Nalcn (sodium leak channel, non-selective) - Rat Genome Database

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Gene: Nalcn (sodium leak channel, non-selective) Chinchilla lanigera
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Symbol: Nalcn
Name: sodium leak channel, non-selective
RGD ID: 8867015
Description: ENCODES a protein that exhibits leak channel activity (ortholog); monoatomic cation channel activity (ortholog); voltage-gated sodium channel activity (ortholog); INVOLVED IN calcium ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); regulation of resting membrane potential (ortholog); ASSOCIATED WITH Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); autism spectrum disorder (ortholog); congenital limbs-face contractures-hypotonia-developmental delay syndrome (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium leak channel, non selective
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554049,603,562 - 9,895,817 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554049,603,567 - 9,894,688 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nalcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554049,603,562 - 9,895,817 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554049,603,567 - 9,894,688 (+)NCBIChiLan1.0ChiLan1.0
NALCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813101,053,776 - 101,417,179 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13101,053,776 - 101,416,508 (-)EnsemblGRCh38hg38GRCh38
GRCh3713101,706,128 - 102,068,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613100,504,131 - 100,866,814 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413100,505,600 - 100,866,707NCBI
Celera1382,551,415 - 82,911,536 (-)NCBICelera
Cytogenetic Map13q32.3-q33.1NCBI
HuRef1382,301,975 - 82,662,087 (-)NCBIHuRef
CHM1_113101,676,115 - 102,038,862 (-)NCBICHM1_1
T2T-CHM13v2.013100,268,892 - 100,632,422 (-)NCBIT2T-CHM13v2.0
Nalcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914123,514,046 - 123,864,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14123,514,046 - 123,864,556 (-)EnsemblGRCm39 Ensembl
GRCm3814123,275,678 - 123,627,330 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14123,276,634 - 123,627,144 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714123,675,863 - 124,026,366 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614122,434,608 - 122,762,324 (-)NCBIMGSCv36mm8
Celera14121,838,270 - 121,890,033 (-)NCBICelera
Celera14122,811,564 - 123,084,265 (-)NCBICelera
Cytogenetic Map14E5NCBI
cM Map1466.04NCBI
Nalcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,805,209 - 107,148,837 (-)NCBIGRCr8
mRatBN7.215100,398,583 - 100,741,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15100,398,615 - 100,741,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15104,339,461 - 104,686,255 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015105,429,004 - 105,781,329 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015102,356,286 - 102,708,574 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015109,734,092 - 110,046,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15109,735,595 - 110,046,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015113,115,691 - 113,426,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415108,414,286 - 108,658,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115108,430,065 - 108,673,975 (-)NCBI
Celera1599,154,725 - 99,456,878 (-)NCBICelera
Cytogenetic Map15q25NCBI
NALCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214102,572,054 - 102,930,688 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113101,239,557 - 101,597,900 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01382,215,094 - 82,573,501 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113101,352,535 - 101,710,917 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13101,354,054 - 101,693,223 (-)Ensemblpanpan1.1panPan2
NALCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12250,821,983 - 51,142,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2250,823,478 - 51,141,644 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2250,601,806 - 50,922,190 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02251,265,000 - 51,586,596 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2251,265,007 - 51,586,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12250,910,597 - 51,250,150 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02250,941,445 - 51,259,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02250,984,648 - 51,306,587 (-)NCBIUU_Cfam_GSD_1.0
Nalcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945186,162,530 - 186,450,079 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364729,502,030 - 9,789,638 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364729,502,054 - 9,789,714 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NALCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1169,710,364 - 70,022,727 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11169,710,355 - 70,023,020 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NALCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1379,663,714 - 80,010,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl379,663,725 - 79,992,503 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604636,176,805 - 36,522,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nalcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247939,915,273 - 10,249,563 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247939,929,980 - 10,248,107 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000005400   ⟹   ENSCLAP00000005304
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554049,603,562 - 9,895,817 (+)Ensembl
RefSeq Acc Id: XM_005374037   ⟹   XP_005374094
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554049,603,567 - 9,894,688 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005374038   ⟹   XP_005374095
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554049,603,606 - 9,894,001 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005374039   ⟹   XP_005374096
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554049,603,567 - 9,894,688 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013515982   ⟹   XP_013371436
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554049,603,567 - 9,894,688 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005374094 (Get FASTA)   NCBI Sequence Viewer  
  XP_005374095 (Get FASTA)   NCBI Sequence Viewer  
  XP_005374096 (Get FASTA)   NCBI Sequence Viewer  
  XP_013371436 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000005304
  ENSCLAP00000005304.1
RefSeq Acc Id: XP_005374094   ⟸   XM_005374037
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UU75 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005374095   ⟸   XM_005374038
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005374096   ⟸   XM_005374039
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013371436   ⟸   XM_013515982
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSCLAP00000005304   ⟸   ENSCLAT00000005400
Protein Domains
Ion transport


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000005400 ENTREZGENE
  ENSCLAT00000005400.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  NALCN UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene Nalcn ENTREZGENE
PANTHER PTHR46141 UniProtKB/TrEMBL
  SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A8C2UU75 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Nalcn  sodium leak channel, non-selective    sodium leak channel, non selective  Symbol and/or name change 5135510 APPROVED
2015-08-25 Nalcn  sodium leak channel, non selective    sodium leak channel, non-selective  Symbol and/or name change 5135510 APPROVED