Decr1 (2,4-dienoyl-CoA reductase 1)

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Gene: Decr1 (2,4-dienoyl-CoA reductase 1) Ictidomys tridecemlineatus

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Symbol:

Decr1

Name:

2,4-dienoyl-CoA reductase 1

RGD ID:

12700904

Description:

ENCODES a protein that exhibits 2,4-dienoyl-CoA reductase (NADPH) activity (inferred); identical protein binding (inferred); NADPH binding (inferred); INVOLVED IN fatty acid beta-oxidation (inferred); positive regulation of cold-induced thermogenesis (inferred); ASSOCIATED WITH 2,4-Dienoyl-CoA Reductase Deficiency (ortholog); lipid metabolism disorder (ortholog); Nijmegen breakage syndrome (ortholog); FOUND IN catalytic complex (inferred); cytosol (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

2,4-dienoyl-CoA reductase 1, mitochondrial; 2,4-dienoyl-CoA reductase 1, transcript variant X1; 2,4-dienoyl-CoA reductase 1, transcript variant X2; 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial; 2,4-dienoyl-CoA reductase, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	43,936,906 - 43,975,997 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	3,816,653 - 3,853,632 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936544	3,816,543 - 3,853,288 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

2,4-Dienoyl-CoA Reductase Deficiency (ISO)

lipid metabolism disorder (ISO)

Nijmegen breakage syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid beta-oxidation (IEA)

positive regulation of cold-induced thermogenesis (IEA)

Cellular Component

catalytic complex (IEA)

cytosol (IEA)

mitochondrion (IEA)

nucleoplasm (IEA)

Molecular Function

2,4-dienoyl-CoA reductase (NADPH) activity (IEA)

identical protein binding (IEA)

NADPH binding (IEA)

oxidoreductase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Decr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	43,936,906 - 43,975,997 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	3,816,653 - 3,853,632 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936544	3,816,543 - 3,853,288 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DECR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	90,001,477 - 90,053,633 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	90,001,405 - 90,053,633 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	91,013,705 - 91,065,861 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	91,082,756 - 91,133,403 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	91,082,755 - 91,133,403	NCBI
Celera	8	87,208,502 - 87,259,149 (+)	NCBI		Celera
Cytogenetic Map	8	q21.3	NCBI
HuRef	8	86,223,894 - 86,274,542 (+)	NCBI		HuRef
CHM1_1	8	91,054,504 - 91,105,151 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	91,125,148 - 91,177,304 (+)	NCBI		T2T-CHM13v2.0

Decr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	15,917,240 - 15,945,377 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	15,917,240 - 15,945,507 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	15,917,240 - 15,945,377 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	15,917,240 - 15,945,507 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	15,844,387 - 15,872,654 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	15,844,387 - 15,872,654 (-)	NCBI		MGSCv36	mm8
Celera	4	15,720,515 - 15,748,774 (-)	NCBI		Celera
Cytogenetic Map	4	A2	NCBI
cM Map	4	6.66	NCBI

Decr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	34,208,195 - 34,236,074 (-)	NCBI		GRCr8
mRatBN7.2	5	29,411,172 - 29,439,054 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	29,411,172 - 29,439,018 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	31,567,474 - 31,595,241 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	33,160,140 - 33,187,907 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	33,120,325 - 33,148,092 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	29,573,893 - 29,601,731 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	29,573,898 - 29,601,748 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	34,253,236 - 34,280,749 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	30,492,196 - 30,520,172 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	30,492,195 - 30,520,172 (-)	NCBI
Celera	5	28,616,707 - 28,644,572 (-)	NCBI		Celera
Cytogenetic Map	5	q13	NCBI

Decr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	6,893,231 - 6,931,754 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	6,893,231 - 6,931,754 (+)	NCBI	ChiLan1.0	ChiLan1.0

DECR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	107,394,558 - 107,461,629 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	82,934,216 - 83,001,276 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	86,690,816 - 86,755,379 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	88,642,676 - 88,693,224 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	88,642,172 - 88,693,224 (+)	Ensembl	panpan1.1		panPan2

DECR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	35,495,348 - 35,544,955 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	35,495,261 - 35,544,955 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	35,646,866 - 35,697,851 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	35,692,661 - 35,742,310 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	35,692,704 - 35,744,794 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	35,684,839 - 35,729,541 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	35,703,896 - 35,747,852 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	36,138,067 - 36,183,640 (+)	NCBI		UU_Cfam_GSD_1.0

DECR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	46,731,360 - 46,767,422 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	46,731,359 - 46,767,427 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	51,207,727 - 51,243,866 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DECR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	85,086,843 - 85,129,267 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	85,086,874 - 85,129,160 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	55,747,223 - 55,792,311 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Decr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624744	1,963,825 - 2,003,643 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624744	1,965,605 - 2,003,299 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005328638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013360105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000009145 ⟹ ENSSTOP00000008199

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936544	3,816,653 - 3,853,632 (+)	Ensembl

RefSeq Acc Id:

XM_005328638 ⟹ XP_005328695

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	43,936,906 - 43,975,997 (-)	NCBI
SpeTri2.0	NW_004936544	3,816,543 - 3,853,288 (+)	NCBI

Sequence:

show sequence

TTACCCAGAAGGGTGTTGGCACTGGGGTGGGCAACGGGGGTGTGTCGCGCGTTTGTGCAATTTT
GCAAACCCTCCTACGGCGCCGGGGTCGGTCCACCCACAACAGGGGCGCCGAAACCGCTATTCCC
GCTCGACAAAACGCTCTGGGTCCAGGCGGCGGGGAGAAAGTGTCCAGGAGGCCCCAAGGTCGTG
TCCTCAGGGGCCGGCGCCTCAGGGACCGCGGGCCTCGGCCCCGGCCCAGCCCCCGGAACTTAGT
TCCCCGGCCCGCCCCGGAGCCCCGCAGTCTTCCGGCCGGAGTTCTGCAGGTGACATGGCTTTTC
CGGGCCGTGTGTTCTTTGGTCGGGCGTCCCAGCTGCCCTGTGGCCTCGGCCCTCGGCGGTTTTT
CAGTTATGGAACAAAAATATTATATCAAAGCATGGAAGCTTCACAGTCTAAATTCTTTCCTCCC
CTTCAAAAAGTGATGCTGCCACCTAATAGCTTTCAAGGAAAAGTGGCGTTCATTACTGGAGGAG
GTACTGGCCTTGGAAAAGCCATGACAACTTTTCTGTCCAGCCTGGGTGCTCAATGTGTGATAGC
CAGCAGGAAGATTGATGTTTTGAAAGCTACTGCAGAACAAATTTCTTCTCAAACTGGAAATAAG
GTTCATGCACTTCAGTGTGATGTGAGGGATCCTGATATGGTTCACAAGACTGTGTTGGAACTGA
TCAAAGTCGCAGGACTTCCTGATATCGTGATAAACAACGCAGCAGGAAATTTTATTTCACCCAC
TGAAAGACTCTCTCCCAATGCTTGGAAGACCATAACAGACATAGTTCTAAATGGCACAGCCTAT
GTGACGCTTGAAATTGGAAAACAGCTTATTAAAGCACAGAAAGGAGCAGCATTTCTTGCCATTA
CAACTATTTATGCTGAGACTGGATCTGGTTTTGTAGTACCAAGTGCTTCTTCCAAAGCAGGTGT
GGAAGCCATGAACAAGTCCCTTGCAGCTGAATGGGGTAAATATGGAATGCGATTCAATGTAATT
CAGCCGGGGCCTATAAAAACTAAAGGTGCCTTTAGCCGTATGGACCCAGCTGGGACATTTGAGA
AAGAAATGATTGACAGAATTCCCTGTGGACGACTGGGGACCATGGAAGAACTTGCAAATCTTGC
TGTTTTTCTTTGTAGTGATTATGCTTCTTGGATTAATGGAGCAACTATTAGATTTGATGGTGGA
GAGGAAGTATTTATATCAGGTGAATTCAACAGCCTAAAGAAGGTCACCAAGGAGGAGTGGGACA
CAATAGAGGGACTCATCCGAAAGACAAAGGGCTCTTAAGATCACTCTGGCCTTAATCTTCGGTG
CCGTAAAATTTAGAGACTAAAAATGATATAAATTGACTGAAATCTTTCAAGTATTTTCAAGTCT
AATAAATTGTTAATTAACAAGCA

hide sequence

RefSeq Acc Id:

XM_013360105 ⟹ XP_013215559

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	43,936,906 - 43,975,886 (-)	NCBI
SpeTri2.0	NW_004936544	3,816,842 - 3,853,288 (+)	NCBI

Sequence:

show sequence

CTGCAGGTGACATGGCTTTTCCGGGCCGTGTGTTCTTTGGTCGGGCGTCCCAGCTGCCCTGTGG
CCTCGGCCCTCGGCGGAGTCTCCTGTGTTAGTTTTTCAGTTATGGAACAAAAATATTATATCAA
AGCATGGAAGCTTCACAGTCTAAATTCTTTCCTCCCCTTCAAAAAGTGATGCTGCCACCTAATA
GCTTTCAAGGAAAAGTGGCGTTCATTACTGGAGGAGGTACTGGCCTTGGAAAAGCCATGACAAC
TTTTCTGTCCAGCCTGGGTGCTCAATGTGTGATAGCCAGCAGGAAGATTGATGTTTTGAAAGCT
ACTGCAGAACAAATTTCTTCTCAAACTGGAAATAAGGTTCATGCACTTCAGTGTGATGTGAGGG
ATCCTGATATGGTTCACAAGACTGTGTTGGAACTGATCAAAGTCGCAGGACTTCCTGATATCGT
GATAAACAACGCAGCAGGAAATTTTATTTCACCCACTGAAAGACTCTCTCCCAATGCTTGGAAG
ACCATAACAGACATAGTTCTAAATGGCACAGCCTATGTGACGCTTGAAATTGGAAAACAGCTTA
TTAAAGCACAGAAAGGAGCAGCATTTCTTGCCATTACAACTATTTATGCTGAGACTGGATCTGG
TTTTGTAGTACCAAGTGCTTCTTCCAAAGCAGGTGTGGAAGCCATGAACAAGTCCCTTGCAGCT
GAATGGGGTAAATATGGAATGCGATTCAATGTAATTCAGCCGGGGCCTATAAAAACTAAAGGTG
CCTTTAGCCGTATGGACCCAGCTGGGACATTTGAGAAAGAAATGATTGACAGAATTCCCTGTGG
ACGACTGGGGACCATGGAAGAACTTGCAAATCTTGCTGTTTTTCTTTGTAGTGATTATGCTTCT
TGGATTAATGGAGCAACTATTAGATTTGATGGTGGAGAGGAAGTATTTATATCAGGTGAATTCA
ACAGCCTAAAGAAGGTCACCAAGGAGGAGTGGGACACAATAGAGGGACTCATCCGAAAGACAAA
GGGCTCTTAAGATCACTCTGGCCTTAATCTTCGGTGCCGTAAAATTTAGAGACTAAAAATGATA
TAAATTGACTGAAATCTTTCAAGTATTTTCAAGTCTAATAAATTGTTAATTAACAAGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005328695	(Get FASTA)	NCBI Sequence Viewer
	XP_013215559	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008199.3
GenBank Protein	KAG3273921	(Get FASTA)	NCBI Sequence Viewer
	KAG3273922	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005328695 ⟸ XM_005328638
- Peptide Label:	isoform X1
- UniProtKB:	I3MD03 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAFPGRVFFGRASQLPCGLGPRRFFSYGTKILYQSMEASQSKFFPPLQKVMLPPNSFQGKVAFI TGGGTGLGKAMTTFLSSLGAQCVIASRKIDVLKATAEQISSQTGNKVHALQCDVRDPDMVHKTV LELIKVAGLPDIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAYVTLEIGKQLIKAQKGAAF LAITTIYAETGSGFVVPSASSKAGVEAMNKSLAAEWGKYGMRFNVIQPGPIKTKGAFSRMDPAG TFEKEMIDRIPCGRLGTMEELANLAVFLCSDYASWINGATIRFDGGEEVFISGEFNSLKKVTKE EWDTIEGLIRKTKGS hide sequence

RefSeq Acc Id:

XP_013215559 ⟸ XM_013360105

- Peptide Label:

isoform X2

- Sequence:

show sequence

MEASQSKFFPPLQKVMLPPNSFQGKVAFITGGGTGLGKAMTTFLSSLGAQCVIASRKIDVLKAT
AEQISSQTGNKVHALQCDVRDPDMVHKTVLELIKVAGLPDIVINNAAGNFISPTERLSPNAWKT
ITDIVLNGTAYVTLEIGKQLIKAQKGAAFLAITTIYAETGSGFVVPSASSKAGVEAMNKSLAAE
WGKYGMRFNVIQPGPIKTKGAFSRMDPAGTFEKEMIDRIPCGRLGTMEELANLAVFLCSDYASW
INGATIRFDGGEEVFISGEFNSLKKVTKEEWDTIEGLIRKTKGS

hide sequence

Ensembl Acc Id:

ENSSTOP00000008199 ⟸ ENSSTOT00000009145

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009147	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009145.3	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
	SDR_fam	UniProtKB/TrEMBL
NCBI Gene	Decr1	ENTREZGENE
PANTHER	2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING], MITOCHONDRIAL	UniProtKB/TrEMBL
	SHORT-CHAIN DEHYDROGENASE/REDUCTASE	UniProtKB/TrEMBL
Pfam	adh_short_C2	UniProtKB/TrEMBL
PRINTS	GDHRDH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	I3MD03	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD