Spr (sepiapterin reductase) - Rat Genome Database

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Gene: Spr (sepiapterin reductase) Mus musculus
Analyze
Symbol: Spr
Name: sepiapterin reductase
RGD ID: 736908
MGI Page MGI
Description: Enables protein homodimerization activity. Acts upstream of or within several processes, including L-phenylalanine metabolic process; catecholamine metabolic process; and voluntary musculoskeletal movement. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and skeleton. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA409688; ENSMUSG00000071345; Gm10328
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gm18049   Gm18050   Gm18052   Gm18053   Gm18054   Gm18055   Gm18056   Gm18057   Gm18058   Gm18059   Gm18060   Gm18061   Gm18062   Gm18063  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,110,662 - 85,114,746 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl685,107,158 - 85,114,748 (-)EnsemblGRCm39 Ensembl
GRCm38685,133,680 - 85,137,764 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,130,176 - 85,137,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,083,674 - 85,087,758 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36685,099,343 - 85,103,476 (-)NCBIMGSCv36mm8
Celera687,104,831 - 87,108,907 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,5-hexanedione  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
fenthion  (EXP)
folic acid  (EXP)
gentamycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosomorpholine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
paracetamol  (ISO)
pentane-2,3-dione  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
propiconazole  (EXP)
pyrogallol  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triptonide  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
mitochondrion  (HDA)
nucleoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. Bonafe L, etal., Am J Hum Genet. 2001 Aug;69(2):269-77. Epub 2001 Jul 6.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7873607   PMID:8304109   PMID:8440319   PMID:9383299   PMID:9405351   PMID:10209270   PMID:10349636   PMID:10727395   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14681479  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16532389   PMID:16602821   PMID:18201550   PMID:18614015   PMID:19273550   PMID:19423573   PMID:21062748   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:23577163   PMID:23640889   PMID:23647001   PMID:25921334   PMID:28320892   PMID:28858620   PMID:31040226   PMID:31381993   PMID:37839992   PMID:38355793  


Genomics

Comparative Map Data
Spr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,110,662 - 85,114,746 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl685,107,158 - 85,114,748 (-)EnsemblGRCm39 Ensembl
GRCm38685,133,680 - 85,137,764 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,130,176 - 85,137,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,083,674 - 85,087,758 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36685,099,343 - 85,103,476 (-)NCBIMGSCv36mm8
Celera687,104,831 - 87,108,907 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.15NCBI
SPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38272,887,408 - 72,892,158 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl272,887,382 - 72,892,158 (+)EnsemblGRCh38hg38GRCh38
GRCh37273,114,537 - 73,119,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36272,968,056 - 72,972,794 (+)NCBINCBI36Build 36hg18NCBI36
Build 34273,026,202 - 73,030,941NCBI
Celera272,965,357 - 72,970,134 (+)NCBICelera
Cytogenetic Map2p13.2NCBI
HuRef272,850,110 - 72,854,887 (+)NCBIHuRef
CHM1_1273,044,688 - 73,049,465 (+)NCBICHM1_1
T2T-CHM13v2.0272,900,349 - 72,905,099 (+)NCBIT2T-CHM13v2.0
Spr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84119,229,447 - 119,233,320 (-)NCBIGRCr8
mRatBN7.24117,671,948 - 117,676,292 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4117,671,949 - 117,675,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4123,153,277 - 123,157,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04118,928,408 - 118,932,143 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04117,541,159 - 117,544,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04116,912,343 - 116,916,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4116,912,351 - 116,916,236 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04181,492,882 - 181,496,612 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44119,365,578 - 119,369,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14119,610,075 - 119,613,765 (-)NCBI
Celera4106,655,853 - 106,659,586 (-)NCBICelera
Cytogenetic Map4q34NCBI
Spr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542412,711,064 - 12,716,000 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542412,711,064 - 12,716,000 (-)NCBIChiLan1.0ChiLan1.0
SPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21253,488,938 - 53,494,005 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A53,491,687 - 53,496,716 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A72,939,621 - 72,944,669 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A74,433,056 - 74,438,105 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A74,433,056 - 74,438,105 (+)Ensemblpanpan1.1panPan2
SPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11749,950,192 - 49,957,455 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1749,950,800 - 49,957,417 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1749,596,415 - 49,603,643 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01750,816,547 - 50,823,891 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1750,816,555 - 50,823,791 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11749,832,663 - 49,840,008 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01749,898,076 - 49,905,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01750,458,363 - 50,465,721 (-)NCBIUU_Cfam_GSD_1.0
Spr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629211,872,315 - 11,877,409 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649116,693,940 - 16,699,040 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,889,452 - 69,894,680 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,889,448 - 69,894,747 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2373,090,291 - 73,095,590 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11434,275,292 - 34,280,579 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1434,275,289 - 34,280,786 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604577,800,011 - 77,804,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624762728,731 - 734,544 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624762729,294 - 734,761 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spr
238 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:686
Count of miRNA genes:335
Interacting mature miRNAs:376
Transcripts:ENSMUST00000045986, ENSMUST00000174286, ENSMUST00000174769
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671958006105958152Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67707698389976982Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671958006105958152Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67797698396976961Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67552133992584431Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67552133994202936Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671552042105552160Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67129960593441074Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7129960586252701Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675424566104480516Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670402880104403016Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670402880104403016Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66346172197461888Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666690851100691013Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670402880104403016Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681476981102176961Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67552133994202936Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse

Markers in Region
RH124882  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38685,133,741 - 85,133,831UniSTSGRCm38
MGSCv37685,083,735 - 85,083,825UniSTSGRCm37
Celera687,104,892 - 87,104,982UniSTS
Cytogenetic Map6C3UniSTS
cM Map637.0UniSTS
Spr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38685,137,538 - 85,137,815UniSTSGRCm38
MGSCv37685,087,532 - 85,087,809UniSTSGRCm37
Celera687,108,681 - 87,108,958UniSTS
Cytogenetic Map6C3UniSTS
cM Map637.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY113096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY590544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK620382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S71375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  W65601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z21947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000045986   ⟹   ENSMUSP00000048111
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl685,110,660 - 85,114,748 (-)Ensembl
GRCm38.p6 Ensembl685,133,678 - 85,137,766 (-)Ensembl
Ensembl Acc Id: ENSMUST00000174286   ⟹   ENSMUSP00000133859
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl685,110,982 - 85,114,744 (-)Ensembl
GRCm38.p6 Ensembl685,134,000 - 85,137,762 (-)Ensembl
Ensembl Acc Id: ENSMUST00000174769   ⟹   ENSMUSP00000134379
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl685,110,669 - 85,114,738 (-)Ensembl
GRCm38.p6 Ensembl685,133,687 - 85,137,756 (-)Ensembl
Ensembl Acc Id: ENSMUST00000204757   ⟹   ENSMUSP00000145412
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl685,107,158 - 85,114,748 (-)Ensembl
GRCm38.p6 Ensembl685,130,176 - 85,137,766 (-)Ensembl
RefSeq Acc Id: NM_011467   ⟹   NP_035597
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,110,662 - 85,114,746 (-)NCBI
GRCm38685,133,680 - 85,137,764 (-)ENTREZGENE
MGSCv37685,083,674 - 85,087,758 (-)RGD
Celera687,104,831 - 87,108,907 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035597   ⟸   NM_011467
- UniProtKB: Q64105 (UniProtKB/Swiss-Prot),   Q63996 (UniProtKB/Swiss-Prot),   Q91XH5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000048111   ⟸   ENSMUST00000045986
Ensembl Acc Id: ENSMUSP00000145412   ⟸   ENSMUST00000204757
Ensembl Acc Id: ENSMUSP00000134379   ⟸   ENSMUST00000174769
Ensembl Acc Id: ENSMUSP00000133859   ⟸   ENSMUST00000174286

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64105-F1-model_v2 AlphaFold Q64105 1-261 view protein structure

Promoters
RGD ID:6840017
Promoter ID:MM_KWN:46665
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:ENSMUST00000095768
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,083,201 - 85,084,352 (+)MPROMDB
RGD ID:6840018
Promoter ID:MM_KWN:46666
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000045986,   UC009CPG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,087,556 - 85,088,062 (-)MPROMDB
RGD ID:6890212
Promoter ID:EPDNEW_M8557
Type:multiple initiation site
Name:Spr_1
Description:Mus musculus sepiapterin reductase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,137,764 - 85,137,824EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103078 AgrOrtholog
Ensembl Genes ENSMUSG00000033735 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045986 ENTREZGENE
  ENSMUST00000045986.8 UniProtKB/TrEMBL
  ENSMUST00000174286.3 UniProtKB/TrEMBL
  ENSMUST00000174769.2 UniProtKB/TrEMBL
  ENSMUST00000204757.3 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Biopterin_syn/organic_redct UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sepiapterin_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20751 UniProtKB/TrEMBL
MGD MGI:103078 ENTREZGENE
NCBI Gene 20751 ENTREZGENE
PANTHER SEPIAPTERIN REDUCTASE UniProtKB/Swiss-Prot
  SEPIAPTERIN REDUCTASE UniProtKB/Swiss-Prot
  SEPIAPTERIN REDUCTASE UniProtKB/TrEMBL
  SEPIAPTERIN REDUCTASE UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spr PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UXX3_MOUSE UniProtKB/TrEMBL
  G3UZ79_MOUSE UniProtKB/TrEMBL
  Q62218_MOUSE UniProtKB/TrEMBL
  Q63996 ENTREZGENE
  Q64105 ENTREZGENE
  Q91XH5 ENTREZGENE, UniProtKB/TrEMBL
  SPRE_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q63996 UniProtKB/Swiss-Prot