STRN3 (striatin 3) - Rat Genome Database

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Gene: STRN3 (striatin 3) Homo sapiens
Analyze
Symbol: STRN3
Name: striatin 3
RGD ID: 737101
HGNC Page HGNC:15720
Description: Enables armadillo repeat domain binding activity; enzyme binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; nucleoplasm; and plasma membrane. Part of FAR/SIN/STRIPAK complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell cycle autoantigen SG2NA; cell cycle S/G2 nuclear autoantigen; nuclear autoantigen; PPP2R6B; s/G2 antigen; S/G2NA; SG2NA; striatin, calmodulin binding protein 3; striatin-3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381430,893,804 - 31,026,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1430,893,799 - 31,026,401 (-)EnsemblGRCh38hg38GRCh38
GRCh371431,363,010 - 31,495,585 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361430,432,756 - 30,565,358 (-)NCBINCBI36Build 36hg18NCBI36
Build 341430,432,760 - 30,565,340NCBI
Celera1411,228,456 - 11,361,095 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1411,480,100 - 11,613,295 (-)NCBIHuRef
CHM1_11431,362,176 - 31,494,809 (-)NCBICHM1_1
T2T-CHM13v2.01425,091,284 - 25,224,212 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA)
dendrite  (IBA,IEA,ISO,ISS)
FAR/SIN/STRIPAK complex  (IBA,IDA)
Golgi apparatus  (IDA)
membrane  (IEA)
neuronal cell body  (IEA,ISO,ISS)
nucleoplasm  (IDA)
nucleus  (IDA)
plasma membrane  (IDA)
postsynapse  (IEA,ISO)
protein-containing complex  (IEA,ISO,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7864889   PMID:7910562   PMID:10681496   PMID:10748158   PMID:11251078   PMID:11319234   PMID:11570823   PMID:12477932   PMID:15302935   PMID:16344560   PMID:16396496   PMID:16964243  
PMID:17353931   PMID:17540176   PMID:18029348   PMID:18434427   PMID:18502210   PMID:18782753   PMID:19156129   PMID:19322201   PMID:19615732   PMID:20360068   PMID:21873635   PMID:22863883  
PMID:22939629   PMID:22990118   PMID:23277359   PMID:23443559   PMID:23455922   PMID:23678272   PMID:24255178   PMID:24366813   PMID:24550388   PMID:25015106   PMID:25531779   PMID:25743393  
PMID:25921289   PMID:26022125   PMID:26186194   PMID:26344197   PMID:26496610   PMID:26673895   PMID:27803151   PMID:28027390   PMID:28330616   PMID:28514442   PMID:28718761   PMID:29117863  
PMID:29299163   PMID:29395067   PMID:29467281   PMID:29509190   PMID:29568061   PMID:30520818   PMID:30595372   PMID:30622739   PMID:31527615   PMID:31594818   PMID:32235678   PMID:32296183  
PMID:32589942   PMID:32640226   PMID:32707033   PMID:32814053   PMID:32877691   PMID:33060197   PMID:33571521   PMID:33633399   PMID:33853758   PMID:33916271   PMID:33961781   PMID:34079125  
PMID:34524948   PMID:34831298   PMID:34857952   PMID:34917906   PMID:35230605   PMID:35256949   PMID:35271311   PMID:35446349   PMID:35575683   PMID:35831314   PMID:35944360   PMID:35973513  
PMID:36168627   PMID:36215168   PMID:36543142   PMID:36602306   PMID:36652389   PMID:36674791   PMID:37536630   PMID:37827155   PMID:37929963   PMID:38429901   PMID:38943005  


Genomics

Comparative Map Data
STRN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381430,893,804 - 31,026,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1430,893,799 - 31,026,401 (-)EnsemblGRCh38hg38GRCh38
GRCh371431,363,010 - 31,495,585 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361430,432,756 - 30,565,358 (-)NCBINCBI36Build 36hg18NCBI36
Build 341430,432,760 - 30,565,340NCBI
Celera1411,228,456 - 11,361,095 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1411,480,100 - 11,613,295 (-)NCBIHuRef
CHM1_11431,362,176 - 31,494,809 (-)NCBICHM1_1
T2T-CHM13v2.01425,091,284 - 25,224,212 (-)NCBIT2T-CHM13v2.0
Strn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391251,655,324 - 51,743,942 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1251,656,415 - 51,738,680 (-)EnsemblGRCm39 Ensembl
GRCm381251,608,541 - 51,692,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1251,609,632 - 51,691,897 (-)EnsemblGRCm38mm10GRCm38
MGSCv371252,709,528 - 52,792,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361252,531,252 - 52,613,506 (-)NCBIMGSCv36mm8
Celera1252,911,780 - 52,995,322 (-)NCBICelera
Cytogenetic Map12B3NCBI
cM Map1222.11NCBI
Strn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8674,783,156 - 74,869,473 (-)NCBIGRCr8
mRatBN7.2669,047,776 - 69,134,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,047,776 - 69,134,102 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx669,469,929 - 69,554,311 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0669,776,579 - 69,860,949 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0669,216,069 - 69,300,471 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0672,376,360 - 72,462,676 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl672,376,330 - 72,462,658 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0681,940,489 - 82,026,830 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4671,708,959 - 71,795,287 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1671,733,236 - 71,798,385 (-)NCBI
Celera667,923,577 - 68,009,729 (-)NCBICelera
Cytogenetic Map6q23NCBI
Strn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540929,529,507 - 29,636,674 (+)NCBIChiLan1.0ChiLan1.0
STRN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21532,220,964 - 32,351,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11431,437,466 - 31,567,771 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01411,668,426 - 11,798,776 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11429,867,827 - 29,997,439 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1429,869,414 - 29,997,838 (-)Ensemblpanpan1.1panPan2
STRN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1810,232,436 - 10,344,238 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl810,233,819 - 10,344,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha810,158,821 - 10,270,764 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0810,333,369 - 10,445,481 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl810,333,467 - 10,445,613 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1810,017,584 - 10,129,196 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0810,093,760 - 10,205,585 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0810,369,298 - 10,489,929 (-)NCBIUU_Cfam_GSD_1.0
Strn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864042,129,196 - 42,216,166 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364945,634,191 - 5,722,462 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364945,635,870 - 5,722,123 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STRN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl768,470,877 - 68,577,273 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1768,470,761 - 68,577,272 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Strn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248201,264,200 - 1,366,342 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248201,264,267 - 1,364,634 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in STRN3
58 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:23548960-41983402)x1 copy number loss See cases [RCV000051490] Chr14:23548960..41983402 [GRCh38]
Chr14:24018169..42452605 [GRCh37]
Chr14:23088009..41522355 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q12-21.2(chr14:30670314-44990595)x3 copy number gain See cases [RCV000052292] Chr14:30670314..44990595 [GRCh38]
Chr14:31139520..45459798 [GRCh37]
Chr14:30209271..44529548 [NCBI36]
Chr14:14q12-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh37/hg19 14q12(chr14:27450705-31529481)x3 copy number gain Epilepsy [RCV001293649] Chr14:27450705..31529481 [GRCh37]
Chr14:14q12		 pathogenic
GRCh38/hg38 14q12-21.1(chr14:30382554-37712341)x1 copy number loss See cases [RCV000135334] Chr14:30382554..37712341 [GRCh38]
Chr14:30851760..38181546 [GRCh37]
Chr14:29921511..37251297 [NCBI36]
Chr14:14q12-21.1		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q12-13.1(chr14:28803988-33234266)x1 copy number loss See cases [RCV000142290] Chr14:28803988..33234266 [GRCh38]
Chr14:29273194..33703472 [GRCh37]
Chr14:28342945..32773223 [NCBI36]
Chr14:14q12-13.1		 pathogenic
GRCh38/hg38 14q12-21.2(chr14:30792271-44685131)x1 copy number loss See cases [RCV000143063] Chr14:30792271..44685131 [GRCh38]
Chr14:31261477..45154334 [GRCh37]
Chr14:30331228..44224084 [NCBI36]
Chr14:14q12-21.2		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3 copy number gain See cases [RCV000143186] Chr14:20022693..44093672 [GRCh38]
Chr14:20490852..44562875 [GRCh37]
Chr14:19560692..43632625 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3 copy number gain See cases [RCV000143748] Chr14:20043513..48642042 [GRCh38]
Chr14:20511672..49111245 [GRCh37]
Chr14:19581512..48180995 [NCBI36]
Chr14:14q11.2-21.3		 pathogenic
GRCh37/hg19 14q11.2-22.2(chr14:23164384-54733411)x3 copy number gain See cases [RCV000447658] Chr14:23164384..54733411 [GRCh37]
Chr14:14q11.2-22.2		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_001128126.3(AP4S1):c.-77G>A single nucleotide variant not provided [RCV004715161]|not specified [RCV000443961] Chr14:31025782 [GRCh38]
Chr14:31494988 [GRCh37]
Chr14:14q12		 benign
GRCh37/hg19 14q11.2-13.1(chr14:19794561-34049214)x3 copy number gain See cases [RCV000448273] Chr14:19794561..34049214 [GRCh37]
Chr14:14q11.2-13.1		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-12(chr14:24233721-31377083)x1 copy number loss See cases [RCV000510673] Chr14:24233721..31377083 [GRCh37]
Chr14:14q11.2-12		 pathogenic
NM_001083893.2(STRN3):c.1621A>G (p.Ile541Val) single nucleotide variant not specified [RCV004304276] Chr14:30911140 [GRCh38]
Chr14:31380346 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.106G>A (p.Gly36Arg) single nucleotide variant not specified [RCV004314889] Chr14:31026080 [GRCh38]
Chr14:31495286 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.2350A>G (p.Ile784Val) single nucleotide variant not specified [RCV004314998] Chr14:30895455 [GRCh38]
Chr14:31364661 [GRCh37]
Chr14:14q12		 uncertain significance
Single allele deletion Mitochondrial complex I deficiency [RCV000678000] Chr14:31012250..32193706 [GRCh38]
Chr14:31481456..32662912 [GRCh37]
Chr14:14q12		 uncertain significance
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q12-13.1(chr14:30448939-35017859)x1 copy number loss not provided [RCV000849105] Chr14:30448939..35017859 [GRCh37]
Chr14:14q12-13.1		 pathogenic
GRCh37/hg19 14q11.2-21.1(chr14:20511672-42881888)x3 copy number gain not provided [RCV001249358] Chr14:20511672..42881888 [GRCh37]
Chr14:14q11.2-21.1		 not provided
NM_001083893.2(STRN3):c.1004C>T (p.Ser335Phe) single nucleotide variant not specified [RCV004286483] Chr14:30929296 [GRCh38]
Chr14:31398502 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.98G>A (p.Gly33Glu) single nucleotide variant not specified [RCV004303856] Chr14:31026088 [GRCh38]
Chr14:31495294 [GRCh37]
Chr14:14q12		 uncertain significance
GRCh37/hg19 14q11.2-21.2(chr14:20511672-44829030)x3 copy number gain not provided [RCV001006605] Chr14:20511672..44829030 [GRCh37]
Chr14:14q11.2-21.2		 pathogenic
GRCh37/hg19 14q11.2-21.3(chr14:20511672-47481203) copy number gain Seizure [RCV002280625] Chr14:20511672..47481203 [GRCh37]
Chr14:14q11.2-21.3		 pathogenic
NC_000014.8:g.(21162263_36986276)_(36987308_50713602)del deletion Brain-lung-thyroid syndrome [RCV002221171] Chr14:36986276..36987308 [GRCh37]
Chr14:14q11.2-21.3		 pathogenic
NM_001083893.2(STRN3):c.478G>C (p.Glu160Gln) single nucleotide variant not specified [RCV004325612] Chr14:30950927 [GRCh38]
Chr14:31420133 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.182A>G (p.Gln61Arg) single nucleotide variant not specified [RCV004107485] Chr14:31026004 [GRCh38]
Chr14:31495210 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1000C>T (p.Leu334Phe) single nucleotide variant not specified [RCV004160406] Chr14:30929300 [GRCh38]
Chr14:31398506 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.868G>C (p.Ala290Pro) single nucleotide variant not specified [RCV004085005] Chr14:30935283 [GRCh38]
Chr14:31404489 [GRCh37]
Chr14:14q12		 uncertain significance
GRCh37/hg19 14q12-13.1(chr14:24959823-33415359)x1 copy number loss not provided [RCV002475721] Chr14:24959823..33415359 [GRCh37]
Chr14:14q12-13.1		 pathogenic
NM_001083893.2(STRN3):c.1232C>T (p.Ala411Val) single nucleotide variant not specified [RCV004074481] Chr14:30918974 [GRCh38]
Chr14:31388180 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.2170G>A (p.Asp724Asn) single nucleotide variant not specified [RCV004154953] Chr14:30895716 [GRCh38]
Chr14:31364922 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1540C>T (p.Pro514Ser) single nucleotide variant not specified [RCV004242834] Chr14:30912017 [GRCh38]
Chr14:31381223 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1958C>A (p.Thr653Asn) single nucleotide variant not specified [RCV004141675] Chr14:30905489 [GRCh38]
Chr14:31374695 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1930C>T (p.Pro644Ser) single nucleotide variant not specified [RCV004181435] Chr14:30905517 [GRCh38]
Chr14:31374723 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1121A>G (p.Tyr374Cys) single nucleotide variant not specified [RCV004203716] Chr14:30919085 [GRCh38]
Chr14:31388291 [GRCh37]
Chr14:14q12		 likely benign
NM_001083893.2(STRN3):c.1942G>A (p.Val648Ile) single nucleotide variant not specified [RCV004078311] Chr14:30905505 [GRCh38]
Chr14:31374711 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1183C>G (p.Gln395Glu) single nucleotide variant not specified [RCV004209537] Chr14:30919023 [GRCh38]
Chr14:31388229 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.2183G>C (p.Ser728Thr) single nucleotide variant not specified [RCV004205467] Chr14:30895703 [GRCh38]
Chr14:31364909 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.290T>C (p.Ile97Thr) single nucleotide variant not specified [RCV004166140] Chr14:30956235 [GRCh38]
Chr14:31425441 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.205C>G (p.Leu69Val) single nucleotide variant not specified [RCV004110079] Chr14:31025981 [GRCh38]
Chr14:31495187 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.512C>T (p.Thr171Met) single nucleotide variant not specified [RCV004193231] Chr14:30950893 [GRCh38]
Chr14:31420099 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.758A>C (p.Asn253Thr) single nucleotide variant not specified [RCV004213661] Chr14:30936583 [GRCh38]
Chr14:31405789 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1915T>C (p.Phe639Leu) single nucleotide variant not specified [RCV004180394] Chr14:30905532 [GRCh38]
Chr14:31374738 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.596G>A (p.Arg199Gln) single nucleotide variant not specified [RCV004096746] Chr14:30947210 [GRCh38]
Chr14:31416416 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.2120T>A (p.Phe707Tyr) single nucleotide variant not specified [RCV004093758] Chr14:30902553 [GRCh38]
Chr14:31371759 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1852A>G (p.Lys618Glu) single nucleotide variant not specified [RCV004093882] Chr14:30906913 [GRCh38]
Chr14:31376119 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.85G>A (p.Gly29Ser) single nucleotide variant not specified [RCV004299695] Chr14:31026101 [GRCh38]
Chr14:31495307 [GRCh37]
Chr14:14q12		 likely benign
NM_001083893.2(STRN3):c.2091A>G (p.Ile697Met) single nucleotide variant not specified [RCV004272419] Chr14:30902582 [GRCh38]
Chr14:31371788 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1076G>A (p.Arg359Gln) single nucleotide variant not specified [RCV004259587] Chr14:30929224 [GRCh38]
Chr14:31398430 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.2389G>A (p.Val797Ile) single nucleotide variant not specified [RCV004285160] Chr14:30895416 [GRCh38]
Chr14:31364622 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1009A>C (p.Thr337Pro) single nucleotide variant not specified [RCV004280031] Chr14:30929291 [GRCh38]
Chr14:31398497 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.763G>A (p.Asp255Asn) single nucleotide variant not specified [RCV004258875] Chr14:30936578 [GRCh38]
Chr14:31405784 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1024G>T (p.Asp342Tyr) single nucleotide variant not specified [RCV004321005] Chr14:30929276 [GRCh38]
Chr14:31398482 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.179C>G (p.Pro60Arg) single nucleotide variant not specified [RCV004354677] Chr14:31026007 [GRCh38]
Chr14:31495213 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.130C>T (p.Pro44Ser) single nucleotide variant not specified [RCV004341330] Chr14:31026056 [GRCh38]
Chr14:31495262 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.572C>T (p.Thr191Ile) single nucleotide variant not specified [RCV004341633] Chr14:30947234 [GRCh38]
Chr14:31416440 [GRCh37]
Chr14:14q12		 uncertain significance
GRCh37/hg19 14q11.2-23.1(chr14:20511673-61826023)x3 copy number gain not provided [RCV003485022] Chr14:20511673..61826023 [GRCh37]
Chr14:14q11.2-23.1		 pathogenic
GRCh37/hg19 14q12(chr14:31230778-31437901)x3 copy number gain not provided [RCV003485025] Chr14:31230778..31437901 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1100G>A (p.Arg367Lys) single nucleotide variant not provided [RCV003425009] Chr14:30919106 [GRCh38]
Chr14:31388312 [GRCh37]
Chr14:14q12		 likely benign
NM_001083893.2(STRN3):c.287G>A (p.Arg96Gln) single nucleotide variant not provided [RCV003425010] Chr14:30956238 [GRCh38]
Chr14:31425444 [GRCh37]
Chr14:14q12		 likely benign
GRCh37/hg19 14q12-21.2(chr14:29190489-45325177)x1 copy number loss not specified [RCV003987053] Chr14:29190489..45325177 [GRCh37]
Chr14:14q12-21.2		 pathogenic
NM_001083893.2(STRN3):c.824A>G (p.Lys275Arg) single nucleotide variant not specified [RCV004458531] Chr14:30936517 [GRCh38]
Chr14:31405723 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1400G>A (p.Arg467Gln) single nucleotide variant not specified [RCV004458521] Chr14:30912157 [GRCh38]
Chr14:31381363 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1704T>G (p.Asp568Glu) single nucleotide variant not specified [RCV004458523] Chr14:30911057 [GRCh38]
Chr14:31380263 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.2191G>A (p.Val731Ile) single nucleotide variant not specified [RCV004458524] Chr14:30895695 [GRCh38]
Chr14:31364901 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.424A>T (p.Asn142Tyr) single nucleotide variant not specified [RCV004458529] Chr14:30955656 [GRCh38]
Chr14:31424862 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1364A>G (p.Tyr455Cys) single nucleotide variant not specified [RCV004458520] Chr14:30913534 [GRCh38]
Chr14:31382740 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1697G>A (p.Ser566Asn) single nucleotide variant not specified [RCV004458522] Chr14:30911064 [GRCh38]
Chr14:31380270 [GRCh37]
Chr14:14q12		 likely benign
NM_001083893.2(STRN3):c.233G>T (p.Arg78Leu) single nucleotide variant not specified [RCV004458525] Chr14:31025953 [GRCh38]
Chr14:31495159 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.401A>T (p.Lys134Ile) single nucleotide variant not specified [RCV004458526] Chr14:30955679 [GRCh38]
Chr14:31424885 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.416C>T (p.Thr139Met) single nucleotide variant not specified [RCV004458527] Chr14:30955664 [GRCh38]
Chr14:31424870 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.746A>G (p.Asn249Ser) single nucleotide variant not specified [RCV004458530] Chr14:30936595 [GRCh38]
Chr14:31405801 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1847A>G (p.Gln616Arg) single nucleotide variant not specified [RCV004681706] Chr14:30906918 [GRCh38]
Chr14:31376124 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.827A>G (p.His276Arg) single nucleotide variant not specified [RCV004681707] Chr14:30936514 [GRCh38]
Chr14:31405720 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1883A>G (p.Asp628Gly) single nucleotide variant not specified [RCV004668210] Chr14:30906882 [GRCh38]
Chr14:31376088 [GRCh37]
Chr14:14q12		 uncertain significance
NM_001083893.2(STRN3):c.1599C>T (p.Ile533=) single nucleotide variant not specified [RCV004668211] Chr14:30911162 [GRCh38]
Chr14:31380368 [GRCh37]
Chr14:14q12		 likely benign
NC_000014.8:g.(?_30046444)_(32635573_?)del deletion Spastic paraplegia [RCV004578072] Chr14:30046444..32635573 [GRCh37]
Chr14:14q12		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1330
Count of miRNA genes:728
Interacting mature miRNAs:850
Transcripts:ENST00000355683, ENST00000357479, ENST00000366206, ENST00000554124, ENST00000554991, ENST00000555152, ENST00000555358, ENST00000556577
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407044163GWAS693139_Hcortical thickness QTL GWAS693139 (human)0.000001cortical thickness143099640830996409Human
407012992GWAS661968_Hmean platelet volume QTL GWAS661968 (human)1e-36mean platelet volumemean platelet volume (CMO:0001348)143090772330907724Human
406984132GWAS633108_Hneuroimaging measurement, brain volume measurement QTL GWAS633108 (human)2e-12neuroimaging measurement, brain volume measurementbrain morphological measurement (CMO:0000136)143091593830915939Human
407280001GWAS928977_Hbrain measurement QTL GWAS928977 (human)1e-41brain measurementbrain measurement (CMO:0000911)143091722030917221Human
406998025GWAS647001_Hbiological sex QTL GWAS647001 (human)3e-09biological sex143092340030923401Human
407051278GWAS700254_Hcortical thickness QTL GWAS700254 (human)6e-09cortical thickness143099640830996409Human
407038284GWAS687260_Hmean platelet volume QTL GWAS687260 (human)2e-30mean platelet volumemean platelet volume (CMO:0001348)143090311530903116Human
407000146GWAS649122_Hmean platelet volume QTL GWAS649122 (human)3e-40mean platelet volumemean platelet volume (CMO:0001348)143090772330907724Human
407333782GWAS982758_Hneuroimaging measurement QTL GWAS982758 (human)7e-15neuroimaging measurement143092775630927757Human
407150742GWAS799718_Hneuroimaging measurement, brain volume measurement QTL GWAS799718 (human)2e-08systolic blood pressuresystolic blood pressure (CMO:0000004)143091214530912146Human
407165655GWAS814631_Hplatelet count QTL GWAS814631 (human)6e-12platelet quantity (VT:0003179)platelet count (CMO:0000029)143091214530912146Human
407260885GWAS909861_Hbrain measurement QTL GWAS909861 (human)3e-09brain measurementbrain measurement (CMO:0000911)143092385130923852Human
407363155GWAS1012131_Hplatelet count QTL GWAS1012131 (human)3e-12platelet quantity (VT:0003179)platelet count (CMO:0000029)143090311530903116Human
407173777GWAS822753_Hcortical surface area measurement QTL GWAS822753 (human)1e-17cerebral cortex morphology trait (VT:0000788)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)143091652730916528Human
406985178GWAS634154_Hcortical surface area measurement, neuroimaging measurement QTL GWAS634154 (human)2e-10cerebral cortex morphology trait (VT:0000788)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)143102288931022890Human
406984347GWAS633323_Hneuroimaging measurement QTL GWAS633323 (human)0.000005neuroimaging measurement143090611630906117Human
406904543GWAS553519_HR-6-hydroxywarfarin measurement QTL GWAS553519 (human)0.000009R-6-hydroxywarfarin measurement143099711630997117Human
406967842GWAS616818_Hbrain connectivity measurement QTL GWAS616818 (human)8e-11brain connectivity measurement143092496530924966Human
407261291GWAS910267_Hwhite matter microstructure measurement QTL GWAS910267 (human)6e-16white matter microstructure measurement143091722030917221Human
407362099GWAS1011075_Hdiastolic blood pressure QTL GWAS1011075 (human)1e-08diastolic blood pressurediastolic blood pressure (CMO:0000005)143091214530912146Human
406985910GWAS634886_Hneuroimaging measurement QTL GWAS634886 (human)0.0000002neuroimaging measurement143095545530955456Human
407357810GWAS1006786_Hdiastolic blood pressure QTL GWAS1006786 (human)3e-08diastolic blood pressurediastolic blood pressure (CMO:0000005)143091214530912146Human
407259056GWAS908032_Hmean fractional anisotropy measurement QTL GWAS908032 (human)8e-10mean fractional anisotropy measurement143095545530955456Human
407239666GWAS888642_Hbrain measurement QTL GWAS888642 (human)3e-17brain measurementbrain measurement (CMO:0000911)143090759230907593Human
407172796GWAS821772_Hbrain connectivity measurement QTL GWAS821772 (human)3e-08brain connectivity measurement143095388030953881Human
407001978GWAS650954_Hvital capacity QTL GWAS650954 (human)1e-09vital capacity143100501531005016Human
407017337GWAS666313_Hplatelet count QTL GWAS666313 (human)3e-15platelet quantity (VT:0003179)platelet count (CMO:0000029)143089885730898858Human
407388531GWAS1037507_Hsystolic blood pressure QTL GWAS1037507 (human)1e-11systolic blood pressuresystolic blood pressure (CMO:0000004)143091214530912146Human
407376885GWAS1025861_Hbrain connectivity measurement QTL GWAS1025861 (human)7e-13brain connectivity measurement143091214530912146Human
407045501GWAS694477_Hplatelet count QTL GWAS694477 (human)2e-12platelet quantity (VT:0003179)platelet count (CMO:0000029)143090611630906117Human
407357304GWAS1006280_Hsystolic blood pressure QTL GWAS1006280 (human)2e-10systolic blood pressuresystolic blood pressure (CMO:0000004)143091214530912146Human

Markers in Region
SGC31556  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,364,359 - 31,364,579UniSTSGRCh37
Build 361430,434,110 - 30,434,330RGDNCBI36
Celera1411,229,811 - 11,230,031RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,481,454 - 11,481,674UniSTS
GeneMap99-GB4 RH Map1450.74UniSTS
Whitehead-RH Map1461.5UniSTS
NCBI RH Map14134.0UniSTS
RH47070  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,452,049 - 31,452,222UniSTSGRCh37
Build 361430,521,800 - 30,521,973RGDNCBI36
Celera1411,317,526 - 11,317,699RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,569,431 - 11,569,604UniSTS
GeneMap99-GB4 RH Map1450.84UniSTS
NCBI RH Map14108.2UniSTS
RH64942  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,474,088 - 31,474,208UniSTSGRCh37
Build 361430,543,839 - 30,543,959RGDNCBI36
Celera1411,339,558 - 11,339,678RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,591,769 - 11,591,889UniSTS
SHGC-81030  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,490,802 - 31,491,099UniSTSGRCh37
Build 361430,560,553 - 30,560,850RGDNCBI36
Celera1411,356,290 - 11,356,587RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,608,490 - 11,608,787UniSTS
TNG Radiation Hybrid Map145766.0UniSTS
D14S175  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,408,205 - 31,408,893UniSTSGRCh37
Build 361430,477,956 - 30,478,644RGDNCBI36
Celera1411,273,680 - 11,274,368RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,525,323 - 11,526,011UniSTS
D14S176  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,408,305 - 31,408,822UniSTSGRCh37
Build 361430,478,056 - 30,478,573RGDNCBI36
Celera1411,273,780 - 11,274,297RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,525,423 - 11,525,940UniSTS
D14S558  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,483,032 - 31,483,241UniSTSGRCh37
Build 361430,552,783 - 30,552,992RGDNCBI36
Celera1411,348,493 - 11,348,725RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,600,693 - 11,600,925UniSTS
D14S569  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,375,146 - 31,375,449UniSTSGRCh37
Build 361430,444,897 - 30,445,200RGDNCBI36
Celera1411,240,594 - 11,240,897RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,492,239 - 11,492,542UniSTS
TNG Radiation Hybrid Map145608.0UniSTS
Stanford-G3 RH Map14701.0UniSTS
Whitehead-YAC Contig Map14 UniSTS
NCBI RH Map14118.8UniSTS
G35594  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,470,792 - 31,470,888UniSTSGRCh37
Build 361430,540,543 - 30,540,639RGDNCBI36
Celera1411,336,258 - 11,336,354RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,588,467 - 11,588,563UniSTS
SHGC-64093  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,388,898 - 31,389,019UniSTSGRCh37
Build 361430,458,649 - 30,458,770RGDNCBI36
Celera1411,254,360 - 11,254,481RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,506,004 - 11,506,125UniSTS
G35940  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371431,459,215 - 31,459,354UniSTSGRCh37
Build 361430,528,966 - 30,529,105RGDNCBI36
Celera1411,324,687 - 11,324,826RGD
Cytogenetic Map14q13-q21UniSTS
HuRef1411,576,895 - 11,577,034UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001083893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005267569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005267570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047431321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054375935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA572712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF243424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK314041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL121808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW070834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC132673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG572065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM453981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA774504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA854600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000355683   ⟹   ENSP00000347909
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1430,893,799 - 31,026,401 (-)Ensembl
Ensembl Acc Id: ENST00000357479   ⟹   ENSP00000350071
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1430,893,804 - 31,026,379 (-)Ensembl
Ensembl Acc Id: ENST00000366206
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1430,912,066 - 30,932,398 (-)Ensembl
Ensembl Acc Id: ENST00000554124
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1430,905,417 - 30,912,311 (-)Ensembl
Ensembl Acc Id: ENST00000554991   ⟹   ENSP00000452542
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1430,913,524 - 30,935,304 (-)Ensembl
Ensembl Acc Id: ENST00000555152   ⟹   ENSP00000451233
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1430,947,112 - 30,964,509 (-)Ensembl
Ensembl Acc Id: ENST00000555358   ⟹   ENSP00000451028
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1430,895,345 - 31,026,319 (-)Ensembl
Ensembl Acc Id: ENST00000556577   ⟹   ENSP00000452092
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1430,913,524 - 30,936,621 (-)Ensembl
RefSeq Acc Id: NM_001083893   ⟹   NP_001077362
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381430,893,804 - 31,026,379 (-)NCBI
GRCh371431,362,985 - 31,495,607 (-)NCBI
Build 361430,432,756 - 30,565,358 (-)NCBI Archive
Celera1411,228,456 - 11,361,095 (-)RGD
HuRef1411,480,100 - 11,613,295 (-)RGD
CHM1_11431,362,176 - 31,494,809 (-)NCBI
T2T-CHM13v2.01425,091,284 - 25,224,212 (-)NCBI
Sequence:
RefSeq Acc Id: NM_014574   ⟹   NP_055389
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381430,893,804 - 31,026,379 (-)NCBI
GRCh371431,362,985 - 31,495,607 (-)NCBI
Build 361430,432,756 - 30,565,358 (-)NCBI Archive
Celera1411,228,456 - 11,361,095 (-)RGD
HuRef1411,480,100 - 11,613,295 (-)RGD
CHM1_11431,362,176 - 31,494,809 (-)NCBI
T2T-CHM13v2.01425,091,284 - 25,224,212 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005267569   ⟹   XP_005267626
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381430,893,804 - 31,026,379 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005267570   ⟹   XP_005267627
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381430,893,804 - 31,026,379 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047431321   ⟹   XP_047287277
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381430,893,804 - 30,960,897 (-)NCBI
RefSeq Acc Id: XM_054375933   ⟹   XP_054231908
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01425,091,284 - 25,158,418 (-)NCBI
RefSeq Acc Id: XM_054375934   ⟹   XP_054231909
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01425,091,284 - 25,224,212 (-)NCBI
RefSeq Acc Id: XM_054375935   ⟹   XP_054231910
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01425,091,284 - 25,224,212 (-)NCBI
RefSeq Acc Id: NP_055389   ⟸   NM_014574
- Peptide Label: isoform 2
- UniProtKB: A0AV58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001077362   ⟸   NM_001083893
- Peptide Label: isoform 1
- UniProtKB: A6NHZ7 (UniProtKB/Swiss-Prot),   A2RTX7 (UniProtKB/Swiss-Prot),   Q9NRA5 (UniProtKB/Swiss-Prot),   Q13033 (UniProtKB/Swiss-Prot),   A0AV58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005267626   ⟸   XM_005267569
- Peptide Label: isoform X2
- UniProtKB: A0AV58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005267627   ⟸   XM_005267570
- Peptide Label: isoform X3
- UniProtKB: A0AV58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000451233   ⟸   ENST00000555152
Ensembl Acc Id: ENSP00000451028   ⟸   ENST00000555358
Ensembl Acc Id: ENSP00000452092   ⟸   ENST00000556577
Ensembl Acc Id: ENSP00000347909   ⟸   ENST00000355683
Ensembl Acc Id: ENSP00000350071   ⟸   ENST00000357479
Ensembl Acc Id: ENSP00000452542   ⟸   ENST00000554991
RefSeq Acc Id: XP_047287277   ⟸   XM_047431321
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054231909   ⟸   XM_054375934
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054231910   ⟸   XM_054375935
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054231908   ⟸   XM_054375933
- Peptide Label: isoform X1
Protein Domains
Striatin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q13033-F1-model_v2 AlphaFold Q13033 1-797 view protein structure

Promoters
RGD ID:6791901
Promoter ID:HG_KWN:19161
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001083893,   NM_014574
Position:
Human AssemblyChrPosition (strand)Source
Build 361430,565,166 - 30,565,666 (-)MPROMDB
RGD ID:7227365
Promoter ID:EPDNEW_H19428
Type:initiation region
Name:STRN3_1
Description:striatin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381431,026,379 - 31,026,439EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15720 AgrOrtholog
COSMIC STRN3 COSMIC
Ensembl Genes ENSG00000196792 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000355683 ENTREZGENE
  ENST00000355683.9 UniProtKB/Swiss-Prot
  ENST00000357479 ENTREZGENE
  ENST00000357479.10 UniProtKB/Swiss-Prot
  ENST00000554991.5 UniProtKB/TrEMBL
  ENST00000555152.1 UniProtKB/TrEMBL
  ENST00000555358.5 UniProtKB/TrEMBL
  ENST00000556577.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000196792 GTEx
HGNC ID HGNC:15720 ENTREZGENE
Human Proteome Map STRN3 Human Proteome Map
InterPro G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Striatin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_repeat_striatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:29966 UniProtKB/Swiss-Prot
NCBI Gene 29966 ENTREZGENE
OMIM 614766 OMIM
PANTHER STRIATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRIATIN-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Striatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38394 PharmGKB
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AV58 ENTREZGENE, UniProtKB/TrEMBL
  A2RTX7 ENTREZGENE
  A6NHZ7 ENTREZGENE
  G3V340_HUMAN UniProtKB/TrEMBL
  G3V3G7_HUMAN UniProtKB/TrEMBL
  H0YJT2_HUMAN UniProtKB/TrEMBL
  H0YJZ4_HUMAN UniProtKB/TrEMBL
  Q13033 ENTREZGENE
  Q9NRA5 ENTREZGENE
  STRN3_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A2RTX7 UniProtKB/Swiss-Prot
  A6NHZ7 UniProtKB/Swiss-Prot
  Q9NRA5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 STRN3  striatin 3    striatin, calmodulin binding protein 3  Symbol and/or name change 5135510 APPROVED