Dus2 (dihydrouridine synthase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Dus2 (dihydrouridine synthase 2) Rattus norvegicus
Analyze
Symbol: Dus2
Name: dihydrouridine synthase 2
RGD ID: 1305612
Description: Predicted to enable several functions, including double-stranded RNA binding activity; nucleotide binding activity; and tRNA dihydrouridine synthase activity. Predicted to be involved in antiviral innate immune response and tRNA dihydrouridine synthesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human DUS2 (dihydrouridine synthase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dihydrouridine synthase 2-like, SMM1 homolog; dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae); Dus2l; LOC291978; RGD1305612; similar to hypothetical protein FLJ20399; tRNA-dihydrouridine synthase 2-like; tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,816,306 - 50,864,559 (+)NCBIGRCr8
mRatBN7.21933,906,517 - 33,954,922 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,911,750 - 33,954,709 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,727,280 - 40,770,256 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,380,597 - 41,423,568 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,679,497 - 43,722,711 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,990,374 - 38,033,590 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,990,374 - 38,033,590 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,857,360 - 48,900,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,858,496 - 35,901,661 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,863,428 - 35,906,542 (+)NCBI
Celera1933,339,293 - 33,382,226 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18096616   PMID:18614015   PMID:26429968  


Genomics

Comparative Map Data
Dus2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,816,306 - 50,864,559 (+)NCBIGRCr8
mRatBN7.21933,906,517 - 33,954,922 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,911,750 - 33,954,709 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,727,280 - 40,770,256 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,380,597 - 41,423,568 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,679,497 - 43,722,711 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,990,374 - 38,033,590 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,990,374 - 38,033,590 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,857,360 - 48,900,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,858,496 - 35,901,661 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,863,428 - 35,906,542 (+)NCBI
Celera1933,339,293 - 33,382,226 (+)NCBICelera
Cytogenetic Map19q12NCBI
DUS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,023,284 - 68,079,320 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,987,746 - 68,079,320 (+)EnsemblGRCh38hg38GRCh38
GRCh371668,057,187 - 68,113,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,614,705 - 66,670,685 (+)NCBINCBI36Build 36hg18NCBI36
Celera1652,565,657 - 52,621,610 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,930,424 - 53,986,377 (+)NCBIHuRef
CHM1_11669,464,865 - 69,521,178 (+)NCBICHM1_1
T2T-CHM13v2.01673,819,064 - 73,875,073 (+)NCBIT2T-CHM13v2.0
Dus2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,738,110 - 106,780,472 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,717,969 - 106,780,472 (+)EnsemblGRCm39 Ensembl
GRCm388106,011,478 - 106,053,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,991,337 - 106,053,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv378108,535,407 - 108,577,719 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,900,610 - 108,942,970 (+)NCBIMGSCv36mm8
Celera8110,239,559 - 110,281,677 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.07NCBI
Dus2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,561,728 - 8,609,947 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,564,015 - 8,609,987 (-)NCBIChiLan1.0ChiLan1.0
DUS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,540,507 - 77,620,481 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,451,732 - 83,531,749 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,355,186 - 48,450,121 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,787,953 - 67,845,287 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,787,953 - 67,845,287 (+)Ensemblpanpan1.1panPan2
DUS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,439,505 - 81,489,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,439,553 - 81,489,640 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,429,401 - 81,479,650 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0581,874,407 - 81,924,724 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,871,631 - 81,924,659 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,701,043 - 81,751,313 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,383,239 - 81,433,537 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,024,836 - 82,075,472 (-)NCBIUU_Cfam_GSD_1.0
LOC101964711
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,128,945 - 41,193,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,358,706 - 18,460,191 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,415,019 - 18,457,369 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,617,408 - 28,661,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,617,350 - 28,661,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,957,781 - 26,002,061 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,352,465 - 59,413,523 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,352,785 - 59,399,921 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,088,063 - 22,145,947 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dus2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,214,301 - 18,269,506 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,216,066 - 18,269,840 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dus2
203 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:51
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000026827
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
RH133444  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,954,495 - 33,954,689 (+)MAPPERmRatBN7.2
Rnor_6.01938,033,377 - 38,033,570NCBIRnor6.0
Rnor_5.01948,900,125 - 48,900,318UniSTSRnor5.0
RGSC_v3.41935,901,448 - 35,901,641UniSTSRGSC3.4
Celera1933,382,013 - 33,382,206UniSTS
RH 3.4 Map19318.3UniSTS
Cytogenetic Map19q12UniSTS
RH140741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,911,318 - 33,911,538 (+)MAPPERmRatBN7.2
Rnor_6.01937,989,943 - 37,990,162NCBIRnor6.0
Rnor_5.01948,856,929 - 48,857,148UniSTSRnor5.0
RGSC_v3.41935,858,065 - 35,858,284UniSTSRGSC3.4
Celera1933,338,862 - 33,339,081UniSTS
RH 3.4 Map19317.7UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 14 22 16 17 16 66 22 38 3
Low 1 29 35 25 2 25 8 11 8 13 3 8 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063277927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000026827   ⟹   ENSRNOP00000026827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,911,750 - 33,954,709 (+)Ensembl
Rnor_6.0 Ensembl1937,990,374 - 38,033,590 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094543   ⟹   ENSRNOP00000082863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1933,911,827 - 33,954,662 (+)Ensembl
RefSeq Acc Id: NM_001106181   ⟹   NP_001099651
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,821,594 - 50,864,559 (+)NCBI
mRatBN7.21933,911,750 - 33,954,709 (+)NCBI
Rnor_6.01937,990,374 - 38,033,590 (+)NCBI
Rnor_5.01948,857,360 - 48,900,338 (+)NCBI
RGSC_v3.41935,858,496 - 35,901,661 (+)RGD
Celera1933,339,293 - 33,382,226 (+)RGD
Sequence:
RefSeq Acc Id: XM_017601231   ⟹   XP_017456720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,821,726 - 50,864,540 (+)NCBI
mRatBN7.21933,912,167 - 33,954,692 (+)NCBI
Rnor_6.01937,990,501 - 38,033,573 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601232   ⟹   XP_017456721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,821,604 - 50,864,540 (+)NCBI
mRatBN7.21933,911,760 - 33,954,692 (+)NCBI
Rnor_6.01937,990,428 - 38,033,573 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097618   ⟹   XP_038953546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,816,306 - 50,864,540 (+)NCBI
mRatBN7.21933,906,517 - 33,954,922 (+)NCBI
RefSeq Acc Id: XM_039097619   ⟹   XP_038953547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,842,234 - 50,864,540 (+)NCBI
mRatBN7.21933,931,299 - 33,954,922 (+)NCBI
RefSeq Acc Id: XM_039097620   ⟹   XP_038953548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,833,948 - 50,864,540 (+)NCBI
mRatBN7.21933,924,096 - 33,954,922 (+)NCBI
RefSeq Acc Id: XM_039097622   ⟹   XP_038953550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,833,948 - 50,864,540 (+)NCBI
mRatBN7.21933,924,096 - 33,954,922 (+)NCBI
RefSeq Acc Id: XM_039097623   ⟹   XP_038953551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,841,150 - 50,864,540 (+)NCBI
mRatBN7.21933,931,299 - 33,954,922 (+)NCBI
RefSeq Acc Id: XM_063277926   ⟹   XP_063133996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,838,893 - 50,864,540 (+)NCBI
RefSeq Acc Id: XM_063277927   ⟹   XP_063133997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,849,318 - 50,864,540 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001099651   ⟸   NM_001106181
- UniProtKB: B0BN89 (UniProtKB/TrEMBL),   A6IYV4 (UniProtKB/TrEMBL),   A0A8I5ZYR8 (UniProtKB/TrEMBL),   F7FLX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456721   ⟸   XM_017601232
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZYR8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456720   ⟸   XM_017601231
- Peptide Label: isoform X1
- UniProtKB: B0BN89 (UniProtKB/TrEMBL),   A6IYV4 (UniProtKB/TrEMBL),   A0A8I5ZYR8 (UniProtKB/TrEMBL),   F7FLX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026827   ⟸   ENSRNOT00000026827
RefSeq Acc Id: XP_038953546   ⟸   XM_039097618
- Peptide Label: isoform X1
- UniProtKB: B0BN89 (UniProtKB/TrEMBL),   A6IYV4 (UniProtKB/TrEMBL),   A0A8I5ZYR8 (UniProtKB/TrEMBL),   F7FLX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953548   ⟸   XM_039097620
- Peptide Label: isoform X3
- UniProtKB: A6IYV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953550   ⟸   XM_039097622
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038953547   ⟸   XM_039097619
- Peptide Label: isoform X3
- UniProtKB: A6IYV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953551   ⟸   XM_039097623
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000082863   ⟸   ENSRNOT00000094543
RefSeq Acc Id: XP_063133996   ⟸   XM_063277926
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063133997   ⟸   XM_063277927
- Peptide Label: isoform X5
Protein Domains
DRBM   DUS-like FMN-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BN89-F1-model_v2 AlphaFold B0BN89 1-493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701100
Promoter ID:EPDNEW_R11624
Type:multiple initiation site
Name:Dus2_1
Description:dihydrouridine synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01937,990,432 - 37,990,492EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305612 AgrOrtholog
BioCyc Gene G2FUF-5793 BioCyc
Ensembl Genes ENSRNOG00000019819 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026827 ENTREZGENE
  ENSRNOT00000026827.6 UniProtKB/TrEMBL
  ENSRNOT00000094543.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
  3.30.160.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9091646 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/TrEMBL
  dsRNA-bd-like UniProtKB/TrEMBL
  DUS-like_FMN-bd UniProtKB/TrEMBL
  DUS2_DSRM UniProtKB/TrEMBL
  tRNA_hU_synthase_CS UniProtKB/TrEMBL
KEGG Report rno:291978 UniProtKB/TrEMBL
MGC_CLONE MGC:187881 IMAGE-MGC_LOAD
NCBI Gene 291978 ENTREZGENE
PANTHER TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE UniProtKB/TrEMBL
  TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE UniProtKB/TrEMBL
Pfam dsrm UniProtKB/TrEMBL
  Dus UniProtKB/TrEMBL
PhenoGen Dus2 PhenoGen
PROSITE DS_RBD UniProtKB/TrEMBL
  UPF0034 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019819 RatGTEx
SMART DSRM UniProtKB/TrEMBL
Superfamily-SCOP dsRNA-binding domain-like UniProtKB/TrEMBL
  FMN-linked oxidoreductases UniProtKB/TrEMBL
UniProt A0A8I5ZYR8 ENTREZGENE, UniProtKB/TrEMBL
  A6IYV4 ENTREZGENE, UniProtKB/TrEMBL
  A6IYV5 ENTREZGENE, UniProtKB/TrEMBL
  B0BN89 ENTREZGENE
  F7FLX6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B0BN89 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 Dus2  dihydrouridine synthase 2  Dus2l  dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Dus2l  dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)  Dus2l_predicted  dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dus2l_predicted  dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) (predicted)  RGD1305612_predicted  similar to hypothetical protein FLJ20399 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1305612_predicted  similar to hypothetical protein FLJ20399 (predicted)  LOC291978_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291978_predicted  similar to hypothetical protein FLJ20399 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL