Decr1 (2,4-dienoyl-CoA reductase 1)

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Gene: Decr1 (2,4-dienoyl-CoA reductase 1) Chinchilla lanigera

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Symbol:

Decr1

Name:

2,4-dienoyl-CoA reductase 1

RGD ID:

9010363

Description:

ENCODES a protein that exhibits 2,4-dienoyl-CoA reductase (NADPH) activity (ortholog); identical protein binding (ortholog); NADPH binding (ortholog); INVOLVED IN fatty acid beta-oxidation (ortholog); positive regulation of cold-induced thermogenesis (ortholog); ASSOCIATED WITH 2,4-Dienoyl-CoA Reductase Deficiency (ortholog); lipid metabolism disorder (ortholog); Nijmegen breakage syndrome (ortholog); FOUND IN catalytic complex (ortholog); cytosol (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

2,4-dienoyl CoA reductase 1, mitochondrial; 2,4-dienoyl-CoA reductase 1, mitochondrial; 2,4-dienoyl-CoA reductase, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	6,893,231 - 6,931,754 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	6,893,231 - 6,931,754 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

2,4-Dienoyl-CoA Reductase Deficiency (ISO)

lipid metabolism disorder (ISO)

Nijmegen breakage syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid beta-oxidation (ISO)

positive regulation of cold-induced thermogenesis (ISO)

Cellular Component

catalytic complex (ISO)

cytosol (ISO)

mitochondrion (ISO)

nucleoplasm (ISO)

Molecular Function

2,4-dienoyl-CoA reductase (NADPH) activity (ISO)

identical protein binding (ISO)

NADPH binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Decr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	6,893,231 - 6,931,754 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	6,893,231 - 6,931,754 (+)	NCBI	ChiLan1.0	ChiLan1.0

DECR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	90,001,477 - 90,053,633 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	90,001,405 - 90,053,633 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	91,013,705 - 91,065,861 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	91,082,756 - 91,133,403 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	91,082,755 - 91,133,403	NCBI
Celera	8	87,208,502 - 87,259,149 (+)	NCBI		Celera
Cytogenetic Map	8	q21.3	NCBI
HuRef	8	86,223,894 - 86,274,542 (+)	NCBI		HuRef
CHM1_1	8	91,054,504 - 91,105,151 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	91,125,148 - 91,177,304 (+)	NCBI		T2T-CHM13v2.0

Decr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	15,917,240 - 15,945,377 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	15,917,240 - 15,945,507 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	15,917,240 - 15,945,377 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	15,917,240 - 15,945,507 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	15,844,387 - 15,872,654 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	15,844,387 - 15,872,654 (-)	NCBI		MGSCv36	mm8
Celera	4	15,720,515 - 15,748,774 (-)	NCBI		Celera
Cytogenetic Map	4	A2	NCBI
cM Map	4	6.66	NCBI

Decr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	34,208,195 - 34,236,074 (-)	NCBI		GRCr8
mRatBN7.2	5	29,411,172 - 29,439,054 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	29,411,172 - 29,439,018 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	31,567,474 - 31,595,241 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	33,160,140 - 33,187,907 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	33,120,325 - 33,148,092 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	29,573,893 - 29,601,731 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	29,573,898 - 29,601,748 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	34,253,236 - 34,280,749 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	30,492,196 - 30,520,172 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	30,492,195 - 30,520,172 (-)	NCBI
Celera	5	28,616,707 - 28,644,572 (-)	NCBI		Celera
Cytogenetic Map	5	q13	NCBI

DECR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	107,394,558 - 107,461,629 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	82,934,216 - 83,001,276 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	86,690,816 - 86,755,379 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	88,642,676 - 88,693,224 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	88,642,172 - 88,693,224 (+)	Ensembl	panpan1.1		panPan2

DECR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	35,495,348 - 35,544,955 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	35,495,261 - 35,544,955 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	35,646,866 - 35,697,851 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	35,692,661 - 35,742,310 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	35,692,704 - 35,744,794 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	35,684,839 - 35,729,541 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	35,703,896 - 35,747,852 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	36,138,067 - 36,183,640 (+)	NCBI		UU_Cfam_GSD_1.0

Decr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	43,936,906 - 43,975,997 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	3,816,653 - 3,853,632 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936544	3,816,543 - 3,853,288 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DECR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	46,731,360 - 46,767,422 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	46,731,359 - 46,767,427 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	51,207,727 - 51,243,866 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DECR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	85,086,843 - 85,129,267 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	85,086,874 - 85,129,160 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	55,747,223 - 55,792,311 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Decr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	1,963,825 - 2,003,643 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624744	1,965,605 - 2,003,299 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005381763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01017994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01036028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000014131 ⟹ ENSCLAP00000013974

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955417	6,893,231 - 6,931,754 (+)	Ensembl

RefSeq Acc Id:

XM_005381763 ⟹ XP_005381820

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955417	6,893,231 - 6,931,754 (+)	NCBI

Sequence:

show sequence

CTGCTACTCCCTGCCTTACAAACCCAGCGGGCCTGGAGCACAAACAAAAGCGTCTGGAGGCCGA
GAGGCAGCGCCCTCTCCCACCCCGGGGACACGCAGGCTCCCTCCGCCGTCCCGCCCCGTCGCTG
CCCCGGCCCACCCCGGATCTCTCTGCTCCGGGCCCGCCCCGCGCCTGCTGCCTTCCGGACAGAT
CTTGCTGACATGGCGTGGCTGGGCCTTGCGCTCTTTGCCCGGGCGTCCCACCTGCCCTGTGGCT
TCTGTCCTCGGCGGTTTTTCAGTCATGGAACAAAAACATTGTATCAAAACATTGAAGCTCCACA
GTCTAAATTCTTTCGTCCCCTTCAGAAAGCTATGCTACCACCTGATACTTTTAAAGGAAAAGTG
GCATTTATTACTGGAGGGGGTACCGGCCTCGGCAAAGCGATGACAACTTATCTGTCCAGCTTGG
GTGCTGAATGTGTGATAGCCAGCCGGAATGCTGATGTTCTGAAAGCTACTGCAGAACAAATTTC
TTCTCAAACTGGAAATAAGGTTCATGCAATTCAGTGTGATGTGAGGAATCCTGACATGGTTCAC
AACACCGTGCTGGAACTGATCAAAGTCGCAGGCCATCCTGATGTCGTGATAAACAACGCAGCAG
GGAATTTTATTTCTCCCACTGAAAGACTCTCTCCTAATGCTTGGAAGACGATATCTGATATAGT
TCTAAATGGCACAGCTTATGTGACACTGGAAATTGGAAAGCAGCTCATTAAAGCACAGAAAGGG
GCAGCATTTCTTGCCATTACAACAATCTATGCTGAGACAGGATCTGGTTTTGTTGTACCAAGTG
CTTCTTCCAAAGCCGGTGTGGAAGCCATGAACAAGTCTCTTGCAGCAGAATGGGGTAAATATGG
AATGAGATTCAATGTCATTCAACCGGGGCCTATAAAAACCAAAGGTGCCTTCAGCCGCCTGGAC
CCAACTGGAACATTTGAGAAAGATATGATTGACAGAATTCCTTGTGGCCGGCTGGGGACTGCGG
AAGAGCTTGCAAATCTCGCTATTTTCCTTTGTAGTGATTATGCTTCCTGGATTAGTGGTGCAGT
CATTAGATTTGATGGTGGAGAGGAAGCATTTATTTCAGGTGAATTCAACAGTTTAAGAAAGGTC
ACCAAGGAAGAGTGGGATACAATAGAAGGACTCATTCGAAAGACAAAAGGCTCCTAAGATCACT
GTACCCCTCATCCAAGACACTGCACCGCTCATACAGATCACTGTACCCCCTCATCCAAGTCCAA
ATTAAGGCGTAGAAATGGTATAAACTGACTGTAATCTTTTGAGTATTTTCAATTCTAATAAAGT
TTTAATTACCACACATTTTCTGACTACATACTATGTGCTAGGCCAGTGGTAGCCATTTATGTAT
TTAAAGGTAAACAAGAGGGGGAAATGATCTCTTTAAAAAAGTTTTTTTAAATGGATGAGAGTAG
GTAGAGGCTTTGATAGAGGTAAAAAATGCTTTGAAATGCAGAGCAAGTAATAGGTTATTTGTAA
TTTGGAAAATCAGTAGAAACCTAATGGGAGAAATAGCATTTCAGTTATGCATTACACCCTGGGT
ATTGTATGGTGTGAAAAGAATGAAATGGAAGATCTACCATAAATTTTAATGGACTCTACCTTTT
CAGCATGTTTCTTTTCATTTAGACTTGTGAATTATCCTCTCTAGAGAGCTTTCCATGTTTATGA
GACCTTATTTTGTAGCCAGATGTTTTATTTAGTACCTAATAACCTATAGCTCTTTGCACTTAAA
ACTTCATTATCCAGCAGGATAGACAGACCTATAAATAATTACTTATGTTACATTGTGGTAACCA
TTATTGCAGCAATACTAAGGTGTAGAGAAGTGGTAGTTCATTTGTCTCCAAGTTTAGAGAAAAT
CACTCCTACGACATAGCATTTCATCTTGGCTTTAAAAGAATAGATTTCTCTGGACAAGAAGGTG
AACAAGTCTCCTAAAATATTTTGTGTATAATTTAATTAAATTTCATATTGGCTAATTTGTAATA
ATGTATTGGCTAATTTGTAATAATGAAAATCTGTATTTGTATTGGCTAATTTGTAATAATGAAA
ATCAGATAATAAAAAAACCAGTCTTAAGTTGAAAAACTTAA

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Protein Sequences


Protein RefSeqs	XP_005381820	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000013974
	ENSCLAP00000013974.1

RefSeq Acc Id:

XP_005381820 ⟸ XM_005381763

- UniProtKB:

A0A8C2VHB4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAWLGLALFARASHLPCGFCPRRFFSHGTKTLYQNIEAPQSKFFRPLQKAMLPPDTFKGKVAFI
TGGGTGLGKAMTTYLSSLGAECVIASRNADVLKATAEQISSQTGNKVHAIQCDVRNPDMVHNTV
LELIKVAGHPDVVINNAAGNFISPTERLSPNAWKTISDIVLNGTAYVTLEIGKQLIKAQKGAAF
LAITTIYAETGSGFVVPSASSKAGVEAMNKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRLDPTG
TFEKDMIDRIPCGRLGTAEELANLAIFLCSDYASWISGAVIRFDGGEEAFISGEFNSLRKVTKE
EWDTIEGLIRKTKGS

hide sequence

Ensembl Acc Id:

ENSCLAP00000013974 ⟸ ENSCLAT00000014131

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000009666	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000014131	ENTREZGENE
	ENSCLAT00000014131.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
NCBI Gene	Decr1	ENTREZGENE
PANTHER	2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING], MITOCHONDRIAL	UniProtKB/TrEMBL
	SHORT-CHAIN DEHYDROGENASE/REDUCTASE	UniProtKB/TrEMBL
Pfam	adh_short_C2	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A8C2VHB4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-12-13	Decr1	2,4-dienoyl-CoA reductase 1		2,4-dienoyl-CoA reductase 1, mitochondrial	Symbol and/or name change	5135510	APPROVED
2016-08-16	Decr1	2,4-dienoyl-CoA reductase 1, mitochondrial		2,4-dienoyl CoA reductase 1, mitochondrial	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD