PSAP (prosaposin) - Rat Genome Database

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Gene: PSAP (prosaposin) Canis lupus familiaris
Analyze
Symbol: PSAP
Name: prosaposin
RGD ID: 12386781
Description: ENCODES a protein that exhibits G protein-coupled receptor binding (ortholog); ganglioside GM1 binding (ortholog); ganglioside GM2 binding (ortholog); INVOLVED IN antigen processing and presentation (ortholog); cellular response to organic substance (ortholog); ceramide metabolic process (ortholog); ASSOCIATED WITH atypical Gaucher's disease due to saposin C deficiency (ortholog); Atypical Krabbe Disease due to Saposin A Deficiency (ortholog); autosomal recessive nonsyndromic deafness 12 (ortholog); FOUND IN aggresome (ortholog); intracellular membrane-bounded organelle (ortholog); late endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,571,095 - 22,603,880 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,572,153 - 22,603,848 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha422,708,767 - 22,741,495 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0422,847,636 - 22,880,854 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl422,847,638 - 22,880,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1422,753,725 - 22,786,399 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,952,336 - 22,985,298 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0423,306,841 - 23,339,591 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

Genomics

Comparative Map Data
PSAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,571,095 - 22,603,880 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,572,153 - 22,603,848 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha422,708,767 - 22,741,495 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0422,847,636 - 22,880,854 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl422,847,638 - 22,880,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1422,753,725 - 22,786,399 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,952,336 - 22,985,298 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0423,306,841 - 23,339,591 (-)NCBIUU_Cfam_GSD_1.0
PSAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381071,816,298 - 71,851,251 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1071,816,298 - 71,851,251 (-)EnsemblGRCh38hg38GRCh38
GRCh371073,576,055 - 73,611,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,246,061 - 73,281,088 (-)NCBINCBI36Build 36hg18NCBI36
Build 341073,246,063 - 73,281,015NCBI
Celera1066,858,625 - 66,893,657 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1067,569,822 - 67,604,837 (-)NCBIHuRef
CHM1_11073,858,033 - 73,893,009 (-)NCBICHM1_1
T2T-CHM13v2.01072,687,031 - 72,721,975 (-)NCBIT2T-CHM13v2.0
Psap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,113,436 - 60,138,379 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,113,449 - 60,138,376 (+)EnsemblGRCm39 Ensembl
GRCm381060,277,628 - 60,302,600 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,277,627 - 60,302,597 (+)EnsemblGRCm38mm10GRCm38
MGSCv371059,740,376 - 59,765,348 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361059,673,095 - 59,697,957 (+)NCBIMGSCv36mm8
Celera1061,374,486 - 61,399,457 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1030.02NCBI
Psap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22028,214,229 - 28,240,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,214,271 - 28,240,498 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2029,228,797 - 29,255,391 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02028,615,101 - 28,641,697 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02029,357,562 - 29,384,161 (+)NCBIRnor_WKY
Rnor_6.02029,831,302 - 29,856,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,831,314 - 29,856,875 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02031,629,564 - 31,668,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42027,595,048 - 27,621,574 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12027,608,847 - 27,635,374 (+)NCBI
Celera2029,653,298 - 29,678,819 (+)NCBICelera
Cytogenetic Map20q11NCBI
Psap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBIChiLan1.0ChiLan1.0
PSAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11070,810,591 - 70,845,593 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1070,810,881 - 70,828,781 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01068,286,359 - 68,321,349 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Psap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721358,483,085 - 58,516,521 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365216,975,844 - 7,009,460 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1474,734,189 - 74,887,763 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11474,734,185 - 74,820,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21480,625,273 - 80,660,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,440,327 - 59,474,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl959,440,311 - 59,474,986 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604820,084,030 - 20,118,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247545,726,681 - 5,753,575 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247545,725,697 - 5,753,575 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 8 5 3
Medium 5 5 14 6 6 6 6 6 7 8 7 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005618989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005618990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005618991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005618992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005618993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038473198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038534261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038534262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038534263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038598576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038598577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038598578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038662848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038662849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038662850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_856497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000022878   ⟹   ENSCAFP00000021252
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl422,572,153 - 22,603,848 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008238   ⟹   ENSCAFP00845006476
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl422,847,638 - 22,880,795 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845008244   ⟹   ENSCAFP00845006480
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl422,847,638 - 22,880,762 (-)Ensembl
RefSeq Acc Id: XM_005618992   ⟹   XP_005619049
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1422,571,095 - 22,603,880 (-)NCBI
Dog10K_Boxer_Tasha422,708,767 - 22,741,495 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005618993   ⟹   XP_005619050
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1422,571,095 - 22,603,880 (-)NCBI
Dog10K_Boxer_Tasha422,708,767 - 22,741,495 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038473198   ⟹   XP_038329126
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1422,753,725 - 22,786,399 (-)NCBI
RefSeq Acc Id: XM_038534261   ⟹   XP_038390189
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0423,306,841 - 23,339,591 (-)NCBI
RefSeq Acc Id: XM_038534262   ⟹   XP_038390190
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0423,306,841 - 23,339,591 (-)NCBI
RefSeq Acc Id: XM_038534263   ⟹   XP_038390191
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0423,306,841 - 23,339,591 (-)NCBI
RefSeq Acc Id: XM_038598576   ⟹   XP_038454504
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0422,952,336 - 22,985,298 (-)NCBI
RefSeq Acc Id: XM_038598577   ⟹   XP_038454505
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0422,952,336 - 22,985,298 (-)NCBI
RefSeq Acc Id: XM_038598578   ⟹   XP_038454506
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0422,952,336 - 22,985,298 (-)NCBI
RefSeq Acc Id: XM_038662848   ⟹   XP_038518776
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0422,847,636 - 22,880,854 (-)NCBI
RefSeq Acc Id: XM_038662849   ⟹   XP_038518777
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0422,847,636 - 22,880,854 (-)NCBI
RefSeq Acc Id: XM_038662850   ⟹   XP_038518778
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0422,847,636 - 22,880,854 (-)NCBI
RefSeq Acc Id: XM_856497   ⟹   XP_861590
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1422,571,095 - 22,603,880 (-)NCBI
Dog10K_Boxer_Tasha422,708,767 - 22,741,495 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005619050   ⟸   XM_005618993
- Peptide Label: isoform X3
- UniProtKB: E2RLF1 (UniProtKB/TrEMBL),   A0A8C0R7L6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005619049   ⟸   XM_005618992
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_861590   ⟸   XM_856497
- Peptide Label: isoform X1
- UniProtKB: E2RLF1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000021252   ⟸   ENSCAFT00000022878
RefSeq Acc Id: XP_038329126   ⟸   XM_038473198
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038454506   ⟸   XM_038598578
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038454505   ⟸   XM_038598577
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038454504   ⟸   XM_038598576
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038518778   ⟸   XM_038662850
- Peptide Label: isoform X3
- UniProtKB: A0A8C0R7L6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038518777   ⟸   XM_038662849
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038518776   ⟸   XM_038662848
- Peptide Label: isoform X1
- UniProtKB: E2RLF1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038390191   ⟸   XM_038534263
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038390190   ⟸   XM_038534262
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038390189   ⟸   XM_038534261
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845006480   ⟸   ENSCAFT00845008244
RefSeq Acc Id: ENSCAFP00845006476   ⟸   ENSCAFT00845008238
Protein Domains
Saposin A-type   Saposin B-type

Promoters
RGD ID:13682916
Promoter ID:EPDNEW_C982
Type:multiple initiation site
Name:PSAP_1
Description:prosaposin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1422,603,835 - 22,603,895EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
4 22574494 22574495 G C snv American Staffordshire Terrier (AS006), Lagotto Romagnolo (LR390), Bullterrier (BT012), French Bulldog (FB046)
4 22576548 22576549 A G snv Chinese indigenous dogs (DQ10)
4 22582873 22582874 G A snv American Staffordshire Terrier (AS006)
4 22587230 22587231 G A snv Wolf (WO002_732)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014388 Ensembl
  ENSCAFG00845004604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845006476 ENTREZGENE
  ENSCAFP00845006476.1 UniProtKB/TrEMBL
  ENSCAFP00845006480.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845008238 ENTREZGENE
  ENSCAFT00845008238.1 UniProtKB/TrEMBL
  ENSCAFT00845008244.1 UniProtKB/TrEMBL
InterPro SAP_A UniProtKB/TrEMBL
  SapB_1 UniProtKB/TrEMBL
  SapB_2 UniProtKB/TrEMBL
  Saposin UniProtKB/TrEMBL
  Saposin-like UniProtKB/TrEMBL
  Saposin_chordata UniProtKB/TrEMBL
  SaposinB_dom UniProtKB/TrEMBL
NCBI Gene PSAP ENTREZGENE
Pfam SapA UniProtKB/TrEMBL
  SapB_1 UniProtKB/TrEMBL
  SapB_2 UniProtKB/TrEMBL
PIRSF Saposin UniProtKB/TrEMBL
PRINTS SAPOSIN UniProtKB/TrEMBL
PROSITE SAP_A UniProtKB/TrEMBL
  SAP_B UniProtKB/TrEMBL
SMART SAPA UniProtKB/TrEMBL
  SapB UniProtKB/TrEMBL
Superfamily-SCOP SSF47862 UniProtKB/TrEMBL
UniProt A0A8C0R7L6 ENTREZGENE
  A0A8I3MQM8_CANLF UniProtKB/TrEMBL
  A0A8I3MTG1_CANLF UniProtKB/TrEMBL
  E2RLF1 ENTREZGENE
VGNC ID VGNC:45080 ENTREZGENE