Arhgef5 (Rho guanine nucleotide exchange factor 5) - Rat Genome Database

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Gene: Arhgef5 (Rho guanine nucleotide exchange factor 5) Chinchilla lanigera
Analyze
Symbol: Arhgef5
Name: Rho guanine nucleotide exchange factor 5
RGD ID: 9065048
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); hematopoietic stem cell homeostasis (ortholog); myeloid dendritic cell chemotaxis (ortholog); ASSOCIATED WITH Genetic Predisposition to Disease (ortholog); Lung Neoplasms (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cell periphery (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Rho guanine nucleotide exchange factor (GEF) 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955491545,342 - 563,543 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955491539,040 - 561,494 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Arhgef5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955491545,342 - 563,543 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955491539,040 - 561,494 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387144,355,402 - 144,380,632 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7144,355,288 - 144,380,632 (+)EnsemblGRCh38hg38GRCh38
GRCh377144,052,495 - 144,077,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367143,683,422 - 143,708,658 (+)NCBINCBI36Build 36hg18NCBI36
Build 347143,490,136 - 143,515,372NCBI
Celera7138,733,824 - 138,751,769 (+)NCBICelera
Cytogenetic Map7q35NCBI
HuRef7138,140,991 - 138,155,879 (+)NCBIHuRef
CHM1_17144,061,000 - 144,086,219 (+)NCBICHM1_1
T2T-CHM13v2.07145,535,577 - 145,560,799 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27143,390,747 - 143,415,984 (+)NCBI
Arhgef5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39643,242,578 - 43,266,250 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl643,242,516 - 43,266,254 (+)EnsemblGRCm39 Ensembl
GRCm38643,265,644 - 43,289,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl643,265,582 - 43,289,320 (+)EnsemblGRCm38mm10GRCm38
MGSCv37643,215,643 - 43,239,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36643,194,207 - 43,218,927 (+)NCBIMGSCv36mm8
Celera643,213,631 - 43,237,307 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map621.15NCBI
Arhgef5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8473,087,240 - 73,112,311 (+)NCBIGRCr8
mRatBN7.2472,087,205 - 72,112,316 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl472,087,247 - 72,111,254 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0472,710,775 - 72,736,415 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl472,718,458 - 72,735,007 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04137,413,739 - 137,438,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4471,036,550 - 71,053,522 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1471,320,405 - 71,322,300 (+)NCBI
Celera467,033,097 - 67,058,406 (+)NCBICelera
Cytogenetic Map4q24NCBI
ARHGEF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,928,249 - 180,953,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1732,938,508 - 32,963,788 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07136,069,598 - 136,094,866 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17148,558,803 - 148,584,078 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7148,558,803 - 148,584,078 (+)Ensemblpanpan1.1panPan2
ARHGEF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1165,648,947 - 5,673,488 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl165,649,944 - 5,673,568 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha166,760,254 - 6,784,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0165,512,244 - 5,536,787 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl165,513,241 - 5,536,878 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1165,442,361 - 5,466,636 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0165,300,545 - 5,325,074 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,371,318 - 5,395,833 (-)NCBIUU_Cfam_GSD_1.0
Arhgef5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511811,502,574 - 11,524,399 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365271,385,119 - 1,400,337 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365271,385,117 - 1,400,847 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,364,879 - 113,394,389 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,364,849 - 113,394,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29124,683,889 - 124,703,521 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,993,339 - 113,021,237 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21113,000,705 - 113,018,050 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660729,769,246 - 9,794,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480010,843,729 - 10,870,392 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480010,846,664 - 10,870,331 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000001771   ⟹   ENSCLAP00000001728
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955491545,342 - 563,543 (+)Ensembl
RefSeq Acc Id: XM_005404726   ⟹   XP_005404783
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955491539,040 - 561,494 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005404727   ⟹   XP_005404784
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955491539,046 - 561,494 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005404783 (Get FASTA)   NCBI Sequence Viewer  
  XP_005404784 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000001728
  ENSCLAP00000001728.1
RefSeq Acc Id: XP_005404783   ⟸   XM_005404726
- UniProtKB: A0A8C2UQI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005404784   ⟸   XM_005404727
- UniProtKB: A0A8C2UQI8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000001728   ⟸   ENSCLAT00000001771
Protein Domains
DH   PH   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001290 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000001771 ENTREZGENE
  ENSCLAT00000001771.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro ARHGEF5/35_N UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Ephexin-like UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  PH_ephexin UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene Arhgef5 ENTREZGENE
PANTHER DH DOMAIN-CONTAINING PROTEIN-RELATED UniProtKB/TrEMBL
  GUANINE NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
Pfam ARHGEF5_35 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A8C2UQI8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Arhgef5  Rho guanine nucleotide exchange factor 5    Rho guanine nucleotide exchange factor (GEF) 5  Symbol and/or name change 5135510 APPROVED