Rbbp7 (RB binding protein 7, chromatin remodeling factor)

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Gene: Rbbp7 (RB binding protein 7, chromatin remodeling factor) Chinchilla lanigera

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Symbol:

Rbbp7

Name:

RB binding protein 7, chromatin remodeling factor

RGD ID:

9015116

Description:

ENCODES a protein that exhibits histone binding (ortholog); RNA binding (ortholog); INVOLVED IN cellular heat acclimation (ortholog); chromatin remodeling (ortholog); negative regulation of cell growth (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; Hedgehog signaling pathway; ISWI family mediated chromatin remodeling pathway; ASSOCIATED WITH autistic disorder (ortholog); Neurodevelopmental Disorders (ortholog); syndromic X-linked intellectual disability Lubs type (ortholog); FOUND IN ATPase complex (ortholog); chromosome, telomeric region (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

histone-binding protein RBBP7; retinoblastoma binding protein 7

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955519	1,460,199 - 1,482,699 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Neurodevelopmental Disorders (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular heat acclimation (ISO)

chromatin remodeling (ISO)

negative regulation of cell growth (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

regulation of DNA-templated transcription (ISO)

response to steroid hormone (ISO)

Cellular Component

ATPase complex (ISO)

chromosome, telomeric region (ISO)

cytosol (ISO)

ESC/E(Z) complex (ISO)

histone deacetylase complex (ISO)

nucleoplasm (ISO)

nucleus (ISO)

NuRD complex (ISO)

NURF complex (ISO)

Molecular Function

histone binding (ISO)

protein binding (ISO)

RNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

CHD family mediated chromatin remodeling pathway (ISO)

Hedgehog signaling pathway (ISO)

ISWI family mediated chromatin remodeling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Rbbp7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955519	1,460,199 - 1,482,699 (+)	NCBI	ChiLan1.0	ChiLan1.0

RBBP7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	16,844,341 - 16,870,362 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	16,839,283 - 16,870,362 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	16,862,464 - 16,888,485 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	16,772,698 - 16,798,386 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	16,622,433 - 16,648,114	NCBI
Celera	X	20,981,704 - 21,007,178 (-)	NCBI		Celera
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	14,623,294 - 14,649,232 (-)	NCBI		HuRef
CHM1_1	X	16,893,198 - 16,918,914 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	16,426,872 - 16,452,877 (-)	NCBI		T2T-CHM13v2.0

Rbbp7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	161,543,368 - 161,562,086 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	161,543,398 - 161,562,088 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	162,760,372 - 162,779,090 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	162,760,402 - 162,779,092 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	159,198,304 - 159,217,022 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	158,104,564 - 158,123,195 (+)	NCBI		MGSCv36	mm8
MGSCv36	X	139,886,392 - 139,905,148 (+)	NCBI		MGSCv36	mm8
Celera	X	145,966,574 - 146,004,291 (+)	NCBI		Celera
Cytogenetic Map	X	F4	NCBI
cM Map	X	74.97	NCBI

Rbbp7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	35,544,873 - 35,563,030 (-)	NCBI		GRCr8
mRatBN7.2	X	31,913,080 - 31,931,245 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	31,913,081 - 31,931,226 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	32,947,379 - 32,965,537 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	36,382,894 - 36,401,051 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	32,571,785 - 32,589,943 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	33,648,682 - 33,665,821 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	33,648,682 - 33,665,821 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	33,995,673 - 34,012,812 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	52,669,703 - 52,688,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	52,723,171 - 52,741,801 (-)	NCBI
Celera	X	32,216,768 - 32,234,925 (-)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

RBBP7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	18,640,519 - 18,667,013 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	18,643,907 - 18,669,548 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	9,465,579 - 9,491,096 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	16,834,802 - 16,859,575 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	16,834,811 - 16,859,575 (-)	Ensembl	panpan1.1		panPan2

RBBP7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	12,981,852 - 13,006,049 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	12,981,860 - 13,006,045 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	12,833,201 - 12,857,396 (-)	NCBI		Dog10K_Boxer_Tasha

Rbbp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	6,107,735 - 6,133,089 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	6,104,510 - 6,133,185 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	6,107,754 - 6,133,136 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RBBP7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	13,280,977 - 13,317,031 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	13,293,278 - 13,317,074 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	14,288,824 - 14,312,580 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RBBP7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	15,268,650 - 15,294,648 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	15,269,026 - 15,294,592 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	17,122,978 - 17,149,020 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rbbp7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	1,544,788 - 1,567,425 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624829	1,544,781 - 1,567,301 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005409144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01067893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01080619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005409144 ⟹ XP_005409201

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955519	1,460,199 - 1,482,699 (+)	NCBI

Sequence:

show sequence

TATTTTTCCCAGGGCGGATGCGCCTGCGCTCAGCTGCCTGGGCGGGCTGGGAGGCGCGGGTTGA
AAAGTCTCGTTCCAAGTTTGGAGAGAGAGAGAAGAGCGCCTCAGACCTCAGTACCCGCGAGCGG
GGAGGAGGCAGGAGAGAAGGCTAGGCGTCTGGGGGGCACCCAGGCGGCAAGACGGACCGCAGCC
TTCCAGAGCCAGGGGTGTGTGACGCGCCTGGGAAAGGCAGGAACCCCAGCGGTCAGGCTGCTCT
TGGCTAGCGAGAGGAGTCCGAGGCGGCAGCGAGGGGCGAACGACCCGACGCAAGATGGCGAGTA
AAGAGATGTTTGAAGATACTGTGGAAGAGCGAGTCATCAATGAAGAATATAAAATCTGGAAGAA
GAATACACCGTTTCTGTATGACCTGGTTATGACCCATGCTCTTCAGTGGCCCAGTCTTACCGTT
CAGTGGCTTCCTGAAGTGACTAAACCAGAAGGAAAAGATTATGCCCTTCATTGGCTGGTGCTGG
GGACTCACACATCTGATGAGCAGAATCATCTGGTGGTTGCTCGAGTCCATATTCCCAATGATGA
TGCGCAGTTCGACGCTTCCCACTGTGACAGTGACAAGGGTGAATTTGGTGGCTTTGGTTCTGTA
ACAGGAAAAATTGAATGTGAAATTAAAATTAATCACGAAGGAGAAGTGAATCGTGCTCGTTACA
TGCCACAAAATCCTCACATCATTGCTACAAAAACACCGTCTTCTGATGTGTTGGTTTTTGACTA
CACAAAACATCCTGCTAAACCAGACCCAAGTGGAGAATGTAATCCTGATCTTAGGTTAAGAGGT
CACCAAAAGGAAGGCTATGGTCTTTCCTGGAATTCTAATTTGAGTGGACATCTCCTAAGTGCAT
CCGACGACCATACTGTCTGCCTGTGGGATATAAATGCAGGACCAAAGGAAGGCAAAATTGTGGA
TGCTAAAGCAATCTTTACCGGCCACTCAGCCGTTGTAGAGGATGTGGCCTGGCATCTGCTGCAT
GAGTCCTTGTTTGGATCGGTCGCTGATGATCAGAAACTCATGATATGGGACACCAGGTCCAACA
CCACCTCAAAGCCCAGCCACTTGGTGGATGCGCATACTGCCGAGGTCAACTGCCTCTCCTTCAA
TCCCTACAGCGAATTCATTCTAGCAACGGGCTCTGCGGATAAGACGGTAGCTTTGTGGGACCTG
CGTAACTTAAAATTAAAACTTCATACCTTCGAATCTCATAAGGATGAGATTTTCCAGGTCCACT
GGTCTCCACATAATGAAACTATTCTGGCTTCAAGTGGTACCGATCGTCGCCTGAACGTGTGGGA
TTTGAGCAAAATTGGAGAAGAACAGTCAGCTGAGGACGCAGAAGATGGGCCTCCAGAACTCCTG
TTTATCCACGGAGGACACACTGCCAAGATTTCGGACTTTAGCTGGAACCCCAATGAGCCTTGGG
TTATCTGCTCAGTGTCTGAGGATAACATCATGCAGATATGGCAAATGGCTGAAAATATTTACAA
TGATGAAGAGTCAGATGTCACAACTTCGGAACTGGAGGGACAAGGATCTTAAACCCAAAGTATG
AGAGCTGTTTTTGTTGAATGTAATGCTACACAAATGCTTGATTTCTCAAGCGCCAAAACAGCGT
TGTATAGTGGGAAATGTTAAGTGGGGTGGCTTATGGCATTCTTGACCCTATGATTCTAGCACTT
TCAAGTGAGCTGTTGCGTTACTGTATCATATTGTAGTTATTAGGGAAGAAGGAACGTTGCTTCA
GAAGGAATATCACGTTGTTTTAAATATAAGTAGCAGGGTACTGCCTTTGATTCAACTGTTCTAA
GCCCTCGTTTTCTCAGACTTAAGTGCTTGCTGTTCCCAAATATGCAAGGGTAACTTTTACACTT
TTTCCTTCCAACACTTCTTGATTGGCTTTGCAGAAATAAAAGTTTTAAAATAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005409201	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000002316
	ENSCLAP00000002316.1
	ENSCLAP00000002317.1

RefSeq Acc Id:

XP_005409201 ⟸ XM_005409144

- UniProtKB:

A0A8C2US12 (UniProtKB/TrEMBL), A0A8C2ULG0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHW
LVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNR
ARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHL
LSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDT
RSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIF
QVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPN
EPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSELEGQGS

hide sequence

Protein Domains

Histone-binding protein RBBP4 N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000001677	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000002365	ENTREZGENE
	ENSCLAT00000002365.1	UniProtKB/TrEMBL
	ENSCLAT00000002366.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	Histone-bd_RBBP4_N	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
	WD_repeat_RBAP46/RBAP48/MSI1	UniProtKB/TrEMBL
NCBI Gene	Rbbp7	ENTREZGENE
PANTHER	HISTONE-BINDING PROTEIN RBBP7	UniProtKB/TrEMBL
	WD40 REPEAT FAMILY	UniProtKB/TrEMBL
Pfam	CAF1C_H4-bd	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A8C2ULG0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2US12	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Rbbp7	RB binding protein 7, chromatin remodeling factor		retinoblastoma binding protein 7	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)