Psap (prosaposin) - Rat Genome Database

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Gene: Psap (prosaposin) Chinchilla lanigera
Analyze
Symbol: Psap
Name: prosaposin
RGD ID: 8929737
Description: ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); ganglioside GM1 binding (ortholog); ganglioside GM2 binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); antigen processing and presentation (ortholog); cellular response to reactive oxygen species (ortholog); ASSOCIATED WITH atypical Gaucher's disease due to saposin C deficiency (ortholog); Atypical Krabbe Disease due to Saposin A Deficiency (ortholog); autosomal recessive nonsyndromic deafness (ortholog); FOUND IN aggresome (ortholog); cytoplasm (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 24 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PsapChinchillaatypical Gaucher's disease due to saposin C deficiency  ISOPSAP (Homo sapiens)8554872ClinVar Annotator: match by term: Atypical Gaucher disease due to saposin C deficiencyClinVarPMID:10196694 more ...
PsapChinchillaAtypical Krabbe Disease due to Saposin A Deficiency  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10196694 more ...
PsapChinchillaautosomal recessive nonsyndromic deafness  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18429043 more ...
PsapChinchillaautosomal recessive nonsyndromic deafness 12  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18429043 more ...
PsapChinchillacombined saposin deficiency  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10196694 more ...
PsapChinchillacombined saposin deficiency  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10196694 more ...
PsapChinchillafocal segmental glomerulosclerosis  ISOPSAP (Homo sapiens)8554872ClinVar Annotator: match by term: Glomerulosclerosis and focalClinVarPMID:24033266 more ...
PsapChinchillagenetic disease  ISOPSAP (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:1350885 more ...
PsapChinchillaHearing Loss  ISOPSAP (Homo sapiens)8554872ClinVar Annotator: match by term: Nonsyndromic Hearing Loss and RecessiveClinVarPMID:18429043 more ...
PsapChinchillaKrabbe disease  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18429043 more ...
PsapChinchillalate onset Parkinson's disease  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10196694 more ...
PsapChinchillametachromatic leukodystrophy  ISOPSAP (Homo sapiens)8554872ClinVar Annotator: match by term: Metachromatic leukodystrophyClinVarPMID:10196694 more ...
PsapChinchillametachromatic leukodystrophy  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10196694 more ...
PsapChinchillametachromatic leukodystrophy  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10196694 more ...
PsapChinchillametachromatic leukodystrophy  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10196694 more ...
PsapChinchillaMetachromatic Leukodystrophy due to Saposin B Deficiency  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10196694 more ...
PsapChinchillaneuromuscular disease  ISOPSAP (Homo sapiens)8554872ClinVar Annotator: match by term: Neuromuscular diseaseClinVarPMID:11309366 more ...
PsapChinchillaretinitis pigmentosa-deafness syndrome  ISOPSAP (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosa-deafness syndromeClinVarPMID:18429043 more ...
PsapChinchillaUsher syndrome  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18429043 more ...
PsapChinchillaUsher syndrome  ISOPSAP (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18429043 more ...
1 to 20 of 24 rows


Biological Process
1 to 20 of 39 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PsapChinchillaadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway involved_inISOPsap (Mus musculus)9068941 PMID:23690594ParkinsonsUK-UCLPMID:23690594
PsapChinchillaantigen processing and presentation acts_upstream_of_or_withinISOMGI:18883789068941 PMID:14684827MGIPMID:14684827
PsapChinchillacellular response to reactive oxygen species involved_inISOPsap (Mus musculus)9068941 PMID:23690594ParkinsonsUK-UCLPMID:23690594
PsapChinchillaceramide metabolic process acts_upstream_of_or_withinISOPsap (Mus musculus)9068941 PMID:17353235MGIPMID:17353235
PsapChinchillaceramide metabolic process acts_upstream_of_or_withinISOMGI:35217469068941 PMID:15345707MGIPMID:15345707
PsapChinchillacerebellar Purkinje cell differentiation acts_upstream_of_or_withinISOMGI:35217469068941 PMID:15345707MGIPMID:15345707
PsapChinchillacochlea development acts_upstream_of_or_withinISOMGI:18883789068941 PMID:17167097MGIPMID:17167097
PsapChinchillacorneocyte development acts_upstream_of_or_withinISOMGI:1888378 and MGI:21838979068941 PMID:24872419MGIPMID:24872419
PsapChinchillacornified envelope assembly acts_upstream_of_or_withinISOMGI:18883789068941 PMID:24872419MGIPMID:24872419
PsapChinchilladevelopmental growth acts_upstream_of_or_withinISOMGI:18883789068941 PMID:11105903MGIPMID:11105903
PsapChinchillaepithelial cell differentiation involved in prostate gland development acts_upstream_of_or_withinISOMGI:18883789068941 PMID:11105903MGIPMID:11105903
PsapChinchillagalactosylceramide catabolic process acts_upstream_of_or_withinISOMGI:21838979068941 PMID:11371512MGIPMID:11371512
PsapChinchillaganglioside GM1 transport to membrane involved_inISOPSAP (Homo sapiens)9068941 PMID:1454804CAFAPMID:1454804
PsapChinchillagene expression acts_upstream_of_or_within_negative_effectISOPsap (Mus musculus)9068941 PMID:27356620MGIPMID:27356620
PsapChinchillaglucosylceramide metabolic process acts_upstream_of_or_withinISOPsap (Mus musculus)9068941 PMID:17353235MGIPMID:17353235
PsapChinchillaglycolipid metabolic process acts_upstream_of_or_withinISOPsap (Mus musculus)9068941 PMID:12810822MGIPMID:12810822
PsapChinchillainclusion body assembly acts_upstream_of_or_withinISOMGI:18883789068941 PMID:9678511MGIPMID:9678511
PsapChinchillaintracellular protein transport acts_upstream_of_or_withinISOPsap (Mus musculus)9068941 PMID:17353235MGIPMID:17353235
PsapChinchillalysosomal protein catabolic process acts_upstream_of_or_withinISOPsap (Mus musculus)9068941 PMID:12813057MGIPMID:12813057
PsapChinchillalysosomal transport involved_inISOPSAP (Homo sapiens)9068941 PMID:26370502UniProtPMID:26370502
1 to 20 of 39 rows

Cellular Component

  

Molecular Function
1 to 20 of 26 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PsapChinchillaG protein-coupled receptor binding enablesISOUniProtKB:O15354 and UniProtKB:O608839068941 PMID:23690594ParkinsonsUK-UCLPMID:23690594
PsapChinchillaganglioside GM1 binding enablesISOPSAP (Homo sapiens)9068941 PMID:1454804CAFAPMID:1454804
PsapChinchillaganglioside GM2 binding enablesISOPSAP (Homo sapiens)9068941 PMID:1454804CAFAPMID:1454804
PsapChinchillaganglioside GM3 binding enablesISOPSAP (Homo sapiens)9068941 PMID:1454804CAFAPMID:1454804
PsapChinchillaganglioside GP1c binding enablesISOPSAP (Homo sapiens)9068941 PMID:1454804CAFAPMID:1454804
PsapChinchillaganglioside GT1b binding enablesISOPSAP (Homo sapiens)9068941 PMID:1454804CAFAPMID:1454804
PsapChinchillaidentical protein binding enablesISOUniProtKB:P07602-19068941 PMID:18462685IntActPMID:18462685
PsapChinchillaidentical protein binding enablesISOPR:Q612079068941 PMID:12867159MGIPMID:12867159
PsapChinchillalipid antigen binding enablesISOPsap (Mus musculus)9068941 PMID:14684827MGIPMID:14684827
PsapChinchillaphospholipid binding enablesISOPSAP (Homo sapiens)9068941 PMID:14674747CAFAPMID:14674747
PsapChinchillaprotease binding enablesISOUniProtKB:P319449068941 PMID:24872419MGIPMID:24872419
PsapChinchillaprotein binding enablesISOUniProtKB:P319449068941 PMID:24872419IntActPMID:24872419
PsapChinchillaprotein binding enablesISOMGI:36092609068941 PMID:17167097MGIPMID:17167097
PsapChinchillaprotein binding enablesISOPR:P116099068941 PMID:14684827MGIPMID:14684827
PsapChinchillaprotein binding enablesISOUniProtKB:P28799 and UniProtKB:Q995239068941 PMID:28541286UniProtPMID:28541286
PsapChinchillaprotein binding enablesISOUniProtKB:P287989068941 PMID:26370502IntActPMID:26370502
PsapChinchillaprotein binding enablesISOUniProtKB:P05067 more ...9068941 PMID:32814053IntActPMID:32814053
PsapChinchillaprotein binding enablesISOUniProtKB:O96006 more ...9068941 PMID:32296183IntActPMID:32296183
PsapChinchillaprotein binding enablesISOUniProtKB:P24668 and UniProtKB:P287999068941 PMID:26370502UniProtPMID:26370502
PsapChinchillaprotein binding enablesISOUniProtKB:O960069068941 PMID:16713569IntActPMID:16713569
1 to 20 of 26 rows


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Psap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBIChiLan1.0ChiLan1.0
PSAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381071,816,298 - 71,851,251 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1071,816,298 - 71,851,251 (-)EnsemblGRCh38hg38GRCh38
GRCh371073,576,055 - 73,611,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,246,061 - 73,281,088 (-)NCBINCBI36Build 36hg18NCBI36
Build 341073,246,063 - 73,281,015NCBI
Celera1066,858,625 - 66,893,657 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1067,569,822 - 67,604,837 (-)NCBIHuRef
CHM1_11073,858,033 - 73,893,009 (-)NCBICHM1_1
T2T-CHM13v2.01072,687,031 - 72,721,975 (-)NCBIT2T-CHM13v2.0
Psap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,113,436 - 60,138,379 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,113,449 - 60,138,376 (+)EnsemblGRCm39 Ensembl
GRCm381060,277,628 - 60,302,600 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,277,627 - 60,302,597 (+)EnsemblGRCm38mm10GRCm38
MGSCv371059,740,376 - 59,765,348 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361059,673,095 - 59,697,957 (+)NCBIMGSCv36mm8
Celera1061,374,486 - 61,399,457 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1030.02NCBI
Psap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82028,756,951 - 28,783,422 (+)NCBIGRCr8
mRatBN7.22028,214,229 - 28,240,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,214,271 - 28,240,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2029,228,797 - 29,255,391 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02028,615,101 - 28,641,697 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,357,562 - 29,384,161 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,831,302 - 29,856,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,831,314 - 29,856,875 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02031,629,564 - 31,668,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42027,595,048 - 27,621,574 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12027,608,847 - 27,635,374 (+)NCBI
Celera2029,653,298 - 29,678,819 (+)NCBICelera
Cytogenetic Map20q11NCBI
PSAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2883,966,632 - 84,001,690 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11083,971,953 - 84,007,011 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01068,286,359 - 68,321,349 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11070,810,591 - 70,845,593 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1070,810,881 - 70,828,781 (-)Ensemblpanpan1.1panPan2
PSAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,571,095 - 22,603,880 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,572,153 - 22,603,848 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha422,708,767 - 22,741,495 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0422,847,636 - 22,880,854 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl422,847,638 - 22,880,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1422,753,725 - 22,786,399 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,952,336 - 22,985,298 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0423,306,841 - 23,339,591 (-)NCBIUU_Cfam_GSD_1.0
Psap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721358,483,085 - 58,516,521 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,975,770 - 7,009,136 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,975,844 - 7,009,460 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1474,734,189 - 74,887,763 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11474,734,185 - 74,820,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21480,625,273 - 80,660,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,440,327 - 59,474,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl959,440,311 - 59,474,986 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604820,084,030 - 20,118,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247545,726,681 - 5,753,575 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247545,725,697 - 5,753,575 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






RefSeq Acc Id: XM_013516831   ⟹   XP_013372285
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516832   ⟹   XP_013372286
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516833   ⟹   XP_013372287
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516835   ⟹   XP_013372289
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516836   ⟹   XP_013372290
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013516837   ⟹   XP_013372291
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBI
Sequence:
Protein RefSeqs XP_013372285 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372286 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372287 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372289 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372290 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372291 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021464.1
RefSeq Acc Id: XP_013372285   ⟸   XM_013516831
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013372287   ⟸   XM_013516833
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013372286   ⟸   XM_013516832
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013372289   ⟸   XM_013516835
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013372290   ⟸   XM_013516836
- Peptide Label: isoform X5
- Sequence:
Saposin B-type



1 to 17 of 17 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000014700 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021667.1 UniProtKB/TrEMBL
Gene3D-CATH Saposin-like UniProtKB/TrEMBL
InterPro SapB_1 UniProtKB/TrEMBL
  SapB_2 UniProtKB/TrEMBL
  Saposin-like UniProtKB/TrEMBL
  SaposinB_dom UniProtKB/TrEMBL
  Sphingo_Act-Surfact_Prot UniProtKB/TrEMBL
NCBI Gene Psap ENTREZGENE
PANTHER PROSAPOSIN UniProtKB/TrEMBL
  SAPOSIN-RELATED UniProtKB/TrEMBL
Pfam SapB_1 UniProtKB/TrEMBL
  SapB_2 UniProtKB/TrEMBL
PROSITE SAP_B UniProtKB/TrEMBL
SMART SapB UniProtKB/TrEMBL
Superfamily-SCOP SSF47862 UniProtKB/TrEMBL
UniProt A0A8C2W3N9_CHILA UniProtKB/TrEMBL
1 to 17 of 17 rows