Spr (sepiapterin reductase) - Rat Genome Database

Name: Spr
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Spr (sepiapterin reductase) Mus musculus

Analyze

Symbol:

Spr

Name:

sepiapterin reductase

RGD ID:

736908

MGI Page

MGI

Description:

Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and skeleton. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; folate metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

AA409688; ENSMUSG00000071345; Gm10328

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPR (sepiapterin reductase)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Spr (sepiapterin reductase)	HGNC	Treefam, EggNOG, OrthoMCL, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Spr (sepiapterin reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SPR (sepiapterin reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPR (sepiapterin reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Spr (sepiapterin reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SPR (sepiapterin reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	SPR (sepiapterin reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Spr (sepiapterin reductase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Spr (sepiapterin reductase)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	SPR (sepiapterin reductase)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	sprb (sepiapterin reductase b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam\|ZFIN)
Danio rerio (zebrafish):	spra (sepiapterin reductase a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam\|ZFIN)
Drosophila melanogaster (fruit fly):	CG12116	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Sptr	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)

Related Pseudogenes:

Gm18049 Gm18050 Gm18052 Gm18053 Gm18054 Gm18055 Gm18056 Gm18057 Gm18058 Gm18059 Gm18060 Gm18061 Gm18062 Gm18063 Spr-ps1

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	85,110,662 - 85,114,746 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	85,107,158 - 85,114,748 (-)	Ensembl
GRCm38	6	85,133,680 - 85,137,764 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	85,130,176 - 85,137,766 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	85,083,674 - 85,087,758 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	85,099,343 - 85,103,476 (-)	NCBI			mm8
Celera	6	87,104,831 - 87,108,907 (-)	NCBI		Celera
Cytogenetic Map	6	C3	NCBI
cM Map	6	37.15	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

dystonia (ISO)

dystonia 5 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Parkinson's disease (IEA)

sepiapterin reductase deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (EXP)

acetamide (ISO)

amiodarone (ISO)

ammonium chloride (ISO)

Aroclor 1254 (EXP)

arsenous acid (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (ISO)

choline (EXP)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

folic acid (EXP)

iron atom (ISO)

iron(0) (ISO)

L-methionine (EXP)

methyl methanesulfonate (ISO)

N-nitrosomorpholine (ISO)

NADP zwitterion (ISO)

NADP(+) (ISO)

ochratoxin A (ISO)

oxaliplatin (ISO)

pentane-2,3-dione (ISO)

phenobarbital (EXP)

propiconazole (EXP)

pyrogallol (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

titanium dioxide (EXP)

topotecan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell morphogenesis involved in neuron differentiation (IMP)

dopamine metabolic process (IMP)

L-phenylalanine metabolic process (IMP)

nitric oxide biosynthetic process (ISO)

norepinephrine metabolic process (IMP)

pteridine metabolic process (IMP)

regulation of multicellular organism growth (IMP)

response to organic substance (ISO)

serotonin metabolic process (IMP)

tetrahydrobiopterin biosynthetic process (IBA,ISO)

tetrahydrobiopterin metabolic process (IMP)

voluntary musculoskeletal movement (IMP)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

mitochondrion (HDA)

nucleoplasm (ISO)

Molecular Function

oxidoreductase activity (IEA)

protein homodimerization activity (IPI)

sepiapterin reductase activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

dopa responsive dystonia pathway (ISO)

folate metabolic pathway (IEA)

Segawa syndrome pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal biopterin level (IAGP)

abnormal dopaminergic neuron morphology (IAGP)

abnormal enzyme/coenzyme level (IAGP)

abnormal locomotor activation (IAGP)

abnormal neopterin level (IAGP)

abnormal neurotransmitter level (IAGP)

bradykinesia (IAGP)

decreased body weight (IAGP)

decreased circulating insulin-like growth factor I level (IAGP)

decreased dopamine level (IAGP)

decreased noradrenaline level (IAGP)

decreased phenylalanine level (IAGP)

decreased serotonin level (IAGP)

hypoactivity (IAGP)

increased circulating phenylalanine level (IAGP)

postnatal growth retardation (IAGP)

premature death (IAGP)

prenatal lethality, incomplete penetrance (IAGP)

tremors (IAGP)

References

References - curated


1.	Bonafe L, etal., Am J Hum Genet. 2001 Aug;69(2):269-77. Epub 2001 Jul 6.
2.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	MGD and Homologene mouse data transfer
4.	MGD data from the GO Consortium
5.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	OMIM Disease Annotation Pipeline
7.	Pipeline to import KEGG annotations from KEGG into RGD
8.	Pipeline to import SMPDB annotations from SMPDB into RGD
9.	RGD automated import pipeline
10.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7873607	PMID:8304109	PMID:8440319	PMID:9383299	PMID:9405351	PMID:10209270	PMID:10349636	PMID:10727395	PMID:11042159	PMID:11076861	PMID:12477932	PMID:14681479
PMID:15782199	PMID:16141072	PMID:16141073	PMID:16532389	PMID:16602821	PMID:18201550	PMID:18614015	PMID:19273550	PMID:19423573	PMID:21062748	PMID:21267068	PMID:21677750
PMID:21873635	PMID:23577163	PMID:23640889	PMID:23647001	PMID:25921334	PMID:28320892	PMID:28858620	PMID:31040226

Genomics

Comparative Map Data

Spr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	85,110,662 - 85,114,746 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	85,107,158 - 85,114,748 (-)	Ensembl
GRCm38	6	85,133,680 - 85,137,764 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	85,130,176 - 85,137,766 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	85,083,674 - 85,087,758 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	85,099,343 - 85,103,476 (-)	NCBI			mm8
Celera	6	87,104,831 - 87,108,907 (-)	NCBI		Celera
Cytogenetic Map	6	C3	NCBI
cM Map	6	37.15	NCBI

SPR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	72,887,382 - 72,892,158 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	72,887,408 - 72,892,158 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	73,114,537 - 73,119,287 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	72,968,056 - 72,972,794 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	73,026,202 - 73,030,941	NCBI
Celera	2	72,965,357 - 72,970,134 (+)	NCBI
Cytogenetic Map	2	p13.2	NCBI
HuRef	2	72,850,110 - 72,854,887 (+)	NCBI		HuRef
CHM1_1	2	73,044,688 - 73,049,465 (+)	NCBI		CHM1_1

Spr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	117,671,948 - 117,676,292 (-)	NCBI
Rnor_6.0 Ensembl	4	116,912,351 - 116,916,236 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	116,912,343 - 116,916,073 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	181,492,882 - 181,496,612 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	119,365,578 - 119,369,308 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	4	119,610,075 - 119,613,765 (-)	NCBI
Celera	4	106,655,853 - 106,659,586 (-)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

Spr
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	12,711,064 - 12,716,000 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	12,711,064 - 12,716,000 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	74,433,056 - 74,438,105 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	74,433,056 - 74,438,105 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	72,939,621 - 72,944,669 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

SPR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	17	49,950,800 - 49,957,417 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	17	49,950,192 - 49,957,455 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Spr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936491	16,693,940 - 16,699,040 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPR
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	69,887,386 - 69,894,758 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	69,889,448 - 69,894,747 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	73,090,291 - 73,095,590 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPR
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	34,275,292 - 34,280,579 (-)	NCBI
ChlSab1.1 Ensembl	14	34,275,289 - 34,280,786 (-)	Ensembl

Spr
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624762	729,294 - 734,761 (-)	NCBI

Position Markers

RH124882

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	6	85,133,741 - 85,133,831	UniSTS	GRCm38
MGSCv37	6	85,083,735 - 85,083,825	UniSTS	GRCm37
Celera	6	87,104,892 - 87,104,982	UniSTS
Cytogenetic Map	6	C3	UniSTS
cM Map	6	37.0	UniSTS

Spr

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	6	85,137,538 - 85,137,815	UniSTS	GRCm38
MGSCv37	6	85,087,532 - 85,087,809	UniSTS	GRCm37
Celera	6	87,108,681 - 87,108,958	UniSTS
Cytogenetic Map	6	C3	UniSTS
cM Map	6	37.0	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
25440480	Moaq2_m	modifier of alien QTL 2 (mouse)					6	1	117500000	Mouse
26884414	Bzwq12_m	bi-zygomatic width QTL 12, 16 week (mouse)					6	3400000	139100000	Mouse
1300556	Cia6_m	collagen induced arthritis QTL 6 (mouse)			Not determined		6	4464884	87426034	Mouse
4142126	W3q3_m	weight 3 weeks QTL 3 (mouse)			Not determined			4503823	96656149	Mouse
4142361	W10q11_m	weight 10 weeks QTL 11 (mouse)			Not determined			4503823	96656149	Mouse
4142271	Egq8_m	early growth QTL 8 (mouse)			Not determined			4503823	96656149	Mouse
4142232	W6q4_m	weight 6 weeks QTL 4 (mouse)			Not determined			4503823	96656149	Mouse
1558984	Cplaq9_m	circadian period of locomotor activity 9 (mouse)			Not determined		6	38669625	92607450	Mouse
1300618	Pgia19_m	proteoglycan induced arthritis 19 (mouse)			Not determined		6	45314059	87426034	Mouse
10412157	Fl1n_m	fatty liver 1 in NSY (mouse)			Not determined		6	45314059	128835032	Mouse
4142259	Tabw2_m	tally ho associated body weight 2 (mouse)			Not determined			46935985	136423692	Mouse
25314319	Histh6_m	histamine hypersensitivity 6 (mouse)					6	48720000	125360000	Mouse
25314320	Histh5_m	histamine hypersensitivity 5 (mouse)					6	48720000	148450000	Mouse
1301962	Eila2_m	ethanol induced locomotor activity 2 (mouse)			Not determined		6	48726556	125356785	Mouse
1301254	Skts11_m	skin tumor susceptibility 11 (mouse)			Not determined		6	51179150	85179300	Mouse
1357683	Igf1sl1_m	IGF-1 serum levels 1 (mouse)			Not determined		6	52161713	116155267	Mouse
4141028	Mclr_m	methylcholanthrene lymphoma resistance (mouse)			Not determined			54373427	88379171	Mouse
15039373	Adip28_m	adiposity 28 (mouse)					6	56308211	90308211	Mouse
15039375	Bw41_m	body weight QTL 41 (mouse)					6	56308211	90308211	Mouse
1558977	Skmw10_m	skeletal muscle weight 10 (mouse)			Not determined		6	58447583	92447710	Mouse
10043972	Obq28_m	obesity QTL 28 (mouse)			Not determined		6	58540433	92540433	Mouse
1301740	Bwq2_m	body weight QTL 2 (mouse)			Not determined		6	60057680	94057799	Mouse
1301369	Im4_m	immunoregulatory 4 (mouse)			Not determined		6	63484738	97484905	Mouse
1300650	Bw18_m	body weight QTL 18 (mouse)			Not determined		6	66713869	100714031	Mouse
1301876	Bits2_m	bitterness sensitivity 2 (mouse)			Not determined		6	70425898	104426034	Mouse
1301813	Skl3_m	skeletal size (tail length) 3 (mouse)			Not determined		6	70425898	104426034	Mouse
1301034	Egrm2_m	early growth rate (mouse)			Not determined		6	70425898	104426034	Mouse
4141990	Etax6_m	ethanol induced ataxia 6 (mouse)			Not determined			71322621	86275719	Mouse
1302020	Bbaa20_m	B.burgdorferi-associated arthritis 20 (mouse)			Not determined		6	71322621	93464093	Mouse
1300869	Stheal5_m	soft tissue heal 5 (mouse)			Not determined		6	71575060	105575178	Mouse
1300954	Fcsa1_m	femoral cross-sectional area 1 (mouse)			Not determined		6	71981024	105981170	Mouse
1301521	Pas1c_m	pulmonary adenoma susceptibility 1c (mouse)			Not determined		6	71981024	105981170	Mouse
13506930	Recrq9_m	recombination rate in male meiosis QTL 9 (mouse)					6	73500000	134700000	Mouse
1301320	Ots1_m	ovarian teratoma susceptibility 1 (mouse)			Not determined		6	75447583	104503555	Mouse
1301571	Arrd1_m	age-related retinal degeneration 1 (mouse)			Not determined		6	75544356	92607450	Mouse
1300674	Nidd3n_m	non-insulin-dependent diabetes mellitus 3 in NSY (mouse)			Not determined		6	75544356	94225955	Mouse
10412195	Efw_m	epididymal fat weight (mouse)			Not determined		6	75544356	94225955	Mouse
10043901	Pfat5_m	predicted fat percentage 5 (mouse)			Not determined		6	75607306	109607450	Mouse
10412208	Cypr4_m	cytokine production 4 (mouse)			Not determined		6	75716503	109716697	Mouse
1357875	Pfat2_m	predicted fat percentage 2 (mouse)			Not determined		6	76463949	110464093	Mouse
14697704	Stsl4_m	Salmonella typhimurium susceptibility locus 4 (mouse)					6	77100000	90000000	Mouse
13824985	Alh1_m	amplitude of lateral head displacement 1 (mouse)					6	78000000	97000000	Mouse
4141376	Dbm1_m	diabetes modifier 1 (mouse)			Not determined		6	78629504	121115387	Mouse
14696731	Pairq1_m	P. aeruginosa infection resistance QTL 1 (mouse)					6	81500000	102200000	Mouse
10043864	T2dm4sa_m	type 2 diabetes mellitus 4 in SMXA RI mice (mouse)			Not determined		6	83713869	147052561	Mouse
11251720	Ewc4_m	ethanol withdrawal and consumption 4 (mouse)					6	84122513	118122513	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	686
Count of miRNA genes:	335
Interacting mature miRNAs:	376
Transcripts:	ENSMUST00000045986, ENSMUST00000174286, ENSMUST00000174769
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_011467	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC153373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH006964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK004941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK154720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK181380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK188293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK207238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK208380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK216452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC010400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC054423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY113096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY590544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK620382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S71375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S77493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	W65601	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Z21947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000045986 ⟹ ENSMUSP00000048111

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	85,133,678 - 85,137,766 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000174286 ⟹ ENSMUSP00000133859

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	85,134,000 - 85,137,762 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000174769 ⟹ ENSMUSP00000134379

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	85,133,687 - 85,137,756 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000204757 ⟹ ENSMUSP00000145412

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	85,130,176 - 85,137,766 (-)	Ensembl

RefSeq Acc Id:

NM_011467 ⟹ NP_035597

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	6	85,110,662 - 85,114,746 (-)	NCBI
GRCm38	6	85,133,680 - 85,137,764 (-)	ENTREZGENE
MGSCv37	6	85,083,674 - 85,087,758 (-)	RGD
Celera	6	87,104,831 - 87,108,907 (-)	RGD
cM Map	6		ENTREZGENE

Sequence:

show sequence

ATGAGTCTGAGTTCCAGGCATGGAGGCAGGCGGGCTGGGCTGCGCTGTGTGCGTGTTGACCGGG
GCCTCCCGGGGCTTTGGTCGCGCCCTGGCCCCGCAGCTGGCCCGGTTGCTGTCTCCCGGTTCCG
TGATGCTCGTAAGCGCACGCAGTGAGTCGATGCTGCGGCAACTGAAGGAGGAGCTGGGCGCTCA
GCAGCCTGACCTGAAAGTGGTGCTGGCAGCCGCCGATCTGGGCACCGAGGCTGGCGTGCAGCGG
TTGCTGAGCGCAGTACGCGAGCTCCCGAGGCCCGAGGGGCTGCAGCGCCTGCTGCTCATCAACA
ACGCAGCCACTCTTGGGGATGTTTCCAAAGGCTTCCTCAACGTGAATGACCTAGCTGAGGTGAA
CAACTACTGGGCTCTGAACCTGACCTCCATGCTCTGTTTGACTTCCGGCACCTTGAATGCCTTC
CAGGATAGCCCTGGCCTGAGCAAGACTGTGGTTAACATCTCATCTCTGTGTGCCCTGCAGCCCT
ACAAAGGCTGGGGTCTGTACTGTGCGGGGAAGGCTGCCCGAGACATGCTCTACCAGGTCCTGGC
TGCTGAGGAACCGAGTGTGCGGGTGCTGAGCTATGCTCCAGGTCCCCTGGACAATGACATGCAG
CAGTTGGCTCGGGAAACCTCCAAGGACCCAGAGTTAAGGAGCAAACTGCAGAAGTTGAAGTCGG
ATGGGGCGCTGGTGGACTGTGGGACTTCAGCCCAGAAACTGCTGGGCTTGCTGCAAAAGGACAC
CTTCCAGTCTGGAGCCCATGTGGACTTCTATGACTGTTAAGCTCATGTCCTGTCACAGTGGCCC
CCTTCTCCCCCCCCCCCCAAGCCCTGCCTAACACACATATAAGCCCTTCAACCCAGCCAGCAGC
GAGCGGTGGGCACTGCCAGTCCTCGGAAGGCTTCTGCAGAGGCTTGGGAGCGAGCTGATGTGCA
CTGGAGTTCTCTGTCCCCTGGAAGAGTGCTTTAGAGGTGGGAAGAGCAGGAGAAGCAGAAACAC
TGGACGGATGAGGTTGAGGCTCTTGTTTGTGGTCAGTCTGTGGGGTGAGGAGGGTGGGCTCTGA
TGCACAGAGAGGACGGAGGGCATCACGTCTGGATGGATGCTCCTTGAACTTCATTTGTTTGTTG
TACTGCCTGCATCCTGTGGTGTTCACTGGTCTTCCCTTGACTCTGGTCCAAATACATAGTTATG
AGGCAGATGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_035597	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB33611	(Get FASTA)	NCBI Sequence Viewer
	AAC69364	(Get FASTA)	NCBI Sequence Viewer
	AAH10400	(Get FASTA)	NCBI Sequence Viewer
	AAH54423	(Get FASTA)	NCBI Sequence Viewer
	AAP19647	(Get FASTA)	NCBI Sequence Viewer
	CAA79942	(Get FASTA)	NCBI Sequence Viewer
	EDK99120	(Get FASTA)	NCBI Sequence Viewer
	EDK99121	(Get FASTA)	NCBI Sequence Viewer
	Q64105	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_035597 ⟸ NM_011467

- UniProtKB:

Q91XH5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAGGLGCAVCVLTGASRGFGRALAPQLARLLSPGSVMLVSARSESMLRQLKEELGAQQPDLKV
VLAAADLGTEAGVQRLLSAVRELPRPEGLQRLLLINNAATLGDVSKGFLNVNDLAEVNNYWALN
LTSMLCLTSGTLNAFQDSPGLSKTVVNISSLCALQPYKGWGLYCAGKAARDMLYQVLAAEEPSV
RVLSYAPGPLDNDMQQLARETSKDPELRSKLQKLKSDGALVDCGTSAQKLLGLLQKDTFQSGAH
VDFYDC

hide sequence

RefSeq Acc Id:

ENSMUSP00000048111 ⟸ ENSMUST00000045986

RefSeq Acc Id:

ENSMUSP00000145412 ⟸ ENSMUST00000204757

RefSeq Acc Id:

ENSMUSP00000134379 ⟸ ENSMUST00000174769

RefSeq Acc Id:

ENSMUSP00000133859 ⟸ ENSMUST00000174286

Promoters

RGD ID:

6840017

Promoter ID:

MM_KWN:46665

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

Kidney, Liver

Transcripts:

ENSMUST00000095768

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	6	85,083,201 - 85,084,352 (+)	MPROMDB

RGD ID:

6840018

Promoter ID:

MM_KWN:46666

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6

Transcripts:

ENSMUST00000045986, UC009CPG.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	6	85,087,556 - 85,088,062 (-)	MPROMDB

RGD ID:

6890212

Promoter ID:

EPDNEW_M8557

Type:

multiple initiation site

Name:

Spr_1

Description:

Mus musculus sepiapterin reductase , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	6	85,137,764 - 85,137,824	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:103078	AgrOrtholog
Ensembl Genes	ENSMUSG00000033735	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000048111	ENTREZGENE, UniProtKB/TrEMBL
	ENSMUSP00000133859	UniProtKB/TrEMBL
	ENSMUSP00000134379	UniProtKB/TrEMBL
	ENSMUSP00000145412	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000045986	ENTREZGENE, UniProtKB/TrEMBL
	ENSMUST00000174286	UniProtKB/TrEMBL
	ENSMUST00000174769	UniProtKB/TrEMBL
	ENSMUST00000204757	UniProtKB/TrEMBL
InterPro	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDR_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sepiapterin_red	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:20751	UniProtKB/TrEMBL
MGD	MGI:103078	ENTREZGENE
NCBI Gene	20751	ENTREZGENE
Pfam	adh_short	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Spr	PhenoGen
PRINTS	GDHRDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	sepiapter_red	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	G3UXX3_MOUSE	UniProtKB/TrEMBL
	G3UZ79_MOUSE	UniProtKB/TrEMBL
	Q62218_MOUSE	UniProtKB/TrEMBL
	Q64105	ENTREZGENE
	Q91XH5	ENTREZGENE, UniProtKB/TrEMBL
	SPRE_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	Q63996	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)