Orc4 (origin recognition complex subunit 4) - Rat Genome Database

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Pathways
Gene: Orc4 (origin recognition complex subunit 4) Chinchilla lanigera
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Symbol: Orc4
Name: origin recognition complex subunit 4
RGD ID: 8905369
Description: ENCODES a protein that exhibits DNA replication origin binding (ortholog); nucleotide binding (ortholog); INVOLVED IN DNA replication (ortholog); DNA replication initiation (ortholog); polar body extrusion after meiotic divisions (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Cancer, Familial (ortholog); cervical cancer (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); nuclear origin of replication recognition complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: origin recognition complex, subunit 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544013,932,495 - 14,006,806 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495544013,933,896 - 14,006,808 (-)NCBIChiLan1.0ChiLan1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Orc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544013,932,495 - 14,006,806 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495544013,933,896 - 14,006,808 (-)NCBIChiLan1.0ChiLan1.0
ORC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382147,930,396 - 148,021,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2147,930,396 - 148,021,784 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh372148,687,965 - 148,779,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,408,202 - 148,495,606 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342148,525,463 - 148,612,868NCBI
Celera2142,405,877 - 142,493,295 (-)NCBICelera
Cytogenetic Map2q23.1NCBI
HuRef2140,685,335 - 140,777,468 (-)NCBIHuRef
CHM1_12148,693,611 - 148,784,819 (-)NCBICHM1_1
T2T-CHM13v2.02148,380,848 - 148,472,005 (-)NCBIT2T-CHM13v2.0
Orc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,792,836 - 48,840,287 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,790,203 - 48,840,289 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38248,902,824 - 48,952,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,902,824 - 48,950,277 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37248,758,274 - 48,804,787 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36248,724,861 - 48,771,243 (-)NCBIMGSCv36mm8
Celera250,575,226 - 50,621,420 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.42NCBI
Orc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,700,046 - 53,743,293 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl353,703,615 - 53,742,264 (-)EnsemblGRCr8
mRatBN7.2333,290,844 - 33,334,022 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,294,355 - 33,333,824 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx336,677,728 - 36,716,383 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,262,461 - 45,301,116 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,084,856 - 43,123,482 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd351,533,990 - 51,577,115 (-)NCBI
Lyon_Normotensive358,503,061 - 58,546,136 (-)NCBI
Lyon_Hypertensive350,460,849 - 50,503,898 (-)NCBI
F344_StmMcwi331,688,483 - 31,731,610 (-)NCBI
Rnor_6.0333,034,913 - 33,075,833 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,037,034 - 33,075,685 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0338,201,914 - 38,240,600 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4329,813,264 - 29,851,852 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera331,495,196 - 31,533,857 (-)NCBICelera
Cytogenetic Map3q12NCBI
ORC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21326,909,798 - 26,997,388 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B26,924,800 - 27,012,354 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,841,808 - 11,931,620 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,291,976 - 152,379,639 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,292,822 - 152,379,487 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
ORC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11949,728,812 - 49,815,599 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1949,728,344 - 49,815,604 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1949,852,526 - 49,939,229 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01951,201,322 - 51,288,103 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,193,458 - 51,288,099 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11949,847,294 - 49,933,994 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01949,981,280 - 50,068,020 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01951,378,650 - 51,465,414 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Orc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap17119,447,723 - 119,509,751 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024405303112,424,304 - 112,486,767 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646929,131,789 - 29,194,863 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646929,131,892 - 29,193,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ORC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl154,096,647 - 4,171,398 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1154,096,539 - 4,176,332 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2153,748,071 - 3,824,433 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ORC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11035,231,782 - 35,319,830 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666040166,136,574 - 166,225,926 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11033,314,020 - 33,401,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,314,271 - 33,355,588 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Orc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624866626,556 - 716,725 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_004624866622,859 - 716,787 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl3109,038,397 - 109,086,749 (+)Ensembl
Orc4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1526,761,554 - 26,794,170 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000004026   ⟹   ENSCLAP00000003947
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544013,932,495 - 14,006,806 (-)Ensembl
RefSeq Acc Id: XM_005390792   ⟹   XP_005390849
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544013,934,246 - 14,006,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517450   ⟹   XP_013372904
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544013,933,896 - 14,006,806 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517451   ⟹   XP_013372905
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544013,933,896 - 14,006,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013517452   ⟹   XP_013372906
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544013,933,896 - 13,961,127 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001235255
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544013,934,244 - 14,006,808 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001235256
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544013,934,976 - 14,006,808 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005390849 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372904 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372905 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372906 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000003947
  ENSCLAP00000003947.1
RefSeq Acc Id: XP_005390849   ⟸   XM_005390792
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013372905   ⟸   XM_013517451
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013372904   ⟸   XM_013517450
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YJU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372906   ⟸   XM_013517452
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSCLAP00000003947   ⟸   ENSCLAT00000004026
Protein Domains
AAA+ ATPase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002811 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004026 ENTREZGENE
  ENSCLAT00000004026.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_16 UniProtKB/TrEMBL
  ORC4 UniProtKB/TrEMBL
  ORC4_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Orc4 ENTREZGENE
PANTHER ORIGIN RECOGNITION COMPLEX SUBUNIT 4 UniProtKB/TrEMBL
  PTHR12087 UniProtKB/TrEMBL
Pfam AAA_16 UniProtKB/TrEMBL
  ORC4_C UniProtKB/TrEMBL
PIRSF ORC4 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2YJU8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Orc4  origin recognition complex subunit 4    origin recognition complex, subunit 4  Symbol and/or name change 5135510 APPROVED