 - 15,612,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1715,390,684 - 15,499,052 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01716,995,723 - 17,104,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,317,444 - 15,425,805 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01715,923,508 - 16,032,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1715,924,048 - 16,032,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01717,986,985 - 18,095,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41721,461,980 - 21,600,361 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11721,462,134 - 21,600,354 (+)NCBI
Celera1715,234,024 - 15,342,287 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. Bhuiyan MIH, etal., J Cereb Blood Flow Metab. 2017 Aug;37(8):2780-2794. doi: 10.1177/0271678X16675368. Epub 2016 Jan 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17667937   PMID:21733846   PMID:23797875   PMID:34918065  


Genomics

Comparative Map Data
Wnk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81715,709,648 - 15,818,874 (+)NCBIGRCr8
mRatBN7.21715,503,672 - 15,612,479 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1715,390,684 - 15,499,052 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01716,995,723 - 17,104,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01715,317,444 - 15,425,805 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01715,923,508 - 16,032,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1715,924,048 - 16,032,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01717,986,985 - 18,095,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41721,461,980 - 21,600,361 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11721,462,134 - 21,600,354 (+)NCBI
Celera1715,234,024 - 15,342,287 (+)NCBICelera
Cytogenetic Map17p14NCBI
WNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38993,184,139 - 93,320,569 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl993,184,122 - 93,320,572 (+)EnsemblGRCh38hg38GRCh38
GRCh37995,946,421 - 96,082,851 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36994,987,033 - 95,122,675 (+)NCBINCBI36Build 36hg18NCBI36
Build 34993,026,766 - 93,162,409NCBI
Celera966,388,916 - 66,525,074 (+)NCBICelera
Cytogenetic Map9q22.31NCBI
HuRef965,623,639 - 65,760,276 (+)NCBIHuRef
CHM1_1996,093,815 - 96,229,891 (+)NCBICHM1_1
T2T-CHM13v2.09105,350,754 - 105,487,952 (+)NCBIT2T-CHM13v2.0
Wnk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391349,189,778 - 49,302,110 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1349,189,779 - 49,301,490 (-)EnsemblGRCm39 Ensembl
GRCm381349,036,302 - 49,148,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1349,036,303 - 49,148,014 (-)EnsemblGRCm38mm10GRCm38
MGSCv371349,131,671 - 49,243,383 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361349,048,239 - 49,160,516 (-)NCBIMGSCv36mm8
Celera1350,126,696 - 50,238,177 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1325.07NCBI
Wnk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555154,729,347 - 4,852,920 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555154,730,647 - 4,852,920 (-)NCBIChiLan1.0ChiLan1.0
WNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21146,102,884 - 46,243,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1946,109,305 - 46,246,187 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0964,307,620 - 64,444,141 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1992,372,410 - 92,506,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl992,372,410 - 92,507,916 (+)Ensemblpanpan1.1panPan2
WNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1198,433,897 - 98,533,427 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl198,454,799 - 98,493,085 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha198,827,313 - 98,927,715 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0199,049,650 - 99,150,488 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl199,049,659 - 99,151,162 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1198,663,461 - 98,763,845 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0198,398,830 - 98,499,197 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0199,154,381 - 99,254,788 (-)NCBIUU_Cfam_GSD_1.0
Wnk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049448,321,159 - 8,440,700 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364872,537,630 - 2,657,173 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364872,537,630 - 2,657,172 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl342,711,444 - 42,834,753 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1342,711,388 - 42,837,650 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2344,130,013 - 44,136,442 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112103,574,377 - 103,713,502 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12103,592,147 - 103,713,321 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603891,848,638 - 92,010,722 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248683,261,766 - 3,387,585 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248683,261,569 - 3,388,273 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnk2
609 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:104
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000050696
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)171398677321975515Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171533061323017269Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat

Markers in Region
RH133678  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21715,512,886 - 15,513,069 (+)MAPPERmRatBN7.2
Rnor_6.01715,932,673 - 15,932,855NCBIRnor6.0
Rnor_5.01717,996,062 - 17,996,244UniSTSRnor5.0
RGSC_v3.41721,470,605 - 21,470,787UniSTSRGSC3.4
Celera1715,242,648 - 15,242,830UniSTS
RH 3.4 Map17175.2UniSTS
Cytogenetic Map17p14UniSTS
RH134232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21715,610,923 - 15,611,115 (+)MAPPERmRatBN7.2
Rnor_6.01716,030,716 - 16,030,907NCBIRnor6.0
Rnor_5.01718,093,696 - 18,093,887UniSTSRnor5.0
RGSC_v3.41721,598,806 - 21,598,997UniSTSRGSC3.4
Celera1715,340,732 - 15,340,923UniSTS
RH 3.4 Map17176.4UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 3 66 8
Low 3 8 13 10 2 10 8 8 8 20 28 11 8
Below cutoff 41 28 17 28 12 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039095665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063276369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000050696   ⟹   ENSRNOP00000039118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
Rnor_6.0 Ensembl1715,924,048 - 16,032,271 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084304   ⟹   ENSRNOP00000075510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
Rnor_6.0 Ensembl1715,966,234 - 16,032,420 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094776   ⟹   ENSRNOP00000081251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109017   ⟹   ENSRNOP00000091659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,609,895 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115946   ⟹   ENSRNOP00000084430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117530   ⟹   ENSRNOP00000079712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,610,352 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117974   ⟹   ENSRNOP00000096453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1715,504,261 - 15,612,479 (+)Ensembl
RefSeq Acc Id: NM_001191556   ⟹   NP_001178485
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,710,657 - 15,818,869 (+)NCBI
mRatBN7.21715,504,261 - 15,612,479 (+)NCBI
Rnor_6.01715,924,048 - 16,032,271 (+)NCBI
Rnor_5.01717,986,985 - 18,095,251 (+)NCBI
Celera1715,234,024 - 15,342,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253715   ⟹   XP_006253777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,652 - 15,818,874 (+)NCBI
mRatBN7.21715,503,672 - 15,611,154 (+)NCBI
Rnor_6.01715,923,508 - 16,029,687 (+)NCBI
Rnor_5.01717,986,985 - 18,095,251 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600515   ⟹   XP_017456004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,658 - 15,818,874 (+)NCBI
mRatBN7.21715,503,672 - 15,612,479 (+)NCBI
Rnor_6.01715,924,128 - 16,032,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600516   ⟹   XP_017456005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,655 - 15,817,544 (+)NCBI
mRatBN7.21715,503,672 - 15,611,154 (+)NCBI
Rnor_6.01715,924,128 - 16,030,946 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095658   ⟹   XP_038951586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,654 - 15,817,544 (+)NCBI
mRatBN7.21715,503,672 - 15,611,154 (+)NCBI
RefSeq Acc Id: XM_039095665   ⟹   XP_038951593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,655 - 15,818,874 (+)NCBI
mRatBN7.21715,503,672 - 15,612,479 (+)NCBI
RefSeq Acc Id: XM_063276355   ⟹   XP_063132425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,650 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276356   ⟹   XP_063132426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,650 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276357   ⟹   XP_063132427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,648 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276358   ⟹   XP_063132428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,649 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276359   ⟹   XP_063132429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,651 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276360   ⟹   XP_063132430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,656 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276361   ⟹   XP_063132431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,654 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276362   ⟹   XP_063132432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,650 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276363   ⟹   XP_063132433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,655 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276364   ⟹   XP_063132434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,653 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276365   ⟹   XP_063132435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,656 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276366   ⟹   XP_063132436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,655 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276367   ⟹   XP_063132437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,653 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276368   ⟹   XP_063132438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,712,626 - 15,818,874 (+)NCBI
RefSeq Acc Id: XM_063276369   ⟹   XP_063132439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81715,709,653 - 15,818,874 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178485 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253777 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456004 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456005 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951586 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951593 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132425 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132426 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132427 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132428 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132429 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132430 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132431 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132432 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132433 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132434 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132435 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132436 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132437 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132438 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132439 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98130 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039118
  ENSRNOP00000039118.5
  ENSRNOP00000075510
  ENSRNOP00000075510.2
  ENSRNOP00000079712.1
  ENSRNOP00000081251.1
  ENSRNOP00000084430.1
  ENSRNOP00000091659.1
  ENSRNOP00000096453.1
RefSeq Acc Id: NP_001178485   ⟸   NM_001191556
- UniProtKB: D3ZMJ7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253777   ⟸   XM_006253715
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AC38 (UniProtKB/TrEMBL),   A0A8I6APM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456004   ⟸   XM_017600515
- Peptide Label: isoform X6
- UniProtKB: A0A0G2KAS8 (UniProtKB/TrEMBL),   A0A8I6APM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456005   ⟸   XM_017600516
- Peptide Label: isoform X7
- UniProtKB: A0A8I6APM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075510   ⟸   ENSRNOT00000084304
RefSeq Acc Id: ENSRNOP00000039118   ⟸   ENSRNOT00000050696
RefSeq Acc Id: XP_038951593   ⟸   XM_039095665
- Peptide Label: isoform X14
- UniProtKB: D3ZMJ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951586   ⟸   XM_039095658
- Peptide Label: isoform X5
- UniProtKB: A0A8I6APM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081251   ⟸   ENSRNOT00000094776
RefSeq Acc Id: ENSRNOP00000079712   ⟸   ENSRNOT00000117530
RefSeq Acc Id: ENSRNOP00000091659   ⟸   ENSRNOT00000109017
RefSeq Acc Id: ENSRNOP00000096453   ⟸   ENSRNOT00000117974
RefSeq Acc Id: ENSRNOP00000084430   ⟸   ENSRNOT00000115946
RefSeq Acc Id: XP_063132427   ⟸   XM_063276357
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132428   ⟸   XM_063276358
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063132426   ⟸   XM_063276356
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132425   ⟸   XM_063276355
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132432   ⟸   XM_063276362
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063132429   ⟸   XM_063276359
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063132434   ⟸   XM_063276364
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063132437   ⟸   XM_063276367
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063132439   ⟸   XM_063276369
- Peptide Label: isoform X20
RefSeq Acc Id: XP_063132431   ⟸   XM_063276361
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063132433   ⟸   XM_063276363
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063132436   ⟸   XM_063276366
- Peptide Label: isoform X17
RefSeq Acc Id: XP_063132430   ⟸   XM_063276360
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063132435   ⟸   XM_063276365
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063132438   ⟸   XM_063276368
- Peptide Label: isoform X19
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMJ7-F1-model_v2 AlphaFold D3ZMJ7 1-2063 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307284 AgrOrtholog
BioCyc Gene G2FUF-9988 BioCyc
Ensembl Genes ENSRNOG00000016684 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050696 ENTREZGENE
  ENSRNOT00000050696.6 UniProtKB/TrEMBL
  ENSRNOT00000084304.2 UniProtKB/TrEMBL
  ENSRNOT00000094776.1 UniProtKB/TrEMBL
  ENSRNOT00000109017.1 UniProtKB/TrEMBL
  ENSRNOT00000115946.1 UniProtKB/TrEMBL
  ENSRNOT00000117530.1 UniProtKB/TrEMBL
  ENSRNOT00000117974.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
NCBI Gene 306811 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE WNK2 UniProtKB/TrEMBL
Pfam OSR1_C UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Wnk2 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016684 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2KAS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZP34_RAT UniProtKB/TrEMBL
  A0A8I5ZRK5_RAT UniProtKB/TrEMBL
  A0A8I5ZXV8_RAT UniProtKB/TrEMBL
  A0A8I6AC38 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APM9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMJ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Wnk2  WNK lysine deficient protein kinase 2  RGD1307284  similar to protein kinase, lysine deficient 1; kinase deficient protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1307284  similar to protein kinase, lysine deficient 1; kinase deficient protein   RGD1307284_predicted  similar to protein kinase, lysine deficient 1; kinase deficient protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1307284_predicted  similar to protein kinase, lysine deficient 1; kinase deficient protein (predicted)  LOC306811_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306811_predicted  similar to protein kinase, lysine deficient 1; kinase deficient protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL