Mylip (myosin regulatory light chain interacting protein) - Rat Genome Database

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Gene: Mylip (myosin regulatory light chain interacting protein) Rattus norvegicus
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Symbol: Mylip
Name: myosin regulatory light chain interacting protein
RGD ID: 1305761
Description: Predicted to enable cytoskeletal protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cholesterol homeostasis; negative regulation of low-density lipoprotein particle clearance; and regulation of protein catabolic process. Predicted to be located in cytoplasm; cytoskeleton; and plasma membrane. Orthologous to human MYLIP (myosin regulatory light chain interacting protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase MYLIP; idol; inducible degrader of the LDL-receptor; LOC306825; MIR; RING-type E3 ubiquitin transferase MYLIP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mylipem2Mcwi   Mylipem3Mcwi   Mylipem1Mcwi  
Genetic Models: SS-Mylipem2Mcwi SS-Mylipem3Mcwi SS-Mylipem1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81719,492,826 - 19,514,490 (-)NCBIGRCr8
mRatBN7.21719,286,649 - 19,308,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1719,286,650 - 19,308,295 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1719,171,096 - 19,192,723 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01720,774,907 - 20,796,527 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01719,098,217 - 19,119,846 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01719,682,040 - 19,703,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1719,682,040 - 19,703,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01721,703,590 - 21,725,205 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41725,308,147 - 25,329,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11725,312,367 - 25,523,199 (-)NCBI
Celera1718,989,082 - 19,010,552 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MylipRatatherosclerosis treatmentISOMylip (Mus musculus)401827839 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MylipRatendometriosis  ISOMYLIP (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20864642

1 to 20 of 151 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MylipRat(-)-epigallocatechin 3-gallate multiple interactionsISOMYLIP (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of MYLIP mRNACTDPMID:22079256
MylipRat1,2-dimethylhydrazine decreases expressionISOMylip (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of MYLIP mRNACTDPMID:22206623
MylipRat1,2-dimethylhydrazine multiple interactionsISOMylip (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MYLIP mRNACTDPMID:22206623
MylipRat17beta-estradiol decreases expressionISOMYLIP (Homo sapiens)6480464Estradiol results in decreased expression of MYLIP mRNACTDPMID:19167446
MylipRat17beta-estradiol increases expressionISOMylip (Mus musculus)6480464Estradiol results in increased expression of MYLIP mRNA and Estradiol results in increased expression of MYLIP proteinCTDPMID:39298647
MylipRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMYLIP (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of MYLIP mRNACTDPMID:21802500
MylipRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MYLIP mRNACTDPMID:33387578
MylipRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of MYLIP mRNACTDPMID:32109520
MylipRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMylip (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of MYLIP mRNACTDPMID:25975270
MylipRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of MYLIP mRNACTDPMID:22298810 and PMID:34747641
MylipRat2-hydroxypropanoic acid increases expressionISOMYLIP (Homo sapiens)6480464Lactic Acid results in increased expression of MYLIP mRNACTDPMID:30851411
MylipRat2-methylcholine affects expressionISOMYLIP (Homo sapiens)6480464beta-methylcholine affects the expression of MYLIP mRNACTDPMID:21179406
MylipRat3,3',5,5'-tetrabromobisphenol A decreases expressionISOMylip (Mus musculus)6480464tetrabromobisphenol A results in decreased expression of MYLIP mRNACTDPMID:25172293
MylipRat3,4-methylenedioxymethamphetamine decreases expressionISOMylip (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of MYLIP mRNACTDPMID:26251327
MylipRat4,4'-sulfonyldiphenol increases expressionISOMylip (Mus musculus)6480464bisphenol S results in increased expression of MYLIP mRNACTDPMID:30951980
MylipRat4,4'-sulfonyldiphenol affects methylationISOMylip (Mus musculus)6480464bisphenol S affects the methylation of MYLIP geneCTDPMID:31683443
MylipRat5-fluorouracil affects expressionISOMYLIP (Homo sapiens)6480464Fluorouracil affects the expression of MYLIP mRNACTDPMID:16584549
MylipRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of MYLIP mRNACTDPMID:30047161
MylipRat8-Br-cAMP decreases expressionISOMYLIP (Homo sapiens)64804648-Bromo Cyclic Adenosine Monophosphate results in decreased expression of MYLIP mRNACTDPMID:22079614
MylipRatacetamide increases expressionEXP 6480464acetamide results in increased expression of MYLIP mRNACTDPMID:31881176

1 to 20 of 151 rows

Biological Process
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MylipRatcholesterol homeostasis involved_inISOMylip (Mus musculus)1624291 PMID:19520913RGDPMID:19520913
MylipRatcholesterol homeostasis involved_inIEAUniProtKB:Q8BM54 and ensembl:ENSMUSP000000474031600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatnegative regulation of low-density lipoprotein particle clearance involved_inISOMylip (Mus musculus)1624291 PMID:19520913RGDPMID:19520913
MylipRatnegative regulation of low-density lipoprotein particle clearance involved_inIEAUniProtKB:Q8BM54 and ensembl:ENSMUSP000000474031600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatnegative regulation of neuron projection development involved_inISOMYLIP (Homo sapiens)1624291 PMID:10593918RGDPMID:10593918
MylipRatnegative regulation of neuron projection development involved_inIEAUniProtKB:Q8WY64 and ensembl:ENSP000003492981600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatnervous system development involved_inISOMYLIP (Homo sapiens)1624291 PMID:10593918RGDPMID:10593918
MylipRatnervous system development involved_inIEAUniProtKB:Q8WY64 and ensembl:ENSP000003492981600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatpositive regulation of protein catabolic process involved_inISOMylip (Mus musculus)1624291 PMID:19520913RGDPMID:19520913
MylipRatpositive regulation of protein catabolic process involved_inIEAUniProtKB:Q8BM54 and ensembl:ENSMUSP000000474031600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatprotein destabilization involved_inISOMylip (Mus musculus)1624291 PMID:19520913RGDPMID:19520913
MylipRatprotein destabilization involved_inIEAUniProtKB:Q8BM54 and ensembl:ENSMUSP000000474031600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatprotein ubiquitination involved_inIEAUniPathway:UPA001431600115GO_REF:0000041UniProtGO_REF:0000041
MylipRatprotein ubiquitination involved_inIEAUniProtKB:Q8WY64 and ensembl:ENSP000003492981600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatprotein ubiquitination involved_inISOMYLIP (Homo sapiens)1624291 PMID:14550572RGDPMID:14550572
MylipRatregulation of low-density lipoprotein particle receptor catabolic process involved_inISOMylip (Mus musculus)1624291 PMID:19520913RGDPMID:19520913
MylipRatregulation of low-density lipoprotein particle receptor catabolic process involved_inIEAUniProtKB:Q8BM54 and ensembl:ENSMUSP000000474031600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatubiquitin-dependent protein catabolic process involved_inIEAUniProtKB:Q8BM54 and ensembl:ENSMUSP000000474031600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatubiquitin-dependent protein catabolic process involved_inISOMylip (Mus musculus)1624291 PMID:19520913RGDPMID:19520913
MylipRatubiquitin-dependent protein catabolic process involved_inIBAFB:FBgn0260866 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MylipRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
MylipRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
MylipRatcytoskeleton located_inIEAInterPro:IPR0002991600115GO_REF:0000002InterProGO_REF:0000002
MylipRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
MylipRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
MylipRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MylipRatcytoskeletal protein binding enablesISOMYLIP (Homo sapiens)1624291 PMID:10593918RGDPMID:10593918
MylipRatcytoskeletal protein binding enablesIEAInterPro:IPR0007981600115GO_REF:0000002InterProGO_REF:0000002
MylipRatcytoskeletal protein binding enablesIEAUniProtKB:Q8WY64 and ensembl:ENSP000003492981600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
MylipRatprotein binding enablesISOMYLIP (Homo sapiens)1624291UniProtKB:A0A6Q8PF08 more ...RGDPMID:12826659 more ...
MylipRattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
MylipRatubiquitin protein ligase activity enablesISOMYLIP (Homo sapiens)1624291 PMID:21685362RGDPMID:21685362
MylipRatubiquitin protein ligase activity enablesIEAUniProtKB:Q8WY64 and ensembl:ENSP000003492981600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatubiquitin protein ligase activity enablesIEAUniProtKB:Q8BM54 and ensembl:ENSMUSP000000474031600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatubiquitin protein ligase activity enablesISOMylip (Mus musculus)1624291 PMID:19520913RGDPMID:19520913
MylipRatubiquitin-protein transferase activity enablesISOMYLIP (Homo sapiens)1624291 PMID:14550572RGDPMID:14550572
MylipRatubiquitin-protein transferase activity enablesIEAUniProtKB:Q8BM54 and ensembl:ENSMUSP000000474031600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatubiquitin-protein transferase activity enablesIBAMGI:2388271 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
MylipRatubiquitin-protein transferase activity enablesISOMylip (Mus musculus)1624291 PMID:19520913RGDPMID:19520913
MylipRatubiquitin-protein transferase activity enablesIEAUniProtKB:Q8WY64 and ensembl:ENSP000003492981600115GO_REF:0000107EnsemblGO_REF:0000107
MylipRatzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
PMID:10593918   PMID:14550572   PMID:19028597   PMID:19520913   PMID:21685362   PMID:23990472   PMID:24166456  



Mylip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81719,492,826 - 19,514,490 (-)NCBIGRCr8
mRatBN7.21719,286,649 - 19,308,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1719,286,650 - 19,308,295 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1719,171,096 - 19,192,723 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01720,774,907 - 20,796,527 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01719,098,217 - 19,119,846 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01719,682,040 - 19,703,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1719,682,040 - 19,703,681 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01721,703,590 - 21,725,205 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41725,308,147 - 25,329,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11725,312,367 - 25,523,199 (-)NCBI
Celera1718,989,082 - 19,010,552 (-)NCBICelera
Cytogenetic Map17p14NCBI
MYLIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38616,129,086 - 16,163,887 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl616,129,086 - 16,151,367 (+)EnsemblGRCh38hg38GRCh38
GRCh37616,129,317 - 16,148,479 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36616,237,296 - 16,256,458 (+)NCBINCBI36Build 36hg18NCBI36
Build 34616,237,295 - 16,256,455NCBI
Celera617,367,147 - 17,386,309 (+)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef616,076,513 - 16,095,715 (+)NCBIHuRef
CHM1_1616,132,017 - 16,151,181 (+)NCBICHM1_1
T2T-CHM13v2.0616,001,663 - 16,037,439 (+)NCBIT2T-CHM13v2.0
Mylip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391345,543,197 - 45,565,498 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1345,543,218 - 45,565,498 (+)EnsemblGRCm39 Ensembl
GRCm381345,389,742 - 45,411,940 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1345,389,742 - 45,412,022 (+)EnsemblGRCm38mm10GRCm38
MGSCv371345,485,111 - 45,507,309 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361345,400,714 - 45,422,912 (+)NCBIMGSCv36mm8
Celera1346,464,431 - 46,486,733 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1321.88NCBI
Mylip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554839,723,023 - 9,745,062 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554839,725,343 - 9,745,041 (-)NCBIChiLan1.0ChiLan1.0
MYLIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2530,794,914 - 30,816,026 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1626,780,496 - 26,801,629 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0615,985,844 - 16,005,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1616,350,852 - 16,370,253 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl616,350,852 - 16,370,253 (+)Ensemblpanpan1.1panPan2
MYLIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13515,257,633 - 15,276,771 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3515,256,885 - 15,275,424 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3515,205,869 - 15,225,698 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03515,352,342 - 15,372,171 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3515,352,164 - 15,370,824 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13515,177,056 - 15,196,883 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03515,228,888 - 15,248,707 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03516,555,131 - 16,574,958 (+)NCBIUU_Cfam_GSD_1.0
Mylip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049469,389,585 - 9,405,771 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365522,325,378 - 2,339,867 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365522,325,161 - 2,341,356 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYLIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl712,117,240 - 12,137,925 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1712,117,240 - 12,137,934 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2712,713,066 - 12,733,740 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYLIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11756,021,151 - 56,040,175 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1756,022,369 - 56,040,169 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604416,181,768 - 16,200,965 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mylip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475610,324,021 - 10,343,787 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475610,324,275 - 10,343,047 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Mylip
141 total Variants

Predicted Target Of
Summary Value
Count of predictions:223
Count of miRNA genes:153
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000024021
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat

1 to 10 of 35 rows
AA818380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21719,286,948 - 19,287,129 (+)MAPPERmRatBN7.2
Rnor_6.01719,682,339 - 19,682,519NCBIRnor6.0
Rnor_5.01721,703,889 - 21,704,069UniSTSRnor5.0
RGSC_v3.41725,308,439 - 25,308,619UniSTSRGSC3.4
Celera1718,989,381 - 18,989,561UniSTS
RH 3.4 Map17246.9UniSTS
Cytogenetic Map17p12UniSTS
AI411450  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21719,306,413 - 19,306,595 (+)MAPPERmRatBN7.2
Rnor_6.01719,701,801 - 19,701,982NCBIRnor6.0
Rnor_5.01721,723,325 - 21,723,506UniSTSRnor5.0
RGSC_v3.41725,328,007 - 25,328,188UniSTSRGSC3.4
Celera1719,008,667 - 19,008,848UniSTS
RH 3.4 Map17248.8UniSTS
Cytogenetic Map17p12UniSTS


This gene Mylip is modified in the following models/strains:




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000024021   ⟹   ENSRNOP00000024021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1719,286,650 - 19,308,295 (-)Ensembl
Rnor_6.0 Ensembl1719,682,040 - 19,703,681 (-)Ensembl
RefSeq Acc Id: NM_001107344   ⟹   NP_001100814
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81719,492,826 - 19,514,471 (-)NCBI
mRatBN7.21719,286,650 - 19,308,295 (-)NCBI
Rnor_6.01719,682,040 - 19,703,681 (-)NCBI
Rnor_5.01721,703,590 - 21,725,205 (-)NCBI
RGSC_v3.41725,308,147 - 25,329,887 (-)RGD
Celera1718,989,082 - 19,010,552 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063276374   ⟹   XP_063132444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81719,492,830 - 19,514,490 (-)NCBI
RefSeq Acc Id: XM_063276375   ⟹   XP_063132445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81719,492,830 - 19,500,989 (-)NCBI
Protein RefSeqs NP_001100814 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132444 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132445 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZDI6 (Get FASTA)   NCBI Sequence Viewer  
  EDL98172 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024021
  ENSRNOP00000024021.4
RefSeq Acc Id: NP_001100814   ⟸   NM_001107344
- UniProtKB: D3ZDI6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024021   ⟸   ENSRNOT00000024021
RefSeq Acc Id: XP_063132444   ⟸   XM_063276374
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063132445   ⟸   XM_063276375
- Peptide Label: isoform X2
FERM

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDI6-F1-model_v2 AlphaFold D3ZDI6 1-445 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700372
Promoter ID:EPDNEW_R10895
Type:single initiation site
Name:Mylip_1
Description:myosin regulatory light chain interacting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01719,703,680 - 19,703,740EPDNEW


1 to 40 of 42 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-9860 BioCyc
Ensembl Genes ENSRNOG00000017579 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024021 ENTREZGENE
  ENSRNOT00000024021.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.80.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro Band_41_domain UniProtKB/Swiss-Prot
  Ez/rad/moesin-like UniProtKB/Swiss-Prot
  FERM/acyl-CoA-bd_prot_sf UniProtKB/Swiss-Prot
  FERM_2 UniProtKB/Swiss-Prot
  FERM_central UniProtKB/Swiss-Prot
  FERM_domain UniProtKB/Swiss-Prot
  FERM_N UniProtKB/Swiss-Prot
  FERM_PH-like_C UniProtKB/Swiss-Prot
  MYLIP_FERM_C UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
KEGG Report rno:306825 UniProtKB/Swiss-Prot
NCBI Gene 306825 ENTREZGENE
PANTHER 4.1 G PROTEIN UniProtKB/Swiss-Prot
  E3 UBIQUITIN-PROTEIN LIGASE MYLIP UniProtKB/Swiss-Prot
Pfam FERM_C UniProtKB/Swiss-Prot
  FERM_M UniProtKB/Swiss-Prot
  FERM_N UniProtKB/Swiss-Prot
  zf-C3HC4_3 UniProtKB/Swiss-Prot
PhenoGen Mylip PhenoGen
PRINTS BAND41 UniProtKB/Swiss-Prot
  ERMFAMILY UniProtKB/Swiss-Prot
PROSITE FERM_3 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017579 RatGTEx
SMART B41 UniProtKB/Swiss-Prot
  FERM_C UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  RING/U-box UniProtKB/Swiss-Prot
  SSF47031 UniProtKB/Swiss-Prot
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Mylip  myosin regulatory light chain interacting protein   Mylip_predicted  myosin regulatory light chain interacting protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mylip_predicted  myosin regulatory light chain interacting protein (predicted)      Symbol and Name status set to approved 70820 APPROVED