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Gene: ARHGEF5 (Rho guanine nucleotide exchange factor 5) Homo sapiens
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Symbol: ARHGEF5
Name: Rho guanine nucleotide exchange factor 5
Description: Exhibits guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of DNA-binding transcription factor activity; positive regulation of JUN kinase activity; and positive regulation of stress fiber assembly. Localizes to cytosol; nucleoplasm; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686N1969; ephexin-3; ephexin3; GEF5; guanine nucleotide regulatory protein TIM; oncogene TIM; P60; p60 TIM; Rho guanine nucleotide exchange factor (GEF) 5; TIM; TIM1; transforming immortalized mammary oncogene
Orthologs:
Mus musculus (house mouse) : Arhgef5 (Rho guanine nucleotide exchange factor (GEF) 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arhgef5 (Rho guanine nucleotide exchange factor 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arhgef5 (Rho guanine nucleotide exchange factor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : ARHGEF5 (Rho guanine nucleotide exchange factor 5)
Canis lupus familiaris (dog) : ARHGEF5 (Rho guanine nucleotide exchange factor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arhgef5 (Rho guanine nucleotide exchange factor 5)
Sus scrofa (pig) : ARHGEF5 (Rho guanine nucleotide exchange factor 5)
Chlorocebus sabaeus (African green monkey) : ARHGEF5 (Rho guanine nucleotide exchange factor 5)
Heterocephalus glaber (naked mole-rat) : Arhgef5 (Rho guanine nucleotide exchange factor 5)
more info ...
Related Pseudogenes: ARHGEF34P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl7144,355,288 - 144,380,632 (+)EnsemblGRCh38hg38GRCh38
GRCh387144,355,396 - 144,380,632 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377144,052,489 - 144,077,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367143,683,422 - 143,708,658 (+)NCBINCBI36hg18NCBI36
Build 347143,490,136 - 143,515,372NCBI
Celera7138,733,824 - 138,751,769 (+)NCBI
Cytogenetic Map7q35NCBI
HuRef7138,140,991 - 138,155,879 (+)NCBIHuRef
CHM1_17144,061,000 - 144,086,219 (+)NCBICHM1_1
CRA_TCAGchr7v27143,390,747 - 143,415,984 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

Genomics

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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

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Nomenclature History
 
More on ARHGEF5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735723
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.