Spr (sepiapterin reductase) - Rat Genome Database
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Gene: Spr (sepiapterin reductase) Mus musculus
Analyze
Symbol: Spr
Name: sepiapterin reductase
RGD ID: 736908
MGI Page MGI
Description: Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and skeleton. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; folate metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA409688; ENSMUSG00000071345; Gm10328
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18049   Gm18050   Gm18052   Gm18053   Gm18054   Gm18055   Gm18056   Gm18057   Gm18058   Gm18059   Gm18060   Gm18061   Gm18062   Gm18063   Spr-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,110,662 - 85,114,746 (-)NCBIGRCm39mm39
GRCm39 Ensembl685,107,158 - 85,114,748 (-)Ensembl
GRCm38685,133,680 - 85,137,764 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,130,176 - 85,137,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,083,674 - 85,087,758 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,099,343 - 85,103,476 (-)NCBImm8
Celera687,104,831 - 87,108,907 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7873607   PMID:8304109   PMID:8440319   PMID:9383299   PMID:9405351   PMID:10209270   PMID:10349636   PMID:10727395   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16532389   PMID:16602821   PMID:18201550   PMID:18614015   PMID:19273550   PMID:19423573   PMID:21062748   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:23577163   PMID:23640889   PMID:23647001   PMID:25921334   PMID:28320892   PMID:28858620   PMID:31040226  


Genomics

Comparative Map Data
Spr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,110,662 - 85,114,746 (-)NCBIGRCm39mm39
GRCm39 Ensembl685,107,158 - 85,114,748 (-)Ensembl
GRCm38685,133,680 - 85,137,764 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,130,176 - 85,137,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,083,674 - 85,087,758 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,099,343 - 85,103,476 (-)NCBImm8
Celera687,104,831 - 87,108,907 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.15NCBI
SPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl272,887,382 - 72,892,158 (+)EnsemblGRCh38hg38GRCh38
GRCh38272,887,408 - 72,892,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37273,114,537 - 73,119,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36272,968,056 - 72,972,794 (+)NCBINCBI36hg18NCBI36
Build 34273,026,202 - 73,030,941NCBI
Celera272,965,357 - 72,970,134 (+)NCBI
Cytogenetic Map2p13.2NCBI
HuRef272,850,110 - 72,854,887 (+)NCBIHuRef
CHM1_1273,044,688 - 73,049,465 (+)NCBICHM1_1
Spr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24117,671,948 - 117,676,292 (-)NCBI
Rnor_6.0 Ensembl4116,912,351 - 116,916,236 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04116,912,343 - 116,916,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04181,492,882 - 181,496,612 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44119,365,578 - 119,369,308 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14119,610,075 - 119,613,765 (-)NCBI
Celera4106,655,853 - 106,659,586 (-)NCBICelera
Cytogenetic Map4q34NCBI
Spr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542412,711,064 - 12,716,000 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542412,711,064 - 12,716,000 (-)NCBIChiLan1.0ChiLan1.0
SPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A74,433,056 - 74,438,105 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A74,433,056 - 74,438,105 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A72,939,621 - 72,944,669 (+)NCBIMhudiblu_PPA_v0panPan3
SPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1749,950,800 - 49,957,417 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11749,950,192 - 49,957,455 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Spr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649116,693,940 - 16,699,040 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,887,386 - 69,894,758 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,889,448 - 69,894,747 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2373,090,291 - 73,095,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11434,275,292 - 34,280,579 (-)NCBI
ChlSab1.1 Ensembl1434,275,289 - 34,280,786 (-)Ensembl
Spr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624762729,294 - 734,761 (-)NCBI

Position Markers
RH124882  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38685,133,741 - 85,133,831UniSTSGRCm38
MGSCv37685,083,735 - 85,083,825UniSTSGRCm37
Celera687,104,892 - 87,104,982UniSTS
Cytogenetic Map6C3UniSTS
cM Map637.0UniSTS
Spr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38685,137,538 - 85,137,815UniSTSGRCm38
MGSCv37685,087,532 - 85,087,809UniSTSGRCm37
Celera687,108,681 - 87,108,958UniSTS
Cytogenetic Map6C3UniSTS
cM Map637.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:686
Count of miRNA genes:335
Interacting mature miRNAs:376
Transcripts:ENSMUST00000045986, ENSMUST00000174286, ENSMUST00000174769
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY113096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY590544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK620382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S71375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W65601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z21947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000045986   ⟹   ENSMUSP00000048111
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,133,678 - 85,137,766 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174286   ⟹   ENSMUSP00000133859
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,134,000 - 85,137,762 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174769   ⟹   ENSMUSP00000134379
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,133,687 - 85,137,756 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204757   ⟹   ENSMUSP00000145412
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,130,176 - 85,137,766 (-)Ensembl
RefSeq Acc Id: NM_011467   ⟹   NP_035597
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,110,662 - 85,114,746 (-)NCBI
GRCm38685,133,680 - 85,137,764 (-)ENTREZGENE
MGSCv37685,083,674 - 85,087,758 (-)RGD
Celera687,104,831 - 87,108,907 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035597   ⟸   NM_011467
- UniProtKB: Q91XH5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000048111   ⟸   ENSMUST00000045986
RefSeq Acc Id: ENSMUSP00000145412   ⟸   ENSMUST00000204757
RefSeq Acc Id: ENSMUSP00000134379   ⟸   ENSMUST00000174769
RefSeq Acc Id: ENSMUSP00000133859   ⟸   ENSMUST00000174286

Promoters
RGD ID:6840017
Promoter ID:MM_KWN:46665
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:ENSMUST00000095768
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,083,201 - 85,084,352 (+)MPROMDB
RGD ID:6840018
Promoter ID:MM_KWN:46666
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000045986,   UC009CPG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,087,556 - 85,088,062 (-)MPROMDB
RGD ID:6890212
Promoter ID:EPDNEW_M8557
Type:multiple initiation site
Name:Spr_1
Description:Mus musculus sepiapterin reductase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,137,764 - 85,137,824EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103078 AgrOrtholog
Ensembl Genes ENSMUSG00000033735 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000048111 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000133859 UniProtKB/TrEMBL
  ENSMUSP00000134379 UniProtKB/TrEMBL
  ENSMUSP00000145412 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045986 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000174286 UniProtKB/TrEMBL
  ENSMUST00000174769 UniProtKB/TrEMBL
  ENSMUST00000204757 UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sepiapterin_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20751 UniProtKB/TrEMBL
MGD MGI:103078 ENTREZGENE
NCBI Gene 20751 ENTREZGENE
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spr PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs sepiapter_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UXX3_MOUSE UniProtKB/TrEMBL
  G3UZ79_MOUSE UniProtKB/TrEMBL
  Q62218_MOUSE UniProtKB/TrEMBL
  Q64105 ENTREZGENE
  Q91XH5 ENTREZGENE, UniProtKB/TrEMBL
  SPRE_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q63996 UniProtKB/Swiss-Prot