HPCA (hippocalcin) - Rat Genome Database

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Gene: HPCA (hippocalcin) Canis lupus familiaris
Analyze
Symbol: HPCA
Name: hippocalcin
RGD ID: 12181497
Description: ENCODES a protein that exhibits kinase binding (ortholog); INVOLVED IN activation of phospholipase D activity (ortholog); calcium-mediated signaling (ortholog); cellular response to electrical stimulus (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); colorectal adenocarcinoma (ortholog); Huntington's disease (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); dendrite membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuron-specific calcium-binding protein hippocalcin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,464,631 - 68,473,661 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,465,280 - 68,473,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,045,221 - 65,053,618 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,030,436 - 69,038,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,029,808 - 69,039,028 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,841,971 - 65,850,366 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,864,436 - 66,872,823 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,856,319 - 67,864,715 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HPCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,464,631 - 68,473,661 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,465,280 - 68,473,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,045,221 - 65,053,618 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,030,436 - 69,038,834 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,029,808 - 69,039,028 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,841,971 - 65,850,366 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,864,436 - 66,872,823 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0267,856,319 - 67,864,715 (-)NCBIUU_Cfam_GSD_1.0
HPCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38132,885,996 - 32,894,646 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl132,885,994 - 32,898,441 (+)EnsemblGRCh38hg38GRCh38
GRCh37133,352,092 - 33,360,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,124,685 - 33,132,834 (+)NCBINCBI36Build 36hg18NCBI36
Build 34133,021,190 - 33,029,339NCBI
Celera131,620,733 - 31,628,882 (+)NCBICelera
Cytogenetic Map1p35.1NCBI
HuRef131,467,222 - 31,475,369 (+)NCBIHuRef
CHM1_1133,467,533 - 33,475,680 (+)NCBICHM1_1
T2T-CHM13v2.0132,745,769 - 32,754,441 (+)NCBIT2T-CHM13v2.0
Hpca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,005,363 - 129,019,712 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4129,005,363 - 129,015,829 (-)EnsemblGRCm39 Ensembl
GRCm384129,111,570 - 129,125,919 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,111,570 - 129,122,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv374128,788,819 - 128,798,984 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364128,613,879 - 128,621,062 (-)NCBIMGSCv36mm8
Celera4127,451,599 - 127,461,862 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map462.88NCBI
Hpca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85146,739,978 - 146,750,961 (-)NCBIGRCr8
mRatBN7.25141,455,616 - 141,466,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5141,455,613 - 141,463,841 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5144,153,733 - 144,162,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05145,923,554 - 145,932,014 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05145,923,306 - 145,931,631 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05147,295,124 - 147,305,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,294,820 - 147,303,346 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,029,882 - 151,040,514 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,267,898 - 148,276,223 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15148,277,936 - 148,286,262 (-)NCBI
Celera5139,935,623 - 139,943,977 (-)NCBICelera
Cytogenetic Map5q36NCBI
Hpca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,140,373 - 11,154,261 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545211,142,282 - 11,150,798 (+)NCBIChiLan1.0ChiLan1.0
HPCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21193,927,688 - 193,936,359 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11193,049,890 - 193,058,560 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0132,176,465 - 32,185,133 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1133,362,921 - 33,371,524 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,363,673 - 33,371,524 (+)Ensemblpanpan1.1panPan2
Hpca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505849,961,196 - 49,969,278 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647415,785,879 - 15,798,740 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647415,786,171 - 15,794,830 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl689,188,133 - 89,197,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1689,187,544 - 89,197,049 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2683,214,827 - 83,224,104 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HPCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12099,974,952 - 99,983,194 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2099,975,742 - 99,980,728 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603316,708,814 - 16,717,377 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476415,990,729 - 15,999,615 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476415,990,910 - 15,999,617 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HPCA
84 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005617615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022411818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038461662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_849499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000016577   ⟹   ENSCAFP00000015339
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl268,465,280 - 68,473,310 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845009442   ⟹   ENSCAFP00845007388
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl269,029,808 - 69,038,222 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845009448   ⟹   ENSCAFP00845007392
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl269,029,808 - 69,037,725 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845009451   ⟹   ENSCAFP00845007395
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl269,029,810 - 69,039,028 (-)Ensembl
RefSeq Acc Id: XM_005617615   ⟹   XP_005617672
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1268,465,262 - 68,473,661 (-)NCBI
Dog10K_Boxer_Tasha265,045,221 - 65,053,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038461662   ⟹   XP_038317590
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha265,045,221 - 65,052,785 (-)NCBI
RefSeq Acc Id: XM_038470336   ⟹   XP_038326264
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1265,841,971 - 65,849,789 (-)NCBI
RefSeq Acc Id: XM_038470337   ⟹   XP_038326265
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1265,841,971 - 65,849,538 (-)NCBI
RefSeq Acc Id: XM_038470338   ⟹   XP_038326266
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1265,841,971 - 65,850,366 (-)NCBI
RefSeq Acc Id: XM_038531181   ⟹   XP_038387109
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0267,856,319 - 67,864,138 (-)NCBI
RefSeq Acc Id: XM_038531182   ⟹   XP_038387110
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0267,856,319 - 67,863,885 (-)NCBI
RefSeq Acc Id: XM_038531183   ⟹   XP_038387111
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0267,856,319 - 67,864,715 (-)NCBI
RefSeq Acc Id: XM_038595403   ⟹   XP_038451331
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0266,864,436 - 66,871,991 (-)NCBI
RefSeq Acc Id: XM_038595405   ⟹   XP_038451333
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0266,864,436 - 66,872,823 (-)NCBI
RefSeq Acc Id: XM_038595406   ⟹   XP_038451334
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0266,864,436 - 66,872,278 (-)NCBI
RefSeq Acc Id: XM_038659484   ⟹   XP_038515412
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0269,030,436 - 69,038,257 (-)NCBI
RefSeq Acc Id: XM_038659485   ⟹   XP_038515413
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0269,030,436 - 69,038,004 (-)NCBI
RefSeq Acc Id: XM_038659486   ⟹   XP_038515414
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0269,030,436 - 69,038,834 (-)NCBI
RefSeq Acc Id: XM_849499   ⟹   XP_854592
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1268,464,631 - 68,473,105 (-)NCBI
Dog10K_Boxer_Tasha265,045,221 - 65,053,040 (-)NCBI
Sequence:
RefSeq Acc Id: XP_854592   ⟸   XM_849499
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHZ4 (UniProtKB/TrEMBL),   A0A8I3MZQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005617672   ⟸   XM_005617615
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHZ4 (UniProtKB/TrEMBL),   A0A8I3MZQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000015339   ⟸   ENSCAFT00000016577
RefSeq Acc Id: XP_038326266   ⟸   XM_038470338
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038326264   ⟸   XM_038470336
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038326265   ⟸   XM_038470337
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038451333   ⟸   XM_038595405
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038451334   ⟸   XM_038595406
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038451331   ⟸   XM_038595403
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038515414   ⟸   XM_038659486
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHZ4 (UniProtKB/TrEMBL),   A0A8I3MZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038515412   ⟸   XM_038659484
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHZ4 (UniProtKB/TrEMBL),   A0A8I3MZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038515413   ⟸   XM_038659485
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHZ4 (UniProtKB/TrEMBL),   A0A8I3MZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317590   ⟸   XM_038461662
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHZ4 (UniProtKB/TrEMBL),   A0A8I3MZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387111   ⟸   XM_038531183
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHZ4 (UniProtKB/TrEMBL),   A0A8I3MZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387109   ⟸   XM_038531181
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHZ4 (UniProtKB/TrEMBL),   A0A8I3MZQ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387110   ⟸   XM_038531182
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LHZ4 (UniProtKB/TrEMBL),   A0A8I3MZQ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845007395   ⟸   ENSCAFT00845009451
Ensembl Acc Id: ENSCAFP00845007388   ⟸   ENSCAFT00845009442
Ensembl Acc Id: ENSCAFP00845007392   ⟸   ENSCAFT00845009448
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010425 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015512 UniProtKB/TrEMBL
  ENSCAFG00845005304 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016577.5 UniProtKB/TrEMBL
  ENSCAFT00000100420.1 UniProtKB/TrEMBL
  ENSCAFT00000108543.1 UniProtKB/TrEMBL
  ENSCAFT00030028587.1 UniProtKB/TrEMBL
  ENSCAFT00845009442 ENTREZGENE
  ENSCAFT00845009442.1 UniProtKB/TrEMBL
  ENSCAFT00845009448.1 UniProtKB/TrEMBL
  ENSCAFT00845009451.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Recoverin UniProtKB/TrEMBL
NCBI Gene HPCA ENTREZGENE
PANTHER NEURON-SPECIFIC CALCIUM-BINDING PROTEIN HIPPOCALCIN UniProtKB/TrEMBL
  PTHR23055 UniProtKB/TrEMBL
Pfam EF-hand_1 UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/TrEMBL
PRINTS RECOVERIN UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A8C0LHZ4 ENTREZGENE
  A0A8C0RKX5_CANLF UniProtKB/TrEMBL
  A0A8I3MVD1_CANLF UniProtKB/TrEMBL
  A0A8I3MY83_CANLF UniProtKB/TrEMBL
  A0A8I3MZQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PQD5_CANLF UniProtKB/TrEMBL
  A0A8P0TRU3_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0SFJ5 UniProtKB/TrEMBL
VGNC ID VGNC:52136 ENTREZGENE