CASC19 (cancer susceptibility 19) - Rat Genome Database

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Gene: CASC19 (cancer susceptibility 19) Homo sapiens
Analyze
Symbol: CASC19
Name: cancer susceptibility 19
RGD ID: 8548766
HGNC Page HGNC:49476
Description: ASSOCIATED WITH Familial Prostate Cancer; INTERACTS WITH benzo[a]pyrene; lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine
Type: ncrna
RefSeq Status: VALIDATED
Previously known as: cancer susceptibility 19 (non-protein coding); cancer susceptibility candidate 19 (non-protein coding); CARLo-6; CARLO6; LINC01245
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388127,187,785 - 127,197,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378128,200,030 - 128,209,872 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map8q24.21NCBI
CHM1_18128,240,359 - 128,250,203 (-)NCBICHM1_1
T2T-CHM13v2.08128,315,169 - 128,325,013 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:24594601   PMID:27262462   PMID:31011255   PMID:31389608   PMID:31422382   PMID:32074771   PMID:32677267   PMID:33155202   PMID:33416169   PMID:33573349   PMID:36651836   PMID:36769373  
PMID:36805849   PMID:37029242   PMID:38544395  


Genomics

Variants

.
Variants in CASC19
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3		 pathogenic
GRCh38/hg38 8q24.21(chr8:127118340-127858575)x3 copy number gain See cases [RCV000050763] Chr8:127118340..127858575 [GRCh38]
Chr8:128130585..128870821 [GRCh37]
Chr8:128199767..128940003 [NCBI36]
Chr8:8q24.21		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3		 pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3		 pathogenic
GRCh38/hg38 8q24.21-24.23(chr8:126626164-137169427)x1 copy number loss See cases [RCV000054306] Chr8:126626164..137169427 [GRCh38]
Chr8:127638409..138181670 [GRCh37]
Chr8:127707591..138250852 [NCBI36]
Chr8:8q24.21-24.23		 pathogenic
GRCh38/hg38 8q24.13-24.21(chr8:122454392-128513076)x3 copy number gain See cases [RCV000133620] Chr8:122454392..128513076 [GRCh38]
Chr8:123466631..129525322 [GRCh37]
Chr8:123535812..129594504 [NCBI36]
Chr8:8q24.13-24.21		 pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3		 pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23		 pathogenic|likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3		 pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3		 pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3		 pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3		 pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3		 pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3		 pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3		 pathogenic
NC_000008.11:g.127196124A>G single nucleotide variant Familial prostate cancer [RCV001257965] Chr8:127196124 [GRCh38]
Chr8:127196124..127196125 [GRCh38]
Chr8:128208369 [GRCh37]
Chr8:128208369..128208370 [GRCh37]
Chr8:8q24.21		 association
NC_000008.11:g.127193633G>T single nucleotide variant Familial prostate cancer [RCV001257964] Chr8:127193633 [GRCh38]
Chr8:128205878 [GRCh37]
Chr8:8q24.21		 association
GRCh38/hg38 8q23.3-24.23(chr8:115586904-135607135)x3 copy number gain Neurodevelopmental disorder [RCV003327615] Chr8:115586904..135607135 [GRCh38]
Chr8:8q23.3-24.23		 pathogenic

Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_120364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC020688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI223175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DW435273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX003871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OA989208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NR_120364
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388127,187,785 - 127,197,627 (-)NCBI
CHM1_18128,240,359 - 128,250,203 (-)NCBI
T2T-CHM13v2.08128,315,169 - 128,325,013 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC CASC19 COSMIC
GTEx CASC19 GTEx
HGNC ID HGNC:49476 ENTREZGENE
Human Proteome Map CASC19 Human Proteome Map
NCBI Gene LINC01245 ENTREZGENE
OMIM 617703 OMIM
RNAcentral URS000075BCC9 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-22 CASC19  cancer susceptibility 19    cancer susceptibility 19 (non-protein coding)  Symbol and/or name change 5135510 APPROVED
2017-01-31 CASC19  cancer susceptibility 19 (non-protein coding)    cancer susceptibility candidate 19 (non-protein coding)  Symbol and/or name change 5135510 APPROVED
2014-09-17 CASC19  cancer susceptibility candidate 19 (non-protein coding)  LINC01245  long intergenic non-protein coding RNA 1245  Symbol and/or name change 5135510 APPROVED