Nalcn (sodium leak channel, non-selective) - Rat Genome Database

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Gene: Nalcn (sodium leak channel, non-selective) Rattus norvegicus
Analyze
Symbol: Nalcn
Name: sodium leak channel, non-selective
RGD ID: 628710
Description: Predicted to enable leak channel activity and voltage-gated sodium channel activity. Predicted to be involved in monoatomic cation transmembrane transport; positive regulation of synaptic transmission; and regulation of resting membrane potential. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Orthologous to human NALCN (sodium leak channel, non-selective); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: brain voltage-gated cation channel; four domain-type voltage-gated ion channel alpha-1 subunit; rb21-channel; sodium leak channel NALCN; sodium leak channel non-selective protein; Vgcnl1; voltage gated channel like 1; voltage gated channel-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,805,209 - 107,148,837 (-)NCBIGRCr8
mRatBN7.215100,398,583 - 100,741,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15100,398,615 - 100,741,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15104,339,461 - 104,686,255 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015105,429,004 - 105,781,329 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015102,356,286 - 102,708,574 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015109,734,092 - 110,046,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15109,735,595 - 110,046,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015113,115,691 - 113,426,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415108,414,286 - 108,658,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115108,430,065 - 108,673,975 (-)NCBI
Celera1599,154,725 - 99,456,878 (-)NCBICelera
Cytogenetic Map15q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mutations in NALCN cause an autosomal-recessive syndrome with severe hypotonia, speech impairment, and cognitive delay. Al-Sayed MD, etal., Am J Hum Genet. 2013 Oct 3;93(4):721-6. doi: 10.1016/j.ajhg.2013.08.001. Epub 2013 Sep 26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism. Köroglu Ç, etal., J Med Genet. 2013 Aug;50(8):515-20. doi: 10.1136/jmedgenet-2013-101634. Epub 2013 Jun 7.
4. Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels. Lee JH, etal., FEBS Lett 1999 Feb 26;445(2-3):231-6.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12498692   PMID:17448995   PMID:33273469  


Genomics

Comparative Map Data
Nalcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,805,209 - 107,148,837 (-)NCBIGRCr8
mRatBN7.215100,398,583 - 100,741,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15100,398,615 - 100,741,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15104,339,461 - 104,686,255 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015105,429,004 - 105,781,329 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015102,356,286 - 102,708,574 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015109,734,092 - 110,046,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15109,735,595 - 110,046,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015113,115,691 - 113,426,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415108,414,286 - 108,658,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115108,430,065 - 108,673,975 (-)NCBI
Celera1599,154,725 - 99,456,878 (-)NCBICelera
Cytogenetic Map15q25NCBI
NALCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813101,053,776 - 101,417,179 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13101,053,776 - 101,416,508 (-)EnsemblGRCh38hg38GRCh38
GRCh3713101,706,128 - 102,068,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613100,504,131 - 100,866,814 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413100,505,600 - 100,866,707NCBI
Celera1382,551,415 - 82,911,536 (-)NCBICelera
Cytogenetic Map13q32.3-q33.1NCBI
HuRef1382,301,975 - 82,662,087 (-)NCBIHuRef
CHM1_113101,676,115 - 102,038,862 (-)NCBICHM1_1
T2T-CHM13v2.013100,268,892 - 100,632,422 (-)NCBIT2T-CHM13v2.0
Nalcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914123,514,046 - 123,864,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14123,514,046 - 123,864,556 (-)EnsemblGRCm39 Ensembl
GRCm3814123,275,678 - 123,627,330 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14123,276,634 - 123,627,144 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714123,675,863 - 124,026,366 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614122,434,608 - 122,762,324 (-)NCBIMGSCv36mm8
Celera14121,838,270 - 121,890,033 (-)NCBICelera
Celera14122,811,564 - 123,084,265 (-)NCBICelera
Cytogenetic Map14E5NCBI
cM Map1466.04NCBI
Nalcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554049,603,562 - 9,895,817 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554049,603,567 - 9,894,688 (+)NCBIChiLan1.0ChiLan1.0
NALCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214102,572,054 - 102,930,688 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113101,239,557 - 101,597,900 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01382,215,094 - 82,573,501 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113101,352,535 - 101,710,917 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13101,354,054 - 101,693,223 (-)Ensemblpanpan1.1panPan2
NALCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12250,821,983 - 51,142,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2250,823,478 - 51,141,644 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2250,601,806 - 50,922,190 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02251,265,000 - 51,586,596 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2251,265,007 - 51,586,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12250,910,597 - 51,250,150 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02250,941,445 - 51,259,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02250,984,648 - 51,306,587 (-)NCBIUU_Cfam_GSD_1.0
Nalcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945186,162,530 - 186,450,079 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364729,502,030 - 9,789,638 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364729,502,054 - 9,789,714 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NALCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1169,710,364 - 70,022,727 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11169,710,355 - 70,023,020 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NALCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1379,663,714 - 80,010,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl379,663,725 - 79,992,503 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604636,176,805 - 36,522,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nalcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247939,915,273 - 10,249,563 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247939,929,980 - 10,248,107 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nalcn
1785 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:96
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000006624, ENSRNOT00000057404
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat

Markers in Region
D14Mit107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,704,919 - 100,705,094 (+)MAPPERmRatBN7.2
Rnor_6.015110,039,366 - 110,039,540NCBIRnor6.0
Rnor_5.015113,418,878 - 113,419,052UniSTSRnor5.0
RGSC_v3.415108,746,313 - 108,746,487UniSTSRGSC3.4
Celera1599,449,515 - 99,449,689UniSTS
Cytogenetic Map15q25UniSTS
PMC126259P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,400,189 - 100,400,264 (+)MAPPERmRatBN7.2
Rnor_6.015109,735,667 - 109,735,741NCBIRnor6.0
Rnor_5.015113,117,266 - 113,117,340UniSTSRnor5.0
RGSC_v3.415108,415,861 - 108,415,935UniSTSRGSC3.4
Celera1599,156,300 - 99,156,374UniSTS
Cytogenetic Map15q25UniSTS
RH130621  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,398,820 - 100,399,032 (+)MAPPERmRatBN7.2
Rnor_6.015109,734,298 - 109,734,509NCBIRnor6.0
Rnor_5.015113,115,897 - 113,116,108UniSTSRnor5.0
RGSC_v3.415108,414,492 - 108,414,703UniSTSRGSC3.4
Celera1599,154,931 - 99,155,142UniSTS
RH 3.4 Map15716.1UniSTS
Cytogenetic Map15q25UniSTS
BE113539  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,399,872 - 100,400,032 (+)MAPPERmRatBN7.2
Rnor_6.015109,735,350 - 109,735,509NCBIRnor6.0
Rnor_5.015113,116,949 - 113,117,108UniSTSRnor5.0
RGSC_v3.415108,415,544 - 108,415,703UniSTSRGSC3.4
Celera1599,155,983 - 99,156,142UniSTS
RH 3.4 Map15716.1UniSTS
Cytogenetic Map15q25UniSTS
RH136716  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,682,552 - 100,682,787 (+)MAPPERmRatBN7.2
Rnor_6.015110,017,848 - 110,018,082NCBIRnor6.0
Rnor_5.015113,397,362 - 113,397,596UniSTSRnor5.0
Celera1599,428,965 - 99,429,199UniSTS
Cytogenetic Map15q25UniSTS
RH138154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215100,607,186 - 100,607,333 (+)MAPPERmRatBN7.2
Rnor_6.015109,942,414 - 109,942,560NCBIRnor6.0
Rnor_5.015113,323,215 - 113,323,361UniSTSRnor5.0
RGSC_v3.415108,629,836 - 108,629,982UniSTSRGSC3.4
Celera1599,353,846 - 99,353,992UniSTS
Cytogenetic Map15q25UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 60
Low 3 7 1 4 1 7 7 14 35 5 7
Below cutoff 3 32 24 17 15 17 1 4 18 6 6 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF078779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY555273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF427668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF492985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000006624   ⟹   ENSRNOP00000006624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15100,399,229 - 100,740,983 (-)Ensembl
Rnor_6.0 Ensembl15109,735,595 - 110,046,687 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000057404   ⟹   ENSRNOP00000054214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15100,399,229 - 100,740,983 (-)Ensembl
Rnor_6.0 Ensembl15109,735,595 - 110,046,687 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089695   ⟹   ENSRNOP00000069957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15100,400,051 - 100,741,001 (-)Ensembl
Rnor_6.0 Ensembl15109,735,595 - 110,046,704 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096914   ⟹   ENSRNOP00000097879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl15100,398,615 - 100,740,983 (-)Ensembl
RefSeq Acc Id: NM_001393693   ⟹   NP_001380622
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,209 - 107,147,858 (-)NCBI
mRatBN7.215100,398,583 - 100,741,243 (-)NCBI
RefSeq Acc Id: NM_001393694   ⟹   NP_001380623
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,209 - 107,147,858 (-)NCBI
mRatBN7.215100,398,583 - 100,741,243 (-)NCBI
RefSeq Acc Id: NM_001393695   ⟹   NP_001380624
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,209 - 107,147,858 (-)NCBI
mRatBN7.215100,398,583 - 100,741,243 (-)NCBI
RefSeq Acc Id: XM_063274038   ⟹   XP_063130108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,214 - 107,148,837 (-)NCBI
RefSeq Acc Id: XM_063274039   ⟹   XP_063130109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,214 - 107,148,837 (-)NCBI
RefSeq Acc Id: XM_063274040   ⟹   XP_063130110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,214 - 107,148,837 (-)NCBI
RefSeq Acc Id: XM_063274041   ⟹   XP_063130111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,214 - 107,148,837 (-)NCBI
RefSeq Acc Id: XM_063274042   ⟹   XP_063130112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,214 - 107,118,884 (-)NCBI
RefSeq Acc Id: XM_063274043   ⟹   XP_063130113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,214 - 107,148,837 (-)NCBI
RefSeq Acc Id: XM_063274044   ⟹   XP_063130114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,214 - 107,148,837 (-)NCBI
RefSeq Acc Id: XM_063274045   ⟹   XP_063130115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815106,805,214 - 107,092,269 (-)NCBI
RefSeq Acc Id: ENSRNOP00000006624   ⟸   ENSRNOT00000006624
RefSeq Acc Id: ENSRNOP00000054214   ⟸   ENSRNOT00000057404
RefSeq Acc Id: ENSRNOP00000069957   ⟸   ENSRNOT00000089695
RefSeq Acc Id: ENSRNOP00000097879   ⟸   ENSRNOT00000096914
RefSeq Acc Id: NP_001380624   ⟸   NM_001393695
- Peptide Label: isoform 3
- UniProtKB: B2BF51 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380623   ⟸   NM_001393694
- Peptide Label: isoform 2
- UniProtKB: Q9Z165 (UniProtKB/Swiss-Prot),   Q6Q760 (UniProtKB/Swiss-Prot),   A6HUN0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380622   ⟸   NM_001393693
- Peptide Label: isoform 1
- UniProtKB: F1LMW5 (UniProtKB/TrEMBL),   B1N8Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130114   ⟸   XM_063274044
- Peptide Label: isoform X6
- UniProtKB: B2BF51 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130113   ⟸   XM_063274043
- Peptide Label: isoform X5
- UniProtKB: Q9Z165 (UniProtKB/Swiss-Prot),   Q6Q760 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063130110   ⟸   XM_063274040
- Peptide Label: isoform X2
- UniProtKB: B1N8Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130111   ⟸   XM_063274041
- Peptide Label: isoform X3
- UniProtKB: F1LS19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130108   ⟸   XM_063274038
- Peptide Label: isoform X1
- UniProtKB: B1N8Y4 (UniProtKB/TrEMBL),   F1LMW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130109   ⟸   XM_063274039
- Peptide Label: isoform X1
- UniProtKB: B1N8Y4 (UniProtKB/TrEMBL),   F1LMW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130112   ⟸   XM_063274042
- Peptide Label: isoform X4
- UniProtKB: B1N8Y4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130115   ⟸   XM_063274045
- Peptide Label: isoform X7
- UniProtKB: B1N8Y4 (UniProtKB/TrEMBL)
Protein Domains
Ion transport

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6Q760-F1-model_v2 AlphaFold Q6Q760 1-1738 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628710 AgrOrtholog
BioCyc Gene G2FUF-12332 BioCyc
Ensembl Genes ENSRNOG00000004752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006624 ENTREZGENE
  ENSRNOT00000006624.8 UniProtKB/TrEMBL
  ENSRNOT00000057404.6 UniProtKB/TrEMBL
  ENSRNOT00000089695.2 UniProtKB/TrEMBL
  ENSRNOT00000096914 ENTREZGENE
  ENSRNOT00000096914.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NALCN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266760 UniProtKB/Swiss-Prot
NCBI Gene 266760 ENTREZGENE
PANTHER PTHR46141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nalcn PhenoGen
RatGTEx ENSRNOG00000004752 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JWP2_RAT UniProtKB/TrEMBL
  A0A8I6AVL4_RAT UniProtKB/TrEMBL
  A6HUN0 ENTREZGENE, UniProtKB/TrEMBL
  B1N8Y4 ENTREZGENE, UniProtKB/TrEMBL
  B2BF51 ENTREZGENE, UniProtKB/TrEMBL
  F1LMW5 ENTREZGENE, UniProtKB/TrEMBL
  F1LS19 ENTREZGENE, UniProtKB/TrEMBL
  NALCN_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z165 ENTREZGENE
UniProt Secondary Q9Z165 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Nalcn  sodium leak channel, non-selective  Vgcnl1  voltage gated channel like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Vgcnl1  voltage gated channel like 1      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Vgcnl1  voltage gated channel like 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_evolution may have evolved from an ancestral four repeat ion channel structure prior to Ca+2 and Na+ channel divergence 634530