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Gene: Psap (prosaposin) Mus musculus
Symbol: Psap
Name: prosaposin
RGD ID: 11178
Description: Exhibits G protein-coupled receptor binding activity; identical protein binding activity; and lipid antigen binding activity. Involved in several processes, including animal organ development; glycosylceramide metabolic process; and protein transport. Localizes to aggresome; extracellular region; and lysosome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study Gaucher's disease; Krabbe disease; combined saposin deficiency; and metachromatic leukodystrophy. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency and combined saposin deficiency. Orthologous to human PSAP (prosaposin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI037048; SGP; SGP-1; snoRNA MBII-198; sulfated glycoprotein 1
Homo sapiens (human) : PSAP (prosaposin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Psap (prosaposin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Psap (prosaposin)
Pan paniscus (bonobo/pygmy chimpanzee) : PSAP (prosaposin)
Canis lupus familiaris (dog) : PSAP (prosaposin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Psap (prosaposin)
Sus scrofa (pig) : PSAP (prosaposin)
Chlorocebus sabaeus (African green monkey) : PSAP (prosaposin)
Heterocephalus glaber (naked mole-rat) : Psap (prosaposin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391060,113,436 - 60,138,379 (+)NCBI
GRCm381060,277,628 - 60,302,600 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,277,627 - 60,302,597 (+)EnsemblGRCm38mm10GRCm38
MGSCv371059,740,376 - 59,765,348 (+)NCBIGRCm37mm9NCBIm37
MGSCv361059,673,095 - 59,697,957 (+)NCBImm8
Celera1061,374,486 - 61,399,457 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1030.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Psap
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11178
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.