ORC4 (origin recognition complex subunit 4) - Rat Genome Database

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Gene: ORC4 (origin recognition complex subunit 4) Chlorocebus sabaeus
Analyze
Symbol: ORC4
Name: origin recognition complex subunit 4
RGD ID: 18584852
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA replication origin binding (inferred); nucleotide binding (inferred); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Cancer, Familial (ortholog); cervical cancer (ortholog); FOUND IN chromosome, telomeric region (inferred); cytoplasm (inferred); nuclear origin of replication recognition complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11035,231,782 - 35,319,830 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666040166,136,574 - 166,225,926 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11033,314,020 - 33,401,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,314,271 - 33,355,588 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ORC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11035,231,782 - 35,319,830 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666040166,136,574 - 166,225,926 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11033,314,020 - 33,401,770 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1033,314,271 - 33,355,588 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ORC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382147,930,396 - 148,021,551 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2147,930,396 - 148,021,784 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh372148,687,965 - 148,779,120 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362148,408,202 - 148,495,606 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342148,525,463 - 148,612,868NCBI
Celera2142,405,877 - 142,493,295 (-)NCBICelera
Cytogenetic Map2q23.1NCBI
HuRef2140,685,335 - 140,777,468 (-)NCBIHuRef
CHM1_12148,693,611 - 148,784,819 (-)NCBICHM1_1
T2T-CHM13v2.02148,380,848 - 148,472,005 (-)NCBIT2T-CHM13v2.0
Orc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39248,792,836 - 48,840,287 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl248,790,203 - 48,840,289 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38248,902,824 - 48,952,902 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl248,902,824 - 48,950,277 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37248,758,274 - 48,804,787 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36248,724,861 - 48,771,243 (-)NCBIMGSCv36mm8
Celera250,575,226 - 50,621,420 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.42NCBI
Orc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8353,700,046 - 53,743,293 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl353,703,615 - 53,742,264 (-)EnsemblGRCr8
mRatBN7.2333,290,844 - 33,334,022 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl333,294,355 - 33,333,824 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx336,677,728 - 36,716,383 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,262,461 - 45,301,116 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,084,856 - 43,123,482 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd351,533,990 - 51,577,115 (-)NCBI
Lyon_Normotensive358,503,061 - 58,546,136 (-)NCBI
Lyon_Hypertensive350,460,849 - 50,503,898 (-)NCBI
F344_StmMcwi331,688,483 - 31,731,610 (-)NCBI
Rnor_6.0333,034,913 - 33,075,833 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl333,037,034 - 33,075,685 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0338,201,914 - 38,240,600 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4329,813,264 - 29,851,852 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera331,495,196 - 31,533,857 (-)NCBICelera
Cytogenetic Map3q12NCBI
Orc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544013,932,495 - 14,006,806 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495544013,933,896 - 14,006,808 (-)NCBIChiLan1.0ChiLan1.0
ORC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21326,909,798 - 26,997,388 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B26,924,800 - 27,012,354 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B11,841,808 - 11,931,620 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B152,291,976 - 152,379,639 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B152,292,822 - 152,379,487 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
ORC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11949,728,812 - 49,815,599 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1949,728,344 - 49,815,604 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1949,852,526 - 49,939,229 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01951,201,322 - 51,288,103 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1951,193,458 - 51,288,099 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11949,847,294 - 49,933,994 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01949,981,280 - 50,068,020 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01951,378,650 - 51,465,414 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Orc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap17119,447,723 - 119,509,751 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024405303112,424,304 - 112,486,767 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646929,131,789 - 29,194,863 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646929,131,892 - 29,193,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ORC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl154,096,647 - 4,171,398 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1154,096,539 - 4,176,332 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2153,748,071 - 3,824,433 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Orc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624866626,556 - 716,725 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_004624866622,859 - 716,787 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl3109,038,397 - 109,086,749 (+)Ensembl
Orc4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1526,761,554 - 26,794,170 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in ORC4
1188 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000014275   ⟹   ENSCSAP00000012251
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1033,314,271 - 33,355,588 (-)Ensembl
RefSeq Acc Id: XM_007964939   ⟹   XP_007963130
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap11035,231,782 - 35,319,830 (-)NCBI
Vero_WHO_p1.0NW_023666040166,136,574 - 166,224,653 (+)NCBI
ChlSab1.11033,314,020 - 33,401,770 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007964940   ⟹   XP_007963131
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap11035,231,782 - 35,319,830 (-)NCBI
Vero_WHO_p1.0NW_023666040166,136,574 - 166,224,656 (+)NCBI
ChlSab1.11033,314,020 - 33,401,762 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007964941   ⟹   XP_007963132
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap11035,231,782 - 35,319,018 (-)NCBI
Vero_WHO_p1.0NW_023666040166,137,414 - 166,224,653 (+)NCBI
ChlSab1.11033,314,020 - 33,401,770 (-)NCBI
Sequence:
RefSeq Acc Id: XM_073019672   ⟹   XP_072875773
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap11035,231,782 - 35,319,014 (-)NCBI
RefSeq Acc Id: XM_073019673   ⟹   XP_072875774
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap11035,231,782 - 35,319,824 (-)NCBI
RefSeq Acc Id: XM_073019674   ⟹   XP_072875775
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap11035,234,681 - 35,319,019 (-)NCBI
RefSeq Acc Id: XR_012094183
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap11035,231,782 - 35,319,824 (-)NCBI
RefSeq Acc Id: XP_007963132   ⟸   XM_007964941
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007963130   ⟸   XM_007964939
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RUG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007963131   ⟸   XM_007964940
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RUG2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000012251   ⟸   ENSCSAT00000014275
RefSeq Acc Id: XP_072875774   ⟸   XM_073019673
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RUG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_072875773   ⟸   XM_073019672
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RUG2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_072875775   ⟸   XM_073019674
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016183 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014275.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_16 UniProtKB/TrEMBL
  ORC4 UniProtKB/TrEMBL
  ORC4_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report csab:103217056 UniProtKB/TrEMBL
NCBI Gene ORC4 ENTREZGENE
PANTHER ORIGIN RECOGNITION COMPLEX SUBUNIT 4 UniProtKB/TrEMBL
  PTHR12087 UniProtKB/TrEMBL
Pfam AAA_16 UniProtKB/TrEMBL
  ORC4_C UniProtKB/TrEMBL
PIRSF ORC4 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9RUG2 ENTREZGENE, UniProtKB/TrEMBL