Advanced Search (OLGA)

Gene: RYR3 (ryanodine receptor 3) Sus scrofa

Analyze

Symbol:

RYR3

Name:

ryanodine receptor 3

RGD ID:

13906535

Description:

ENCODES a protein that exhibits calcium-induced calcium release activity (ortholog); ryanodine-sensitive calcium-release channel activity (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); negative regulation of cytosolic calcium ion concentration (ortholog); response to hypoxia (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH amenorrhea (ortholog); arthrogryposis multiplex congenita (ortholog); Bloom syndrome (ortholog); FOUND IN cytoplasmic side of plasma membrane (ortholog); junctional membrane complex (ortholog); perinuclear region of cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

brain ryanodine receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RYR3 (ryanodine receptor 3)	HGNC	Ensembl, NCBI, OrthoDB
Mus musculus (house mouse):	Ryr3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ryr3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ryr3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RYR3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RYR3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ryr3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ryr3 (ryanodine receptor 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	80,640,123 - 81,208,491 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	80,640,030 - 81,208,576 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Pig Cytomap	7	q22-q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

arthrogryposis multiplex congenita (ISO)

Bloom syndrome (ISO)

colorectal cancer (ISO)

congenital myopathy 20 (ISO)

Contracture (ISO)

developmental and epileptic encephalopathy (ISO)

epilepsy (ISO)

fetal akinesia deformation sequence syndrome 1 (ISO)

Generalized Epilepsy (ISO)

genetic disease (ISO)

gestational diabetes (ISO)

hepatocellular carcinoma (ISO)

Hydrops Fetalis (ISO)

Monomelic Amyotrophy (ISO)

pre-eclampsia (ISO)

primary ovarian insufficiency (ISO)

pulmonary hypertension (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion transmembrane transport (IEA)

calcium ion transport (IEA)

calcium-mediated signaling (IEA)

intracellular calcium ion homeostasis (IEA,ISO)

negative regulation of cytosolic calcium ion concentration (ISO)

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (IBA)

response to hypoxia (ISO)

striated muscle contraction (IBA,ISO)

Cellular Component

calcium channel complex (IBA)

cytoplasmic side of plasma membrane (ISO)

junctional membrane complex (ISO)

membrane (IEA)

perinuclear region of cytoplasm (ISO)

sarcolemma (IBA)

sarcoplasmic reticulum (IEA)

sarcoplasmic reticulum membrane (IBA,IEA)

smooth endoplasmic reticulum (IBA)

Z disc (IBA)

Molecular Function

calcium channel activity (IEA)

calcium ion binding (IEA)

calcium-induced calcium release activity (ISO)

calmodulin binding (IEA)

intracellularly gated calcium channel activity (IEA)

ryanodine-sensitive calcium-release channel activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium transport pathway (ISO)

calcium/calcium-mediated signaling pathway (ISO)

References

Additional References at PubMed

PMID:7989322	PMID:10072592	PMID:10902927	PMID:14681463	PMID:17145712	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

RYR3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	80,640,123 - 81,208,491 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	80,640,030 - 81,208,576 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Pig Cytomap	7	q22-q23	NCBI

RYR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	33,310,967 - 33,866,102 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	33,310,962 - 33,866,121 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	33,603,168 - 34,158,303 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	31,390,469 - 31,945,595 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	31,390,468 - 31,945,594	NCBI
Celera	15	10,404,754 - 10,960,825 (+)	NCBI		Celera
Cytogenetic Map	15	q13.3-q14	NCBI
HuRef	15	10,464,756 - 11,021,191 (+)	NCBI		HuRef
CHM1_1	15	33,721,203 - 34,276,301 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	31,107,439 - 31,663,747 (+)	NCBI		T2T-CHM13v2.0

Ryr3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	112,461,699 - 113,047,755 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	112,461,700 - 113,047,441 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	112,631,354 - 113,217,405 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	112,631,355 - 113,217,096 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	112,471,537 - 112,870,488 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	112,432,219 - 112,831,170 (-)	NCBI		MGSCv36	mm8
Celera	2	113,779,152 - 114,176,095 (-)	NCBI		Celera
Cytogenetic Map	2	E3- E4	NCBI
cM Map	2	57.2	NCBI

Ryr3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	119,886,129 - 120,433,465 (-)	NCBI		GRCr8
mRatBN7.2	3	99,431,755 - 99,979,125 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	99,432,505 - 99,704,961 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	104,117,307 - 104,665,151 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	104,118,063 - 104,504,204 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	110,710,040 - 111,249,930 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	98,476,626 - 98,872,629 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	98,375,910 - 98,382,386 (-)	NCBI
Celera	3	98,415,656 - 98,961,847 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

Ryr3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	713,373 - 1,259,885 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	712,506 - 1,260,111 (-)	NCBI	ChiLan1.0	ChiLan1.0

RYR3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	22,089,131 - 22,652,150 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	26,810,910 - 27,373,696 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	11,816,430 - 12,379,101 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	30,652,244 - 31,215,359 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	30,817,428 - 31,214,494 (+)	Ensembl	panpan1.1		panPan2

RYR3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	1,179,575 - 1,533,352 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	1,180,359 - 1,533,619 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	1,223,971 - 1,742,310 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	1,278,037 - 1,798,290 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	1,278,037 - 1,798,542 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	1,224,326 - 1,741,522 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	1,323,490 - 1,840,773 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	1,451,015 - 1,969,019 (-)	NCBI		UU_Cfam_GSD_1.0

Ryr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	79,716,961 - 80,219,351 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936673	1,932,755 - 2,434,066 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936673	2,078,095 - 2,434,872 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Ryr3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	467,295 - 1,030,212 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	467,207 - 1,030,873 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in RYR3
17412 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	2	22	3	5	11	10	22	2	6	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021099907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ133741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ133742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK394706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT826372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU469106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01128066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U15975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X95846	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000046623 ⟹ ENSSSCP00000046204

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	7	80,640,247 - 81,208,491 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000074288 ⟹ ENSSSCP00000069017

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	7	80,640,123 - 81,208,491 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000077872 ⟹ ENSSSCP00000069907

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	7	80,640,245 - 81,208,334 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000090710 ⟹ ENSSSCP00000067792

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	7	80,640,247 - 81,208,491 (-)	Ensembl

RefSeq Acc Id:

XM_021099907 ⟹ XP_020955566

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	7	80,640,030 - 81,208,576 (-)	NCBI

Sequence:

show sequence

CCCGCTGCCGCCGCGCACTTGGCTGGGGCGAGAGGCGAGAGGGTAGGCGGGCTGCTTGGTTGGC
GTTGGCGCTCTGCAGTGCAGTGGAGTGTTAGCCCAGCTCCCTATATGGTCGGGGATTAGCTCGG
CGCAGCTGAGGCTGAGCCAGGAGTCGGAGGAGGAGGAGGAAGAGGAGGGGAAGAAGGAGGAGGA
GAAAGAGCGCAGCAGCAGCGGGCGCACGCCGAGCGGCTGCCGGGGGAAGCAGAGGCGCCGGAGG
CTGGGGCACCGCCGACGCCTCGGGAGCCATGACCGAAGGGGGAGAAGGAGGCGAGGACGAGATC
CAGTTCCTGCGGACTGAAGATGAAGTGGTCCTCCAGTGCATCGCCAACGTTCACAAGGAGCAGA
GGAAGTTCTGTCTGGCAGCTGAGGGACTTGGGAATCGCCTGTGCTTCTTGGAACCTACTTCAGA
AGCCAAGTATGTTCCTCCAGATCTCTGCGTCTGCAATTTTGTGCTGGAACAGTCCCTCTCTGTC
AGAGCCCTTCAGGAAATGCTTGCCAACACAGGTGAAAATGGCGGCGAAGGGGCGGCACAAGGGG
GTGGCCACAGGACCCTGCTCTACGGCCACGCGATTCTCCTGCGGCACTCTTTCAGCGGAATGTA
TCTAACATGTTTGACTACATCAAGATCCCAGACAGATAAACTTGCCTTTGATGTAGGTCTACGG
GAACATGCCACAGGAGAAGCCTGTTGGTGGACCATACATCCCGCTTCCAAGCAGAGGTCTGAGG
GAGAAAAGGTTCGAATTGGCGATGACCTCATCCTTGTCAGCGTGTCCTCTGAAAGATACCTTCA
TCTCTCAATATCAAATGGTAACATACAAGTGGACGCCTCCTTCATGCAAACCCTCTGGAATGTA
CATCCCACTTGCTCAGGAAGCAGCGTCGAAGAAGGATACCTACTTGGTGGCCACGTAGTACGTC
TTTTCCACGGTCATGATGAGTGTATGACGATACCATCTACAGACCAGAATGATTCCCAGCACAG
GAGGATATTCTACGAAGCCGGAGGAGCTGGCACAAGAGCCAGATCATTGTGGAGAGTAGAACCC
CTTCGGATAAGCTGGAGTGGCAGTAACATCAGATGGGGCCAGGCTTTCCGACTTCGGCATCTTA
CTACAGGCCACTACTTGGCCTTGACAGAGGACCAAGGCCTTATACTGCAGGACAGGGGAAAATC
AGACACCAAGTCCACAGCCTTCTCCTTTCGGGCATCAAAGGAAATCAAGGAGAAATTGGATTCC
AGCCACAAGCGCGATATAGAAGGCATGGGAGTCCCAGAAATCAAGTATGGAGACTCCATCTGCT
TTGTCCAGCACGTAGCCAGTGGTCTGTGGGTGACCTACAAAGCACAAGATGCCAAGACATCCCG
CCTTGGACCTCTGAAAAGAAAGGTCATACTCCATCAGGAAGGCCACATGGATGATGGGTTAACT
CTGCAGAGATGCCAGCGTGAGGAGTCCCAGGCCGCTCGGATCATCCGGAACACGACAGCCTTAT
TCAGCCAGTTTGTAAGTGGAAACAACCGCACAGCCGCCCCTGTCACCTTGCCAATAGAAGAGGT
CCTGCAGACCTTACACGACTTGATTGCCTACTTCCAGCCCCCCGAGGAGGAGATGCAGCACGAG
GATAAGCAGAACAAGCTCCGCTCGCTCAAAAACAGACAGAACCTTTTCAAGGAAGAGGGAATGT
TGGCCCTTGTGTTGAACTGCATTGATCGCTTAAATATCTACAATAGCATAGCACACTTTGCAGG
GATTGCCAGGGAGGAGAGTGGCATGGCCTGGAAAGAAATTCTGAACCTCCTGTACAAATTGCTG
GCTGCTCTCATTCGTGGAAACAGAAACAACTGCGCTCAATTCTCCAATAACCTTGACTGGCTAA
TCAGCAAATTGGACAGACTAGAATCTTCCTCAGGTATCTTGGAAGTTTTGCACTGCATCCTGAT
TGAAAGCCCGGAAGCCTTAAATCTGATAGCAGAGGGTCACATCAAGTCCATCATCTCCCTGTTG
GATAAGCACGGGAGGAACCACAAGGTTCTGGATGTGCTGTGTTCCCTCTGTCTCTGCAATGGAG
TCGCCGTGAGGGCCAACCAGAATCTGATCTGTGACAACTTGCTGCCCCGAAGAAACCTGCTCCT
GCAGACGCGGCTGATTAACGATGTGACAAGTATTCGGCCGAACATCTTCCTGGGAGTTGCTGAG
GGCTCTGCACAGTATAAGAAGTGGTACTTTGAGCTCATCATCGACCAGGTGGACCCCTTCCTCA
CAGCAGAGCCCACACACCTACGGGTGGGCTGGGCCTCCTCCTCAGGCTATGCCCCGTACCCTGG
AGGTGGAGAAGGCTGGGGAGGCAACGGAGTTGGTGATGACCTGTACTCCTATGGCTTCGATGGA
CTTCAGCTTTGGTCAGGTCGCATACCCAGAGCTGTGGCCTCCATCAACCAGCACCTCCTGAAGT
CGGACGATGTGGTGAGCTGCTGCCTGGACCTCGGAGCACCCAGCATCTCCTTCCGTATCAACGG
GCAGCCTGTGCAGGGGATGTTTGAGAATTTCAACACAGATGGGCTCTTCTTCCCTGTGGTGAGC
TTTTCAGCAGGTGTCAAAGTACGTTTCCTGATGGGTGGACGTCATGGAGAATTTAAGTTCCTGC
CTCCTTCTGGCTATGCTCCTTGCTATGAAGCCTTACTTCCAAAAGAAAAGATGAGACTGGAGCC
TGTCAAAGAGTATAAACGTGATGCTGAAGGCATTCGAGATCTGTTGGGTACCACACAGTTCCTC
TCCCAAGCTTCTTTCATCCCGTGCCCCATAGACACCAGTCAGGTGGTTTTGCCACCTCACCTAG
AGAAGATCCGAGACAGGCTGGCTGAAAACATCCATGAGCTTTGGGGAATGAATAAAATAGAGCT
TGGCTGGACTTTTGGCAAGATACGGGATGACAATAAAAGACAACACCCCTGCCTTGTCGAGTTT
TCAAAGCTGCCTGAAACTGAGAAGAATTATAACCTACAGATGTCAACTGAAACCTTAAAAACCC
TCCTGGCCCTGGGCTGCCACATTGCTCATGTTAACCCAGCTGCTGAGGAGGAGCTCAAGAAGGT
CAAATTGCCCAAAAACTACATGATGTCCAACGGCTATAAGCCAGCCCCTTTGGATTTGTCTGAT
GTGAAGCTGTTACCTTCCCAAGAAATTTTAGTGGATAAGCTTGCAGAAAATGCACACAATGTTT
GGGCAAAAGACAGGATAAAACAAGGATGGACCTATGGCATTCAACAGGATTTAAAAAACAAAAG
AAATCCCCGTCTGGTGCCTTATGCACTACTGGATGAGCGGACCAAGAAGTCAAACAGAGATAGC
CTTCGTGAGGCTGTTCGGACATTTGTTGGTTATGGCTATAACATTGAACCGTCAGACCAAGAAC
TAGCTGACCCAGCCGTGGAGAAAGTCAGCATAGACAAGATCCGATTTTTCCGGNGTGAACGCTC
TTATGCAGTGAGATCAGGAAAGTGGTATTTTGAGTTTGAGGTGGTGACCGGAGGAGACATGCGG
GTCGGCTGGGCCAGGCCAGGCTGTCGGCCTGACATCGAGCTGGGGGCTGACGACCAAGCCTTTG
TGTTTGAAGGCAGCAGGGGTCAGCGTTGGCATCAAGGGAGTGGGTATTTTGGACGGACCTGGCA
GCCAGGAGATGTGGTTGGATGTATGATCAACCTCGAAGATGCTTCAATGATCTTCACGCTGAAT
GGGGAGCTGCTGATCACCAACAAAGGCTCTGAACTTGCCTTCGCTGACTATGAGATTGACAACG
GCTTTGTACCCATCTGCTCTCTGGGACTGTCTCAGATTGGCCGCATGAATCTTGGGATGGACGC
CAGCACCTTCAAATTTTATACCATGTGTGGCCTACAAGAGGGCTTTGAGCCTTTCGCTGTCAAC
ATGAACCGCGACGTGGCCATGTGGTTCAGCAAGCGCCTCCCGACGTTTGTCAATGTGCCAAAGG
ACCATCCACAGATAGAGGTCGTGAGGATTGACGGCACCATGGACAGCCCTCCTTGCCTCAAGGT
GACCCACAAGACGTTCGGCACACAGAACAGCAGCGCCACCATGGTCTACTGCCGTCTGAGCATG
CCCGTCGAGTGCCACTCGTCCTTCAGTCATAGCCCCTGTCTGGACAGTGAAGCTTTCCAGAAAA
GGAAACAGATGCAAGAACTACTCTCTCAAACAACAACACAGTGCTACTACGCAATCCGCATCTT
TGCTGGACAGGACCCCTCCTGCGTCTGGGTCGGATGGGTCACTCCAGACTATCACTTGTACAGT
GAAAAGTTTGACCTGAATAAAAACTGCACCGTGACTGTCACTCTGGGGGATGAGAGAGGCCGGG
TCCACGAAAGTGTGAAACGCAGCAACTGCTACATGGTCTGGGGTGGGGACATCGTAGCTACCTC
CCAAAGAACAAGTCGCAGCAACGTGGACCTGGAGATCGGCTGCCTTGTGGACCTGGCGATGGGC
ATGTTGTCCTTCTCTGCCAACGGGCGGGAACTCGGCACCTGCTACCAGGTGGAGCCCAATACCA
AAGTGTTTCCAGCAGTCTTCCTGCAGCCTACGAGCACTTCATTGTTTCAGTTCGAACTCGGGAA
GCTGAAGAATGCCATGCCCCTGTCGGCAGCCATATTCAAGAGCGAAGAGAAGAACCCAGTCCCA
CAGTGCCCGCCTCGGCTGGACGTCCAGACCATCCAGCCCGTGCTCTGGAGCCGCATGCCCAACA
GCTTCCTGAAAGTGGAGATGGAGCGGGTGAGCGAGCGCCACGGCTGGATGGTGCAGTGCCTGGA
GCCCCTGCAGATGATGGCGCTGCACATCCCTGAGGAGAACAGGTGTGTGGACATCCTGGAGCTC
TGCGAGCAGGAGGACCTGATGCGGTTCCACTACCACACGCTGAGACTCTACAGCGCCGTGTGTG
CCCTGGGAAACAACCGGGTGGCCTATGCACTGTGCAGCCACGTGGACCTCTCCCAGCTGCTCCA
CTCCATTGACAACAAGTACCTCCCCGGCCTCTTGCGCTCCGGCTTCTACGACCTGCTCATCAGC
ATCCACCTGGCCAGCGCCAAGGAGAGGAAGCTGATGATGAAGAATGAATACATCATCCCCATCG
CCAGCGCCACCAGGAAAATCCGCCTATACCCGGACGAGTCCAAGAGGCATGGGCTCCCTGGGGT
GGGATTGAGAACCTGCCTCAAGCCGGGGTTCAGGTTCTCCACCCCCTGCTTTGTCGCCACGGGC
GAGGAGCACCAGAAGCAGAGCCCTGAGATCCCCCTGGAGCTTCTCAAGACGAAGGCGCTGAGCA
TGCTGACCGAGGCGGTGCAGTGCAGCGGAGCCCACATCCGGGACCCTGTCGGGGGGTCAGTGGA
GTTCCAGTTCGTGCCTGTGCTGAAGCTCATCGGAACCCTGCTGGTCATGGGGGTGTTCGACGAT
GACGATGTTCGGCAGATCCTCCTCCTCATCGATCCCTCCGTGTTCGGGGAGCACAGTGGGGAGT
CAGAGGAGGGCGCAGAGAAGGAGGAGGTGACCCAGGTGGAAGAGAAGGCGGTGGAGGCTGGGGA
AAAGGCCAACAAGGAGGCTCCTGTCAAAGGCTTGTTGCAGACTCGATTACCGGAGTCGGTCAAG
CTGCAGATGTGTGAACTCCTCAGCTATCTCTGTGACTGTGAGCTGCAGCACCGGGTGGAGGCCA
TTGTGGCATTTGGTGACATTTATGTCTCCAAGCTCCAGGCAAATCAGAAGTTCCGCTACAATGA
GCTCATGCAGGCCCTGAACATGTCTGCAGCCCTGACCGCCCGGAAGACCAGGGAGTTCCGCTCA
CCCCCACAGGAGCAGATCAACATGCTTCTTAACTTTCAACTGGGAGAGAACTGCCCGTGTCCAG
AAGAGATCCGGGAGGAGCTGTACGACTTCCACGAGGACCTTCTCCTTCACTGTGGGGTTCCCTT
GGAGGAAGAGGAAGAGGAAGAAGAGGACGTATCCTGGACTGGAAAATTCCGTGCCTTGGTGTAT
AAAATCAGAGGGCCTCCCAAGCCAGAGAAGGAGCAGCCAACAGAGGAGGAGGAGAGATGCCCTA
CAACGCTGAAGGAGCTCATCTCACAGACCATGATCCGCTGGGCCCAGGAGGACCAGATCCAGGA
TGCCGAGCTGGTCCGAATGATGTTCAACCTCCTACAGAGGCAGTATGACAGCATTGGGGAGCTG
CTGCAGGCGCTGCGGAAAACCTACACCATCAGCCAGGCCTCTGTGAGCGACACCCTCAGCCTGC
TGGCCGCCCTGGGCCAGATCCGCTGCTTGCTCAGTGTGCGGATGGGCAAAGAGGAGGAGCTGCT
CATGATCAACGGGCTGGGAGACATAATGAACAATAAGGTGTTTTACCAGCACCCCAACCTCATG
CGAGTCCTTGGCATGCACGAGACAGTGATGGAGGTGATGGTGAACGTGCTGGGCACAGAGAAAT
CTCAGATTGCCTTTCCAAAGATGGTTGCTAGCTGTTGCCGCTTCCTTTGCTACTTCTGTCGAAT
CAGCCGGCAAAATCAGAAGGCCATGTTCGAGCACCTGAGTTACCTGCTGGAGAATAGCAGTGTT
GGCCTAGCCTCCCCTTCGATGAGAGGATCCACCCCACTGGATGTGGCTGCTTCCTCTGTGATGG
ACAACAACGAGTTAGCTCTGGGCTTGGAGGAGCCAGACCTCGAGAAGGTGGTGACCTACTTGGC
AGGCTGTGGCCTGCAGAGCTGCCCCATGCTTCTGGCCAAAGGGTATCCTGATGTCGGCTGGAAC
CCCATCGAAGGGGAGCGCTACCTGTCCTTCCTGAGGTTTGCCGTCTTCGTGAACAGTGAAAGTG
TGGAAGAAAATGCTAGTGTCGTGGTCAAGCTGCTCATCAGACGCCCCGAGTGCTTTGGCCCGGC
CCTGCGGGGCGAAGGAGGAAACGGTCTGTTGGCGGCCATGCAAGGCGCCATTAAGATCTCTGAG
AACCCAGCCCTTGACCTCCCCTCTCAGGGATACAAGAGAGACGTCAGCACGGAGGACAATGAAA
ATGAAGAGGAGATTGTGCACATGGGCAATGCAATTATGTCATTCTATTCAGCCCTGATAGACCT
GCTGGGCCGCTGTGCCCCTGAAATGCATCTTATCCAGACAGGAAAGGGGGAAGCCCTCCGGATC
AGGTCCATTCTACGCTCCCTGGTCCCCACCGAGGACTTGGTTGGGATCATCAGCATCCCCTTGA
AACTGCCCTCCCTGAACAAAGATGGGTCTGTCAGTGAACCAGACATGGCAGCCAACTTCTGCCC
CGACCACAAGGCACCCATGGTGCTGTTCTTGGACCGCGTTTATGGCATCAAGGACCAAGCTTTT
CTGCTCCACTTGCTGGAGGTTGGGTTTTTACCTGACTTAAGAGCTTCTGCCTCTCTAGATACAG
TTTCCCTCAGCACGACAGAGGCTGCGCTGGCACTGAACAGGTACATATGCTCAGCGGTGCTGCC
GCTGCTCACAAGGTGCGCCCCTCTATTTGCCGGAACAGAGCACTACACCTCTTTGATCGACTCG
ACACTCCAGACGATATACAGGCTCTCCAAGGGGCGCTCCCTCACCAAAGCTCAGAGGGACACCA
TAGAGGAGTGTCTGCTCGCCATTTGCAATCACCTGAGGCCTTCCATGTTACAGCAGCTCCTGCG
ACGTCTGGTTTTTGATGTACCCCAACTCAATGAATACTGCAAAATGCCTCTGAAGCTTCTGACA
AATCACTACGAACAGTGCTGGAAGTATTACTGTCTGCCTTCGGGATGGGGGAGCTACGGTCTGG
CTGTGGAGGAAGAGCTGCATCTGACGGAGAAGCTCTTTTGGGGGATTTTTGACTCCCTCTCCCA
CAAGAGGTACGACCAGGATCTTTTCCGAATGGCCCTGCCTTGTCTCAGTGCTATCGCTGGGGCT
CTGCCTCCAGATTATTTAGATACCAGAATCTCCACCACATTGGAGAAACAGATCTCAGTGGATG
CAGATGGCAACTTTGACCCCAAACCTATCAACACTATGAATTTCTCCTTGCCTGAAAAATTGGA
ATACATCGTCACCAAGTACGCGGAGCATTCACATGATAAATGGGCCTGTGACAAGAGTCAGAAT
GGATGGAAATATGGAATTTCCCTGGATGAAAATGTGAAGACCCATCCACTGATCAGGCCTTTCA
AGACATTAACGGAGAAGGAGAAGGAAATTTATCGCTGGCCTGCCAGAGAGTCCCTGAAAACCAT
GCTGGCTGTAGGCTGGACAGTGGAGAGGACCAAAGAGGGAGAAGCCCTAGTTCAACAGCGGGAA
AACGAGAAGCTTCGAAGCGTGTCCCAGGCCAGCCAGGGCAACAGCTACAGCCCTGCTCCCCTGG
ACCTCTCCAATGTCGTGCTGTCCAGAGAACTCCAGGGGATGGTGGAGGTGGTAGCTGAGAACTA
TCACAATATCTGGGCCAAGAAGAAGAAGCTGGAGCTGGAGAGCAAAGGTGGCGGCAGTCACCCT
CTTTTGGTCCCATATGACACCTTGACTGCCAAGGAAAAGTTCAGGGACCGAGAGAAGGCACAGG
ACCTGTTTAAGTTCCTCCAAGTGAATGGCATTGTGGTTTCTAGAGCTATGAAGGATATGGAGCT
GGATGCCTCCTCCATGGAAAAGAGGTTTGCCTATAAGTTTTTAAAGAAGATCCTGAAGTATGTT
GACTCTGCTCAAGAGTTTATTGCCCATTTGGAAGCCATTGTCAGCAGTGGGAAAACTGAAAAGT
CTCCCCATGACCAGGAGATTAAATTCTTTGCCAAGGTCCTCCTCCCTCTGGTTGACCAGTACTT
CACCAATCACCGCCTCTACTTCCTGTCCTCCCCTCTGAAGCCCCTGAGCAGCAGTGGGTATGCC
TCCCATAAGGAGAAAGAAATGGTGGCCAGCCTGTTCTGCAAACTCGCTGCTCTTGTTCGACACA
GGATTTCCCTCTTCGGGAGCGATTCTACTACAATGGTGAGCTGTCTTCACATCTTAGCTCAGAC
ACTTGACACAAGGACAGTCATGAAGTCAGGCTCGGAGCTGGTGAAGGCTGGGTTACGAGCATTC
TTTGAAAATGCAGCAGAAGATTTAGAGAAGACTTCCGAAAACCTGAAGCTCGGGAAGTTTACCC
ATTCCAGAACACAGATTAAAGGTGTTTCTCAGAATATCAACTATACCACGGTGGCTCTGCTCCC
CATCCTGACGTCCATCTTTGAGCACGTGGCTCAGCATCAGTTTGGGGTGGATTTACTCTTGGGT
GACGTGCAGATTTCATGCTATCACATACTGTGCAGCCTCTACTCCCTCGGGACCGGAAAGAACA
TCTATGTTGAAAGGCAACGGCCTGCCCTTGGAGAATGCCTGGCCTCCCTGGCAGCTGCCATACC
TGTGGCATTCCTGGAGCCTGCCCTTAACCGCTACAATCCACTCTCGGTCTTCAACACCAAAACC
CCCAGGGAGAGGTCTATTCTGGGGATGCCAGACACGGTGGAGGAGATGTGCCCGGACATCCCCC
AGCTGGAAGGCCTGATGAAGGAAATCAACGACCTGGCCGAGTCAGGGGCCCGGTACACAGAGAT
GCCCCACGTCATCGAGGTGATCCTGCCCATGCTCTGCAACTACCTGTCCTACTGGTGGGAGCGG
GGACCTGAGCACCTGCCGCCCAGCACAGGGCCCTGGTGCACCAAAGTCACCTCCGAACACCTCA
GTGTCATCCTGGGCAACATTCTGAAAATCATTAACAACAACCTGGGCATCGACGAGGCCTCCTG
GATGAAGCGCATTGCAGTGTACGCCCAGCCAATCATCAGCAAAGCCAGACCAGACCTGCTGAGA
AGCCACTTCATCCCAACACTGGAGAAGCTAAAGAAGAAGGCTGTCAAGACTGTGCAGGAAGAGG
AGCAGCTGAAAGCCGACAGCAAAGGGGACACTCAGGAGGCAGAGCTCCTCATCCTGGACGAGTT
TGCCGTCCTCTGCCGGGATCTCTACGCCTTCTACCCCATGCTGATCCGCTACGTGGACAACAAC
AGATCTAACTGGCTCAAAAGCCCAGATGCTGACTCTGACCAGCTCTTCCGCATGGTGGCAGAGG
TCTTCATCCTGTGGTGCAAATCTCACAACTTCAAGCGGGAAGAACAAAATTTTGTGATTCAGAA
TGAAATTAATAATTTGGCGTTCTTAACTGGAGACAGCAAAAGCAAGATGTCAAAAGCCATGCAA
GTAAAGTCTGGAGGACAGGACCAGGAGCGGAAGAAGACAAAGCGGAGGGGAGACTTGTATTCCA
TCCAGACCTCCCTCATCGTGGCTGCGCTCAAGAAAATGCTGCCCATCGGTTTGAATATGTGCAC
CCCAGGTGATCAGGAGCTGATCTCCCTCGCAAAATCACGATACAGCTGTAGGGACACAGATGAA
GAGGTGAAGGGACACCTGCGGAATAATTTGCACTTGCAAGAAAAGTCTGATGACCCAGCTGTAA
AGTGGCAACTGAACCTATACAAGGATGTTTTGAAGAGTGAAGAACCTTCCAACCCAGAAAAGAC
AGTGGAGCGTGTACAAAGAATTTCAGCAGCTGTCTTCCACCTGGAGCAGGTGGAACAGCCTTTG
AGGTCCAAGAAGGCAGTCTGGCACAAACTGCTATCAAAGCAGCGGAAACGGGCAGTGGTGGCCT
GTTTCAGAATGGCCCCTCTCTACAACCTTCCCAGGCACCGCTCTATTAACCTCTTCCTCCATGG
CTATCAGAGATTTTGGATAGAAACAGAGGAGTATTCCTTTGAAGAGAAACTAGTACAGGATTTG
GCTAAATCTCCCAAGGTGGAAGAGGAGGAGGAGGAGGAGACAGACAAGCAGCCAGACCCGCTTC
ATCAGATCATCCTCCACTTTAGCCGCAATGCTCTGACGGAGAGGAGCAAACTGGAAGACGACCC
TTTGTACACCTCCTATTCTAGCATGATGGCCAAGAGTTGTCAGAGTGGGGAAGATGAAGAAGAG
GAGGAAGACAAGGAAAAAACATTTGAAGAAAAAGAAATGGAAAAGCAGAAAACCCTCTATCAGC
AAGCTCGTCTGCATGAGCGTGGAGCTGCTGAGATGGTCCTTCAGATGATAAGCGCCAGCAAAGG
TGAGATGAGCCCCATGGTGGTTGAGACTCTGAAGCTGGGGATTGCCATCCTGAACGGGGGTAAC
GCCGGCGTGCAGCAGAAAATGCTAGATTACCTAAAGGAGAAAAAGGATGCCGGGTTCTTTCAAA
GCCTTTCTGGTCTTATGCAGTCTTGCAGTGTCCTTGATTTGAATGCATTTGAGAGGCAGAATAA
AGCTGAAGGCCTGGGGATGGTTACTGAGGAAGGAACACTGATTGTTCGTGAACGGGGTGAAAAA
GTACTCCAGAATGACGAGTTTACACGTGATCTCTTTAGATTCCTACAGTTACTTTGTGAAGGAC
ATAACAGTGACTTCCAGAACTTCCTGCGGACTCAGATGGGCAACACCACCACCGTGAACGTCAT
CATCAGTACCGTGGACTATCTCCTCCGTCTGCAGGAATCAATCAGTGATTTCTACTGGTATTAT
TCAGGGAAAGACATCATTGATGAGTCTGGGCAGCACAATTTTTCCAAAGCCCTAGCCGTCACCA
AGCAGATTTTCAACTCTCTTACAGAATACATTCAGGGCCCCTGCATTGGGAACCAGCAGAGCCT
GGCTCACAGTAGGCTGTGGGACGCAGTGGTTGGCTTCCTCCATGTATTTGCTAACATGCAGATG
AAACTCTCTCAGGATTCCAGTCAGATCGAGCTGCTGAAGGAACTCTTGGATCTCCTTCAGGACA
TGGTGGTGATGCTTCTGTCCCTCCTGGAAGGGAATGTGGTAAATGGAACTATTGGCAAGCAGAT
GGTTGACACACTGGTAGAGTCATCTACCAATGTAGAAATGATCTTGAAATTCTTTGACATGTTC
TTGAAACTTAAAGACTTAACCAGCTCAGACACCTTCCAAGAATATGACCCCGATGGGAAAGGGA
TCCTCTCCAAAAAGGAATTCCAGAAGGCCATGGAAGGGCAAAAACAGTACACACAGTCAGAGAT
TGACTTTCTCCTTTCGTGTGCCGAAGCTGATGAGAATGACATGTTTAATTACATGGATTTTGTA
GACCGGTTCCACGAGCCGGCCAAGGACATAGGGTTTAACGTGGCCGTGCTCCTGACAAATCTTT
CTGAACATATGCCAAATGATTCTCGCCTCAAGTGTCTGCTGGACCCAGCAGAAAGTGTGCTGAA
TTACTTTGAACCCTACCTGGGACGCATTGAGATCATGGGTGGGGCCAAGAAAATTGAGCGTGTT
TATTTTGAGATCAGCGAATCCAGCCGAACTCAGTGGGAAAAGCCCCAGGTGAAGGAGTCTAAGC
GTCAGTTCATCTTTGATGTCGTCAATGAAGGCGGAGAACAAGAGAAGATGGAGCTGTTTGTGAA
CTTCTGTGAGGATACCATCTTTGAAATGCAGTTAGCATCTCAGATCTCAGAATCGGACTCAGCC
GACCGTCCAGAAGAGGAGGAGGAAGAGGATGAAGAGTCTTCTTATCCGTTAGAAGTTGAGGACG
AAGAGGAGGACAACAGGTCTTTTGAATGTGCCTCTGCATTTGCCGTAGCCTGTGCCTCAGTGAA
GAGAAACGTGGCCCGCTTTCTGCAGAGGGCCACCCTGAAGAACCTCAGGAAGCAGTACAGGAAG
GTAAAGAAGATGACCCTGAAGGAGCTGGTGAGGGTGTTCTTCTCCTTCTTCTGGATGCTGTTCG
TGGGGCTCTTCCACTTGCTCTTCACCATATTGGGAGGAATCTTTCAGATCCTCTGGAGCACAGT
GTTTGGAGGGGGCCTTGTAGAAGGGGCCAAGAACATCAGAGTCACCAAGATCCTGGGGGACATG
CCTGACCCAACCCAGTTTGGGATCCACGATGATGCTCTGGAGGCTGAGAGGGCAGAAGTGCCTG
AGACGGGCGTCCCCACGGAACTTGTACACTTCGTCAAGGGGGAGAAGGGAGATGCAGATATTAT
GTCAAATCTCTTTGGATTCCACGCAAAGAGGGAAGGTGCCTTAAAGCATGGGCCCGAAGTGGGT
TTGGGTGACCTCTCTGAGATTATTGGCAAAGATGAGCCCCCTACATTAGAGAGTACTGTACAGA
AGAAAAGGAAAGCACAGGCAGCAGAGATGAGAGCAGCTCATGAAGCAGAGGGAAAAGTAGATTC
TGAGAAAGCAGACATGGAAGATGGGGAGAAAGAGGACACGGCTAAAGAGGAAGAGCAAGCCGAG
GCCCTGTGGGCAGATGTGACAAAGAAGAAGAAGCGCCGGTGTGGCCAGAAAGTTGAGAAGCCTG
AAGCCTTCATGGCCAATTTCTTTAAGGGGCTGGAAATCTATCAGACCAAGTTGCTGCACTACCT
GGCCAGGAATTTCTACAACCTGAGGTTCCTTGCTCTGTTTGTAGCCTTCGCTATCAACTTCATC
CTGCTCTTTTATAAGGTCACCGAAGAACCTTTAGAAGAAGAGACAGAGGATGTTGCAAACCTGT
GGAATTCCTTTAATGATGATGAAGAGGAAGACGCGGTGGTATTCTTTGTCCTGCAGGAAAGCAC
TGGGTATATGGCACCCACACTTCGGGCCCTGGCCATTATCCACACCATCATCTCTTTAGTCTGC
GTGGTGGGCTATTACTGCCTAAAGGTCCCTTTGGTGGTATTCAAAAGAGAAAAAGAAATTGCCA
GGAAGCTGGAGTTCGATGGGCTGTACATCACCGAACAGCCTTCTGAGGATGACATCAAGGGGCA
GTGGGATCGTTTGGTGATCAACACACCATCTTTTCCTAACAACTACTGGGACAAGTTTGTAAAG
AGAAAGGTGATCAACAAGTATGGTGATCTCTACGGAGCAGAACGCATTGCTGAACTCCTGGGTT
TGGACAAAAATGCCCTTGACTTTAGCCCAGTGGAAGAGACCAAAGCGGAGNGCGCCTCTCTGGT
GTCATGGCTAAGTTCCATCGACATGAAGTACCATATCTGGAAACTGGGCGTTGTTTTTACTGAC
AATTCCTTTCTCTACCTTGCCTGGTACACAACCATGTCAGTCCTGGGCCACTACAACAACTTCT
TCTTCGCTGCTCATCTGCTGGATATTGCAATGGGCTTCAAGACCCTGAGGACTATTCTGTCATC
TGTCACTCACAACGGCAAACAGTTGGTCCTGACTGTTGGTCTCCTGGCCGTGGTGGTTTATCTC
TACACTGTGGTGGCATTCAACTTCTTCCGCAAGTTCTACAACAAAAGCGAAGATGATGATGAGC
CTGACATGAAGTGCGATGACATGATGACGTGTTACCTGTTCCACATGTACGTGGGAGTGAGAGC
GGGAGGTGGCATTGGTGATGAAATTGAAGACCCTGCTGGGGACCCGTACGAAATGTACCGCATC
GTCTTTGACATCACTTTCTTCTTCTTCGTCATTGTCATCCTGCTGGCCATCATCCAAGGTCTCA
TTATTGATGCCTTTGGAGAGCTGAGAGACCAGCAGGAACAAGTACGAGAGGATATGGAGACGAA
ATGTTTCATCTGTGGGATTGGCAATGACTACTTTGACACGACCCCTCATGGTTTTGAAACACAC
ACCTTACAAGAACACAACTTAGCCAACTACTTGTTCTTCCTGATGTATTTGATTAATAAAGATG
AAACAGAGCACACAGGCCAGGAATCTTATGTCTGGAAGATGTACCAGGAAAGGTGTTGGGATTT
CTTCCCAGCTGGTGACTGCTTCCGGAAACAGTACGAAGATCAGCTTGGATAAATGATGTGAATG
AAAGAAGCCGCCACTATGCTGGACCCTCAGCTTCCAGTGAAATAAAATCCCCCTCTTAGAAGTT
CTGCACACACATTTAAAAAGTGCTGTTTCCTAAATGCCTCCCTTACAAGAAAGTGTGTGTCAAA
ACCCTGTGATGTTTTGGAATTGATTTGGCTTTTTGTGCCTAATGGAGGTACACTGTGGGAGATA
ACTTGTTACAAGAAAAAAAAGGCAAAGCACCAAGGAAGCTCTAGCTGAATGCCGTCATGTTTTT
CAGTTCAAACTAAGTCATTGGGATGGCAGCACTGAGGGAAGGGCTAGAGGAGCAGGATGTTTTG
AATGCAAATAATACCTGGAATTTTAAACACCTGAATGCCATGATATGCTGCTATCCCACTCGTG
TCTCCTGGTCTGAGCTACAAAAAAATCATCTTAACTGCAGCCTAATTTTTCCCATGGTACTTGC
TAGTGAATGTATCCAGAATCAGCTTGAAAAGCTTTAAGCAGTTAAAGAAATAGAAACAAAAACC
ACCACTTTGTCGACTCTGAAACATCGATTAAGTGCCTTAAAAACCTCTTTAGATATAGCTATGC
AAGTTTTTTATGTTTATGTTCAAGATGGACTATTCATTAATTAGTTGTGTTGATCTTCTGTCTT
ACTTTATGAAACTGCACTTGAAGGTTATTCATATAATTGTTTTCAGTAACAGCTTGTCAACTGC
TGTTATTAGGAGAAAAGTACTGTACTGAAAATTCAGAAAAATCTCAATCTTATGCCAAACTGAG
TAATGCTTTATGGTCCCTTGTAAGTAGTGGAGCTGCTATGTTTAGGTGAATCTCCTTAAATAAA
ATGAAGTGCCCACTGCAATAAAGTAATACACACCAATCCGTGCTCTGTCCTCTTGTCATGCACC
ATTTTCTGGACGATTTACCACCACCCTGAGACTGCTGGGAAAAGGGACAGGAGACAAACAGCCC
AAGGCTTCCCCCACAAGAAAGAAAAAAAATCCACAGACCAGCATTTTGTTTATTTTGACCAAAT
GCATGCCTGGTTGCTTGTCGCTCTATTCTTCAGCAGCACCTGCGATGCTGTCAACAAT

hide sequence

Protein Sequences


Protein RefSeqs	XP_020955566	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA60469	(Get FASTA)	NCBI Sequence Viewer
	CAA65104	(Get FASTA)	NCBI Sequence Viewer
	CAB99492	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000046204
	ENSSSCP00000046204.3
	ENSSSCP00000067792.1
	ENSSSCP00000069017.1
	ENSSSCP00015002900.1
	ENSSSCP00015002903.1
	ENSSSCP00015002907.1
	ENSSSCP00035021511.1
	ENSSSCP00035021521.1
	ENSSSCP00035021528.1
	ENSSSCP00035021533.1
	ENSSSCP00045012362.1
	ENSSSCP00045012576.1
	ENSSSCP00045012780.1
	ENSSSCP00045013096.1
	ENSSSCP00055002273.1
	ENSSSCP00055002325.1
	ENSSSCP00055002356.1
	ENSSSCP00070030964.1
	ENSSSCP00070031037.1
	ENSSSCP00070031135.1
	ENSSSCP00070031189.1
	ENSSSCP00070031249.1

RefSeq Acc Id:

XP_020955566 ⟸ XM_021099907

- UniProtKB:

A0A287AQ64 (UniProtKB/TrEMBL), A0A4X1UNZ5 (UniProtKB/TrEMBL), A0A5G2R700 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTEGGEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPPDLC
VCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTSRS
QTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSISNGNIQ
VDASFMQTLWNVHPTCSGSSVEEGYLLGGHVVRLFHGHDECMTIPSTDQNDSQHRRIFYEAGGA
GTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLILQDRGKSDTKSTAFSF
RASKEIKEKLDSSHKRDIEGMGVPEIKYGDSICFVQHVASGLWVTYKAQDAKTSRLGPLKRKVI
LHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRTAAPVTLPIEEVLQTLHDLIA
YFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSIAHFAGIAREESGMA
WKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLI
AEGHIKSIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVT
SIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNG
VGDDLYSYGFDGLQLWSGRIPRAVASINQHLLKSDDVVSCCLDLGAPSISFRINGQPVQGMFEN
FNTDGLFFPVVSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAE
GIRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRD
DNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEELKKVKLPKNYMMS
NGYKPAPLDLSDVKLLPSQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYAL
LDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRXERSYAVRSGKWY
FEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMI
NLEDASMIFTLNGELLITNKGSELAFADYEIDNGFVPICSLGLSQIGRMNLGMDASTFKFYTMC
GLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQIEVVRIDGTMDSPPCLKVTHKTFGTQN
SSATMVYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQELLSQTTTQCYYAIRIFAGQDPSCVW
VGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVATSQRTSRSNVD
LEIGCLVDLAMGMLSFSANGRELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSA
AIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVEMERVSERHGWMVQCLEPLQMMALHI
PEENRCVDILELCEQEDLMRFHYHTLRLYSAVCALGNNRVAYALCSHVDLSQLLHSIDNKYLPG
LLRSGFYDLLISIHLASAKERKLMMKNEYIIPIASATRKIRLYPDESKRHGLPGVGLRTCLKPG
FRFSTPCFVATGEEHQKQSPEIPLELLKTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKL
IGTLLVMGVFDDDDVRQILLLIDPSVFGEHSGESEEGAEKEEVTQVEEKAVEAGEKANKEAPVK
GLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSA
ALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED
VSWTGKFRALVYKIRGPPKPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVRMMFN
LLQRQYDSIGELLQALRKTYTISQASVSDTLSLLAALGQIRCLLSVRMGKEEELLMINGLGDIM
NNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMF
EHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPM
LLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGL
LAAMQGAIKISENPALDLPSQGYKRDVSTEDNENEEEIVHMGNAIMSFYSALIDLLGRCAPEMH
LIQTGKGEALRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLF
LDRVYGIKDQAFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPLF
AGTEHYTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQL
NEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKRYDQDLFR
MALPCLSAIAGALPPDYLDTRISTTLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEH
SHDKWACDKSQNGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVER
TKEGEALVQQRENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKK
LELESKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRAMKDMELDASSMEKRF
AYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLS
SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKS
GSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHV
AQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPALN
RYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILP
MLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIINNNLGIDEASWMKRIAVYAQ
PIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADSKGDTQEAELLILDEFAVLCRDLYA
FYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLT
GDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISL
AKSRYSCRDTDEEVKGHLRNNLHLQEKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISA
AVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETE
EYSFEEKLVQDLAKSPKVEEEEEEETDKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMM
AKSCQSGEDEEEEEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVET
LKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTE
EGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLR
LQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV
VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESST
NVEMILKFFDMFLKLKDLTSSDTFQEYDPDGKGILSKKEFQKAMEGQKQYTQSEIDFLLSCAEA
DENDMFNYMDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRI
EIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEM
QLASQISESDSADRPEEEEEEDEESSYPLEVEDEEEDNRSFECASAFAVACASVKRNVARFLQR
ATLKNLRKQYRKVKKMTLKELVRVFFSFFWMLFVGLFHLLFTILGGIFQILWSTVFGGGLVEGA
KNIRVTKILGDMPDPTQFGIHDDALEAERAEVPETGVPTELVHFVKGEKGDADIMSNLFGFHAK
REGALKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRKAQAAEMRAAHEAEGKVDSEKADMEDGE
KEDTAKEEEQAEALWADVTKKKKRRCGQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRF
LALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSFNDDEEEDAVVFFVLQESTGYMAPTLRA
LAIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTP
SFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEXASLVSWLSSIDMK
YHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLV
LTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIE
DPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGND
YFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRK
QYEDQLG

hide sequence

Ensembl Acc Id:

ENSSSCP00000069017 ⟸ ENSSSCT00000074288

Ensembl Acc Id:

ENSSSCP00000067792 ⟸ ENSSSCT00000090710

Ensembl Acc Id:

ENSSSCP00000046204 ⟸ ENSSSCT00000046623

Ensembl Acc Id:

ENSSSCP00000069907 ⟸ ENSSSCT00000077872

Protein Domains

B30.2/SPRY EF-hand Inositol 1,4,5-trisphosphate/ryanodine receptor MIR

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000033958	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015005344	UniProtKB/TrEMBL
	ENSSSCG00035040248	UniProtKB/TrEMBL
	ENSSSCG00045010494	UniProtKB/TrEMBL
	ENSSSCG00055001575	UniProtKB/TrEMBL
	ENSSSCG00070018208	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000046623	ENTREZGENE
	ENSSSCT00000046623.3	UniProtKB/TrEMBL
	ENSSSCT00000074288.2	UniProtKB/TrEMBL
	ENSSSCT00000090710.2	UniProtKB/TrEMBL
	ENSSSCT00015007179.1	UniProtKB/TrEMBL
	ENSSSCT00015007191.1	UniProtKB/TrEMBL
	ENSSSCT00015007206.1	UniProtKB/TrEMBL
	ENSSSCT00035053476.1	UniProtKB/TrEMBL
	ENSSSCT00035053494.1	UniProtKB/TrEMBL
	ENSSSCT00035053508.1	UniProtKB/TrEMBL
	ENSSSCT00035053522.1	UniProtKB/TrEMBL
	ENSSSCT00045017951.1	UniProtKB/TrEMBL
	ENSSSCT00045018245.1	UniProtKB/TrEMBL
	ENSSSCT00045018534.1	UniProtKB/TrEMBL
	ENSSSCT00045019082.1	UniProtKB/TrEMBL
	ENSSSCT00055003030.1	UniProtKB/TrEMBL
	ENSSSCT00055003100.1	UniProtKB/TrEMBL
	ENSSSCT00055003147.1	UniProtKB/TrEMBL
	ENSSSCT00070037026.1	UniProtKB/TrEMBL
	ENSSSCT00070037113.1	UniProtKB/TrEMBL
	ENSSSCT00070037245.1	UniProtKB/TrEMBL
	ENSSSCT00070037312.1	UniProtKB/TrEMBL
	ENSSSCT00070037376.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.70	UniProtKB/TrEMBL
	1.10.490.160	UniProtKB/TrEMBL
	2.60.120.920	UniProtKB/TrEMBL
	2.80.10.50	UniProtKB/TrEMBL
	6.20.350.10	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
	IP3 receptor type 1 binding core, RIH domain	UniProtKB/TrEMBL
InterPro	B30.2/SPRY	UniProtKB/TrEMBL
	B30.2/SPRY_sf	UniProtKB/TrEMBL
	ConA-like_dom_sf	UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	Ins145_P3_rcpt	UniProtKB/TrEMBL
	Ion_trans_dom	UniProtKB/TrEMBL
	MIR_dom_sf	UniProtKB/TrEMBL
	MIR_motif	UniProtKB/TrEMBL
	RIH_assoc-dom	UniProtKB/TrEMBL
	RIH_dom	UniProtKB/TrEMBL
	Ryan_recept	UniProtKB/TrEMBL
	Ryanodine_IP3_receptor	UniProtKB/TrEMBL
	Ryanodine_rcpt	UniProtKB/TrEMBL
	Ryanrecept_TM4-6	UniProtKB/TrEMBL
	RYDR_Jsol	UniProtKB/TrEMBL
	RyR/IP3R_RIH_dom_sf	UniProtKB/TrEMBL
	SPRY1_RyR	UniProtKB/TrEMBL
	SPRY2_RyR	UniProtKB/TrEMBL
	SPRY3_RyR	UniProtKB/TrEMBL
	SPRY_dom	UniProtKB/TrEMBL
NCBI Gene	RYR3	ENTREZGENE
PANTHER	B30.2/SPRY DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	RYANODINE RECEPTOR 3	UniProtKB/TrEMBL
Pfam	Ins145_P3_rec	UniProtKB/TrEMBL
	Ion_trans	UniProtKB/TrEMBL
	MIR	UniProtKB/TrEMBL
	RIH_assoc	UniProtKB/TrEMBL
	RR_TM4-6	UniProtKB/TrEMBL
	RYDR_ITPR	UniProtKB/TrEMBL
	RYDR_Jsol	UniProtKB/TrEMBL
	RyR	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
PRINTS	RYANODINER	UniProtKB/TrEMBL
PROSITE	B302_SPRY	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	MIR	UniProtKB/TrEMBL
SMART	MIR	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF100909	UniProtKB/TrEMBL
	SSF47473	UniProtKB/TrEMBL
	SSF49899	UniProtKB/TrEMBL
	SSF82109	UniProtKB/TrEMBL
UniProt	A0A287AQ64	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1UM99_PIG	UniProtKB/TrEMBL
	A0A4X1UNZ5	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1URU1_PIG	UniProtKB/TrEMBL
	A0A4X1US97_PIG	UniProtKB/TrEMBL
	A0A4X1USK3_PIG	UniProtKB/TrEMBL
	A0A5G2QSI9_PIG	UniProtKB/TrEMBL
	A0A5G2R700	ENTREZGENE
	A0A5G2RDZ9_PIG	UniProtKB/TrEMBL
	A0A8D0MFL3_PIG	UniProtKB/TrEMBL
	A0A8D0MHW7_PIG	UniProtKB/TrEMBL
	A0A8D0MI24_PIG	UniProtKB/TrEMBL
	A0A8D0ZU34_PIG	UniProtKB/TrEMBL
	A0A8D0ZWB3_PIG	UniProtKB/TrEMBL
	A0A8D1H569_PIG	UniProtKB/TrEMBL
	A0A8D1KUR2_PIG	UniProtKB/TrEMBL
	A0A8D1P892_PIG	UniProtKB/TrEMBL
	A0A8D1PDW7_PIG	UniProtKB/TrEMBL
	A0A8D1PEE2_PIG	UniProtKB/TrEMBL
	Q9MYU5_PIG	UniProtKB/TrEMBL
UniProt Secondary	A0A5G2R700	UniProtKB/TrEMBL
VGNC ID	VGNC:109410	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations