Hpca (hippocalcin) - Rat Genome Database

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Gene: Hpca (hippocalcin) Chinchilla lanigera
Analyze
Symbol: Hpca
Name: hippocalcin
RGD ID: 8957073
Description: ENCODES a protein that exhibits actin binding (ortholog); calcium ion binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of phospholipase D activity (ortholog); calcium-mediated signaling (ortholog); cellular response to calcium ion (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); colorectal adenocarcinoma (ortholog); Huntington's disease (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuron-specific calcium-binding protein hippocalcin
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,140,373 - 11,154,261 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545211,142,282 - 11,150,798 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HpcaChinchillacolorectal adenocarcinoma severityISORGD:7354219068941mRNA, protein:increased expression:colon carcinoma (human)RGDPMID:22696308|REF_RGD_ID:9693683
HpcaChinchillaHuntington's disease  ISORGD:7354219068941mRNA:decreased expression:brain (human)RGDPMID:19686238|REF_RGD_ID:9693681
HpcaChinchillaisolated growth hormone deficiency  ISORGD:7354229068941protein:altered expression:cerebral cortex, cerebellum, hippocampus (mouse)RGDPMID:7882001|REF_RGD_ID:9693682
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HpcaChinchillaCharcot-Marie-Tooth disease dominant intermediate C  ISORGD:7354218554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate CClinVarPMID:28492532
HpcaChinchillatorsion dystonia 2  ISORGD:7354218554872ClinVar Annotator: match by term: HPCA-related condition | ClinVar Annotator: match by term: Torsion dystonia more ...ClinVarPMID:14694054|PMID:25741868|PMID:25799108|PMID:28492532|PMID:6115727
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HpcaChinchillatorsion dystonia 2  ISORGD:7354217240710 OMIM 


Biological Process
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HpcaChinchillaactivation of phospholipase D activity  ISORGD:6200609068941 RGDPMID:11211872|REF_RGD_ID:9686445
HpcaChinchillacalcium-mediated signaling  ISORGD:6200609068941 RGDPMID:20704590|REF_RGD_ID:9686447
HpcaChinchillacellular response to calcium ion involved_inISORGD:7354219068941 PMID:28398555UniProtPMID:28398555
HpcaChinchillacellular response to electrical stimulus  ISORGD:6200609068941 RGDPMID:20704590|REF_RGD_ID:9686447
HpcaChinchillacellular response to L-glutamate  ISORGD:6200609068941 RGDPMID:20704590|REF_RGD_ID:9686447
HpcaChinchillainner ear development acts_upstream_of_or_withinISORGD:7354229068941 PMID:21795542MGIPMID:21795542
HpcaChinchillanegative regulation of guanylate cyclase activity  ISORGD:6200609068941 RGDPMID:15336960|REF_RGD_ID:9686438
HpcaChinchillapositive regulation of adenylate cyclase activity  ISORGD:6200609068941 RGDPMID:15336960|REF_RGD_ID:9686438
HpcaChinchillapositive regulation of phospholipase activity  ISORGD:6200609068941 RGDPMID:11211872|REF_RGD_ID:9686445
HpcaChinchillapositive regulation of protein targeting to membrane  ISORGD:6200609068941 RGDPMID:23142228|REF_RGD_ID:9686444
HpcaChinchillaregulation of postsynaptic neurotransmitter receptor internalization involved_inISORGD:6200609068941PMID:20852624SynGOPMID:20852624|REF_RGD_ID:13702412
HpcaChinchillaregulation of voltage-gated calcium channel activity involved_inISORGD:7354219068941 PMID:28398555UniProtPMID:28398555
HpcaChinchillaresponse to Aroclor 1254  ISORGD:6200609068941 RGDPMID:18602130|REF_RGD_ID:2303788
HpcaChinchillaresponse to ketamine  ISORGD:6200609068941 RGDPMID:12614903|REF_RGD_ID:9686446
HpcaChinchillaresponse to L-glutamate  ISORGD:6200609068941 RGDPMID:20704590|REF_RGD_ID:9686447
HpcaChinchillaretina development in camera-type eye  ISORGD:6200609068941 RGDPMID:7789406|REF_RGD_ID:9686441
1 to 16 of 16 rows

Cellular Component
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HpcaChinchillaaxon  ISORGD:6200609068941 RGDPMID:7789406|REF_RGD_ID:9686441
HpcaChinchillacytoplasm located_inISORGD:7354219068941 PMID:28398555UniProtPMID:28398555
HpcaChinchillacytosol located_inISORGD:6200609068941PMID:1543495UniProtPMID:1543495|REF_RGD_ID:9686440
HpcaChinchilladendrite cytoplasm  ISORGD:6200609068941 RGDPMID:8233019|REF_RGD_ID:9686436
HpcaChinchilladendrite membrane  ISORGD:6200609068941 RGDPMID:8233019|REF_RGD_ID:9686436
HpcaChinchilladendritic spine head  ISORGD:6200609068941 RGDPMID:20704590|REF_RGD_ID:9686447
HpcaChinchillaglutamatergic synapse is_active_inISORGD:6200609068941PMID:20704590SynGOPMID:20704590|REF_RGD_ID:9686447
HpcaChinchillaglutamatergic synapse is_active_inISORGD:6200609068941PMID:20852624SynGOPMID:20852624|REF_RGD_ID:13702412
HpcaChinchillamembrane located_inISORGD:6200609068941PMID:8360179UniProtPMID:8360179|REF_RGD_ID:12907550
HpcaChinchillamembrane located_inISORGD:6200609068941PMID:1543495UniProtPMID:1543495|REF_RGD_ID:9686440
HpcaChinchillaneuronal cell body membrane  ISORGD:6200609068941 RGDPMID:8233019|REF_RGD_ID:9686436
HpcaChinchillaperikaryon  ISORGD:6200609068941 RGDPMID:8233019|REF_RGD_ID:9686436
HpcaChinchillapostsynapse is_active_inISORGD:6200609068941PMID:20704590SynGOPMID:20704590|REF_RGD_ID:9686447
1 to 13 of 13 rows

Molecular Function
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HpcaChinchillaactin binding enablesISORGD:7354219068941 PMID:11964161UniProtPMID:11964161
HpcaChinchillacalcium ion binding enablesISORGD:7354219068941 PMID:28398555UniProtPMID:28398555
HpcaChinchillacalcium ion binding enablesISORGD:6200609068941PMID:8360179UniProtPMID:8360179|REF_RGD_ID:12907550
HpcaChinchillacalcium ion binding enablesISORGD:6200609068941PMID:1543495UniProtPMID:1543495|REF_RGD_ID:9686440
HpcaChinchillaidentical protein binding enablesISORGD:7354219068941 PMID:28398555UniProtPMID:28398555
HpcaChinchillakinase binding  ISORGD:23579068941 RGDPMID:23142228|REF_RGD_ID:9686444
HpcaChinchillaprotein binding enablesISOUniProtKB:Q86UW99068941 PMID:33961781IntActPMID:33961781
HpcaChinchillaprotein binding enablesISOPR:Q3TDX89068941 PMID:14739275MGIPMID:14739275
HpcaChinchillaprotein binding enablesISOUniProtKB:Q084609068941 PMID:19423573IntActPMID:19423573
HpcaChinchillaprotein binding enablesISOUniProtKB:O15427|UniProtKB:P0CG20|UniProtKB:P12532|UniProtKB:P14927|UniProtKB:P55197-2|UniProtKB:Q03060-25|UniProtKB:Q2TAL6|UniProtKB:Q86UW9|UniProtKB:Q969H8|UniProtKB:Q96N21|UniProtKB:Q9BWX5|UniProtKB:Q9BXJ5|UniProtKB:Q9UBH09068941 PMID:32296183IntActPMID:32296183
HpcaChinchillaprotein binding enablesISOUniProtKB:P141009068941PMID:16470652IntActPMID:16470652|REF_RGD_ID:8554798
1 to 11 of 11 rows


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Hpca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,140,373 - 11,154,261 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545211,142,282 - 11,150,798 (+)NCBIChiLan1.0ChiLan1.0
HPCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,885,996 - 32,894,646 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,885,994 - 32,898,441 (+)EnsemblGRCh38hg38GRCh38
GRCh37133,352,092 - 33,360,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,124,685 - 33,132,834 (+)NCBINCBI36Build 36hg18NCBI36
Build 34133,021,190 - 33,029,339NCBI
Celera131,620,733 - 31,628,882 (+)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,467,222 - 31,475,369 (+)NCBIHuRef
CHM1_1133,467,533 - 33,475,680 (+)NCBICHM1_1
T2T-CHM13v2.0132,745,769 - 32,754,441 (+)NCBIT2T-CHM13v2.0
Hpca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,005,363 - 129,019,712 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,005,363 - 129,015,829 (-)EnsemblGRCm39 Ensembl
GRCm384129,111,570 - 129,125,919 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,111,570 - 129,122,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv374128,788,819 - 128,798,984 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364128,613,879 - 128,621,062 (-)NCBIMGSCv36mm8
Celera4127,451,599 - 127,461,862 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map462.88NCBI
Hpca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,739,978 - 146,750,961 (-)NCBIGRCr8
mRatBN7.25141,455,616 - 141,466,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,455,613 - 141,463,841 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,153,733 - 144,162,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05145,923,554 - 145,932,014 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05145,923,306 - 145,931,631 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,295,124 - 147,305,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,294,820 - 147,303,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,029,882 - 151,040,514 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,267,898 - 148,276,223 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,277,936 - 148,286,262 (-)NCBI
Celera5139,935,623 - 139,943,977 (-)NCBICelera
Cytogenetic Map5q36NCBI
HPCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21193,927,688 - 193,936,359 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11193,049,890 - 193,058,560 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,176,465 - 32,185,133 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,362,921 - 33,371,524 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,363,673 - 33,371,524 (+)Ensemblpanpan1.1panPan2
HPCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,464,631 - 68,473,661 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,465,280 - 68,473,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,045,221 - 65,053,618 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,030,436 - 69,038,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,029,808 - 69,039,028 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,841,971 - 65,850,366 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,864,436 - 66,872,823 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,856,319 - 67,864,715 (-)NCBIUU_Cfam_GSD_1.0
Hpca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,961,196 - 49,969,278 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,785,879 - 15,798,740 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,786,171 - 15,794,830 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl689,188,133 - 89,197,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1689,187,544 - 89,197,049 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2683,214,827 - 83,224,104 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HPCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12099,974,952 - 99,983,194 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2099,975,742 - 99,980,728 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603316,708,814 - 16,717,377 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,990,729 - 15,999,615 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476415,990,910 - 15,999,617 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000011131   ⟹   ENSCLAP00000010996
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495545211,140,373 - 11,154,261 (+)Ensembl
RefSeq Acc Id: XM_005395099   ⟹   XP_005395156
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545211,142,674 - 11,149,996 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005395100   ⟹   XP_005395157
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495545211,142,282 - 11,150,798 (+)NCBI
Sequence:
Protein RefSeqs XP_005395156 (Get FASTA)   NCBI Sequence Viewer  
  XP_005395157 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000010996
  ENSCLAP00000010996.1
RefSeq Acc Id: XP_005395157   ⟸   XM_005395100
- UniProtKB: A0A8C2V7U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005395156   ⟸   XM_005395099
- UniProtKB: A0A8C2V7U9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000010996   ⟸   ENSCLAT00000011131
EF-hand



1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000007589 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000011131 ENTREZGENE
  ENSCLAT00000011131.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Recoverin UniProtKB/TrEMBL
NCBI Gene Hpca ENTREZGENE
PANTHER NEURON-SPECIFIC CALCIUM-BINDING PROTEIN HIPPOCALCIN UniProtKB/TrEMBL
  PTHR23055 UniProtKB/TrEMBL
Pfam EF-hand_1 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
PRINTS RECOVERIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8C2V7U9 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows