DECR1 (2,4-dienoyl-CoA reductase 1) - Rat Genome Database

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Gene: DECR1 (2,4-dienoyl-CoA reductase 1) Homo sapiens
Analyze
Symbol: DECR1
Name: 2,4-dienoyl-CoA reductase 1
RGD ID: 733605
HGNC Page HGNC
Description: Exhibits 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding activity; and identical protein binding activity. Involved in fatty acid beta-oxidation. Localizes to several cellular components, including cytosol; mitochondrion; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 2,4-dienoyl CoA reductase 1, mitochondrial; 2,4-dienoyl-CoA reductase 1, mitochondrial; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial; 2,4-dienoyl-CoA reductase, mitochondrial; 4-enoyl-CoA reductase; DECR; NADPH; SDR18C1; short chain dehydrogenase/reductase family 18C member 1; short chain dehydrogenase/reductase family 18C, member 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl890,001,405 - 90,053,633 (+)EnsemblGRCh38hg38GRCh38
GRCh38890,001,437 - 90,053,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37891,013,705 - 91,065,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36891,082,756 - 91,133,403 (+)NCBINCBI36hg18NCBI36
Build 34891,082,755 - 91,133,403NCBI
Celera887,208,502 - 87,259,149 (+)NCBI
Cytogenetic Map8q21.3NCBI
HuRef886,223,894 - 86,274,542 (+)NCBIHuRef
CHM1_1891,054,504 - 91,105,151 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (ISO)
2-methylcholine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
arsenous acid  (EXP)
atrazine  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (ISO)
cadmium atom  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
dorsomorphin  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
farnesol  (EXP)
fenofibrate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
gemfibrozil  (ISO)
glutathione  (ISO)
GW 4064  (EXP)
indometacin  (EXP)
L-ethionine  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
limonene  (ISO)
methapyrilene  (ISO)
N-nitrosomorpholine  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nefazodone  (ISO)
nickel atom  (EXP)
niclosamide  (EXP)
nimesulide  (ISO)
oleic acid  (EXP)
omeprazole  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
picrotoxin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
sodium arsenite  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (EXP)
Tesaglitazar  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
troglitazone  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vinclozolin  (ISO)
zaragozic acid A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1495956   PMID:1859445   PMID:7263650   PMID:7818482   PMID:8300563   PMID:8993540   PMID:9403065   PMID:10318788   PMID:10497069   PMID:11591162   PMID:12397064   PMID:12477932  
PMID:15489334   PMID:15531764   PMID:15629123   PMID:16421571   PMID:18029348   PMID:18193341   PMID:18472006   PMID:18568448   PMID:19019082   PMID:19027726   PMID:19049547   PMID:19578400  
PMID:19738201   PMID:19773279   PMID:20360068   PMID:20379614   PMID:20877624   PMID:21182205   PMID:21630459   PMID:21832049   PMID:22360420   PMID:22623428   PMID:22658674   PMID:23376485  
PMID:23446634   PMID:24326071   PMID:25921289   PMID:26186194   PMID:26344197   PMID:26496610   PMID:26549023   PMID:27609421   PMID:28514442   PMID:28515276   PMID:28718761   PMID:29142217  
PMID:29467282   PMID:29509190   PMID:29568061   PMID:29802200   PMID:30196744   PMID:30463901   PMID:30833792   PMID:31048545   PMID:31152661   PMID:31536960   PMID:31980649   PMID:32041737  
PMID:32129710   PMID:32427840   PMID:32686647   PMID:32780723   PMID:32877691  


Genomics

Comparative Map Data
DECR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl890,001,405 - 90,053,633 (+)EnsemblGRCh38hg38GRCh38
GRCh38890,001,437 - 90,053,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37891,013,705 - 91,065,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36891,082,756 - 91,133,403 (+)NCBINCBI36hg18NCBI36
Build 34891,082,755 - 91,133,403NCBI
Celera887,208,502 - 87,259,149 (+)NCBI
Cytogenetic Map8q21.3NCBI
HuRef886,223,894 - 86,274,542 (+)NCBIHuRef
CHM1_1891,054,504 - 91,105,151 (+)NCBICHM1_1
Decr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39415,917,240 - 15,945,377 (-)NCBIGRCm39mm39
GRCm39 Ensembl415,917,240 - 15,945,507 (-)Ensembl
GRCm38415,917,240 - 15,945,377 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl415,917,240 - 15,945,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv37415,844,387 - 15,872,654 (-)NCBIGRCm37mm9NCBIm37
MGSCv36415,844,387 - 15,872,654 (-)NCBImm8
Celera415,720,515 - 15,748,774 (-)NCBICelera
Cytogenetic Map4A2NCBI
Decr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2529,411,172 - 29,439,054 (-)NCBI
Rnor_6.0 Ensembl529,573,898 - 29,601,748 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0529,573,893 - 29,601,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0534,253,236 - 34,280,749 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4530,492,196 - 30,520,172 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1530,492,195 - 30,520,172 (-)NCBI
Celera528,616,707 - 28,644,572 (-)NCBICelera
Cytogenetic Map5q13NCBI
Decr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554176,893,231 - 6,931,754 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554176,893,231 - 6,931,754 (+)NCBIChiLan1.0ChiLan1.0
DECR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1888,642,676 - 88,693,224 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl888,642,172 - 88,693,224 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0886,690,816 - 86,755,379 (+)NCBIMhudiblu_PPA_v0panPan3
DECR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12935,495,348 - 35,544,955 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2935,495,261 - 35,544,955 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2935,646,866 - 35,697,851 (+)NCBI
ROS_Cfam_1.02935,692,661 - 35,742,310 (+)NCBI
UMICH_Zoey_3.12935,684,839 - 35,729,541 (+)NCBI
UNSW_CanFamBas_1.02935,703,896 - 35,747,852 (+)NCBI
UU_Cfam_GSD_1.02936,138,067 - 36,183,640 (+)NCBI
Decr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530343,936,906 - 43,975,997 (-)NCBI
SpeTri2.0NW_0049365443,816,543 - 3,853,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DECR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl446,730,461 - 46,767,427 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1446,731,359 - 46,767,427 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2451,207,727 - 51,243,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DECR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1885,086,843 - 85,129,267 (+)NCBI
ChlSab1.1 Ensembl885,086,874 - 85,129,160 (+)Ensembl
Decr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247441,965,605 - 2,003,299 (-)NCBI

Position Markers
RH99111  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37891,025,724 - 91,025,858UniSTSGRCh37
Build 36891,094,900 - 91,095,034RGDNCBI36
Celera887,220,646 - 87,220,780RGD
Cytogenetic Map8q21.3UniSTS
HuRef886,236,038 - 86,236,172UniSTS
GeneMap99-GB4 RH Map8425.55UniSTS
RH122269  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37891,054,274 - 91,054,550UniSTSGRCh37
Build 36891,123,450 - 91,123,726RGDNCBI36
Celera887,249,196 - 87,249,472RGD
Cytogenetic Map8q21.3UniSTS
HuRef886,264,588 - 86,264,864UniSTS
TNG Radiation Hybrid Map844781.0UniSTS
RH78738  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37891,015,410 - 91,015,530UniSTSGRCh37
Build 36891,084,586 - 91,084,706RGDNCBI36
Celera887,210,332 - 87,210,452RGD
Cytogenetic Map8q21.3UniSTS
HuRef886,225,724 - 86,225,844UniSTS
GeneMap99-GB4 RH Map8425.55UniSTS
NCBI RH Map8899.7UniSTS
RH17524  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37891,015,506 - 91,015,668UniSTSGRCh37
Build 36891,084,682 - 91,084,844RGDNCBI36
Celera887,210,428 - 87,210,590RGD
Cytogenetic Map8q21.3UniSTS
HuRef886,225,820 - 86,225,982UniSTS
GeneMap99-GB4 RH Map8425.55UniSTS
NCBI RH Map8899.7UniSTS
RH18400  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q21.3UniSTS
GeneMap99-GB4 RH Map8425.55UniSTS
NCBI RH Map8899.7UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2499
Count of miRNA genes:749
Interacting mature miRNAs:862
Transcripts:ENST00000220764, ENST00000517301, ENST00000517314, ENST00000517597, ENST00000517761, ENST00000518725, ENST00000519007, ENST00000519328, ENST00000519410, ENST00000520148, ENST00000520227, ENST00000520859, ENST00000521603, ENST00000521668, ENST00000522161, ENST00000522583, ENST00000523447, ENST00000524326, ENST00000524332
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2427 2848 1725 624 1856 465 4355 2146 3527 416 1449 1570 173 1 1203 2786 3 2
Low 12 143 1 95 2 51 207 3 10 31 1 1 2 2
Below cutoff 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017013148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA247499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA725334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF049895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF069291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB104585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR737790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  H98841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF495760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L26050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U49352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000220764   ⟹   ENSP00000220764
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,477 - 90,053,633 (+)Ensembl
RefSeq Acc Id: ENST00000517301
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,030,455 - 90,051,847 (+)Ensembl
RefSeq Acc Id: ENST00000517314   ⟹   ENSP00000428533
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,446 - 90,042,748 (+)Ensembl
RefSeq Acc Id: ENST00000517597   ⟹   ENSP00000429551
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,476 - 90,051,972 (+)Ensembl
RefSeq Acc Id: ENST00000517761   ⟹   ENSP00000427936
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,488 - 90,036,918 (+)Ensembl
RefSeq Acc Id: ENST00000518725   ⟹   ENSP00000430759
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,480 - 90,020,912 (+)Ensembl
RefSeq Acc Id: ENST00000519007
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,477 - 90,029,464 (+)Ensembl
RefSeq Acc Id: ENST00000519328   ⟹   ENSP00000431045
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,405 - 90,051,920 (+)Ensembl
RefSeq Acc Id: ENST00000519410   ⟹   ENSP00000430561
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,476 - 90,036,885 (+)Ensembl
RefSeq Acc Id: ENST00000520148   ⟹   ENSP00000428162
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,042,733 - 90,052,092 (+)Ensembl
RefSeq Acc Id: ENST00000520227   ⟹   ENSP00000429096
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,517 - 90,036,879 (+)Ensembl
RefSeq Acc Id: ENST00000520859
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,477 - 90,006,233 (+)Ensembl
RefSeq Acc Id: ENST00000521603   ⟹   ENSP00000428701
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,458 - 90,037,021 (+)Ensembl
RefSeq Acc Id: ENST00000521668
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,478 - 90,017,169 (+)Ensembl
RefSeq Acc Id: ENST00000522161   ⟹   ENSP00000429779
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,477 - 90,051,999 (+)Ensembl
RefSeq Acc Id: ENST00000522583
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,016,734 - 90,018,966 (+)Ensembl
RefSeq Acc Id: ENST00000523447
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,001,463 - 90,044,985 (+)Ensembl
RefSeq Acc Id: ENST00000524326
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,018,564 - 90,036,881 (+)Ensembl
RefSeq Acc Id: ENST00000524332
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl890,042,479 - 90,051,950 (+)Ensembl
RefSeq Acc Id: NM_001330575   ⟹   NP_001317504
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38890,001,477 - 90,053,633 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001359   ⟹   NP_001350
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38890,001,477 - 90,053,633 (+)NCBI
GRCh37891,013,580 - 91,064,232 (+)NCBI
Build 36891,082,756 - 91,133,403 (+)NCBI Archive
HuRef886,223,894 - 86,274,542 (+)ENTREZGENE
CHM1_1891,054,504 - 91,105,151 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005250808   ⟹   XP_005250865
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38890,001,437 - 90,052,004 (+)NCBI
GRCh37891,013,580 - 91,064,232 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516880   ⟹   XP_011515182
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38890,001,463 - 90,052,004 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017013148   ⟹   XP_016868637
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38890,001,483 - 90,052,004 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001350   ⟸   NM_001359
- Peptide Label: isoform 1 precursor
- UniProtKB: Q16698 (UniProtKB/Swiss-Prot),   A0A024R9D7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005250865   ⟸   XM_005250808
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011515182   ⟸   XM_011516880
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016868637   ⟸   XM_017013148
- Peptide Label: isoform X2
- UniProtKB: Q16698 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001317504   ⟸   NM_001330575
- Peptide Label: isoform 2
- UniProtKB: Q16698 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000427936   ⟸   ENST00000517761
RefSeq Acc Id: ENSP00000429551   ⟸   ENST00000517597
RefSeq Acc Id: ENSP00000428533   ⟸   ENST00000517314
RefSeq Acc Id: ENSP00000430759   ⟸   ENST00000518725
RefSeq Acc Id: ENSP00000430561   ⟸   ENST00000519410
RefSeq Acc Id: ENSP00000431045   ⟸   ENST00000519328
RefSeq Acc Id: ENSP00000429096   ⟸   ENST00000520227
RefSeq Acc Id: ENSP00000428162   ⟸   ENST00000520148
RefSeq Acc Id: ENSP00000428701   ⟸   ENST00000521603
RefSeq Acc Id: ENSP00000429779   ⟸   ENST00000522161
RefSeq Acc Id: ENSP00000220764   ⟸   ENST00000220764

Promoters
RGD ID:7213727
Promoter ID:EPDNEW_H12608
Type:initiation region
Name:DECR1_1
Description:2,4-dienoyl-CoA reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38890,001,477 - 90,001,537EPDNEW
RGD ID:6806597
Promoter ID:HG_KWN:61665
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001359
Position:
Human AssemblyChrPosition (strand)Source
Build 36891,082,366 - 91,082,867 (+)MPROMDB
RGD ID:6853464
Promoter ID:EP74557
Type:multiple initiation site
Name:HS_DECR1
Description:2,4-dienoyl CoA reductase 1, mitochondrial.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36891,082,881 - 91,082,941EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-22.1(chr8:85835757-93610142)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053676]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053676]|See cases [RCV000053676] Chr8:85835757..93610142 [GRCh38]
Chr8:86847986..94622370 [GRCh37]
Chr8:86917086..94691546 [NCBI36]
Chr8:8q21.2-22.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-21.3(chr8:77765431-91839285)x1 copy number loss See cases [RCV000054261] Chr8:77765431..91839285 [GRCh38]
Chr8:78677666..92851513 [GRCh37]
Chr8:78840221..92920689 [NCBI36]
Chr8:8q21.13-21.3
pathogenic
GRCh38/hg38 8q21.13-22.1(chr8:78672463-95366868)x1 copy number loss See cases [RCV000054262] Chr8:78672463..95366868 [GRCh38]
Chr8:79584698..96379096 [GRCh37]
Chr8:79747253..96448272 [NCBI36]
Chr8:8q21.13-22.1
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q13.1-22.1(chr8:66171669-93505509)x3 copy number gain See cases [RCV000137050] Chr8:66171669..93505509 [GRCh38]
Chr8:67083904..94517737 [GRCh37]
Chr8:67246458..94586913 [NCBI36]
Chr8:8q13.1-22.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.3(chr8:90742314-91017575)x1 copy number loss See cases [RCV000447277] Chr8:90742314..91017575 [GRCh37]
Chr8:8q21.3
uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
NM_001359.2(DECR1):c.77G>A (p.Ser26Asn) single nucleotide variant 2,4-Dienoyl-CoA reductase deficiency [RCV000642296] Chr8:90017131 [GRCh38]
Chr8:91029359 [GRCh37]
Chr8:8q21.3
likely benign
GRCh37/hg19 8q21.3(chr8:90717375-91029121)x1 copy number loss See cases [RCV000512288] Chr8:90717375..91029121 [GRCh37]
Chr8:8q21.3
uncertain significance
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3(chr8:90737258-91091402)x3 copy number gain not provided [RCV000747708] Chr8:90737258..91091402 [GRCh37]
Chr8:8q21.3
benign
NM_001359.2(DECR1):c.719C>T (p.Pro240Leu) single nucleotide variant not provided [RCV000926271] Chr8:90042781 [GRCh38]
Chr8:91055009 [GRCh37]
Chr8:8q21.3
likely benign
NC_000008.11:g.(?_89935041)_(90051917_?)dup duplication Microcephaly, normal intelligence and immunodeficiency [RCV001033505] Chr8:90947269..91064145 [GRCh37]
Chr8:8q21.3
uncertain significance
NM_001359.2(DECR1):c.366T>C (p.Asp122=) single nucleotide variant not provided [RCV000864294] Chr8:90019121 [GRCh38]
Chr8:91031349 [GRCh37]
Chr8:8q21.3
benign
NM_001359.2(DECR1):c.432T>C (p.Asn144=) single nucleotide variant not provided [RCV000875423] Chr8:90020923 [GRCh38]
Chr8:91033151 [GRCh37]
Chr8:8q21.3
benign
NM_001359.2(DECR1):c.885+9del deletion not provided [RCV000871427] Chr8:90045003 [GRCh38]
Chr8:91057231 [GRCh37]
Chr8:8q21.3
benign
NM_001359.2(DECR1):c.879T>C (p.Asn293=) single nucleotide variant not provided [RCV000942393] Chr8:90044989 [GRCh38]
Chr8:91057217 [GRCh37]
Chr8:8q21.3
likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
NM_001359.2(DECR1):c.202G>A (p.Gly68Ser) single nucleotide variant 2,4-Dienoyl-CoA reductase deficiency [RCV000791138] Chr8:90017256 [GRCh38]
Chr8:91029484 [GRCh37]
Chr8:8q21.3
uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q21.3(chr8:90758337-91556317)x3 copy number gain See cases [RCV001007451] Chr8:90758337..91556317 [GRCh37]
Chr8:8q21.3
uncertain significance
GRCh37/hg19 8q21.3(chr8:88194550-91779543)x3 copy number gain not provided [RCV001259018] Chr8:88194550..91779543 [GRCh37]
Chr8:8q21.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2753 AgrOrtholog
COSMIC DECR1 COSMIC
Ensembl Genes ENSG00000104325 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000220764 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000427936 UniProtKB/TrEMBL
  ENSP00000428162 UniProtKB/TrEMBL
  ENSP00000428533 UniProtKB/TrEMBL
  ENSP00000428701 UniProtKB/TrEMBL
  ENSP00000429096 UniProtKB/TrEMBL
  ENSP00000429551 UniProtKB/TrEMBL
  ENSP00000429779 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000430561 UniProtKB/TrEMBL
  ENSP00000430759 UniProtKB/TrEMBL
  ENSP00000431045 UniProtKB/TrEMBL
Ensembl Transcript ENST00000220764 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000517314 UniProtKB/TrEMBL
  ENST00000517597 UniProtKB/TrEMBL
  ENST00000517761 UniProtKB/TrEMBL
  ENST00000518725 UniProtKB/TrEMBL
  ENST00000519328 UniProtKB/TrEMBL
  ENST00000519410 UniProtKB/TrEMBL
  ENST00000520148 UniProtKB/TrEMBL
  ENST00000520227 UniProtKB/TrEMBL
  ENST00000521603 UniProtKB/TrEMBL
  ENST00000522161 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000104325 GTEx
HGNC ID HGNC:2753 ENTREZGENE
Human Proteome Map DECR1 Human Proteome Map
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1666 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1666 ENTREZGENE
OMIM 222745 OMIM
Pfam adh_short UniProtKB/TrEMBL
PharmGKB PA141 PharmGKB
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R9D7 ENTREZGENE, UniProtKB/TrEMBL
  DECR_HUMAN UniProtKB/Swiss-Prot
  E5RFV2_HUMAN UniProtKB/TrEMBL
  E5RGS6_HUMAN UniProtKB/TrEMBL
  E5RHR1_HUMAN UniProtKB/TrEMBL
  E5RID6_HUMAN UniProtKB/TrEMBL
  E5RJD2_HUMAN UniProtKB/TrEMBL
  E5RJG7_HUMAN UniProtKB/TrEMBL
  H0YAW3_HUMAN UniProtKB/TrEMBL
  Q16698 ENTREZGENE
UniProt Secondary B7Z6B8 UniProtKB/Swiss-Prot
  Q2M304 UniProtKB/Swiss-Prot
  Q93085 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-12-13 DECR1  2,4-dienoyl-CoA reductase 1    2,4-dienoyl-CoA reductase 1, mitochondrial  Symbol and/or name change 5135510 APPROVED
2015-11-17 DECR1  2,4-dienoyl-CoA reductase 1, mitochondrial    2,4-dienoyl CoA reductase 1, mitochondrial  Symbol and/or name change 5135510 APPROVED
2011-08-16 DECR1  2,4-dienoyl CoA reductase 1, mitochondrial  DECR1  2,4-dienoyl CoA reductase 1, mitochondrial  Symbol and/or name change 5135510 APPROVED