NALCN (sodium leak channel, non-selective) - Rat Genome Database

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Gene: NALCN (sodium leak channel, non-selective) Pan paniscus
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Symbol: NALCN
Name: sodium leak channel, non-selective
RGD ID: 11672783
Description: ENCODES a protein that exhibits leak channel activity (ortholog); INVOLVED IN calcium ion transmembrane transport (ortholog); potassium ion transmembrane transport (ortholog); regulation of resting membrane potential (ortholog); ASSOCIATED WITH Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); autism spectrum disorder (ortholog); congenital limbs-face contractures-hypotonia-developmental delay syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium leak channel NALCN
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214102,572,054 - 102,930,688 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113101,239,557 - 101,597,900 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01382,215,094 - 82,573,501 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113101,352,535 - 101,710,917 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13101,354,054 - 101,693,223 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NALCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214102,572,054 - 102,930,688 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113101,239,557 - 101,597,900 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01382,215,094 - 82,573,501 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113101,352,535 - 101,710,917 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13101,354,054 - 101,693,223 (-)Ensemblpanpan1.1panPan2
NALCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813101,053,776 - 101,417,179 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13101,053,776 - 101,416,508 (-)EnsemblGRCh38hg38GRCh38
GRCh3713101,706,128 - 102,068,859 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613100,504,131 - 100,866,814 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413100,505,600 - 100,866,707NCBI
Celera1382,551,415 - 82,911,536 (-)NCBICelera
Cytogenetic Map13q32.3-q33.1NCBI
HuRef1382,301,975 - 82,662,087 (-)NCBIHuRef
CHM1_113101,676,115 - 102,038,862 (-)NCBICHM1_1
T2T-CHM13v2.013100,268,892 - 100,632,422 (-)NCBIT2T-CHM13v2.0
Nalcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914123,514,046 - 123,864,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14123,514,046 - 123,864,556 (-)EnsemblGRCm39 Ensembl
GRCm3814123,275,678 - 123,627,330 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14123,276,634 - 123,627,144 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714123,675,863 - 124,026,366 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614122,434,608 - 122,762,324 (-)NCBIMGSCv36mm8
Celera14121,838,270 - 121,890,033 (-)NCBICelera
Celera14122,811,564 - 123,084,265 (-)NCBICelera
Cytogenetic Map14E5NCBI
cM Map1466.04NCBI
Nalcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,805,209 - 107,148,837 (-)NCBIGRCr8
mRatBN7.215100,398,583 - 100,741,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15100,398,615 - 100,741,001 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15104,339,461 - 104,686,255 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015105,429,004 - 105,781,329 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015102,356,286 - 102,708,574 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015109,734,092 - 110,046,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15109,735,595 - 110,046,704 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015113,115,691 - 113,426,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415108,414,286 - 108,658,195 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115108,430,065 - 108,673,975 (-)NCBI
Celera1599,154,725 - 99,456,878 (-)NCBICelera
Cytogenetic Map15q25NCBI
Nalcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554049,603,562 - 9,895,817 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554049,603,567 - 9,894,688 (+)NCBIChiLan1.0ChiLan1.0
NALCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12250,821,983 - 51,142,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2250,823,478 - 51,141,644 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2250,601,806 - 50,922,190 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02251,265,000 - 51,586,596 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2251,265,007 - 51,586,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12250,910,597 - 51,250,150 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02250,941,445 - 51,259,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02250,984,648 - 51,306,587 (-)NCBIUU_Cfam_GSD_1.0
Nalcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945186,162,530 - 186,450,079 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364729,502,030 - 9,789,638 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364729,502,054 - 9,789,714 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NALCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1169,710,364 - 70,022,727 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11169,710,355 - 70,023,020 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NALCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1379,663,714 - 80,010,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl379,663,725 - 79,992,503 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604636,176,805 - 36,522,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nalcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247939,915,273 - 10,249,563 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247939,929,980 - 10,248,107 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000048166   ⟹   ENSPPAP00000025339
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl13101,354,054 - 101,693,223 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000048171   ⟹   ENSPPAP00000025344
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl13101,354,054 - 101,693,223 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000048174   ⟹   ENSPPAP00000025347
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl13101,354,054 - 101,693,223 (-)Ensembl
RefSeq Acc Id: XM_034936922   ⟹   XP_034792813
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214102,572,054 - 102,930,415 (-)NCBI
NHGRI_mPanPan113101,239,557 - 101,597,811 (-)NCBI
Mhudiblu_PPA_v01382,215,094 - 82,573,453 (-)NCBI
RefSeq Acc Id: XM_034936923   ⟹   XP_034792814
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214102,572,054 - 102,930,688 (-)NCBI
NHGRI_mPanPan113101,239,557 - 101,597,900 (-)NCBI
Mhudiblu_PPA_v01382,216,611 - 82,573,501 (-)NCBI
RefSeq Acc Id: XM_063595852   ⟹   XP_063451922
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214102,572,054 - 102,920,440 (-)NCBI
RefSeq Acc Id: XM_063595853   ⟹   XP_063451923
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214102,572,054 - 102,930,415 (-)NCBI
RefSeq Acc Id: XM_063595854   ⟹   XP_063451924
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214102,572,054 - 102,930,686 (-)NCBI
RefSeq Acc Id: XM_063595855   ⟹   XP_063451925
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214102,572,054 - 102,920,440 (-)NCBI
RefSeq Acc Id: XP_034792813   ⟸   XM_034936922
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BE86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034792814   ⟸   XM_034936923
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BE86 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000025339   ⟸   ENSPPAT00000048166
Ensembl Acc Id: ENSPPAP00000025347   ⟸   ENSPPAT00000048174
Ensembl Acc Id: ENSPPAP00000025344   ⟸   ENSPPAT00000048171
RefSeq Acc Id: XP_063451924   ⟸   XM_063595854
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063451923   ⟸   XM_063595853
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063451925   ⟸   XM_063595855
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063451922   ⟸   XM_063595852
- Peptide Label: isoform X1
Protein Domains
Ion transport


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035645 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048166.1 UniProtKB/TrEMBL
  ENSPPAT00000048171.1 UniProtKB/TrEMBL
  ENSPPAT00000048174.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  NALCN UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene NALCN ENTREZGENE
PANTHER PTHR46141 UniProtKB/TrEMBL
  SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A2R9B6Y1_PANPA UniProtKB/TrEMBL
  A0A2R9BE80_PANPA UniProtKB/TrEMBL
  A0A2R9BE86 ENTREZGENE, UniProtKB/TrEMBL