RBBP7 (RB binding protein 7, chromatin remodeling factor)

Gene: RBBP7 (RB binding protein 7, chromatin remodeling factor) Pan paniscus

Analyze

Symbol:

RBBP7

Name:

RB binding protein 7, chromatin remodeling factor

RGD ID:

11903271

Description:

ENCODES a protein that exhibits histone binding (inferred); nucleosome binding (inferred); RNA binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); response to steroid hormone (ortholog); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; Hedgehog signaling pathway; ISWI family mediated chromatin remodeling pathway; ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN ATPase complex (ortholog); NURF complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

histone-binding protein RBBP7

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	18,640,519 - 18,667,013 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	18,643,907 - 18,669,548 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	9,465,579 - 9,491,096 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	16,834,802 - 16,859,575 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	16,834,811 - 16,859,575 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular heat acclimation (IEA)

chromatin remodeling (IEA)

DNA replication (IEA)

negative regulation of cell growth (IEA)

negative regulation of DNA-templated transcription (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

response to steroid hormone (ISO)

Cellular Component

ATPase complex (IEA,ISO)

chromosome, telomeric region (IEA)

cytosol (IEA)

ESC/E(Z) complex (IEA)

histone deacetylase complex (IEA)

nucleoplasm (IEA)

nucleus (IEA)

NuRD complex (IEA)

NURF complex (IEA,ISO)

Molecular Function

histone binding (IEA)

nucleosome binding (IEA)

protein binding (ISO)

RNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

CHD family mediated chromatin remodeling pathway (ISO)

Hedgehog signaling pathway (ISO)

ISWI family mediated chromatin remodeling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

RBBP7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	18,640,519 - 18,667,013 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	18,643,907 - 18,669,548 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	9,465,579 - 9,491,096 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	16,834,802 - 16,859,575 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	16,834,811 - 16,859,575 (-)	Ensembl	panpan1.1		panPan2

RBBP7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	16,844,341 - 16,870,362 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	16,839,283 - 16,870,362 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	16,862,464 - 16,888,485 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	16,772,698 - 16,798,386 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	16,622,433 - 16,648,114	NCBI
Celera	X	20,981,704 - 21,007,178 (-)	NCBI		Celera
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	14,623,294 - 14,649,232 (-)	NCBI		HuRef
CHM1_1	X	16,893,198 - 16,918,914 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	16,426,872 - 16,452,877 (-)	NCBI		T2T-CHM13v2.0

Rbbp7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	161,543,368 - 161,562,086 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	161,543,398 - 161,562,088 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	162,760,372 - 162,779,090 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	162,760,402 - 162,779,092 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	159,198,304 - 159,217,022 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	158,104,564 - 158,123,195 (+)	NCBI		MGSCv36	mm8
MGSCv36	X	139,886,392 - 139,905,148 (+)	NCBI		MGSCv36	mm8
Celera	X	145,966,574 - 146,004,291 (+)	NCBI		Celera
Cytogenetic Map	X	F4	NCBI
cM Map	X	74.97	NCBI

Rbbp7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	35,544,873 - 35,563,030 (-)	NCBI		GRCr8
mRatBN7.2	X	31,913,080 - 31,931,245 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	31,913,081 - 31,931,226 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	32,947,379 - 32,965,537 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	36,382,894 - 36,401,051 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	32,571,785 - 32,589,943 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	33,648,682 - 33,665,821 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	33,648,682 - 33,665,821 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	33,995,673 - 34,012,812 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	52,669,703 - 52,688,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	52,723,171 - 52,741,801 (-)	NCBI
Celera	X	32,216,768 - 32,234,925 (-)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

Rbbp7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955519	1,460,199 - 1,482,699 (+)	NCBI	ChiLan1.0	ChiLan1.0

RBBP7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	12,981,852 - 13,006,049 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	12,981,860 - 13,006,045 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	12,833,201 - 12,857,396 (-)	NCBI		Dog10K_Boxer_Tasha

Rbbp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	6,107,735 - 6,133,089 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	6,104,510 - 6,133,185 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	6,107,754 - 6,133,136 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RBBP7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	13,280,977 - 13,317,031 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	13,293,278 - 13,317,074 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	14,288,824 - 14,312,580 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RBBP7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	15,268,650 - 15,294,648 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	15,269,026 - 15,294,592 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	17,122,978 - 17,149,020 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rbbp7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	1,544,788 - 1,567,425 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624829	1,544,781 - 1,567,301 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003819525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034950427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000050017 ⟹ ENSPPAP00000027178

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	X	16,834,811 - 16,859,575 (-)	Ensembl

RefSeq Acc Id:

XM_003819525 ⟹ XP_003819573

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	X	18,640,519 - 18,665,578 (-)	NCBI
NHGRI_mPanPan1	X	18,643,907 - 18,668,944 (-)	NCBI
Mhudiblu_PPA_v0	X	9,465,579 - 9,490,597 (-)	NCBI
PanPan1.1	X	16,834,802 - 16,859,575 (-)	NCBI

Sequence:

show sequence

CGCGCGCGCGCGCGTTGACCGCCTCGGGGTCGCGGCCCTTGTCCGGGGGTTGCCGGAGCCCTCA
GGCCTATGGCTGCCGAGGCGGGCGTCGTGGGAGCTGGGGCCTCCCCTGATGGGGATTGGAGAGA
CCAGGCCTGTGGGCTTCTGCTACACGTGCATTTGTCTTCCCGACTGGGTCGCGCAGCCCCTGTA
CGTACAGGTCGTCATCTTAGAACAGTGTTTGAAGATACTGTGGAGGAGCGTGTCATCAATGAAG
AATATAAAATCTGGAAGAAGAATACACCGTTTCTATATGACCTGGTTATGACCCATGCTCTTCA
GTGGCCCAGTCTTACCGTTCAGTGGCTTCCTGAAGTGACTAAACCTGAAGGAAAAGATTATGCC
CTTCATTGGCTAGTGCTGGGGACTCATACGTCTGATGAGCAGAATCATCTGGTGGTTGCTCGAG
TACATATTCCCAATGATGATGCACAGTTTGATGCTTCCCATTGTGACAGTGACAAGGGTGAATT
TGGTGGCTTTGGTTCTGTAACAGGAAAAATTGAATGTGAAATTAAAATCAATCACGAAGGAGAA
GTAAACCGTGCTCGTTACATGCCGCAGAATCCTCACATCATTGCTACAAAAACACCATCTTCTG
ATGTGTTGGTTTTTGACTATACAAAACACCCTGCTAAACCAGACCCAAGTGGAGAATGTAATCC
TGATCTCAGATTAAGAGGTCACCAGAAGGAAGGCTATGGTCTCTCCTGGAATTCAAATTTGAGT
GGACATCTCCTAAGTGCATCTGATGACCATACTGTTTGTCTGTGGGATATAAACGCAGGACCAA
AAGAAGGCAAAATTGTGGATGCTAAAGCCATCTTTACTGGCCACTCAGCTGTTGTAGAGGATGT
GGCCTGGCACCTGCTGCACGAGTCATTGTTTGGATCTGTTGCTGATGATCAGAAACTTATGATA
TGGGACACCAGGTCCAATACCACCTCCAAGCCGAGCCACTTGGTGGATGCGCACACTGCCGAAG
TCAACTGCCTCTCATTCAATCCCTACAGCGAATTTATTCTAGCCACCGGCTCTGCGGATAAGAC
CGTAGCTTTATGGGATCTGCGTAACTTAAAATTAAAACTCCATACCTTCGAATCTCATAAAGAT
GAAATTTTCCAGGTCCACTGGTCTCCACATAATGAAACTATTCTGGCTTCAAGTGGTACTGACC
GCCGCCTGAATGTGTGGGATTTAAGTAAAATTGGGGAAGAACAATCAGCAGAAGATGCAGAAGA
TGGGCCTCCAGAACTCCTGTTTATTCATGGAGGACACACTGCTAAGATTTCAGATTTTAGCTGG
AACCCCAATGAGCCTTGGGTCATTTGCTCAGTGTCTGAGGATAACATCATGCAGATATGGCAAA
TGGCTGAAAATATTTACAATGATGAAGAGTCAGATGTCACGACATCCGAACTGGAGGGACAAGG
ATCTTAAACCCAAAGTACGAGAGATGTTTCTGTTGAATGTAATGCTACATGAATGCTTGATTTA
TCAAGCGCCAAAAAGGCATTGTATAGTAGGAAATGTAAGTGGGGTGGCTTATGGCTTCTTTATC
CTCTGATTCTAGCACTTTCAAGTGAGCTGTTGCGTACTGTATCATATTGTAGCTATTAGGGAAG
AGAAGAATGTTGCTTAAGAAAGAACATCACCATTGATTTTAAATACAAGTAGCAGGGTATTGCC
TTTGATTCAACTGTTTTAAGTCCTCATTTTCTCAAACTAAGTGCTTGCTGTTCCCAAATATGCA
AGAATAACTTTTACACTTTTTCCTTCCAACACTTCTTGATTGGCTTTGCAGAAATAAAGTTTTA
AAATAAAA

hide sequence

RefSeq Acc Id:

XM_034950427 ⟹ XP_034806318

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	X	18,640,519 - 18,667,013 (-)	NCBI
NHGRI_mPanPan1	X	18,643,907 - 18,669,548 (-)	NCBI
Mhudiblu_PPA_v0	X	9,465,579 - 9,491,096 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003819573	(Get FASTA)	NCBI Sequence Viewer
	XP_034806318	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000027178
	ENSPPAP00000027178.1

RefSeq Acc Id:	XP_003819573 ⟸ XM_003819525
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9BC22 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAEAGVVGAGASPDGDWRDQACGLLLHVHLSSRLGRAAPVRTGRHLRTVFEDTVEERVINEEY KIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVH IPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDV LVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKE GKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVN CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRR LNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMA ENIYNDEESDVTTSELEGQGS hide sequence

RefSeq Acc Id:	XP_034806318 ⟸ XM_034950427
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSPPAP00000027178 ⟸ ENSPPAT00000050017

Protein Domains

Histone-binding protein RBBP4 N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000036647	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000050017.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	Histone-bd_RBBP4_N	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	pps:100975672	UniProtKB/TrEMBL
NCBI Gene	RBBP7	ENTREZGENE
PANTHER	HISTONE-BINDING PROTEIN RBBP7	UniProtKB/TrEMBL
	WD40 REPEAT FAMILY	UniProtKB/TrEMBL
Pfam	CAF1C_H4-bd	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A2R9BC22	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)