PSMB5 (proteasome 20S subunit beta 5) - Rat Genome Database

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Gene: PSMB5 (proteasome 20S subunit beta 5) Homo sapiens
Analyze
Symbol: PSMB5
Name: proteasome 20S subunit beta 5
RGD ID: 735704
HGNC Page HGNC:9542
Description: Enables peptidase activity. Acts upstream of or within proteolysis. Located in centrosome and nucleoplasm. Part of proteasome core complex. Is active in cytoplasm and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: beta-5; LMPX; macropain epsilon chain; MB1; MGC104214; multicatalytic endopeptidase complex epsilon chain; proteasome (prosome, macropain) subunit, beta type 5; proteasome (prosome, macropain) subunit, beta type, 5; proteasome beta 5 subunit; proteasome catalytic subunit 3; proteasome chain 6; proteasome epsilon chain; proteasome subunit beta 5; proteasome subunit beta type-5; proteasome subunit MB1; proteasome subunit X; proteasome subunit, beta type, 5; PSX large multifunctional protease X; testicular tissue protein Li 153; X
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC100422275  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,025,851 - 23,035,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,016,543 - 23,035,230 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,495,060 - 23,504,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,564,900 - 22,573,949 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,564,899 - 22,573,949NCBI
Celera143,357,950 - 3,367,323 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,612,363 - 3,621,723 (-)NCBIHuRef
CHM1_11423,493,694 - 23,503,063 (-)NCBICHM1_1
T2T-CHM13v2.01417,226,471 - 17,235,840 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PSMB5HumanBrain-Lung-Thyroid Syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Brain-lung-thyroid syndromeClinVarPMID:25741868
PSMB5Humanlysinuric protein intolerance  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Lysinuric protein intoleranceClinVarPMID:28492532
PSMB5HumanSpecific Granule Deficiency  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Specific granule deficiencyClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
PSMB5HumanMyocardial Ischemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533

1 to 20 of 163 rows

  
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Original Reference(s)
PSMB5Human(1->4)-beta-D-glucan multiple interactionsISOPsmb5 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PSMB5 mRNACTDPMID:36331819
PSMB5Human1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOPsmb5 (Mus musculus)6480464o and p'-DDT results in increased expression of PSMB5 mRNACTDPMID:24096037
PSMB5Human1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOPsmb5 (Rattus norvegicus)6480464o and p'-DDT results in increased expression of PSMB5 mRNACTDPMID:24096037
PSMB5Human1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionISOPsmb5 (Rattus norvegicus)6480464o and p'-DDT affects the expression of PSMB5 mRNACTDPMID:17984292
PSMB5Human1,3-dinitrobenzene affects expressionISOPsmb5 (Rattus norvegicus)64804643-dinitrobenzene affects the expression of PSMB5 mRNACTDPMID:16988215
PSMB5Human17alpha-ethynylestradiol affects expressionISOPsmb5 (Mus musculus)6480464Ethinyl Estradiol affects the expression of PSMB5 mRNACTDPMID:17555576
PSMB5Human17alpha-ethynylestradiol increases expressionISOPsmb5 (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of PSMB5 mRNACTDPMID:16174780 more ...
PSMB5Human17alpha-ethynylestradiol increases expressionISOPsmb5 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of PSMB5 mRNACTDPMID:16174780 more ...
PSMB5Human17alpha-ethynylestradiol multiple interactionsISOPsmb5 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMB5 mRNACTDPMID:17942748
PSMB5Human17beta-estradiol affects expressionISOPsmb5 (Mus musculus)6480464Estradiol affects the expression of PSMB5 mRNACTDPMID:15598610
PSMB5Human1H-pyrazole increases expressionISOPsmb5 (Mus musculus)6480464pyrazole results in increased expression of PSMB5 mRNACTDPMID:17945193
PSMB5Human2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOPsmb5 (Mus musculus)64804642 more ...CTDPMID:25639565
PSMB5Human2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOPsmb5 (Mus musculus)6480464troxerutin inhibits the reaction [2 more ...CTDPMID:25639565
PSMB5Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPsmb5 (Mus musculus)6480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PSMB5 mRNA and [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMB5 mRNACTDPMID:16214954 and PMID:17942748
PSMB5Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPsmb5 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of PSMB5 mRNACTDPMID:33387578
PSMB5Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPsmb5 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PSMB5 mRNACTDPMID:21570461
PSMB5Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPsmb5 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PSMB5 mRNACTDPMID:17942748 and PMID:18796159
PSMB5Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPsmb5 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of PSMB5 mRNACTDPMID:16723119
PSMB5Human2,4,6-trinitrotoluene affects expressionISOPsmb5 (Rattus norvegicus)6480464Trinitrotoluene affects the expression of PSMB5 mRNACTDPMID:21346803
PSMB5Human2,6-dimethoxyphenol multiple interactionsEXP 6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in decreased expression of PSMB5 proteinCTDPMID:38598786

1 to 20 of 163 rows

Biological Process

  
Object Symbol
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Reference
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Source
Original Reference(s)
PSMB5Humanproteasome assembly involved_inTAS 150520179 ReactomeReactome:R-HSA-9907900
PSMB5Humanproteasome-mediated ubiquitin-dependent protein catabolic process acts_upstream_of_or_withinIEAUniProtKB:O55234 and ensembl:ENSMUSP00000022803150520179 EnsemblGO_REF:0000107
PSMB5Humanproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIBAFB:FBgn0002284 more ...150520179 GO_CentralGO_REF:0000033
PSMB5Humanproteasome-mediated ubiquitin-dependent protein catabolic process involved_inNAS 150520179 PMID:19489727ComplexPortalPMID:19489727
PSMB5Humanproteolysis acts_upstream_of_or_withinIDA 150520179 PMID:17540904MGIPMID:17540904
PSMB5Humanproteolysis involved_inIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
PSMB5Humanproteolysis involved in protein catabolic process involved_inIEAInterPro:IPR000243 more ...150520179 InterProGO_REF:0000002
PSMB5Humanresponse to oxidative stress acts_upstream_of_or_withinIEAUniProtKB:O55234 and ensembl:ENSMUSP00000022803150520179 EnsemblGO_REF:0000107

Cellular Component
1 to 20 of 24 rows

  
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Original Reference(s)
PSMB5Humancentrosome located_inIDA 150520179 HPAGO_REF:0000052
PSMB5Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
PSMB5Humancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
PSMB5Humancytoplasm is_active_inIDA 150520179 PMID:34711951UniProtPMID:34711951
PSMB5Humancytosol is_active_inIBAPANTHER:PTN002613347 more ...150520179 GO_CentralGO_REF:0000033
PSMB5Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-1168640 more ...
PSMB5Humanextracellular exosome located_inHDA 150520179 PMID:19056867UniProtPMID:19056867
PSMB5Humannucleoplasm located_inTAS 150520179 ReactomeReactome:R-HSA-174058 more ...
PSMB5Humannucleoplasm located_inIDA 150520179 HPAGO_REF:0000052
PSMB5Humannucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
PSMB5Humannucleus is_active_inIBAPANTHER:PTN002613348 more ...150520179 GO_CentralGO_REF:0000033
PSMB5Humannucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043
PSMB5Humannucleus is_active_inIDA 150520179 PMID:34711951UniProtPMID:34711951
PSMB5Humannucleus located_inHDA 150520179 PMID:21630459UniProtPMID:21630459
PSMB5Humanproteasome complex part_ofNAS 150520179 PMID:29636472ComplexPortalPMID:29636472
PSMB5Humanproteasome complex part_ofIDA 150520179 PMID:17323924UniProtPMID:17323924
PSMB5Humanproteasome complex part_ofTAS 150520179 PMID:8811196PINCPMID:8811196
PSMB5Humanproteasome complex part_ofIEAUniProtKB-KW:KW-0647150520179 UniProtGO_REF:0000043
PSMB5Humanproteasome core complex part_ofIEAUniProtKB:O55234 and ensembl:ENSMUSP00000022803150520179 EnsemblGO_REF:0000107
PSMB5Humanproteasome core complex part_ofIDA 150520179 PMID:34711951UniProtPMID:34711951
1 to 20 of 24 rows

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
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Original Reference(s)
PSMB5Humanendopeptidase activity enablesIBAPANTHER:PTN000175708 more ...150520179 GO_CentralGO_REF:0000033
PSMB5Humanendopeptidase activity enablesTAS 150520179 ReactomeReactome:R-HSA-9908101
PSMB5Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
PSMB5Humanpeptidase activity enablesIDA 150520179 PMID:17540904MGIPMID:17540904
PSMB5Humanpeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
PSMB5Humanpeptidase activity enablesIEAUniProtKB:O55234 and ensembl:ENSMUSP00000022803150520179 EnsemblGO_REF:0000107
PSMB5Humanprotein binding enablesIPIUniProtKB:P20618 more ...150520179 PMID:17948026IntActPMID:17948026
PSMB5Humanprotein binding enablesIPIUniProtKB:Q99436150520179 PMID:20723761IntActPMID:20723761
PSMB5Humanprotein binding enablesIPIUniProtKB:O15116150520179 PMID:15231747IntActPMID:15231747
PSMB5Humanprotein binding enablesIPIUniProtKB:O15116 more ...150520179 PMID:32296183IntActPMID:32296183
PSMB5Humanprotein binding enablesIPIUniProtKB:P20618 more ...150520179 PMID:14733938IntActPMID:14733938
PSMB5Humanprotein binding enablesIPIUniProtKB:P20618 and UniProtKB:Q9Y244150520179 PMID:35271311IntActPMID:35271311
PSMB5Humanprotein binding enablesIPIUniProtKB:P20618 more ...150520179 PMID:28514442 and PMID:33961781IntActPMID:28514442 and PMID:33961781
PSMB5Humanprotein binding enablesIPIUniProtKB:P49721150520179 PMID:35858375IntActPMID:35858375
PSMB5Humanthreonine-type endopeptidase activity enablesIEAUniProtKB-KW:KW-0888150520179 UniProtGO_REF:0000043
PSMB5Humanthreonine-type endopeptidase activity enablesIEAInterPro:IPR000243150520179 InterProGO_REF:0000002
1 to 16 of 16 rows

Imported Annotations - KEGG (archival)

Object Symbol
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Reference
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Source
Original Reference(s)
PSMB5Humanubiquitin/proteasome degradation pathway  IEA 6907045 KEGGhsa:03050

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 10 of 22 rows
PMID:2306472   PMID:7811265   PMID:7820546   PMID:7864893   PMID:8066462   PMID:8125298   PMID:8753855   PMID:8811196   PMID:9079628   PMID:9311996   PMID:9382924   PMID:9811770  
PMID:9846577   PMID:10692467   PMID:10816564   PMID:10893419   PMID:11205743   PMID:11285280   PMID:11745344   PMID:12167863   PMID:12419264   PMID:12477932   PMID:12719574   PMID:12750511  
PMID:12791267   PMID:12808465   PMID:12808466   PMID:12809610   PMID:12830140   PMID:12840737   PMID:12859895   PMID:12914693   PMID:12920286   PMID:12970355   PMID:14527406   PMID:14528300  
PMID:14528301   PMID:14550573   PMID:14557625   PMID:14564014   PMID:14614829   PMID:14733938   PMID:14743216   PMID:15029244   PMID:15231747   PMID:15488952   PMID:15489334   PMID:15887188  
PMID:15944226   PMID:16196087   PMID:16263121   PMID:17189198   PMID:17207965   PMID:17262013   PMID:17314511   PMID:17323924   PMID:17353931   PMID:17506986   PMID:17540904   PMID:17573772  
PMID:17948026   PMID:18303054   PMID:18502982   PMID:18519783   PMID:18562081   PMID:18565852   PMID:18711014   PMID:18781797   PMID:18922472   PMID:19013454   PMID:19056867   PMID:19193609  
PMID:19243813   PMID:19426847   PMID:19489727   PMID:19490893   PMID:19596235   PMID:19615732   PMID:19738201   PMID:20007692   PMID:20555361   PMID:20723761   PMID:20811636   PMID:20980621  
PMID:21081666   PMID:21139048   PMID:21145461   PMID:21289309   PMID:21301993   PMID:21565611   PMID:21628461   PMID:21630459   PMID:21853274   PMID:21873635   PMID:21890473   PMID:21906983  
PMID:21920470   PMID:21963094   PMID:21978467   PMID:22118674   PMID:22119785   PMID:22505724   PMID:22523338   PMID:22645313   PMID:22658674   PMID:22781773   PMID:22863883   PMID:22898364  
PMID:22939629   PMID:23000965   PMID:23018640   PMID:23376485   PMID:23443559   PMID:23503661   PMID:23602568   PMID:23824909   PMID:24121268   PMID:24393841   PMID:24457600   PMID:24627483  
1 to 10 of 22 rows



PSMB5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381423,025,851 - 23,035,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1423,016,543 - 23,035,230 (-)EnsemblGRCh38hg38GRCh38
GRCh371423,495,060 - 23,504,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361422,564,900 - 22,573,949 (-)NCBINCBI36Build 36hg18NCBI36
Build 341422,564,899 - 22,573,949NCBI
Celera143,357,950 - 3,367,323 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef143,612,363 - 3,621,723 (-)NCBIHuRef
CHM1_11423,493,694 - 23,503,063 (-)NCBICHM1_1
T2T-CHM13v2.01417,226,471 - 17,235,840 (-)NCBIT2T-CHM13v2.0
Psmb5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391454,851,577 - 54,855,452 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1454,851,576 - 54,855,479 (-)EnsemblGRCm39 Ensembl
GRCm381454,614,120 - 54,617,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1454,614,119 - 54,618,022 (-)EnsemblGRCm38mm10GRCm38
MGSCv371455,232,957 - 55,236,832 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361453,568,325 - 53,572,200 (-)NCBIMGSCv36mm8
Celera1452,402,497 - 52,406,386 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1427.86NCBI
Psmb5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81532,042,784 - 32,047,379 (-)NCBIGRCr8
mRatBN7.21528,072,772 - 28,077,367 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1528,072,781 - 28,077,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1529,911,955 - 29,916,437 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01531,059,168 - 31,063,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01529,308,790 - 29,313,379 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01533,259,039 - 33,263,634 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1533,259,043 - 33,263,659 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01537,143,058 - 37,147,105 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41532,689,859 - 32,694,364 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11532,705,562 - 32,710,051 (-)NCBI
Celera1527,651,286 - 27,655,779 (-)NCBICelera
Cytogenetic Map15p13NCBI
Psmb5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540937,268,980 - 37,279,937 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540937,269,319 - 37,278,957 (+)NCBIChiLan1.0ChiLan1.0
PSMB5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21524,458,581 - 24,467,983 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11423,675,069 - 23,684,471 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0143,845,951 - 3,855,335 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11421,943,432 - 21,952,169 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1421,943,432 - 21,952,169 (-)Ensemblpanpan1.1panPan2
PSMB5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.183,344,157 - 3,349,921 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl83,344,233 - 3,349,926 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha83,292,754 - 3,298,523 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.083,452,136 - 3,457,902 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl83,452,139 - 3,457,839 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.183,143,540 - 3,149,316 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.083,204,769 - 3,210,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.083,466,833 - 3,472,610 (-)NCBIUU_Cfam_GSD_1.0
Psmb5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864035,095,360 - 35,103,510 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367221,285,482 - 1,295,106 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367221,285,488 - 1,293,637 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMB5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1776,014,576 - 76,021,922 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2781,329,736 - 81,337,082 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSMB5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12923,394,820 - 23,403,953 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2923,390,401 - 23,403,658 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605923,013,024 - 23,022,186 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmb5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248209,505,725 - 9,513,034 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248209,506,119 - 9,513,034 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in PSMB5
20 total Variants

1 to 10 of 45 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 14q11.2(chr14:20151149-23442195)x3 copy number gain See cases [RCV000050914] Chr14:20151149..23442195 [GRCh38]
Chr14:20619308..23911404 [GRCh37]
Chr14:19689148..22981244 [NCBI36]
Chr14:14q11.2
pathogenic
GRCh38/hg38 14q11.2-12(chr14:20151149-27723796)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|See cases [RCV000051484] Chr14:20151149..27723796 [GRCh38]
Chr14:20619308..28193002 [GRCh37]
Chr14:19689148..27262842 [NCBI36]
Chr14:14q11.2-12
pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2
pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1
pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q11.2-12(chr14:20412587-25018120)x3 copy number gain See cases [RCV000137725] Chr14:20412587..25018120 [GRCh38]
Chr14:20880746..25487326 [GRCh37]
Chr14:19950586..24557166 [NCBI36]
Chr14:14q11.2-12
likely pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20022693-44093672)x3 copy number gain See cases [RCV000143186] Chr14:20022693..44093672 [GRCh38]
Chr14:20490852..44562875 [GRCh37]
Chr14:19560692..43632625 [NCBI36]
Chr14:14q11.2-21.2
pathogenic
GRCh38/hg38 14q11.2-21.3(chr14:20043513-48642042)x3 copy number gain See cases [RCV000143748] Chr14:20043513..48642042 [GRCh38]
Chr14:20511672..49111245 [GRCh37]
Chr14:19581512..48180995 [NCBI36]
Chr14:14q11.2-21.3
pathogenic
1 to 10 of 45 rows

Predicted Target Of
Summary Value
Count of predictions:1269
Count of miRNA genes:490
Interacting mature miRNAs:548
Transcripts:ENST00000334454, ENST00000361611, ENST00000425762, ENST00000460922, ENST00000493471, ENST00000555895
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 12 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597583628GWAS1640488_Hmean corpuscular hemoglobin concentration QTL GWAS1640488 (human)3e-22mean corpuscular hemoglobin concentrationmean corpuscular hemoglobin concentration (CMO:0000291)142302842023028421Human
597616780GWAS1673640_Hmean corpuscular hemoglobin concentration QTL GWAS1673640 (human)8e-16mean corpuscular hemoglobin concentrationmean corpuscular hemoglobin concentration (CMO:0000291)142302842023028421Human
406968594GWAS617570_Hreticulocyte count QTL GWAS617570 (human)3e-26reticulocyte quantity (VT:0003135)total reticulocyte count (CMO:0003020)142303011223030113Human
406976165GWAS625141_Hmean corpuscular hemoglobin QTL GWAS625141 (human)1e-15mean corpuscular hemoglobinmean corpuscular hemoglobin (CMO:0000290)142303011223030113Human
597082032GWAS1178106_Hreticulocyte measurement QTL GWAS1178106 (human)2e-22reticulocyte morphology trait (VT:0002424)red blood cell measurement (CMO:0001356)142302842023028421Human
597599576GWAS1656436_Hmean corpuscular hemoglobin concentration QTL GWAS1656436 (human)1e-52mean corpuscular hemoglobin concentrationmean corpuscular hemoglobin concentration (CMO:0000291)142302842023028421Human
597612534GWAS1669394_Hmean corpuscular hemoglobin concentration QTL GWAS1669394 (human)3e-23mean corpuscular hemoglobin concentrationmean corpuscular hemoglobin concentration (CMO:0000291)142302842023028421Human
407084891GWAS733867_Hobsolete_red blood cell distribution width QTL GWAS733867 (human)1e-14obsolete_red blood cell distribution width142303481223034813Human
596976765GWAS1096284_HRed cell distribution width QTL GWAS1096284 (human)1e-14Red cell distribution width142303481223034813Human
597583171GWAS1640031_Hmean corpuscular hemoglobin concentration QTL GWAS1640031 (human)1e-11mean corpuscular hemoglobin concentrationmean corpuscular hemoglobin concentration (CMO:0000291)142302842023028421Human

1 to 10 of 12 rows
SHGC-132389  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371423,495,115 - 23,495,321UniSTSGRCh37
Build 361422,564,955 - 22,565,161RGDNCBI36
Celera143,358,005 - 3,358,211RGD
Cytogenetic Map14q11.2UniSTS
HuRef143,612,418 - 3,612,624UniSTS
TNG Radiation Hybrid Map141020.0UniSTS
WI-7398  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371423,495,085 - 23,495,296UniSTSGRCh37
Build 361422,564,925 - 22,565,136RGDNCBI36
Celera143,357,975 - 3,358,186RGD
Cytogenetic Map14q11.2UniSTS
HuRef143,612,388 - 3,612,599UniSTS
GeneMap99-GB4 RH Map1418.82UniSTS
Whitehead-RH Map1418.8UniSTS
NCBI RH Map1431.0UniSTS
HUM00D0F11  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371423,495,098 - 23,495,325UniSTSGRCh37
Build 361422,564,938 - 22,565,165RGDNCBI36
Celera143,357,988 - 3,358,215RGD
Cytogenetic Map14q11.2UniSTS
HuRef143,612,401 - 3,612,628UniSTS
Stanford-G3 RH Map14262.0UniSTS
Stanford-G3 RH Map14274.0UniSTS
NCBI RH Map1430.0UniSTS
GeneMap99-G3 RH Map14274.0UniSTS
GeneMap99-G3 RH Map14262.0UniSTS
PSMB5_3419  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371423,495,000 - 23,495,580UniSTSGRCh37
Build 361422,564,840 - 22,565,420RGDNCBI36
Celera143,357,890 - 3,358,470RGD
HuRef143,612,303 - 3,612,883UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1


1 to 21 of 21 rows
RefSeq Transcripts NM_001130725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001144932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK225888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL132780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU539357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU632351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX248299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX538001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD048996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 21 of 21 rows

Ensembl Acc Id: ENST00000334454   ⟹   ENSP00000334973
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1423,026,297 - 23,034,885 (-)Ensembl
Ensembl Acc Id: ENST00000361611   ⟹   ENSP00000355325
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1423,025,856 - 23,034,900 (-)Ensembl
Ensembl Acc Id: ENST00000425762   ⟹   ENSP00000395206
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1423,025,902 - 23,035,230 (-)Ensembl
Ensembl Acc Id: ENST00000460922   ⟹   ENSP00000451286
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1423,025,858 - 23,034,894 (-)Ensembl
Ensembl Acc Id: ENST00000493471   ⟹   ENSP00000452424
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1423,025,858 - 23,034,890 (-)Ensembl
Ensembl Acc Id: ENST00000555895   ⟹   ENSP00000451816
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1423,016,543 - 23,034,727 (-)Ensembl
RefSeq Acc Id: NM_001130725   ⟹   NP_001124197
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381423,025,851 - 23,035,220 (-)NCBI
GRCh371423,485,752 - 23,504,429 (-)NCBI
HuRef143,612,363 - 3,621,723 (-)ENTREZGENE
CHM1_11423,493,694 - 23,503,063 (-)NCBI
T2T-CHM13v2.01417,226,471 - 17,235,840 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001144932   ⟹   NP_001138404
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381423,025,856 - 23,034,900 (-)NCBI
GRCh371423,485,752 - 23,504,429 (-)NCBI
HuRef143,612,363 - 3,621,723 (-)ENTREZGENE
CHM1_11423,493,694 - 23,502,988 (-)NCBI
T2T-CHM13v2.01417,226,476 - 17,235,520 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002797   ⟹   NP_002788
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381423,025,856 - 23,034,900 (-)NCBI
GRCh371423,485,752 - 23,504,429 (-)NCBI
Build 361422,564,900 - 22,573,949 (-)NCBI Archive
HuRef143,612,363 - 3,621,723 (-)ENTREZGENE
CHM1_11423,493,694 - 23,502,988 (-)NCBI
T2T-CHM13v2.01417,226,476 - 17,235,520 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001124197   ⟸   NM_001130725
- Peptide Label: isoform 2
- UniProtKB: A0A140VJS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_002788   ⟸   NM_002797
- Peptide Label: isoform 1
- UniProtKB: Q86T01 (UniProtKB/Swiss-Prot),   Q7Z3B5 (UniProtKB/Swiss-Prot),   Q6PEW2 (UniProtKB/Swiss-Prot),   Q16242 (UniProtKB/Swiss-Prot),   E9PAV2 (UniProtKB/Swiss-Prot),   D3DS43 (UniProtKB/Swiss-Prot),   B4DUM9 (UniProtKB/Swiss-Prot),   B2R4N9 (UniProtKB/Swiss-Prot),   Q9TNN9 (UniProtKB/Swiss-Prot),   P28074 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001138404   ⟸   NM_001144932
- Peptide Label: isoform 3
- UniProtKB: P28074 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000451816   ⟸   ENST00000555895
Ensembl Acc Id: ENSP00000395206   ⟸   ENST00000425762

Name Modeler Protein Id AA Range Protein Structure
AF-P28074-F1-model_v2 AlphaFold P28074 1-263 view protein structure

RGD ID:6791813
Promoter ID:HG_KWN:18986
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000361611,   NM_001130725,   OTTHUMT00000071698,   UC001WIJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361422,573,836 - 22,574,357 (-)MPROMDB
RGD ID:6853398
Promoter ID:EP74524
Type:initiation region
Name:HS_PSMB5
Description:Proteasome (prosome, macropain) subunit, beta type, 5.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361422,573,936 - 22,573,996EPD
RGD ID:7227095
Promoter ID:EPDNEW_H19293
Type:initiation region
Name:PSMB5_1
Description:proteasome subunit beta 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19294  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381423,034,885 - 23,034,945EPDNEW
RGD ID:7227097
Promoter ID:EPDNEW_H19294
Type:initiation region
Name:PSMB5_2
Description:proteasome subunit beta 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19293  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381423,035,155 - 23,035,215EPDNEW


1 to 40 of 51 rows
Database
Acc Id
Source(s)
COSMIC PSMB5 COSMIC
Ensembl Genes ENSG00000100804 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000361611 ENTREZGENE
  ENST00000361611.11 UniProtKB/Swiss-Prot
  ENST00000425762 ENTREZGENE
  ENST00000425762.2 UniProtKB/Swiss-Prot
  ENST00000493471 ENTREZGENE
  ENST00000493471.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.20.10 UniProtKB/Swiss-Prot
GTEx ENSG00000100804 GTEx
HGNC ID HGNC:9542 ENTREZGENE
Human Proteome Map PSMB5 Human Proteome Map
InterPro Ntn_hydrolases_N UniProtKB/Swiss-Prot
  Pept_T1A_subB UniProtKB/Swiss-Prot
  Proteasome_bsu_CS UniProtKB/Swiss-Prot
  Proteasome_sua/b UniProtKB/Swiss-Prot
  Proteasome_suB-type UniProtKB/Swiss-Prot
KEGG Report hsa:5693 UniProtKB/Swiss-Prot
NCBI Gene 5693 ENTREZGENE
OMIM 600306 OMIM
PANTHER METALLOPROTEASE TLDD UniProtKB/Swiss-Prot
  PROTEASOME SUBUNIT BETA UniProtKB/Swiss-Prot
Pfam Proteasome UniProtKB/Swiss-Prot
PharmGKB PA33887 PharmGKB
PRINTS PROTEASOME UniProtKB/Swiss-Prot
PROSITE PROTEASOME_BETA_1 UniProtKB/Swiss-Prot
  PROTEASOME_BETA_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot
UniProt A0A140VJS7 ENTREZGENE, UniProtKB/TrEMBL
  B2R4N9 ENTREZGENE
  B4DUM9 ENTREZGENE
  D3DS43 ENTREZGENE
  E9PAV2 ENTREZGENE
  G3V3K3_HUMAN UniProtKB/TrEMBL
  G8JLC2_HUMAN UniProtKB/TrEMBL
  H0YJM8_HUMAN UniProtKB/TrEMBL
  P28074 ENTREZGENE, UniProtKB/Swiss-Prot
  Q16242 ENTREZGENE
  Q6PEW2 ENTREZGENE
  Q7Z3B5 ENTREZGENE
1 to 40 of 51 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-03 PSMB5  proteasome 20S subunit beta 5  PSMB5  proteasome subunit beta 5  Symbol and/or name change 5135510 APPROVED
2015-08-18 PSMB5  proteasome subunit beta 5  PSMB5  proteasome (prosome, macropain) subunit, beta type, 5  Symbol and/or name change 5135510 APPROVED