RGD Reference Report - Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome. - Rat Genome Database

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Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome.

Authors: Sanchez-Carbayo, M  Capodieci, P  Cordon-Cardo, C 
Citation: Sanchez-Carbayo M, etal., Am J Pathol. 2003 Feb;162(2):609-17.
RGD ID: 2292136
Pubmed: PMID:12547718   (View Abstract at PubMed)
PMCID: PMC1851149   (View Article at PubMed Central)
DOI: DOI:10.1016/S0002-9440(10)63854-0   (Journal Full-text)

The expression profiles of nine bladder cancer cell lines were compared against a pool containing equal total RNA quantities of each of them. Lower expression of KiSS-1 was revealed in cells derived from the most advanced bladder tumors. When comparing 15 primary bladder tumors versus a pool of four bladder cancer cell lines, lower transcript levels of KiSS-1 were observed in the invasive bladder carcinomas as compared to superficial tumors. KiSS-1 expression ratios provided prognostic information. The expression pattern of KiSS-1 transcripts was analyzed using in situ hybridization in nine bladder cancer cells, paired normal urothelium and bladder tumor samples (n = 25), and tissue microarrays of bladder tumors (n = 173). We observed complete loss of KiSS-1 in all invasive tumors under study as compared to their respective normal urothelium. The expression of KiSS-1 was found to be significantly associated with histopathological stage. Patients with lower KiSS-1 expression showed a direct correlation with overall survival in a subset of bladder tumors whose follow-up was available (n = 69). We did not observe any significant differential KiSS-1 expression along cell cycle by sorting analysis. A potential tumor suppressor role in bladder cancer was revealed for KiSS-1. Moreover, it showed predictive value by identifying patients with poor outcome.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
urinary bladder cancer  IEP 2292136mRNA:decreased expression:tumor:loss of expression in all invasive tumors vs normal urothelium and ecpression also associated with histological stage and overall survivalRGD 
urinary bladder cancer  ISOKISS1 (Homo sapiens)2292136; 2292136 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kiss1  (KiSS-1 metastasis-suppressor)

Genes (Mus musculus)
Kiss1  (KiSS-1 metastasis-suppressor)

Genes (Homo sapiens)
KISS1  (KiSS-1 metastasis suppressor)


Additional Information