Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of SECTM1 mRNA | CTD | PMID:27840820 | 1,2-dimethylhydrazine | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SECTM1A mRNA | CTD | PMID:22206623 | 1-nitropyrene | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | 1-nitropyrene results in decreased expression of SECTM1 mRNA | CTD | PMID:19041380 | 17beta-estradiol | multiple interactions | ISO | SECTM1 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of SECTM1 mRNA and [Progesterone co-treated with Estradiol] results in increased expression of SECTM1 mRNA | CTD | PMID:17404688 and PMID:30165855 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of SECTM1A mRNA | CTD | PMID:32145629 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of SECTM1A mRNA | CTD | PMID:26496021 | 2,2',5,5'-tetrachlorobiphenyl | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:36804509 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SECTM1 mRNA | CTD | PMID:21632981 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sectm1a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SECTM1A mRNA | CTD | PMID:21570461 and PMID:26377647 | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:26705709 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of SECTM1A mRNA | CTD | PMID:21346803 | aflatoxin B1 | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of SECTM1A mRNA | CTD | PMID:19770486 | Aflatoxin B2 alpha | decreases methylation | ISO | SECTM1 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of SECTM1 intron | CTD | PMID:30157460 | antirheumatic drug | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of SECTM1 mRNA | CTD | PMID:24449571 | arsenous acid | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of SECTM1 mRNA | CTD | PMID:19128835 | arsenous acid | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of SECTM1 mRNA | CTD | PMID:22521957 | benzo[a]pyrene | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SECTM1 mRNA | CTD | PMID:20064835 and PMID:20106945 | benzo[a]pyrene | affects methylation | ISO | SECTM1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SECTM1 5' UTR and Benzo(a)pyrene affects the methylation of SECTM1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | SECTM1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SECTM1 3' UTR | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SECTM1A mRNA | CTD | PMID:19770486 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of SECTM1A mRNA | CTD | PMID:26496021 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SECTM1A mRNA | CTD | PMID:32145629 | bisphenol A | decreases methylation | ISO | Sectm1a (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of SECTM1A promoter | CTD | PMID:27312807 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SECTM1 mRNA | CTD | PMID:25181051 | cadmium dichloride | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of SECTM1 mRNA | CTD | PMID:25596134 | calcitriol | multiple interactions | ISO | SECTM1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SECTM1 mRNA | CTD | PMID:21592394 | calcitriol | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of SECTM1 mRNA | CTD | PMID:21592394 | cefaloridine | increases expression | EXP | | 6480464 | Cephaloridine results in increased expression of SECTM1A mRNA | CTD | PMID:18500788 | ceric oxide | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | ceric oxide analog results in decreased expression of SECTM1 mRNA | CTD | PMID:24821434 | chloroacetaldehyde | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | chloroacetaldehyde results in increased expression of SECTM1 mRNA | CTD | PMID:25596134 | chromium(6+) | affects expression | ISO | Sectm1a (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of SECTM1A mRNA | CTD | PMID:28472532 | clodronic acid | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Clodronic Acid results in increased expression of SECTM1 mRNA | CTD | PMID:25596134 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of SECTM1 mRNA | CTD | PMID:26577399 and PMID:27523638 | diarsenic trioxide | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of SECTM1 mRNA | CTD | PMID:19128835 | diarsenic trioxide | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of SECTM1 mRNA | CTD | PMID:22521957 | dichloroacetic acid | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | Dichloroacetic Acid results in increased expression of SECTM1A mRNA | CTD | PMID:28962523 | dicrotophos | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SECTM1 mRNA | CTD | PMID:28302478 | dimethylarsinic acid | multiple interactions | ISO | Sectm1a (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of SECTM1A mRNA | CTD | PMID:34876320 | dioxygen | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of SECTM1 mRNA | CTD | PMID:25596134 | doxorubicin | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of SECTM1 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of SECTM1A mRNA | CTD | PMID:29391264 | entinostat | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | entinostat results in increased expression of SECTM1 mRNA | CTD | PMID:27188386 | epoxiconazole | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | epoxiconazole results in increased expression of SECTM1A mRNA | CTD | PMID:35436446 | genistein | decreases expression | ISO | Sectm1a (Mus musculus) | 6480464 | Genistein results in decreased expression of SECTM1 mRNA and Genistein results in decreased expression of SECTM1A mRNA | CTD | PMID:32186404 | glycine betaine | increases expression | EXP | | 6480464 | Betaine results in increased expression of SECTM1A mRNA | CTD | PMID:26391144 | inulin | multiple interactions | ISO | Sectm1a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SECTM1A mRNA | CTD | PMID:36331819 | iron dichloride | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of SECTM1 mRNA | CTD | PMID:35984750 | kojic acid | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | kojic acid results in decreased expression of SECTM1 mRNA | CTD | PMID:16595896 | lucanthone | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Lucanthone results in increased expression of SECTM1 mRNA | CTD | PMID:21148553 | methylarsonic acid | multiple interactions | ISO | Sectm1a (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of SECTM1A mRNA | CTD | PMID:34876320 | methylisothiazolinone | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in decreased expression of SECTM1 mRNA | CTD | PMID:31629900 | N-nitrosodiethylamine | multiple interactions | ISO | Sectm1a (Mus musculus) | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SECTM1A mRNA | CTD | PMID:24535843 | N-nitrosodiethylamine | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | Diethylnitrosamine results in increased expression of SECTM1A mRNA | CTD | PMID:24535843 | nickel atom | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Nickel results in decreased expression of SECTM1 mRNA | CTD | PMID:23195993 | nickel atom | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Nickel results in increased expression of SECTM1 mRNA | CTD | PMID:25583101 | nickel sulfate | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | nickel sulfate results in decreased expression of SECTM1 mRNA | CTD | PMID:22714537 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Sectm1a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SECTM1A mRNA | CTD | PMID:36331819 | perfluorooctanoic acid | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of SECTM1 mRNA | CTD | PMID:37738295 | phenobarbital | multiple interactions | ISO | Sectm1a (Mus musculus) | 6480464 | [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of SECTM1A mRNA and NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SECTM1A mRNA] | CTD | PMID:19482888 and PMID:24535843 | phenobarbital | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | Phenobarbital results in increased expression of SECTM1A mRNA | CTD | PMID:19482888 | potassium dichromate | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of SECTM1A mRNA | CTD | PMID:23608068 | progesterone | multiple interactions | ISO | SECTM1 (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in increased expression of SECTM1 mRNA | CTD | PMID:17404688 | progesterone | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Progesterone results in increased expression of SECTM1 mRNA | CTD | PMID:17404688 | silicon dioxide | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of SECTM1A mRNA | CTD | PMID:29341224 | sodium arsenate | multiple interactions | ISO | Sectm1a (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of SECTM1A mRNA | CTD | PMID:34876320 | sodium arsenite | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SECTM1 mRNA | CTD | PMID:22714537 | sodium arsenite | decreases expression | ISO | Sectm1a (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of SECTM1A mRNA | CTD | PMID:37682722 | sodium arsenite | multiple interactions | ISO | Sectm1a (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of SECTM1A mRNA | CTD | PMID:34876320 | sodium arsenite | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SECTM1 mRNA | CTD | PMID:34032870 | tert-butyl hydroperoxide | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of SECTM1 mRNA | CTD | PMID:15336504 | testosterone | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Testosterone results in increased expression of SECTM1 mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | ISO | SECTM1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of SECTM1 mRNA | CTD | PMID:21592394 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SECTM1A mRNA | CTD | PMID:34492290 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of SECTM1A mRNA | CTD | PMID:33387578 | triptonide | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | triptonide results in increased expression of SECTM1A mRNA | CTD | PMID:33045310 | tris(2-butoxyethyl) phosphate | affects expression | ISO | SECTM1 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of SECTM1 mRNA | CTD | PMID:29024780 | urethane | decreases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of SECTM1 mRNA | CTD | PMID:28818685 | valproic acid | increases expression | ISO | SECTM1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SECTM1 mRNA | CTD | PMID:29154799 | valproic acid | increases methylation | ISO | SECTM1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SECTM1 gene | CTD | PMID:29154799 | vancomycin | increases expression | ISO | Sectm1a (Mus musculus) | 6480464 | Vancomycin results in increased expression of SECTM1 mRNA | CTD | PMID:18930951 | zinc atom | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of SECTM1 mRNA | CTD | PMID:19111725 | zinc(0) | increases expression | EXP | | 6480464 | Zinc deficiency results in increased expression of SECTM1 mRNA | CTD | PMID:19111725 | |