Kiss1 (KiSS-1 metastasis suppressor)

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Gene: Kiss1 (KiSS-1 metastasis suppressor) Chinchilla lanigera

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Symbol:

Kiss1

Name:

KiSS-1 metastasis suppressor

RGD ID:

9008896

Description:

ENCODES a protein that exhibits kisspeptin receptor binding (ortholog); INVOLVED IN decidualization (ortholog); G protein-coupled receptor signaling pathway (ortholog); generation of ovulation cycle rhythm (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Breast Neoplasms (ortholog); Delayed Puberty (ortholog); FOUND IN apical plasma membrane (ortholog); extracellular space (ortholog); neuronal cell body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

KiSS-1 metastasis-suppressor; metastasis-suppressor KiSS-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	40,043,133 - 40,045,386 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	40,043,139 - 40,045,973 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Breast Neoplasms (ISO)

Delayed Puberty (ISO)

disorder of sexual development (ISO)

endometrial carcinoma (ISO)

familial adult myoclonic epilepsy 5 (ISO)

gastrointestinal stromal tumor (ISO)

head and neck squamous cell carcinoma (ISO)

hypogonadotropic hypogonadism 13 with or without anosmia (ISO)

Hypokalemic Periodic Paralysis, Type 1 (ISO)

invasive ductal carcinoma (ISO)

Lymphatic Metastasis (ISO)

Neoplasm Metastasis (ISO)

ovarian carcinoma (ISO)

parathyroid carcinoma (ISO)

pre-eclampsia (ISO)

Stomach Neoplasms (ISO)

transitional cell carcinoma (ISO)

trophoblastic neoplasm (ISO)

urinary bladder cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

decidualization (ISO)

G protein-coupled receptor signaling pathway (ISO)

generation of ovulation cycle rhythm (ISO)

negative regulation of cell migration (ISO)

negative regulation of cell population proliferation (ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of growth hormone secretion (ISO)

positive regulation of luteinizing hormone secretion (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of stress-activated MAPK cascade (ISO)

positive regulation of synaptic transmission (ISO)

Cellular Component

apical plasma membrane (ISO)

extracellular space (ISO)

neuronal cell body (ISO)

Molecular Function

kisspeptin receptor binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Kiss1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	40,043,133 - 40,045,386 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	40,043,139 - 40,045,973 (-)	NCBI	ChiLan1.0	ChiLan1.0

KISS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	204,190,341 - 204,196,491 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	204,190,341 - 204,196,491 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	204,159,469 - 204,165,619 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	202,426,092 - 202,432,242 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	200,891,126 - 200,897,271	NCBI
Celera	1	177,294,719 - 177,301,077 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	175,324,487 - 175,330,608 (-)	NCBI		HuRef
CHM1_1	1	205,583,149 - 205,589,536 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	203,454,485 - 203,461,086 (-)	NCBI		T2T-CHM13v2.0

Kiss1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	133,249,625 - 133,257,460 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	133,254,950 - 133,257,460 (+)	Ensembl		GRCm39 Ensembl
GRCm39 Ensembl	1	133,237,565 - 133,257,460 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	133,321,887 - 133,329,722 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	133,321,875 - 133,329,901 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	1	133,309,827 - 133,329,722 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	135,223,789 - 135,226,299 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	135,154,758 - 135,157,263 (+)	NCBI		MGSCv36	mm8
Celera	1	135,939,680 - 135,942,194 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	57.91	NCBI

Kiss1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	47,327,159 - 47,332,759 (+)	NCBI		GRCr8
mRatBN7.2	13	44,775,106 - 44,780,707 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	44,774,823 - 44,780,612 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	47,388,122 - 47,390,621 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	48,676,226 - 48,678,725 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	45,934,083 - 45,936,581 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	50,529,506 - 50,537,603 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	50,529,510 - 50,535,389 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	55,582,365 - 55,590,432 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	46,244,786 - 46,247,288 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	46,258,828 - 46,261,331 (+)	NCBI
Celera	13	45,110,972 - 45,113,474 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

KISS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	45,178,903 - 45,187,434 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	45,144,115 - 45,152,454 (+)	NCBI		NHGRI_mPanPan1

KISS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	768,333 - 774,328 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	768,585 - 773,382 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	863,956 - 869,800 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	763,801 - 769,645 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	38	760,344 - 766,184 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	1,151,734 - 1,157,575 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	1,351,942 - 1,357,788 (-)	NCBI		UU_Cfam_GSD_1.0

Kiss1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	71,346,799 - 71,352,256 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	584,443 - 586,837 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936567	584,443 - 595,045 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KISS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	25,151,642 - 25,159,723 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	25,913,552 - 25,920,197 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kiss1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	6,803,265 - 6,805,433 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	6,800,144 - 6,805,555 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005375288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01006652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01059228	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000025200 ⟹ ENSCLAP00000024957

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955406	40,043,133 - 40,045,386 (-)	Ensembl

RefSeq Acc Id:

XM_005375288 ⟹ XP_005375345

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955406	40,043,139 - 40,045,973 (-)	NCBI

Sequence:

show sequence

TTTTTCTAGAAAAGATAAAGAATTGGGTTTCTATTGTAGCAGGAGGGAACAGGCCCGATCTAGG
AAGTTATGGATCTGTGCAGACCCAGCAGGCAGAGGAGAAGTGCATGGTCCCAGGCCTCAGAAAG
AAGGGCTGAACCTCAGAGTCTCGGGGACCTGAAGATCTGACCCTGTATCCCCCAACCCACCCTT
ACAAACTACATTCCACCTCTGTTGTCTCCAGACTTCTCTCAAGCAAACCTGAGATTGAGAATCC
TGACACTTCCAACCCAAGAAGTCCCTTCCTTCCACCGAATGGGATCCTCCCTTCCTGACCTTAC
TGGTCCCACCTCCTCCAGGAAGCCCTCCTGAGGATGCTCACCTAGCACGAACTCAGAGTTGATG
GCCCTGTGCAGGCTGTGTCAATCACACTTGCCCGTTCTAAGTGTTTGGGCGTATCCCTCCGCCA
GGAGCCTCCAAGCACAGAGGCCTTCTCTCTGCCAGGGCTCAGCCTCTAGCACCTGGCCCTGATG
CAGTGCCTGACCTCATCCCTGTTCTTTCTCTCTGCCTTGGCCTTGGGGCATTCCTAGGACCTGC
CTCTTACCAGGATGAACTCACTGGCTTCCTGGCAACTACTGCTCTTCCTCTGTGTCACCTCCTT
GGGAGAACCCCTGGCGAAGGTGGCACCTGTGCAGAATCTTAGACCCACAGGACAGAGGCTGGGA
GCCCTGGCCCTCATGGCCCCCTCGGCTCAGGGCCTGCGGTGTTCGGAGGAGAAGCCCCAGTCTG
CCGGGCCGCGCCCTCGGGGGGCCTCGCTGTGCCCACCCGGCGAGAGTGAGAGATCGGTGGAGCC
CGCGCGGCCCGGCCTGTGCATCGGACGCAGCCGCCTGATCCCCGCACCGCGGGGCGCTGTGCTG
GTGCAGCGCGAGAAGGACCTGTCCGCCTACAACTGGAACTCCTTCGGCCTGCGCTACGGCAAGC
GGCAGGCGGCACCGGGCAGCTGCGGGGGCGGCGGCGCGCGGGGCTGAGCACGCAGGTGCAAGTG
CAGGTCCGGGCCTTGAACTTCAGACCTCAGCCCGCGCCAGTGAGCAGGGCTGCGGGGCAACGGG
GCGGCCCTGGATAAAACAGAATAAAAGAATGCTGCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005375345	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000024957
	ENSCLAP00000024957.1

RefSeq Acc Id:	XP_005375345 ⟸ XM_005375288
- UniProtKB:	A0A8C2W483 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNSLASWQLLLFLCVTSLGEPLAKVAPVQNLRPTGQRLGALALMAPSAQGLRCSEEKPQSAGPR PRGASLCPPGESERSVEPARPGLCIGRSRLIPAPRGAVLVQREKDLSAYNWNSFGLRYGKRQAA PGSCGGGGARG hide sequence

Ensembl Acc Id:

ENSCLAP00000024957 ⟸ ENSCLAT00000025200

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000017136	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000025200	ENTREZGENE
	ENSCLAT00000025200.1	UniProtKB/TrEMBL
InterPro	Metastasis-suppressor_KiSS-1	UniProtKB/TrEMBL
NCBI Gene	Kiss1	ENTREZGENE
PANTHER	METASTASIS-SUPPRESSOR KISS-1	UniProtKB/TrEMBL
	PTHR16955	UniProtKB/TrEMBL
Pfam	Kisspeptin	UniProtKB/TrEMBL
UniProt	A0A8C2W483	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-01-09	Kiss1	KiSS-1 metastasis suppressor		KiSS-1 metastasis-suppressor	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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