Orc4 (origin recognition complex subunit 4) - Rat Genome Database

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Gene: Orc4 (origin recognition complex subunit 4) Heterocephalus glaber
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Symbol: Orc4
Name: origin recognition complex subunit 4
RGD ID: 18931219
Description: ENCODES a protein that exhibits nucleotide binding (ortholog); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 1 (ortholog); genetic disease (ortholog); Meier-Gorlin syndrome (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624866622,859 - 716,787 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624866626,556 - 716,725 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Orc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624866622,859 - 716,787 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624866626,556 - 716,725 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ORC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382147,930,396 - 148,021,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2147,930,396 - 148,021,604 (-)EnsemblGRCh38hg38GRCh38
GRCh372148,687,965 - 148,779,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,408,202 - 148,495,606 (-)NCBINCBI36Build 36hg18NCBI36
Build 342148,525,463 - 148,612,868NCBI
Celera2142,405,877 - 142,493,295 (-)NCBICelera
Cytogenetic Map2q23.1NCBI
HuRef2140,685,335 - 140,777,468 (-)NCBIHuRef
CHM1_12148,693,611 - 148,784,819 (-)NCBICHM1_1
T2T-CHM13v2.02148,380,848 - 148,472,005 (-)NCBIT2T-CHM13v2.0
Orc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,792,836 - 48,840,287 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,792,836 - 48,840,289 (-)EnsemblGRCm39 Ensembl
GRCm38248,902,824 - 48,952,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,902,824 - 48,950,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv37248,758,274 - 48,804,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36248,724,861 - 48,771,243 (-)NCBIMGSCv36mm8
Celera250,575,226 - 50,621,420 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.42NCBI
Orc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,700,046 - 53,743,293 (-)NCBIGRCr8
mRatBN7.2333,290,844 - 33,334,022 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,294,355 - 33,333,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx336,677,728 - 36,716,383 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,262,461 - 45,301,116 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,084,856 - 43,123,482 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0333,034,913 - 33,075,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,037,034 - 33,075,685 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0338,201,914 - 38,240,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4329,813,264 - 29,851,852 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera331,495,196 - 31,533,857 (-)NCBICelera
Cytogenetic Map3q12NCBI
Orc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544013,932,495 - 14,006,806 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544013,933,896 - 14,006,808 (-)NCBIChiLan1.0ChiLan1.0
ORC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21326,909,798 - 26,997,388 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B26,924,800 - 27,012,354 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,841,808 - 11,931,620 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,291,976 - 152,379,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,292,822 - 152,379,487 (-)Ensemblpanpan1.1panPan2
ORC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11949,728,812 - 49,815,599 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1949,728,344 - 49,815,604 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1949,852,526 - 49,939,229 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01951,201,322 - 51,288,103 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,193,458 - 51,288,099 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11949,847,294 - 49,933,994 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01949,981,280 - 50,068,020 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01951,378,650 - 51,465,414 (-)NCBIUU_Cfam_GSD_1.0
Orc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303112,424,304 - 112,486,767 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646929,131,789 - 29,194,863 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646929,131,892 - 29,193,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ORC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl154,096,647 - 4,171,398 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1154,096,539 - 4,176,332 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2153,748,071 - 3,824,433 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ORC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11033,314,020 - 33,401,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,314,271 - 33,355,588 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040166,136,574 - 166,225,926 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000000423   ⟹   ENSHGLP00000000387
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624866622,859 - 716,787 (-)Ensembl
RefSeq Acc Id: XM_004869984   ⟹   XP_004870041
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624866626,556 - 716,725 (-)NCBI
RefSeq Acc Id: XM_004869985   ⟹   XP_004870042
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624866626,556 - 716,725 (-)NCBI
RefSeq Acc Id: XM_013067535   ⟹   XP_012922989
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624866626,556 - 716,725 (-)NCBI
RefSeq Acc Id: XM_021248423   ⟹   XP_021104082
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624866626,556 - 716,636 (-)NCBI
RefSeq Acc Id: XM_021248424   ⟹   XP_021104083
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624866626,556 - 716,630 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004870041 (Get FASTA)   NCBI Sequence Viewer  
  XP_004870042 (Get FASTA)   NCBI Sequence Viewer  
  XP_012922989 (Get FASTA)   NCBI Sequence Viewer  
  XP_021104082 (Get FASTA)   NCBI Sequence Viewer  
  XP_021104083 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB05350 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000387
GenBank Protein JAO00940 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004870042   ⟸   XM_004869985
- Peptide Label: isoform X3
- UniProtKB: G5B7T9 (UniProtKB/TrEMBL),   A0AAX6QCF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012922989   ⟸   XM_013067535
- Peptide Label: isoform X2
- UniProtKB: G5B7T9 (UniProtKB/TrEMBL),   A0AAX6QPI9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004870041   ⟸   XM_004869984
- Peptide Label: isoform X1
- UniProtKB: G5B7T9 (UniProtKB/TrEMBL),   A0AAX6QBV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104082   ⟸   XM_021248423
- Peptide Label: isoform X4
- UniProtKB: G5B7T9 (UniProtKB/TrEMBL),   A0AAX6S239 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021104083   ⟸   XM_021248424
- Peptide Label: isoform X5
- UniProtKB: G5B7T9 (UniProtKB/TrEMBL),   A0AAX6S7P2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000000387   ⟸   ENSHGLT00000000423


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000361 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000000423 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_16 UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  ORC4 UniProtKB/TrEMBL
  ORC4_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Orc4 ENTREZGENE
PANTHER ORIGIN RECOGNITION COMPLEX SUBUNIT 4 UniProtKB/TrEMBL
  PTHR12087 UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  AAA_16 UniProtKB/TrEMBL
  ORC4_C UniProtKB/TrEMBL
PIRSF ORC4 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0AAX6QBV5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QCF2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QPI9 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S239 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6S7P2 ENTREZGENE, UniProtKB/TrEMBL
  G5B7T9 ENTREZGENE, UniProtKB/TrEMBL