Itgae (integrin subunit alpha E) - Rat Genome Database

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Gene: Itgae (integrin subunit alpha E) Chinchilla lanigera
Analyze
Symbol: Itgae
Name: integrin subunit alpha E
RGD ID: 9001027
Description: PARTICIPATES IN E-cadherin signaling pathway; integrin mediated signaling pathway; ASSOCIATED WITH Canavan disease (ortholog); genetic disease (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin alpha-E; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1, alpha polypeptide)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546713,042,712 - 13,114,481 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546713,052,920 - 13,112,896 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Itgae
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546713,042,712 - 13,114,481 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546713,052,920 - 13,112,896 (+)NCBIChiLan1.0ChiLan1.0
ITGAE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38173,714,628 - 3,801,188 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl173,714,628 - 3,801,188 (-)EnsemblGRCh38hg38GRCh38
GRCh37173,617,922 - 3,704,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36173,564,668 - 3,651,286 (-)NCBINCBI36Build 36hg18NCBI36
Build 34173,564,671 - 3,651,286NCBI
Celera173,629,624 - 3,716,332 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef173,508,127 - 3,594,881 (-)NCBIHuRef
CHM1_1173,627,230 - 3,713,866 (-)NCBICHM1_1
T2T-CHM13v2.0173,603,214 - 3,689,865 (-)NCBIT2T-CHM13v2.0
Itgae
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,981,396 - 73,038,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,981,409 - 73,038,272 (+)EnsemblGRCm39 Ensembl
GRCm381173,090,505 - 73,147,449 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,090,583 - 73,147,446 (+)EnsemblGRCm38mm10GRCm38
MGSCv371172,904,097 - 72,960,951 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,906,778 - 72,963,636 (+)NCBIMGSCv36mm8
Celera1180,625,197 - 80,681,905 (+)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1145.22NCBI
Itgae
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81058,203,331 - 58,262,606 (+)NCBIGRCr8
mRatBN7.21057,704,813 - 57,764,093 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1057,591,753 - 57,764,093 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1057,591,753 - 57,751,210 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1062,365,493 - 62,419,913 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01061,853,971 - 61,908,393 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01057,353,064 - 57,407,516 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01059,652,324 - 59,711,885 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1059,539,405 - 59,711,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01059,391,989 - 59,450,857 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1056,829,172 - 56,887,357 (+)NCBICelera
Cytogenetic Map10q24NCBI
ITGAE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21911,325,204 - 11,410,344 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11713,290,694 - 13,374,339 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0173,763,813 - 3,851,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1173,758,511 - 3,841,729 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl173,758,730 - 3,844,444 (-)Ensemblpanpan1.1panPan2
ITGAE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1947,510,846 - 47,596,830 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl947,533,305 - 47,596,209 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha946,693,946 - 46,758,709 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0948,377,007 - 48,441,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl948,378,185 - 48,441,334 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1947,154,687 - 47,219,366 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0947,443,915 - 47,508,339 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0947,499,773 - 47,564,748 (-)NCBIUU_Cfam_GSD_1.0
Itgae
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560255,450,241 - 55,508,679 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936677392,282 - 450,849 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936677392,352 - 450,929 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1249,810,051 - 49,877,731 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11249,810,050 - 49,878,142 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21251,720,275 - 51,809,551 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,215,758 - 3,288,801 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605918,496,232 - 18,580,496 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgae
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247866,354,616 - 6,410,710 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247866,354,344 - 6,425,240 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017860   ⟹   ENSCLAP00000017685
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495546713,042,712 - 13,114,481 (+)Ensembl
RefSeq Acc Id: XM_005399709   ⟹   XP_005399766
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546713,052,923 - 13,112,896 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013522229   ⟹   XP_013377683
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546713,052,920 - 13,100,883 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013522230   ⟹   XP_013377684
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495546713,069,865 - 13,100,883 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005399766 (Get FASTA)   NCBI Sequence Viewer  
  XP_013377683 (Get FASTA)   NCBI Sequence Viewer  
  XP_013377684 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017685
  ENSCLAP00000017685.1
Reference Protein Sequences
RefSeq Acc Id: XP_005399766   ⟸   XM_005399709
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VR83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013377683   ⟸   XM_013522229
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VR83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013377684   ⟸   XM_013522230
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VR83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000017685   ⟸   ENSCLAT00000017860
Protein Domains
VWFA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012127 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017860 ENTREZGENE
  ENSCLAT00000017860.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene Itgae ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-E UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PRINTS INTEGRINA UniProtKB/TrEMBL
  VWFADOMAIN UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A8C2VR83 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Itgae  integrin subunit alpha E    integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)  Symbol and/or name change 5135510 APPROVED