Pip5k1a (phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha) - Rat Genome Database

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Gene: Pip5k1a (phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha) Rattus norvegicus
Analyze
Symbol: Pip5k1a
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
RGD ID: 1306127
Description: Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Predicted to act upstream of or within fibroblast migration and phosphatidylinositol biosynthetic process. Predicted to be located in several cellular components, including lamellipodium; nuclear speck; and ruffle membrane. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in plasma membrane. Orthologous to human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha); PARTICIPATES IN Arf family mediated signaling pathway; E-cadherin signaling pathway; phosphoinositide metabolic pathway; INTERACTS WITH 4,4'-sulfonyldiphenol; acrylamide; allethrin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; LOC365865; phosphatidylinositol 4-phosphate 5-kinase type I alpha; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PIP5K1-alpha; Pip5k1b; PIP5KIalpha; ptdIns(4)P-5-kinase 1 alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,317,319 - 185,361,859 (-)NCBIGRCr8
mRatBN7.22182,628,299 - 182,671,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,628,300 - 182,671,598 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,292,988 - 190,336,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,089,077 - 188,132,194 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02182,925,465 - 182,968,650 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,227,669 - 196,270,949 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,227,670 - 196,270,826 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02215,722,370 - 215,765,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42189,962,527 - 190,005,684 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12189,923,204 - 189,966,433 (-)NCBI
Celera2175,165,145 - 175,208,290 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pip5k1aRatautosomal dominant intellectual developmental disorder 60 with seizures  ISOPIP5K1A (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual developmental disorder 60 with seizuresClinVarPMID:25741868
Pip5k1aRatDravet syndrome  ISOPIP5K1A (Homo sapiens)8554872ClinVar Annotator: match by term: Severe myoclonic epilepsy in infancyClinVarPMID:28492532
Pip5k1aRatgastrointestinal stromal tumor  ISOPIP5K1A (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Pip5k1aRatimmunodeficiency 42  ISOPIP5K1A (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiencyClinVarPMID:28492532
Pip5k1aRatMHC class II deficiency  ISOPIP5K1A (Homo sapiens)8554872ClinVar Annotator: match by term: MHC class II deficiencyClinVarPMID:28492532
Pip5k1aRatparathyroid carcinoma  ISOPIP5K1A (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Pip5k1aRatsevere congenital neutropenia 3  ISOPIP5K1A (Homo sapiens)8554872ClinVar Annotator: match by term: Kostmann syndromeClinVarPMID:28492532
Pip5k1aRatsevere congenital neutropenia 5  ISOPIP5K1A (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital neutropenia-myelofibrosis-nephromegaly syndromeClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pip5k1aRatExperimental Neoplasms  ISOPIP5K1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34755307
Pip5k1aRatLymphatic Metastasis  ISOPIP5K1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34755307
Pip5k1aRatNeoplasm Invasiveness  ISOPIP5K1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34755307
Pip5k1aRaturinary bladder cancer  ISOPIP5K1A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:34755307

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Original Reference(s)
Pip5k1aRat1,2-dimethylhydrazine increases expressionISOPip5k1a (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PIP5K1A mRNACTDPMID:22206623
Pip5k1aRat1-octadec-9-enoylglycero-3-phosphate multiple interactionsISOPip5k1a (Mus musculus)64804641-Butanol inhibits the reaction [lysophosphatidic acid results in increased activity of PIP5K1A protein] and DGKA protein promotes the reaction [lysophosphatidic acid results in increased activity of PIP5K1A protein]CTDPMID:10913605
Pip5k1aRat1-octadec-9-enoylglycero-3-phosphate increases activityISOPip5k1a (Mus musculus)6480464lysophosphatidic acid results in increased activity of PIP5K1A proteinCTDPMID:10913605
Pip5k1aRat17beta-estradiol multiple interactionsISOPIP5K1A (Homo sapiens)6480464ESR1 protein affects the reaction [Estradiol results in increased expression of PIP5K1A mRNA]CTDPMID:15223131
Pip5k1aRat17beta-estradiol increases expressionISOPIP5K1A (Homo sapiens)6480464Estradiol results in increased expression of PIP5K1A mRNACTDPMID:15223131 and PMID:19167446
Pip5k1aRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPip5k1a (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PIP5K1A mRNACTDPMID:21570461
Pip5k1aRat2-hydroxypropanoic acid increases expressionISOPIP5K1A (Homo sapiens)6480464Lactic Acid results in increased expression of PIP5K1A mRNACTDPMID:30851411
Pip5k1aRat3,4-methylenedioxymethamphetamine increases expressionISOPip5k1a (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PIP5K1A mRNACTDPMID:26251327
Pip5k1aRat3,4-methylenedioxymethamphetamine increases methylationISOPip5k1a (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of PIP5K1A promoterCTDPMID:26251327
Pip5k1aRat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of PIP5K1A mRNACTDPMID:36041667
Pip5k1aRat5-azacytidine decreases expressionISOPIP5K1A (Homo sapiens)6480464Azacitidine results in decreased expression of PIP5K1A mRNACTDPMID:19194470
Pip5k1aRatacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of PIP5K1A mRNACTDPMID:28959563
Pip5k1aRatallethrin multiple interactionsEXP 6480464[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in decreased expression of PIP5K1A proteinCTDPMID:34896426
Pip5k1aRatamiodarone increases expressionISOPIP5K1A (Homo sapiens)6480464Amiodarone results in increased expression of PIP5K1A mRNACTDPMID:19774075
Pip5k1aRatarsane affects methylationISOPIP5K1A (Homo sapiens)6480464Arsenic affects the methylation of PIP5K1A geneCTDPMID:25304211
Pip5k1aRatarsane multiple interactionsISOPIP5K1A (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of PIP5K1A mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PIP5K1A mRNACTDPMID:39836092
Pip5k1aRatarsenic atom affects methylationISOPIP5K1A (Homo sapiens)6480464Arsenic affects the methylation of PIP5K1A geneCTDPMID:25304211
Pip5k1aRatarsenic atom multiple interactionsISOPIP5K1A (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in increased expression of PIP5K1A mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PIP5K1A mRNACTDPMID:39836092
Pip5k1aRatbenzo[a]pyrene increases expressionISOPip5k1a (Mus musculus)6480464Benzo(a)pyrene results in increased expression of PIP5K1A mRNACTDPMID:27195522
Pip5k1aRatbenzo[a]pyrene increases methylationISOPIP5K1A (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of PIP5K1A 5' UTRCTDPMID:27901495

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Biological Process
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Original Reference(s)
Pip5k1aRatactin cytoskeleton organization involved_inISOPIP5K1A (Homo sapiens)1624291 PMID:20660631RGDPMID:20660631
Pip5k1aRatactin cytoskeleton organization involved_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatactivation of GTPase activity involved_inISOPIP5K1A (Homo sapiens)1624291 PMID:20660631RGDPMID:20660631
Pip5k1aRatcell chemotaxis involved_inISOPIP5K1A (Homo sapiens)1624291 PMID:20660631RGDPMID:20660631
Pip5k1aRatcell chemotaxis involved_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatfibroblast migration acts_upstream_of_or_withinISOPip5k1a (Mus musculus)1624291 PMID:15870270RGDPMID:15870270
Pip5k1aRatfibroblast migration acts_upstream_of_or_withinIEAUniProtKB:P70182 and ensembl:ENSMUSP000001028521600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatfocal adhesion assembly involved_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatfocal adhesion assembly involved_inISOPIP5K1A (Homo sapiens)1624291 PMID:20660631RGDPMID:20660631
Pip5k1aRatlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Pip5k1aRatphosphatidylinositol biosynthetic process acts_upstream_of_or_withinISOPip5k1a (Mus musculus)1624291MGI:1298224 PMID:20622009RGDPMID:20622009
Pip5k1aRatphosphatidylinositol biosynthetic process acts_upstream_of_or_withinIEAUniProtKB:P70182 and ensembl:ENSMUSP000001028521600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatphosphatidylinositol metabolic process involved_inIEAUniRule:UR0004005191600115GO_REF:0000104UniProtGO_REF:0000104
Pip5k1aRatphosphatidylinositol metabolic process acts_upstream_of_or_withinIEAUniProtKB:P70182 and ensembl:ENSMUSP000001028521600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatphosphatidylinositol metabolic process acts_upstream_of_or_withinISOPip5k1a (Mus musculus)1624291 PMID:8798574RGDPMID:8798574
Pip5k1aRatphosphatidylinositol metabolic process involved_inIEAInterPro:IPR0024981600115GO_REF:0000002InterProGO_REF:0000002
Pip5k1aRatphosphatidylinositol phosphate biosynthetic process involved_inIBAFB:FBgn0039924 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pip5k1aRatphospholipid biosynthetic process involved_inISOPIP5K1A (Homo sapiens)1624291 PMID:15157668RGDPMID:15157668
Pip5k1aRatphospholipid biosynthetic process involved_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatprotein localization to plasma membrane involved_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Pip5k1aRatcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Pip5k1aRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Pip5k1aRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Pip5k1aRatcytosol located_inIEAUniProtKB:P70182 and ensembl:ENSMUSP000001028521600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatcytosol located_inISOPIP5K1A (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Pip5k1aRatcytosol located_inISOPip5k1a (Mus musculus)1624291 PMID:20622009RGDPMID:20622009
Pip5k1aRatcytosol located_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatlamellipodium located_inISOPIP5K1A (Homo sapiens)1624291 PMID:15157668RGDPMID:15157668
Pip5k1aRatlamellipodium located_inIEAUniProtKB-SubCell:SL-02911600115GO_REF:0000044UniProtGO_REF:0000044
Pip5k1aRatlamellipodium located_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Pip5k1aRatmRNA cleavage and polyadenylation specificity factor complex located_inISOPIP5K1A (Homo sapiens)1624291 PMID:18305108RGDPMID:18305108
Pip5k1aRatmRNA cleavage and polyadenylation specificity factor complex located_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatnuclear speck located_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatnuclear speck located_inIEAUniProtKB-SubCell:SL-01861600115GO_REF:0000044UniProtGO_REF:0000044
Pip5k1aRatnuclear speck located_inISOPIP5K1A (Homo sapiens)1624291 PMID:18288197RGDPMID:18288197
Pip5k1aRatnucleoplasm located_inISOPIP5K1A (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Pip5k1aRatnucleoplasm located_inIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatnucleus located_inISOPIP5K1A (Homo sapiens)1624291 PMID:15157668RGDPMID:15157668
Pip5k1aRatnucleus located_inIEAUniProtKB:P70182 and ensembl:ENSMUSP000001028521600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Pip5k1aRat1-phosphatidylinositol-4-phosphate 5-kinase activity enablesISSUniProtKB:Q997551600115GO_REF:0000024UniProtGO_REF:0000024
Pip5k1aRat1-phosphatidylinositol-4-phosphate 5-kinase activity enablesIEAEC:2.7.1.681600115GO_REF:0000003UniProtGO_REF:0000003
Pip5k1aRat1-phosphatidylinositol-4-phosphate 5-kinase activity enablesIBACGD:CAL0000192511 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pip5k1aRat1-phosphatidylinositol-4-phosphate 5-kinase activity enablesISOPip5k1a (Mus musculus)1624291MGI:1298224 PMID:20622009 more ...RGDPMID:20622009 more ...
Pip5k1aRat1-phosphatidylinositol-4-phosphate 5-kinase activity enablesIEARHEA:144251600115GO_REF:0000116RHEAGO_REF:0000116
Pip5k1aRat1-phosphatidylinositol-4-phosphate 5-kinase activity enablesISOPIP5K1A (Homo sapiens)1624291 PMID:15157668 more ...RGDPMID:15157668 more ...
Pip5k1aRat1-phosphatidylinositol-4-phosphate 5-kinase activity enablesIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRat1-phosphatidylinositol-4-phosphate 5-kinase activity enablesIEAUniProtKB:P70182 and ensembl:ENSMUSP000001028521600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRat1-phosphatidylinositol-4-phosphate 5-kinase activity enablesISSUniProtKB:P701821600115GO_REF:0000024UniProtGO_REF:0000024
Pip5k1aRatATP binding enablesIEAUniRule:UR0004005191600115GO_REF:0000104UniProtGO_REF:0000104
Pip5k1aRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Pip5k1aRatkinase activity enablesIEAUniRule:UR0004005191600115GO_REF:0000104UniProtGO_REF:0000104
Pip5k1aRatkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Pip5k1aRatkinase binding enablesISOPIP5K1A (Homo sapiens)1624291 PMID:15157668RGDPMID:15157668
Pip5k1aRatkinase binding enablesIEAUniProtKB:Q99755 and ensembl:ENSP000003578831600115GO_REF:0000107EnsemblGO_REF:0000107
Pip5k1aRatnucleotide binding enablesIEAUniRule:UR0004005191600115GO_REF:0000104UniProtGO_REF:0000104
Pip5k1aRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Pip5k1aRatphosphatidylinositol kinase activity enablesIEAInterPro:IPR0024981600115GO_REF:0000002InterProGO_REF:0000002
Pip5k1aRatprotein binding enablesIPIUniProtKB:O0856013792527PMID:15157668UniProt 
Pip5k1aRatprotein binding enablesISOPip5k1a (Mus musculus)1624291PR:Q6U7H8 more ...RGDPMID:14701839 and PMID:15870270
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Imported Annotations - SMPDB

Object Symbol
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Original Reference(s)
Pip5k1aRatphosphoinositide metabolic pathway  ISOPIP5K1A (Homo sapiens)10402751 SMPDBSMP:00463

Imported Annotations - KEGG (archival)

Object Symbol
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Term
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Evidence
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Reference
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Original Reference(s)
Pip5k1aRatendocytosis pathway  IEA 6907045 KEGGrno:04144
Pip5k1aRatFc gamma receptor mediated signaling pathway  IEA 6907045 KEGGrno:04666
Pip5k1aRatinositol phosphate metabolic pathway  IEA 6907045 KEGGrno:00562
Pip5k1aRatphosphatidylinositol 3-kinase signaling pathway  IEA 6907045 KEGGrno:04070

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Pip5k1aRatArf family mediated signaling pathway  ISOPIP5K1A (Homo sapiens)6484113 PIDPID:200195
Pip5k1aRatE-cadherin signaling pathway  ISOPIP5K1A (Homo sapiens)6484113 PIDPID:200147

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. Luo B, etal., Cell Signal. 2004 Aug;16(8):891-7. doi: 10.1016/j.cellsig.2004.01.010.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:8798574   PMID:15870270   PMID:18288197   PMID:18305108   PMID:20622009   PMID:20660631   PMID:21423176   PMID:27739494   PMID:32686865  



Pip5k1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82185,317,319 - 185,361,859 (-)NCBIGRCr8
mRatBN7.22182,628,299 - 182,671,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2182,628,300 - 182,671,598 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2190,292,988 - 190,336,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02188,089,077 - 188,132,194 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02182,925,465 - 182,968,650 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02196,227,669 - 196,270,949 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,227,670 - 196,270,826 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02215,722,370 - 215,765,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42189,962,527 - 190,005,684 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12189,923,204 - 189,966,433 (-)NCBI
Celera2175,165,145 - 175,208,290 (-)NCBICelera
Cytogenetic Map2q34NCBI
PIP5K1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381151,195,419 - 151,249,531 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1151,197,949 - 151,249,536 (+)EnsemblGRCh38hg38GRCh38
GRCh371151,171,028 - 151,222,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,437,696 - 149,488,629 (+)NCBINCBI36Build 36hg18NCBI36
Build 341147,984,144 - 148,035,078NCBI
Celera1124,286,312 - 124,337,297 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1122,549,129 - 122,599,938 (+)NCBIHuRef
CHM1_11152,566,349 - 152,617,334 (+)NCBICHM1_1
T2T-CHM13v2.01150,319,124 - 150,373,243 (+)NCBIT2T-CHM13v2.0
Pip5k1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,965,841 - 95,014,241 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl394,965,841 - 95,014,241 (-)EnsemblGRCm39 Ensembl
GRCm38395,058,530 - 95,106,930 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,058,530 - 95,106,930 (-)EnsemblGRCm38mm10GRCm38
MGSCv37394,863,517 - 94,910,780 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36395,144,999 - 95,192,262 (-)NCBIMGSCv36mm8
Celera396,490,835 - 96,538,184 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.74NCBI
Pip5k1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955588555,821 - 605,723 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955588555,818 - 605,459 (+)NCBIChiLan1.0ChiLan1.0
PIP5K1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,584,132 - 98,635,394 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1198,335,345 - 98,386,612 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,547,793 - 126,598,618 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11130,195,974 - 130,246,198 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,195,974 - 130,246,198 (+)Ensemblpanpan1.1panPan2
PIP5K1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,257,017 - 60,295,866 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,257,332 - 60,295,866 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1759,700,905 - 59,739,406 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01761,273,137 - 61,312,006 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1761,273,153 - 61,312,003 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11760,102,170 - 60,140,685 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01760,187,481 - 60,226,180 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01760,915,268 - 60,954,258 (+)NCBIUU_Cfam_GSD_1.0
Pip5k1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505822,369,145 - 22,417,998 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365801,399,954 - 1,446,769 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365801,399,492 - 1,448,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIP5K1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,012,945 - 98,056,815 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,012,941 - 98,062,166 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,265,724 - 107,314,945 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIP5K1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12012,439,726 - 12,490,331 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603812,017,486 - 12,069,455 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pip5k1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477218,616,121 - 18,658,286 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477218,616,095 - 18,658,016 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pip5k1a
184 total Variants

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:148
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000028609
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 70 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat

1 to 10 of 70 rows
RH127674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22182,628,385 - 182,628,565 (+)MAPPERmRatBN7.2
Rnor_6.02196,227,756 - 196,227,935NCBIRnor6.0
Rnor_5.02215,722,457 - 215,722,636UniSTSRnor5.0
RGSC_v3.42189,962,614 - 189,962,793UniSTSRGSC3.4
Celera2175,165,232 - 175,165,411UniSTS
RH 3.4 Map21199.0UniSTS
Cytogenetic Map2q34UniSTS
RH143262  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22182,664,652 - 182,664,805 (+)MAPPERmRatBN7.2
Rnor_6.02196,264,019 - 196,264,171NCBIRnor6.0
Rnor_5.02215,758,447 - 215,758,599UniSTSRnor5.0
RGSC_v3.42189,998,877 - 189,999,029UniSTSRGSC3.4
Celera2175,201,483 - 175,201,635UniSTS
RH 3.4 Map21193.11UniSTS
Cytogenetic Map2q34UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000028609   ⟹   ENSRNOP00000028609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2182,628,300 - 182,671,477 (-)Ensembl
Rnor_6.0 Ensembl2196,227,670 - 196,270,826 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113159   ⟹   ENSRNOP00000093572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2182,633,245 - 182,647,835 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117151   ⟹   ENSRNOP00000097963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2182,628,300 - 182,671,461 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119756   ⟹   ENSRNOP00000086696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2182,628,300 - 182,671,598 (-)Ensembl
RefSeq Acc Id: NM_001042621   ⟹   NP_001036086
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,317,319 - 185,360,476 (-)NCBI
mRatBN7.22182,628,299 - 182,671,461 (-)NCBI
Rnor_6.02196,227,669 - 196,270,826 (-)NCBI
Rnor_5.02215,722,370 - 215,765,396 (-)NCBI
RGSC_v3.42189,962,527 - 190,005,684 (-)RGD
Celera2175,165,145 - 175,208,290 (-)RGD
Sequence:
RefSeq Acc Id: XM_008761315   ⟹   XP_008759537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,317,319 - 185,361,859 (-)NCBI
mRatBN7.22182,628,299 - 182,671,584 (-)NCBI
Rnor_6.02196,227,669 - 196,270,949 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761316   ⟹   XP_008759538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,317,319 - 185,361,859 (-)NCBI
mRatBN7.22182,628,299 - 182,671,584 (-)NCBI
Rnor_6.02196,227,669 - 196,270,949 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102779   ⟹   XP_038958707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,317,319 - 185,361,859 (-)NCBI
mRatBN7.22182,628,299 - 182,671,584 (-)NCBI
RefSeq Acc Id: XM_039102780   ⟹   XP_038958708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82185,317,319 - 185,361,859 (-)NCBI
mRatBN7.22182,628,299 - 182,671,584 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_001036086 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759537 (Get FASTA)   NCBI Sequence Viewer  
  XP_008759538 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958707 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958708 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZSI8 (Get FASTA)   NCBI Sequence Viewer  
  EDL85755 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028609
  ENSRNOP00000086696
1 to 9 of 9 rows
RefSeq Acc Id: NP_001036086   ⟸   NM_001042621
- UniProtKB: D3ZSI8 (UniProtKB/Swiss-Prot),   A0A8I6ANU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759538   ⟸   XM_008761316
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A5T8 (UniProtKB/TrEMBL),   A6K2U4 (UniProtKB/TrEMBL),   A0A8I6ANU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759537   ⟸   XM_008761315
- Peptide Label: isoform X3
- UniProtKB: A0A8I6ANU4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028609   ⟸   ENSRNOT00000028609
RefSeq Acc Id: XP_038958708   ⟸   XM_039102780
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QH45 (UniProtKB/TrEMBL),   A0A8I6ANU4 (UniProtKB/TrEMBL)
PIPK

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZSI8-F1-model_v2 AlphaFold D3ZSI8 1-546 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691537
Promoter ID:EPDNEW_R2062
Type:initiation region
Name:Pip5k1a_1
Description:phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02196,270,913 - 196,270,973EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-52116 BioCyc
BioCyc Pathway PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis] BioCyc
  PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6351 BioCyc
  PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000021068 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028609 ENTREZGENE
  ENSRNOT00000119756 ENTREZGENE
Gene3D-CATH 2-Layer Sandwich UniProtKB/Swiss-Prot
  3.30.800.10 UniProtKB/Swiss-Prot
InterPro PInositol-4-P-4/5-kinase_C_sf UniProtKB/Swiss-Prot
  PInositol-4-P-5-kinase UniProtKB/Swiss-Prot
  PInositol-4-P-5-kinase_core UniProtKB/Swiss-Prot
  PInositol-4-P-5-kinase_N UniProtKB/Swiss-Prot
NCBI Gene 365865 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 ALPHA UniProtKB/Swiss-Prot
  PTHR23086 UniProtKB/Swiss-Prot
Pfam PIP5K UniProtKB/Swiss-Prot
PhenoGen Pip5k1a PhenoGen
PROSITE PIPK UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021068 RatGTEx
SMART PIPKc UniProtKB/Swiss-Prot
Superfamily-SCOP SAICAR synthase-like UniProtKB/Swiss-Prot
UniProt A0A8I6A5T8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJ67_RAT UniProtKB/TrEMBL
  A0A8I6ANU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QH45 ENTREZGENE, UniProtKB/TrEMBL
  A6K2U4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSI8 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Pip5k1a  phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha   Pip5k1a_predicted  phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (predicted)  'predicted' is removed 2292626 APPROVED
2007-03-22 Pip5k1a_predicted  phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (predicted)  Pip5k1b_predicted  phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Pip5k1b_predicted  phosphatidylinositol-4-phosphate 5-kinase, type 1 beta (predicted)      Symbol and Name status set to approved 70820 APPROVED