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Gene: Ryr3 (ryanodine receptor 3) Chinchilla lanigera

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Symbol:

Ryr3

Name:

ryanodine receptor 3

RGD ID:

8995179

Description:

ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); intracellularly gated calcium channel activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN calcium ion transport (ortholog); intracellular calcium ion homeostasis (ortholog); negative regulation of cytosolic calcium ion concentration (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH amenorrhea (ortholog); arthrogryposis multiplex congenita (ortholog); Bloom syndrome (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RYR3 (ryanodine receptor 3)	NCBI	Ortholog
Mus musculus (house mouse):	Ryr3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ryr3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RYR3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RYR3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ryr3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RYR3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ryr3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	713,373 - 1,259,885 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	712,506 - 1,260,111 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

arthrogryposis multiplex congenita (ISO)

Bloom syndrome (ISO)

colorectal cancer (ISO)

congenital myopathy 20 (ISO)

Contracture (ISO)

developmental and epileptic encephalopathy (ISO)

epilepsy (ISO)

fetal akinesia deformation sequence syndrome 1 (ISO)

Generalized Epilepsy (ISO)

genetic disease (ISO)

gestational diabetes (ISO)

hepatocellular carcinoma (ISO)

Hydrops Fetalis (ISO)

Monomelic Amyotrophy (ISO)

pre-eclampsia (ISO)

primary ovarian insufficiency (ISO)

pulmonary hypertension (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion transport (ISO)

intracellular calcium ion homeostasis (ISO)

negative regulation of cytosolic calcium ion concentration (ISO)

response to hypoxia (ISO)

striated muscle contraction (ISO)

Cellular Component

cytoplasmic side of plasma membrane (ISO)

junctional membrane complex (ISO)

perinuclear region of cytoplasm (ISO)

sarcoplasmic reticulum membrane (ISO)

Molecular Function

calcium-induced calcium release activity (ISO)

intracellularly gated calcium channel activity (ISO)

ryanodine-sensitive calcium-release channel activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ryr3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	713,373 - 1,259,885 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	712,506 - 1,260,111 (-)	NCBI	ChiLan1.0	ChiLan1.0

RYR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	33,310,967 - 33,866,102 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	33,310,962 - 33,866,121 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	33,603,168 - 34,158,303 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	31,390,469 - 31,945,595 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	31,390,468 - 31,945,594	NCBI
Celera	15	10,404,754 - 10,960,825 (+)	NCBI		Celera
Cytogenetic Map	15	q13.3-q14	NCBI
HuRef	15	10,464,756 - 11,021,191 (+)	NCBI		HuRef
CHM1_1	15	33,721,203 - 34,276,301 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	31,107,439 - 31,663,747 (+)	NCBI		T2T-CHM13v2.0

Ryr3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	112,461,699 - 113,047,755 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	112,461,700 - 113,047,441 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	112,631,354 - 113,217,405 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	112,631,355 - 113,217,096 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	112,471,537 - 112,870,488 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	112,432,219 - 112,831,170 (-)	NCBI		MGSCv36	mm8
Celera	2	113,779,152 - 114,176,095 (-)	NCBI		Celera
Cytogenetic Map	2	E3- E4	NCBI
cM Map	2	57.2	NCBI

Ryr3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	119,886,129 - 120,433,465 (-)	NCBI		GRCr8
mRatBN7.2	3	99,431,755 - 99,979,125 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	99,432,505 - 99,704,961 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	104,117,307 - 104,665,151 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	104,118,063 - 104,504,204 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	110,710,040 - 111,249,930 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	98,476,626 - 98,872,629 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	98,375,910 - 98,382,386 (-)	NCBI
Celera	3	98,415,656 - 98,961,847 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

RYR3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	22,089,131 - 22,652,150 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	26,810,910 - 27,373,696 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	11,816,430 - 12,379,101 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	30,652,244 - 31,215,359 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	30,817,428 - 31,214,494 (+)	Ensembl	panpan1.1		panPan2

RYR3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	1,179,575 - 1,533,352 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	1,180,359 - 1,533,619 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	1,223,971 - 1,742,310 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	1,278,037 - 1,798,290 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	1,278,037 - 1,798,542 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	1,224,326 - 1,741,522 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	1,323,490 - 1,840,773 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	1,451,015 - 1,969,019 (-)	NCBI		UU_Cfam_GSD_1.0

Ryr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	79,716,961 - 80,219,351 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936673	1,932,755 - 2,434,066 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936673	2,078,095 - 2,434,872 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RYR3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	80,640,123 - 81,208,491 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	80,640,030 - 81,208,576 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Pig Cytomap	7	q22-q23	NCBI

Ryr3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	467,295 - 1,030,212 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	467,207 - 1,030,873 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005381167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01016819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016829	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016830	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01016831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01280043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000012906 ⟹ ENSCLAP00000012758

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955416	713,373 - 1,259,885 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000012907 ⟹ ENSCLAP00000012759

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955416	713,373 - 1,259,885 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000012908 ⟹ ENSCLAP00000012760

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955416	713,373 - 1,259,885 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000012909 ⟹ ENSCLAP00000012761

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955416	713,373 - 1,259,885 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000012910 ⟹ ENSCLAP00000012762

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955416	713,373 - 1,098,231 (-)	Ensembl

RefSeq Acc Id:

XM_005381167 ⟹ XP_005381224

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955416	712,506 - 1,260,111 (-)	NCBI

Sequence:

show sequence

GGGCTGCTGGGTTGGCGCTGGCGCTCTGCAGTGCAGTGGAGTGTTAGCCCAGCTCCCTATATGG
TTGGGGATTAGCTCGGCGCTCCTGAGACTGAGCCAGGAGCCAGAGGAGGAGGAAGAGGCGGAGG
AGGCGGAGGACAAAGAGCGCAGCAGCCGTCAGCGCGCCGCGCGGCTGCCGGGGAAGCAGAGCGC
CGGAGGCTGGGACACCGCCGACGCCTCGGGAGCCATGGCCGAGGGAGGAGAAGGCGGCGAGGAC
GAGATCCAGTTCCTGCGGACTGAAGATGAAGTGGTTCTACAGTGCATTGCCAACGTTCACAAGG
AGCAGAGGAAGTTCTGCCTGGCGGCCGAGGGACTTGGGAATCGCCTGTGCTTCTTGGAACCCAC
CTCAGAAGCAAAGTATATTCCTCCAGATCTCTGCATCTGCAATTTTGTGCTGGAACAGTCTCTC
TCTGTCAGAGCCCTGCAGGAAATGCTTGCCAACACGGGTGAAAATGGTGGCGAAGGGGCAGCAC
AAGGGGGTGGCCACAGGACCTTGTTATATGGCCACGCAATTCTCCTGCGGCACTCTTTCAGTGG
AATGTATCTAACATGTTTGACTACGTCAAGATCCCAGACAGATAAACTTGCCTTTGATGTAGGT
CTCCGGGAACACGCCGCAGGAGAAGCCTGCTGGTGGACCATACATCCTGCTTCCAAACAGAGGT
CTGAGGGAGAGAAAGTGCGAATTGGCGATGACCTTATCCTTGTCAGTGTGTCCTCTGAAAGATA
CCTTCATCTCTCAATATCCAATGGTAACATACAAGTGGATGCCTCCTTCATACAGACCCTCTGG
AATGTACATCCTACGTGCTCAGGAAGTAGCATCGAAGAAGGCTATCTACTTGGTGGGCATGTGG
TACGCCTTTTTCATGGTCATGATGAGTGTTTGACAATACCATCCACAGATCAGAATGACCCCCA
GCACAGGAGAGTATTCTATGAAGCTGGAGGAGCTGGGCAGAGAGCCAGGTCCCTGTGGAGAGTG
GAGCCCCTTCGCATAAGCTGGAGTGGCAGCAACATCAGATGGGGCCAGGCTTTCCGACTGCGGC
ACCTCACTACAGGCCACTACCTGGCTTTGACAGAGGACCAAGGCCTTCTGCTGCAAGACCGGGG
AAAGTCAGACACCAAGTCCACAGCCTTCTCTTTCCGGGCATCAAAGGAAATCAAGGAGAAACTG
GATTCTAGTCACAAGCGAGATATGGAAGGCATGGGAGTTCCCGAAATCAAGTACGGAGATTCTG
TCTGCTTTGTCCAGCACGTAGCCAGTGGTCTCTGGGTCACCTACAAAGCACAAGATGCCAAAAC
ATCTCGCCTGGGACCTCTGAAAAGAAAGGTCATTCTGCATCAGGAAGGCCACATGGATGATGGG
TTAACACTGCAGAGATGCCAGCGCGAGGAGTCCCAGGCTGCTCGGATCATCAGGAACACGACAG
CATTATTCAGCCGGTTTGTCAGTGGAAACAATCGCACAGCTGCCCCCATCACCCTGCCAACAGA
AGAGGTCCTGCAGACCTTACAGGACTTGATCGCCTACTTCCAGCCTCCAGAGGAGGAGATGAAG
CATGAAGACAAGCAAAACAAGCTCCGCTCCCTCAAAAACAGACAGAATCTTTTCAAGGAAGAGG
GGATGTTGGCTCTTGTGTTAAACTGCATTGACCGCTTAAATATCTACAATAGCGTAGCCCACTT
TGCGGGGATTGCGAGGGAAGAGAGTGGCATGGCCTGGAAAGAAATTCTGAACCTCCTCTACAAG
CTGCTGGCTGCTCTGATTCGTGGAAACAGAAACAACTGTGCTCAATTCTCCAATAACCTTGACT
GGCTAATCAGTAAATTGGACAGGCTAGAGTCTTCCTCAGGTATCTTAGAGGTTTTGCACTGTAT
CTTGATTGAAAGCCCAGAAGCCTTAAACCTGATAGCCGAAGGCCACATCAAGTCCATCATCTCT
CTGTTGGACAAACATGGACGGAATCACAAGGTCCTGGATGTCCTGTGCTCACTCTGCCTTTGCA
ATGGGGTTGCAGTGAGAGCCAACCAAAACCTGATCTGTGACAACTTACTGCCCCGGAGAAATCT
GCTCCTGCAGACACGGCTAATTAATGATGTGACCAGTATTCGGCCTAACATCTTCCTGGGAGTT
GCTGAAGGCTCAGCCCAGTACAAGAAATGGTACTTTGAGCTAATTATCGACCAAGTGGACCCTT
TCCTAACAGCAGAGCCTACTCACCTGCGGGTAGGCTGGGCCTCCTCCTCAGGCTATGCCCCTTA
CCCAGGAGGAGGAGAAGGATGGGGAGGCAACGGTGTTGGTGATGACCTGTACTCCTATGGCTTT
GATGGACTTCATCTCTGGTCAGGCCGGATACCCAGAGCTGTGGCCTCCATCAACCAGCACCTAT
TGAGATCGGATGATGTGGTGAGCTGCTGTCTCGACCTCGGAGTACCTAGCATCTCTTTCCGCAT
CAATGGGCAACCTGTGCAAGGGATGTTTGAGAACTTCAACACTGATGGCCTCTTCTTCCCTGTG
ATGAGTTTTTCAGCAGGTGTCAAAGTACGTTTCCTCATGGGTGGACGCCATGGAGAATTTAAGT
TCCTGCCTCCCTCTGGCTATGCGCCTTGCTATGAAGCCCTACTTCCAAAAGAGAAGATGAGATT
GGAGCCTGTCAAAGAATATAAACGTGATGCTGATGGTGTCAGAGATCTGTTGGGTACCACACAA
TTCCTGTCCCAAGCCTCGTTCATCCCATGCCCCATTGACACCAGTCAGGTTGTTTTGCCACCTC
ACCTAGAGAAGATCCGAGATAGATTGGCTGAGAACATCCATGAGCTTTGGGGAATGAATAAAAT
AGAGCTTGGCTGGACTTTTGGCAAGATACGAGATGACAATAAAAGACAACACCCCTGCCTTGTG
GAGTTTTCAAAGCTCCCTGAAACTGAGAAGAATTATAACCTGCAAATGTCAACTGAAACCTTAA
AAACTCTCCTGGCCCTGGGCTGCCACATCGCTCACGTTAACCCAGCTGCTGAGGAGGACCTCAA
GAAGGTCAAACTGCCCAAAAACTACATGATGACCAATGGCTATAAGCCAGCGCCTTTGGATTTG
TCTGATGTGAAGCTGTTACCTTCTCAAGAAATCTTAGTGGATAAGCTGGCAGAAAATGCACACA
ATGTTTGGGCAAAAGACAGAATAAAACAAGGATGGACCTATGGCATTCAACAGGATTTGAAGAA
CAAAAGAAATCCCCGTCTGGTGCCATATGCATTGCTGGATGAGCGTACCAAGAAGTCAAACAGG
GATAGCCTGCGCGAAGCCATCCGGACGTTTATCGGTTATGGGTATAACATTGAGCCATCAGACC
AAGAACTTGCTGATCCAGCTATAGAGAAAGTCAGTATAGACAAGATTCGATTTTTCCGGGTAGA
GCGGTCTTATGCAGTGAGATCTGGAAAGTGGTATTTTGAGTTTGAAGCAGTGACCGGAGGAGAC
ATGCGTGTTGGCTGGGCCAGGCCAGGCTGCCGGCCGGACATTGAGCTGGGTGCTGATGACCAAG
CCTTTGTGTTCGAAGGCAGCAGGGGCCAGCGCTGGCATCAAGGAAGTGGCTATTTTGGGAGAAC
CTGGCAGCCAGGAGATGTGGTTGGATGTATGATTAACCTGGATGATGCCTCAATGATCTTCACA
CTGAATGGGGAGCTACTGATCACCAACAAAGGCTCTGAACTTGCCTTCGCTGACTATGAGATTG
AGAATGGGTTCGTGCCCATCTGCTGTCTGGGGCTATCTCAGATTGGCCGCATGAATCTCGGGAC
AGATGCCAGTACCTTCAAGTTTTATACCATGTGTGGCCTCCAAGAGGGCTTTGAGCCTTTTGCT
GTCAACATGAACCGAGATGTTGCAATGTGGTTCAGCAAGCGCCTCCCGACATTTGTCAATGTGC
CAGAGGATCATCCACACATAGAGGTCATGAGGATCGATGGCACCATGGACAGCCCTCCATGCCT
CAAGGTGACACACAAGACATTTGGCACACAGAATAGCAGTGCCAGCATGATCTACTGCCGCCTG
AGCATGCCTGTTGAGTGCTACTCCTCCTTCAGCCACAGTCCCTGTCTGGACAGTGATGCTTTCC
AGAAAAGGAAACAGATGCAAGAAATACTCTCTCCTACAACAACACAATGCTACTATGCCATCCG
CATCTTCGCGGGGCAGGACCCCTCCTGTGTCTGGGTTGGATGGGTGACTCCAGACTATCACTTG
TACAGTGAAAAGTTTGACCTGAATAAAAACTGTACAGTGACGGTCACCCTCGGGGACGAGAGAG
GTCGGGTCCATGAAAGTGTGAAACGCAGCAACTGCTACATGGTATGGGGTGGAGACATTGTGGC
TAGTTCTCAAAGGTCAAGTCGAAGCAACGTGGACCTGGAGATCGGCTGCCTTGTGGATCTGGCA
ATGGGCATGTTGTCCTTCTCAGCCAATGGGAAAGAACTTGGAACCTGCTACCAGGTGGAACCCA
ACACGAAAGTGTTTCCAGCTGTTTTCCTGCAGCCTACGAGCACATCTCTGTTTCAGTTTGAACT
TGGGAAGTTGAAGAATGCAATGCCTTTGTCTGCGGCCATATTTAAGAGTGAAGAGAAGAACCCA
GTCCCCCAGTGTCCTCCTCGGCTGGACGTCCAAACCATCCAGCCGGTGCTCTGGAGCCGCATGC
CCAACAGCTTCCTCAAGGTGGAGACAGAGCGGGTGAGCGAGCGCCATGGCTGGGTGGTCCAGTG
CCTGGAGCCCCTGCAAATGATGGCCCTCCACATCCCAGAGGAGAACAGATGTGTGGACATCCTG
GAGCTCTGTGAGCAGGAAGACCTGATGCGGTTCCACTACCACACACTGAGGCTGTACAGCGCCG
TGTGTGCTCTGGGAAACAGCCGGGTTGCCTACGCCCTGTGCAGCCACGTGGATCTCTCTCAACT
CTTCTATGCTATTGACAACAAGTATCTCCCAGGCCTCCTGCGGTCTGGCTTCTATGACCTGCTC
ATCAGCATCCACTTGGCCAATGCTAAGGAGAGGAAGCTGATGATGAAGAATGAGTACATCATCC
CCATCACCAGCACCACTAGGAATATCCGCTTATACCCAGATGAGTCCAAGAGGCATGGGCTTCC
TGGGGTGGGTCTGAGAACGTGCCTTAAGCCAGGCTTCAGGTTTTCTACCCCTTGCTTCGTTGTA
ACCAGTGAGGAGCACCAGAAACAGAGCCCTGAGATCCCTTTGGAGATTCTCAAGACAAAGGCAT
TGAGCATGCTGACAGAAGCAGTGCACTGTAGTGGGGCCCACATCCGAGACCCCGTTGGGGGGTC
CATCGAGTTCCAGTTTGTGCCTGTGCTGAAGCTCATTGGAACTCTGCTGGTCATAGGCGTTTTT
GATGATGATGATGTTCGCCAGATCCTGCTCCTGATTGATCCCTCTGTCTTTGGGGAGCACAGTG
GGGAGACAGAGGAGGGAGCAGAAAAAGAAGAAGTGACCCAAGTGGAGGAAAAGGCAGTGGAGGC
TGGGGAAAAGGCCAGCAAGGAGGCTCCAGTCAAAGGCTTGTTGCAGACCCGACTACCTGAGTCC
GTCAAGCTGCAGATGTGTGAGCTCCTCAGCTATCTGTGTGACTGTGAGCTGCAGCACCGAGTGG
AGGCCATTGTGGCATTTGGTGACATTTATGTCTCCAAGCTGCAGGCAAATCAGAAGTTCCGCTA
CAACGAGCTCATGCAGGCCCTGAACATGTCTGCAGCCCTCACTGCCCGGAAGACCAGGGAGTTC
CGTTCACCCCCACAGGAGCAGATCAACATGCTTCTCAATTTTCAACTGGGAGAGAACTGCCCCT
GCCCAGAGGAGATCCGGGAGGAGCTGTATGACTTCCACGAGGACCTGCTCATTCACTGCGGGGT
TCCCTTGGAGGAAGCGGAGGAGGAGGAGGAGGACACCTCCTGGACAGGAAAGCTGTGTGCCTTG
GTGCACAAAATCAAAGGCCCACCCAAGCCAGAGAAGGAGCAACCAGCAGAGGAAGAGGAGAGAT
GTCCTGCAACACTGAAGGAACTAGTGTCACAGACAATGATCCGCTGGGCCCAAGAAGACCAGAT
CCAGGATGCAGAGCTGGTGCGGATGATGTTCAACCTGCTCCGGAGGCAGTATGACAGCATTGGG
GAGCTATTGCAGGCTTTGCGGAAGACCTATACCATCAGCCAGGCCTCTGTGAGCGACACCATCA
ACCTGCTGGCTGCCCTGGGCCAGATCCGGTCGCTCCTCAGTGTGAGGATGGGCAAGGAAGAGGA
GCTGCTCATGATCAATGGGCTGGGGGACATCATGAACAACAAGGTGTTTTACCAGCATCCCAAC
CTCATGAGAGTCCTAGGCATGCACGAGACCGTGATGGAGGTGATGGTGAATGTGCTGGGTACAG
AGAAATCACAGATTGCTTTCCCAAAGATGGTTGCTAGCTGTTGCCGCTTCCTTTGCTATTTCTG
TCGAATTAGCCGGCAAAATCAGAAGGCAATGTTTGAGCATCTGAGTTACCTGCTAGAGAACAGC
AGCGTGGGCCTAGCCTCCCCGTCGATGAGGGGGTCCACCCCATTGGATGTGGCTGCCTCCTCTG
TCATGGACAACAATGAATTAGCCCTGGGCTTAGAAGAACCCGACCTCGAGAAGGTGGTGACCTA
CTTGGCAGGCTGCGGCCTACAGAGCTGCCCCATGCTTCTGGCCAAAGGATACCCTGATGTTGGC
TGGAATCCCATCGAAGGGGAGCGCTACCTGTCCTTCCTGAGGTTTGCCGTCTTTGTGAACAGTG
AGAGTGTGGAAGAAAACGCTAGTGTTGTGGTCAAGCTGCTCATCAGACGCCCGGAGTGCTTCGG
CCCGGCCCTGCGGGGCGAAGGAGGAAATGGCCTGTTGGCAGCCATGCAAGGGGCCATCAAGATC
TCGGAGAACCCAGCGCTGGACCTCCCCTCTCAGGGATATAAGAGAGCAGTCACAGAGGATCATG
AAGAGGAAGAAGAGATTGTGTATATGGGCAATGCCATTATGTCATTTTATTCAGCTCTTATAGA
TCTCCTGGGCCGCTGTGCTCCTGAAATGCATCTTATCCAGACAGGAAAAGGGGAAGCCATCCGG
ATCCGGTCCATCTTGCGCTCCCTAGTCCCCACGGAGGACCTGGTTGGGATCATCAGCATCCCCC
TGAAACTGCCTTCCCTCAACAAAGATGGGTCAGTCAGCGAGCCCGATATGGCGGCCAACTTCTG
CCCTGACCACAAGGCACCCATGGTGCTGTTCTTGGACCGTGTTTATGGCATTAAGGATCAAACT
TTTCTGCTCCATCTGCTGGAGGTTGGATTTTTACCTGACTTGAGAGCCTCTGCCTCTTTAGATA
CAGTGTCCCTCAGCACCACAGAGGCTGCGCTGGCGCTCAACAGGTATATATGCTCTGCGGTGCT
CCCACTCCTTACCAGATGTGCCCCGCTCTTTGCCGGGACAGAGCACTACACCTCTCTGATCGAT
TCTACGCTGCAGACCATATACAGGCTTTCCAAGGGACGTTCCCTCACCAAGGCACAGAGGGACA
CCATAGAAGAATGTTTGCTTGCCATTTGCAATCACTTGCGGCCTTCCATGTTACAACAGCTCCT
ACGACGTCTGGTTTTCGATGTACCACAACTGAACGAATACTGCAAAATGCCTCTGAAGCTTCTG
ACGAATCACTATGAGCAGTGCTGGAAGTATTACTGTCTGCCTTCAGGATGGGGCAGCTATGGGC
TGGCCGTGGAGGAGGAGCTGCACCTCACAGAGAAGCTCTTCTGGGGGATTTTTGACTCCCTCTC
CCATAAGAAATATGACCCCGATCTCTTCCGAATGGCCTTGCCTTGTCTCAGTGCTATTGCGGGG
GCCTTGCCACCGGATTATTTAGACACCAGAATCACGGCCACATTGGAGAAACAGGTCTCTGTGG
ATGCAGAAGGCAACTTTGACCCCAAACCCATCAACACAATGAATTTTTCCTTGCCTGAAAAATT
GGAATACATCGTCACCAAGTATGCTGAGCATTCACATGATAAATGGGCCTGTGACAAGAGTCAG
AGTGGATGGAAATATGGAATTTCCCTGGATGAAAATGTGAAGACCCACCCACTGATAAGGCCTT
TCAAGACATTAACAGAGAAGGAGAAAGAAATTTATCGTTGGCCTGCCAGAGAGTCTCTGAAAAC
CATGCTGGCTGTGGGCTGGACTGTGGAGAGGACCAAAGAGGGAGAAGCTTTGGTTCAACAACGA
GAAAATGAGAAACTTCGCAATGTGTCCCAGACAAGCCAGGGCAACAGCTACAGCCCTGCTCCCC
TAGACCTCTCAAATGTCGTGCTCTCCAGGGAGCTCCAGGGAATGGTGGAGGTAGTGGCTGAGAA
CTATCACAATATCTGGGCCAAAAAGAAGAAGCTGGAACTGGAGAGCAAAGGCGGTGGCAGTCAC
CCCCTTTTGGTACCATATGATACCTTGACTGCAAAGGAAAAGTTCAGGGATCGAGAAAAGGCAC
AGGACCTGTTTAAGTTCCTCCAAGTGAATGGCGTTATAGTTTCTAGAGGTCTCAAGGGTATGGA
ACTGGATGCCTCCTCCATGGAAAAGAGGTTTGCCTACAAATTTTTGAAGAAGATCCTGAAATAC
GTTGATTCTGCTCAAGAATTTATTGCTCACTTGGAAGCCATTGTCAGCAGTGGAAAAACTGAAA
AGTCTCCACATGACCAAGAGATCAAATTCTTTGCCAAAGTTCTCCTCCCACTAGTTGACCAGTA
CTTCACTAATCACCGCCTCTACTTTCTGTCGTCTCCTCTGAAGCCCCTCAGTAGCAGCGGTTAT
GCCTCCCATAAGGAGAAAGAAATGGTGGCCAGCCTATTCTGCAAACTCGCTGCTCTTGTTAGAC
ACAGGATTTCCCTCTTCGGGAGTGATTCTGCTACAATGGTGAGCTGTCTCCACATCTTAGCTCA
GACCCTTGACACAAGGACAGTCATGAAGTCAGGCTCAGAGCTGGTGAAGGCTGGGTTGCGAGGA
TTCTTTGAAAATGCTGCAGAAGACTTAGAGAAGACTTCGGAGAACTTGAAGCTTGGGAAGTTTA
CCCATTCTAGAACACAGATCAAAGGGGTTTCCCAGAATATCAATTACACCACAGTGGCTCTGCT
TCCCATCCTGACATCGATCTTTGAGCATGTCGCCCAGCATCAGTTTGGGGTGGATCTACTCTTG
AGTGATGTGCAGATTTCATGCTACCATATACTGTGCAGCCTTTACTCCCTTGGGACAGGAAAAA
ACATCTATGTTGAAAGGCAACGCCCTGCCCTTGGAGAATGTCTGGCTTCACTGGCGGCTGCCAT
ACCAGTGGCATTCCTGGAGCCCACCCTTAACCGCTATAATCCTCTCTCAGTCTTCAACACCAAA
ACCCCCAGAGAGAGATCTATTCTAGGGATGCCAGACACGGTGGAAGAGATGTGTCCTGACATTC
CCCAGCTGGATGGCCTCATGAAGGAAATCAACGAGCTGGCTGAGTCCGGGGCCCGGTACACGGA
GATGCCCCACGTCATCGAGGTGATCTTACCCATGCTCTGCAACTACCTGTCCTACTGGTGGGAG
CGGGGACCTGAGAACCTGCCTCCCAGCACAGGGCCCTGCTGCACCAAGGTCACCTCTGAACACC
TCAGCCTCATCCTGGGCAACATCCTGAAAATAATCAACAACAACCTAGGCATTGATGAGGCCTC
TTGGATGAAGCGGATTGCAGTGTTCGCCCAGCCGATCATCAGCAAAGCCAGGCCTGACCTGCTG
AGAAGCCACTTCATCCCCACTCTGGAGAAGTTAAAAAAGAAGGCTGTCAAGACCGTGCAGGAGG
AGGAACAGCTGAAAGCTGACGGCAAAGGGGACACCCAGGAGGCAGAGCTGCTCATCCTGGATGA
GTTTGCCATCCTCTGCAGAGATCTCTATGCCTTCTACCCTATGCTAATCCGCTATGTGGACAAC
AACAGATCTAACTGGCTCAAAAGCCCAGATGATGATTCAGACCAGCTCTTCCGAATGGTGGCAG
AGGTCTTCATCCTGTGGTGTAAATCTCATAACTTCAAGAGGGAAGAGCAAAATTTTGTGATTCA
AAACGAAATTAACAATTTGGCATTTTTAACTGGAGACAGCAAAAGCAAGATGTCAAAAGCCATG
CAAGTAAAGTCTGGAGGACAGGACCAGGAACGGAAGAAGACAAAGCGCAGGGGAGACTTCTATT
CCATCCAGACCTCCCTCATCGTGGCTGCACTCAAGAAAATGCTGCCCATTGGTCTGAATATGTG
CACCCCAGGCGACCAGGAGCTGATCTCCCTTGCAAAATCACGATACAGCTGTAGGGACACAGAT
GAAGAGGTCAAGGAGCATCTGCGGAATAACCTGCACTTGCAGGAGAAGTCTGATGACCCAGCTG
TAAAATGGCAGCTGAACCTCTATAAGGATGTTCTGAGGAATGAAGAGCCTACTACTCCAGAGAA
GACTGTGGAGCGGGTGCAGAGGATTTCAGCAGCTGTCTTCCACCTGGAGCAGGTAGAACAGCCT
TTGAGATCCAAGAAGGCGGTGTGGCACAAACTATTGTCAAAGCAACGGAAACGGGCAGTGGTGG
CCTGTTTCAGGATGGCTCCTCTCTACAACCTGCCCAGGCACCGCTCTATTAACCTCTTCCTCCA
TGGCTATCAGAGATTTTGGATAGAAACAGAGGCGTATTCCTTTGAAGAGAAACTAGTACAGGAT
TTGGCTAAATCTCCCAAGGTAGAAGAGGAGGAGGAGGAAGAGATGGAAAACCAACCCGACCCTC
TTCATCAGATCATTCTCTATTTTAGTCGCAATGCGCTCACGGAGAGGAGCAAACTTGAAGATGA
CCCTTTATACACCTCCTATTCCAGCATGATGGCCAAGAGCTGTCAGAGTGGTGAGGATGAAGAA
GAGGAAGACAAGGAAAAGACATTTGAAGAAAAAGAGATGGAGAAACAGAAAACCCTGTATCAAC
AGGCTCGGCTGCATGAGCGTGGTGCTGCAGAGATGGTCCTGCAGATGATAAGCGCCAGCAAAGG
TGAGATGAGCCCCATGGTGGTGGAGACTCTGAAGCTGGGGATCGCCATTCTGAATGGAGGCAAC
ACTGGTGTGCAACAGAAAATGCTAGATTACTTAAAGGAGAAAAAGGACGCTGGATTCTTTCAAA
GCCTTTCTGGTCTTATGCAGTCTTGCAGTGTCCTTGATTTGAATGCATTTGAGAGGCAGAATAA
AGCTGAAGGCCTGGGGATGGTTACGGAAGAAGGAACACTCATTGTTCGCGAACGTGGTGAAAAA
GTACTCCAGAATGATGAGTTCACACGAGATCTCTTTAGATTCCTACAGTTACTTTGTGAAGGAC
ATAACAGTGACTTTCAGAACTTCCTTCGGACGCAGATGGGAAACACCACCACCGTGAATATCAT
CATCAGCACCGTGGATTACCTGCTGCGACTGCAGGAATCAATCAGTGATTTCTACTGGTACTAT
TCAGGAAAGGATATCATTGATGAATCTGGACAGCACAATTTTTCTAAAGCTCTAGCAGTCACCA
AGCAGATTTTCAATTCTCTTACAGAGTATATCCAGGGCCCTTGCATTGGGAACCAGCAGAGCCT
GGCTCACAGCAGGCTGTGGGATGCAGTGGTCGGCTTCCTCCATGTATTTGCTAACATGCAGATG
AAACTCTCTCAGGATTCCAGTCAGATCGAGCTGCTGAAGGAACTCTTGGATCTCCTTCAGGACA
TGGTGGTGATGCTTCTGTCCCTCCTGGAAGGGAATGTGGTAAATGGAACTATCGGCAAGCAGAT
GGTTGACACACTGGTAGAATCATCTACTAATGTAGAAATGATCTTGAAATTCTTTGACATGTTC
TTGAAACTCAAAGACTTAACCAGCTCAGACACCTTCAAAGAATATGACCCAGATGGTAAAGGGA
TCATCTCCAAAAAGGAATTCCAGAAGGCCATGGAGGGGCAAAAGCAGTATACACAGTCAGAGAT
TGATTTTCTCCTGTCCTGCACAGAAGCTGATGAAAATGACATGTTTAATTACATTGATTTTGTG
AACCGGTTCCATGAGCCTGCCAAAGACATAGGGTTTAATGTCGCAGTGTTACTGACAAATCTTT
CTGAGCACATGCCTAATGATTCTCGCCTGAAGTGTCTCTTGGACCCCGCAGAGAGTGTGTTAAA
TTACTTCGAACCATATCTAGGTCGAATTGAGATCATGGGTGGTGCCAAGAAAATCGAGCGTGTT
TACTTCGAGATCAGTGAATCCAGTCGAACTCAGTGGGAGAAGCCTCAAGTGAAGGAATCTAAGC
GGCAGTTCATTTTTGATGTTGTCAATGAAGGTGGGGAGCAAGAAAAGATGGAGCTGTTTGTGAA
CTTCTGTGAGGACACAATCTTTGAGATGCAACTGGCATCTCAGATCTCTGAATCTGATTCAGCT
GACAGGCCAGAAGAGGAGGAGGAAGAAAATGATTCTTCGTATGTGTTAGAAATGGAGGGCGAGG
AGGAGGAAGACAAGTCTTCCGAGCCTGCCTCTGCGTTTGCCATGGCCTGTGCCTCCGCAAAGAG
AAATGTTTCCAACCTTCTAAAGAGGGCAACTCTGAAGAACCTCAGGAAGCAGCACCGCAGTGTG
AGAAGGATGAGTGCGAAGGAGCTGGTGAAGGTGCTCTTCTCCTTTCACTGGATGTTTTTTGTGG
GGCTATTCCAGATGTTCTTCACCATATTCGGAGGAATCTTTCAGATCCTCTGGAATACAGTGTT
TGGAGGGGGACTAGTAGAAGGGGCAAAAAACATCAGAGTGACCAAGATCCTGGGTGACATGCCA
GATCCAACCCAGTTTGGGATCCACGATGATGCCGTGGAGGCTGAGAGGGCAGATGTGGTTGAGC
CAGGTCTCACCGCTGAGCTAGTGCACTGTGTGAAGGGTGAGAAGGGAGACAAAGACATCATGTC
AGACCTCTTTGGACTCCACCCAAAAAAAGAAGGCAGCTTAAAGCATGGATCTGAAGTGGGTTTG
GGTGACCTCTCTGAAATTATTGGCAAGGATGAGCCCCCTACATTAGAGAGTACTGTGCAGAAGA
AAAGGAAAGCACAGGCAGCAGAGATGAAGGCAGCACATGAAGTGGAAGGAAAAGTAGAATCTGA
GAAGGCAGACATGGAAGACAGAGAAAAGGAGGACAAAGCCAAAGAGGAAGAGCAAGCAGAGTAC
CTGTGGGCAGAAGTGACAAAGAAAAAGAAGCGACGGCGTGGTCAGAAGGTTGAGAAACCTGAAG
CCTTCATGGCCAATTTCTTTAAAGGGCTAGAAATCTATCAGACCAAGTTATTGCATTACCTGGC
CAGAAATTTCTACAACCTGAGGTTCCTTGCTCTGTTTGTAGCCTTCGCTATCAACTTCATCCTG
CTTTTTTATAAGGTCACTGAAGAACCTCTGGAAGAGGAGACTGAGGACATTGTGAACCTGTGGA
ATTCCTTTAATGACGAAGAAGAGGAAGAAGCGATGGTGTTCTTCGTCCTGCAGGAGAGTACCGG
CTACATGGCACCCACACTGCGTGCCCTGGCTGTTGTCCACACCATTGTCTCGCTCGTCTGTGTT
GTCGGCTATTACTGCCTGAAGGTCCCTTTGGTGGTATTCAAAAGGGAAAAAGAAATTGCCAGGA
AGCTGGAGTTTGATGGCCTCTACATCACTGAGCAGCCATCTGAGGACGACATCAAGGGGCAGTG
GGACCGCTTAGTCATCAACACTCCATCCTTCCCTAATAACTACTGGGACAAGTTTGTGAAGAGA
AAGGTGATCAACAAGTACGGAGATCTCTACGGAGCAGAGCGCATTGCTGAACTCCTGGGTTTGG
ACAAAAATGCCCTTGACTTTAGCCCAGTGGAAGAGACCAAAGCGGAGGCAGCTTCTCTGGTGTC
ATGGCTGAGCTCCATCGACATGAAATACCATATCTGGAAGCTGGGGGTTGTTTTCACTGACAAT
TCCTTTCTCTACCTTGCCTGGTATACAACCATGTCGATCCTGGGCCACTACAACAACTTCTTCT
TTGCTGCTCACTTATTGGATATCGCAATGGGCTTCAAGACCTTGAGGACTATTCTGTCATCTGT
AACTCACAATGGCAAACAGCTGGTTCTGACTGTGGGTCTCCTGGCGGTGGTGGTTTACCTCTAC
ACGGTGGTGGCTTTCAACTTCTTCCGCAAGTTCTACAACAAGAGTGAAGATGACGATGAGCCCG
ACATGAAGTGTGATGACATGATGACGTGTTACCTTTTCCACATGTACGTAGGAGTGAGAGCAGG
AGGCGGCATTGGCGATGAAATTGAAGACCCTGCTGGTGATCCTTACGAGATGTATCGCATTGTC
TTTGACATTACCTTTTTCTTCTTTGTCATTGTCATCTTGCTGGCCATCATTCAAGGTCTCATTA
TTGATGCTTTTGGAGAGCTACGAGACCAGCAGGAACAAGTGCGAGAAGATATGGAGACGAAATG
TTTCATCTGCGGCATTGGCAATGACTACTTTGACACAACCCCTCACGGTTTTGAAACACACACA
CTACAAGAGCACAACTTAGCCAACTACTTGTTTTTTCTGATGTATCTGATTAACAAAGATGAAA
CAGAGCACACGGGTCAGGAATCTTATGTGTGGAAGATGTACCAAGAAAGGTGCTGGGATTTCTT
CCCAGCTGGTGACTGCTTTCGTAAGCAATATGAAGACCAGCTTGGATAATCTGAACAAAAGATG
TGCCACAGTCCTGGATGGTCAGCTTCCAGTGAAACAAAACCCTCCTTTTACAGTTCTGCAACAT
ATTTGATACGTGACATTTTCTAAATGCCTCCTCTATAGGAAAGTATTTGTTAAAATTTTGTGAT
ATTTGGAAGTTGATTTGGCTTTTTGTGCCTGATGGACATATACTGCGAGTGACAACCTATCAAG
ATGTGAACAAAGTGAAAAAGGGGACGACGGCGAGGAATTCCTACTTGAATGCCTGCGAAGTTTT
TCACCTCTAATGTAACTAATCTGCTGCAGTGGCAGCACTGATAAAAGGTCCAAAAAGTCTTGAA
TGCATAACACCTAAAATTTTAAACACCTGAATGTCATACAACAGTTTTCACCAGTGGCTCATGG
TCTGAACTACACAAAATCATGTTAACTGCAGTCTAATTTTTCCCATGGTACTTGCTAGTGACTG
TAACCAGAATCAGCTTGAAAAGCTTTAAGCAGTTAATGAAATAGAAAACAAACCAATACTTCAT
CGACACTGAAACACTGATTAAGTGCCTTACAAACCTCTTTAGATATAGCTATGCAAGTTTTTTA
TGTTTGTGCTCCAGAAAGACAGTTCCATTAAACAGTTGTGTTCAGTCTTACTTTCTAAAACTGC
ACTGGAAGGTTATTCATAATTTTTTCAGTAACAGCTTGTCAACTGCTGTTATTAGGAGAAAAGT
ACTGTACTGAAAATTCAGAAAAATCTCAATCTTATGGCAAAATTGAGTAATGCTTTAGGGTCCC
TTGTAAGTAGTGGAGCTGCTACGTTTTAGGTGAATTTCTCAAATAAAATGAAGTGCCCACTGCA
ATAAAAGTAACACATACCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005381224	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000012758
	ENSCLAP00000012758.1
	ENSCLAP00000012759.1
	ENSCLAP00000012760.1
	ENSCLAP00000012761.1
	ENSCLAP00000012762.1

RefSeq Acc Id:

XP_005381224 ⟸ XM_005381167

- UniProtKB:

A0A8C2YP11 (UniProtKB/TrEMBL), A0A8C2VB65 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAEGGEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDLC
ICNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTSRS
QTDKLAFDVGLREHAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSISNGNIQ
VDASFIQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTDQNDPQHRRVFYEAGGA
GQRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLLLQDRGKSDTKSTAFSF
RASKEIKEKLDSSHKRDMEGMGVPEIKYGDSVCFVQHVASGLWVTYKAQDAKTSRLGPLKRKVI
LHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSRFVSGNNRTAAPITLPTEEVLQTLQDLIA
YFQPPEEEMKHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMA
WKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLI
AEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVT
SIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNG
VGDDLYSYGFDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFEN
FNTDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAD
GVRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRD
DNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMT
NGYKPAPLDLSDVKLLPSQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYAL
LDERTKKSNRDSLREAIRTFIGYGYNIEPSDQELADPAIEKVSIDKIRFFRVERSYAVRSGKWY
FEFEAVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMI
NLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGRMNLGTDASTFKFYTMC
GLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPEDHPHIEVMRIDGTMDSPPCLKVTHKTFGTQN
SSASMIYCRLSMPVECYSSFSHSPCLDSDAFQKRKQMQEILSPTTTQCYYAIRIFAGQDPSCVW
VGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVASSQRSSRSNVD
LEIGCLVDLAMGMLSFSANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSA
AIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHI
PEENRCVDILELCEQEDLMRFHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPG
LLRSGFYDLLISIHLANAKERKLMMKNEYIIPITSTTRNIRLYPDESKRHGLPGVGLRTCLKPG
FRFSTPCFVVTSEEHQKQSPEIPLEILKTKALSMLTEAVHCSGAHIRDPVGGSIEFQFVPVLKL
IGTLLVIGVFDDDDVRQILLLIDPSVFGEHSGETEEGAEKEEVTQVEEKAVEAGEKASKEAPVK
GLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSA
ALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEAEEEEED
TSWTGKLCALVHKIKGPPKPEKEQPAEEEERCPATLKELVSQTMIRWAQEDQIQDAELVRMMFN
LLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIM
NNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMF
EHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPM
LLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGL
LAAMQGAIKISENPALDLPSQGYKRAVTEDHEEEEEIVYMGNAIMSFYSALIDLLGRCAPEMHL
IQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFL
DRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPLFA
GTEHYTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLN
EYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRM
ALPCLSAIAGALPPDYLDTRITATLEKQVSVDAEGNFDPKPINTMNFSLPEKLEYIVTKYAEHS
HDKWACDKSQSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERT
KEGEALVQQRENEKLRNVSQTSQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKL
ELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGVIVSRGLKGMELDASSMEKRFA
YKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS
PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSATMVSCLHILAQTLDTRTVMKSG
SELVKAGLRGFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVA
QHQFGVDLLLSDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNR
YNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLDGLMKEINELAESGARYTEMPHVIEVILPM
LCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEASWMKRIAVFAQP
IISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAELLILDEFAILCRDLYAF
YPMLIRYVDNNRSNWLKSPDDDSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTG
DSKSKMSKAMQVKSGGQDQERKKTKRRGDFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLA
KSRYSCRDTDEEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLRNEEPTTPEKTVERVQRISAA
VFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEA
YSFEEKLVQDLAKSPKVEEEEEEEMENQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMA
KSCQSGEDEEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLK
LGIAILNGGNTGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEG
TLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQ
ESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVG
FLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNV
EMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCTEADE
NDMFNYIDFVNRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEI
MGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQL
ASQISESDSADRPEEEEEENDSSYVLEMEGEEEEDKSSEPASAFAMACASAKRNVSNLLKRATL
KNLRKQHRSVRRMSAKELVKVLFSFHWMFFVGLFQMFFTIFGGIFQILWNTVFGGGLVEGAKNI
RVTKILGDMPDPTQFGIHDDAVEAERADVVEPGLTAELVHCVKGEKGDKDIMSDLFGLHPKKEG
SLKHGSEVGLGDLSEIIGKDEPPTLESTVQKKRKAQAAEMKAAHEVEGKVESEKADMEDREKED
KAKEEEQAEYLWAEVTKKKKRRRGQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLAL
FVAFAINFILLFYKVTEEPLEEETEDIVNLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAV
VHTIVSLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFP
NNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHI
WKLGVVFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTV
GLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPA
GDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFD
TTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYE
DQLG

hide sequence

Ensembl Acc Id:

ENSCLAP00000012761 ⟸ ENSCLAT00000012909

Ensembl Acc Id:

ENSCLAP00000012760 ⟸ ENSCLAT00000012908

Ensembl Acc Id:

ENSCLAP00000012759 ⟸ ENSCLAT00000012907

Ensembl Acc Id:

ENSCLAP00000012758 ⟸ ENSCLAT00000012906

Ensembl Acc Id:

ENSCLAP00000012762 ⟸ ENSCLAT00000012910

Protein Domains

B30.2/SPRY EF-hand MIR

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008810	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000012906	ENTREZGENE
	ENSCLAT00000012906.1	UniProtKB/TrEMBL
	ENSCLAT00000012907.1	UniProtKB/TrEMBL
	ENSCLAT00000012908.1	UniProtKB/TrEMBL
	ENSCLAT00000012909.1	UniProtKB/TrEMBL
	ENSCLAT00000012910.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.70	UniProtKB/TrEMBL
	1.10.490.160	UniProtKB/TrEMBL
	2.60.120.920	UniProtKB/TrEMBL
	2.80.10.50	UniProtKB/TrEMBL
	6.20.350.10	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
	IP3 receptor type 1 binding core, RIH domain	UniProtKB/TrEMBL
InterPro	B30.2/SPRY	UniProtKB/TrEMBL
	B30.2/SPRY_sf	UniProtKB/TrEMBL
	ConA-like_dom_sf	UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	Ins145_P3_rcpt	UniProtKB/TrEMBL
	Ion_trans_dom	UniProtKB/TrEMBL
	MIR_dom_sf	UniProtKB/TrEMBL
	MIR_motif	UniProtKB/TrEMBL
	RIH_assoc-dom	UniProtKB/TrEMBL
	RIH_dom	UniProtKB/TrEMBL
	Ryan_recept	UniProtKB/TrEMBL
	Ryanodine_IP3_receptor	UniProtKB/TrEMBL
	Ryanodine_rcpt	UniProtKB/TrEMBL
	Ryanrecept_TM4-6	UniProtKB/TrEMBL
	RYDR_Jsol	UniProtKB/TrEMBL
	RyR/IP3R_RIH_dom_sf	UniProtKB/TrEMBL
	SPRY1_RyR	UniProtKB/TrEMBL
	SPRY2_RyR	UniProtKB/TrEMBL
	SPRY3_RyR	UniProtKB/TrEMBL
	SPRY_dom	UniProtKB/TrEMBL
NCBI Gene	Ryr3	ENTREZGENE
PANTHER	B30.2/SPRY DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	RYANODINE RECEPTOR 3	UniProtKB/TrEMBL
Pfam	Ins145_P3_rec	UniProtKB/TrEMBL
	Ion_trans	UniProtKB/TrEMBL
	MIR	UniProtKB/TrEMBL
	RIH_assoc	UniProtKB/TrEMBL
	RR_TM4-6	UniProtKB/TrEMBL
	RYDR_ITPR	UniProtKB/TrEMBL
	RYDR_Jsol	UniProtKB/TrEMBL
	RyR	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
PRINTS	RYANODINER	UniProtKB/TrEMBL
PROSITE	B302_SPRY	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	MIR	UniProtKB/TrEMBL
SMART	MIR	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF100909	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
	SSF49899	UniProtKB/TrEMBL
	SSF82109	UniProtKB/TrEMBL
UniProt	A0A8C2VB65	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2VC76_CHILA	UniProtKB/TrEMBL
	A0A8C2VE97_CHILA	UniProtKB/TrEMBL
	A0A8C2VHG8_CHILA	UniProtKB/TrEMBL
	A0A8C2YP11	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations