Nalcn (sodium leak channel, non-selective) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Nalcn (sodium leak channel, non-selective) Rattus norvegicus
Analyze
Symbol: Nalcn
Name: sodium leak channel, non-selective
RGD ID: 628710
Description: Predicted to enable leak channel activity and voltage-gated sodium channel activity. Predicted to be involved in inorganic cation transmembrane transport; positive regulation of synaptic transmission; and regulation of resting membrane potential. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Orthologous to human NALCN (sodium leak channel, non-selective); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: brain voltage-gated cation channel; four domain-type voltage-gated ion channel alpha-1 subunit; rb21-channel; sodium leak channel NALCN; sodium leak channel non-selective protein; Vgcnl1; voltage gated channel like 1; voltage gated channel-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.215100,398,615 - 100,712,283 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl15100,398,615 - 100,741,001 (-)Ensembl
Rnor_6.015109,734,092 - 110,046,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15109,735,595 - 110,046,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015113,115,691 - 113,426,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415108,414,286 - 108,658,195 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115108,430,065 - 108,673,975 (-)NCBI
Celera1599,154,725 - 99,456,878 (-)NCBICelera
Cytogenetic Map15q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mutations in NALCN cause an autosomal-recessive syndrome with severe hypotonia, speech impairment, and cognitive delay. Al-Sayed MD, etal., Am J Hum Genet. 2013 Oct 3;93(4):721-6. doi: 10.1016/j.ajhg.2013.08.001. Epub 2013 Sep 26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism. Köroglu Ç, etal., J Med Genet. 2013 Aug;50(8):515-20. doi: 10.1136/jmedgenet-2013-101634. Epub 2013 Jun 7.
4. Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels. Lee JH, etal., FEBS Lett 1999 Feb 26;445(2-3):231-6.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12498692   PMID:17448995   PMID:33273469  


Genomics

Comparative Map Data
Nalcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.215100,398,615 - 100,712,283 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl15100,398,615 - 100,741,001 (-)Ensembl
Rnor_6.015109,734,092 - 110,046,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15109,735,595 - 110,046,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015113,115,691 - 113,426,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415108,414,286 - 108,658,195 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115108,430,065 - 108,673,975 (-)NCBI
Celera1599,154,725 - 99,456,878 (-)NCBICelera
Cytogenetic Map15q25NCBI
NALCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813101,053,776 - 101,417,179 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl13101,053,776 - 101,416,508 (-)EnsemblGRCh38hg38GRCh38
GRCh3713101,706,128 - 102,068,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613100,504,131 - 100,866,814 (-)NCBINCBI36hg18NCBI36
Build 3413100,505,600 - 100,866,707NCBI
Celera1382,551,415 - 82,911,536 (-)NCBI
Cytogenetic Map13q32.3-q33.1NCBI
HuRef1382,301,975 - 82,662,087 (-)NCBIHuRef
CHM1_113101,676,115 - 102,038,862 (-)NCBICHM1_1
T2T-CHM13v2.013100,268,892 - 100,631,686 (-)NCBI
Nalcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914123,514,046 - 123,864,846 (-)NCBIGRCm39mm39
GRCm39 Ensembl14123,514,046 - 123,864,556 (-)Ensembl
GRCm3814123,275,678 - 123,627,330 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14123,276,634 - 123,627,144 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714123,675,863 - 124,026,366 (-)NCBIGRCm37mm9NCBIm37
MGSCv3614122,434,608 - 122,762,324 (-)NCBImm8
Celera14121,838,270 - 121,890,033 (-)NCBICelera
Celera14122,811,564 - 123,084,265 (-)NCBICelera
Cytogenetic Map14E5NCBI
Nalcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554049,603,562 - 9,895,817 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554049,603,567 - 9,894,688 (+)NCBIChiLan1.0ChiLan1.0
NALCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113101,352,535 - 101,710,917 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13101,354,054 - 101,693,223 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01382,215,094 - 82,573,501 (-)NCBIMhudiblu_PPA_v0panPan3
NALCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12250,821,983 - 51,142,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2250,823,478 - 51,141,644 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2250,601,806 - 50,922,190 (-)NCBI
ROS_Cfam_1.02251,265,000 - 51,586,596 (-)NCBI
ROS_Cfam_1.0 Ensembl2251,265,007 - 51,586,235 (-)Ensembl
UMICH_Zoey_3.12250,910,597 - 51,250,150 (-)NCBI
UNSW_CanFamBas_1.02250,941,445 - 51,259,292 (-)NCBI
UU_Cfam_GSD_1.02250,984,648 - 51,306,587 (-)NCBI
Nalcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945186,162,530 - 186,450,079 (-)NCBI
SpeTri2.0NW_0049364729,502,054 - 9,789,714 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NALCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1169,710,364 - 70,022,727 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11169,710,355 - 70,023,020 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NALCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1379,663,714 - 80,010,361 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl379,663,725 - 79,992,503 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604636,176,805 - 36,522,145 (-)NCBIVero_WHO_p1.0
Nalcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247939,915,273 - 10,249,563 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247939,929,980 - 10,248,107 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D14Mit107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,704,919 - 100,705,094 (+)MAPPERmRatBN7.2
Rnor_6.015110,039,366 - 110,039,540NCBIRnor6.0
Rnor_5.015113,418,878 - 113,419,052UniSTSRnor5.0
RGSC_v3.415108,746,313 - 108,746,487UniSTSRGSC3.4
Celera1599,449,515 - 99,449,689UniSTS
Cytogenetic Map15q25UniSTS
PMC126259P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,400,189 - 100,400,264 (+)MAPPERmRatBN7.2
Rnor_6.015109,735,667 - 109,735,741NCBIRnor6.0
Rnor_5.015113,117,266 - 113,117,340UniSTSRnor5.0
RGSC_v3.415108,415,861 - 108,415,935UniSTSRGSC3.4
Celera1599,156,300 - 99,156,374UniSTS
Cytogenetic Map15q25UniSTS
RH130621  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,398,820 - 100,399,032 (+)MAPPERmRatBN7.2
Rnor_6.015109,734,298 - 109,734,509NCBIRnor6.0
Rnor_5.015113,115,897 - 113,116,108UniSTSRnor5.0
RGSC_v3.415108,414,492 - 108,414,703UniSTSRGSC3.4
Celera1599,154,931 - 99,155,142UniSTS
RH 3.4 Map15716.1UniSTS
Cytogenetic Map15q25UniSTS
BE113539  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,399,872 - 100,400,032 (+)MAPPERmRatBN7.2
Rnor_6.015109,735,350 - 109,735,509NCBIRnor6.0
Rnor_5.015113,116,949 - 113,117,108UniSTSRnor5.0
RGSC_v3.415108,415,544 - 108,415,703UniSTSRGSC3.4
Celera1599,155,983 - 99,156,142UniSTS
RH 3.4 Map15716.1UniSTS
Cytogenetic Map15q25UniSTS
RH136716  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,682,552 - 100,682,787 (+)MAPPERmRatBN7.2
Rnor_6.015110,017,848 - 110,018,082NCBIRnor6.0
Rnor_5.015113,397,362 - 113,397,596UniSTSRnor5.0
Celera1599,428,965 - 99,429,199UniSTS
Cytogenetic Map15q25UniSTS
RH138154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,607,186 - 100,607,333 (+)MAPPERmRatBN7.2
Rnor_6.015109,942,414 - 109,942,560NCBIRnor6.0
Rnor_5.015113,323,215 - 113,323,361UniSTSRnor5.0
RGSC_v3.415108,629,836 - 108,629,982UniSTSRGSC3.4
Celera1599,353,846 - 99,353,992UniSTS
Cytogenetic Map15q25UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:96
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000006624, ENSRNOT00000057404
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 60
Low 3 7 1 4 1 7 7 14 35 5 7
Below cutoff 3 32 24 17 15 17 1 4 18 6 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006624   ⟹   ENSRNOP00000006624
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15100,399,229 - 100,740,983 (-)Ensembl
Rnor_6.0 Ensembl15109,735,595 - 110,046,687 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000057404   ⟹   ENSRNOP00000054214
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15100,399,229 - 100,740,983 (-)Ensembl
Rnor_6.0 Ensembl15109,735,595 - 110,046,687 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089695   ⟹   ENSRNOP00000069957
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15100,400,051 - 100,741,001 (-)Ensembl
Rnor_6.0 Ensembl15109,735,595 - 110,046,704 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096914   ⟹   ENSRNOP00000097879
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15100,398,615 - 100,740,983 (-)Ensembl
RefSeq Acc Id: NM_153630   ⟹   NP_705894
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.215100,398,615 - 100,712,283 (-)NCBI
Rnor_6.015109,734,092 - 110,046,729 (-)NCBI
Rnor_5.015113,115,691 - 113,426,241 (-)NCBI
RGSC_v3.415108,414,286 - 108,658,195 (-)RGD
Celera1599,154,725 - 99,456,878 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_705894   ⟸   NM_153630
- Sequence:
RefSeq Acc Id: ENSRNOP00000006624   ⟸   ENSRNOT00000006624
RefSeq Acc Id: ENSRNOP00000054214   ⟸   ENSRNOT00000057404
RefSeq Acc Id: ENSRNOP00000069957   ⟸   ENSRNOT00000089695
RefSeq Acc Id: ENSRNOP00000097879   ⟸   ENSRNOT00000096914

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6Q760-F1-model_v2 AlphaFold Q6Q760 1-1738 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628710 AgrOrtholog
BioCyc Gene G2FUF-12332 BioCyc
Ensembl Genes ENSRNOG00000004752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006624.7 UniProtKB/TrEMBL
  ENSRNOP00000054214.4 UniProtKB/TrEMBL
  ENSRNOP00000069957.2 UniProtKB/TrEMBL
  ENSRNOP00000097879.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006624.8 UniProtKB/TrEMBL
  ENSRNOT00000057404.6 UniProtKB/TrEMBL
  ENSRNOT00000089695.2 UniProtKB/TrEMBL
  ENSRNOT00000096914.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NALCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266760 UniProtKB/Swiss-Prot
NCBI Gene 266760 ENTREZGENE
PANTHER PTHR46141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nalcn PhenoGen
UniProt A0A0G2JWP2_RAT UniProtKB/TrEMBL
  A0A8I6AVL4_RAT UniProtKB/TrEMBL
  F1LMW5_RAT UniProtKB/TrEMBL
  F1LS19_RAT UniProtKB/TrEMBL
  NALCN_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9Z165 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Nalcn  sodium leak channel, non-selective  Vgcnl1  voltage gated channel like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Vgcnl1  voltage gated channel like 1      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Vgcnl1  voltage gated channel like 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_evolution may have evolved from an ancestral four repeat ion channel structure prior to Ca+2 and Na+ channel divergence 634530