Cpb1 (carboxypeptidase B1) - Rat Genome Database

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Gene: Cpb1 (carboxypeptidase B1) Mus musculus
Analyze
Symbol: Cpb1
Name: carboxypeptidase B1
RGD ID: 734226
MGI Page MGI
Description: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in alimentary system; brain; genitourinary system; thymus; and trachea. Orthologous to human CPB1 (carboxypeptidase B1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0910001A18Rik; 1810063F02Rik; 2210008M23Rik; AI504870; carboxypeptidase B; carboxypeptidase B1 (tissue); pancreatic carboxypeptidase B1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39320,303,643 - 20,339,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl320,302,428 - 20,329,897 (-)EnsemblGRCm39 Ensembl
GRCm38320,249,479 - 20,275,733 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl320,248,264 - 20,275,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv37320,149,383 - 20,174,651 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36320,441,534 - 20,466,802 (-)NCBIMGSCv36mm8
Celera320,238,683 - 20,264,826 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map36.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11707070   PMID:12226475   PMID:12466851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:19717511  
PMID:21677750   PMID:21873635   PMID:24194600   PMID:25063451   PMID:25186293   PMID:27626380   PMID:37829188   PMID:38355793  


Genomics

Comparative Map Data
Cpb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39320,303,643 - 20,339,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl320,302,428 - 20,329,897 (-)EnsemblGRCm39 Ensembl
GRCm38320,249,479 - 20,275,733 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl320,248,264 - 20,275,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv37320,149,383 - 20,174,651 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36320,441,534 - 20,466,802 (-)NCBIMGSCv36mm8
Celera320,238,683 - 20,264,826 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map36.29NCBI
CPB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383148,827,811 - 148,860,187 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3148,791,102 - 148,860,187 (+)EnsemblGRCh38hg38GRCh38
GRCh373148,545,598 - 148,577,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363150,028,278 - 150,060,664 (+)NCBINCBI36Build 36hg18NCBI36
Build 343150,028,285 - 150,060,668NCBI
Celera3146,955,960 - 146,988,049 (+)NCBICelera
Cytogenetic Map3q24NCBI
HuRef3145,918,017 - 145,950,076 (+)NCBIHuRef
CHM1_13148,508,723 - 148,540,807 (+)NCBICHM1_1
T2T-CHM13v2.03151,578,867 - 151,610,937 (+)NCBIT2T-CHM13v2.0
Cpb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82104,684,275 - 104,744,824 (-)NCBIGRCr8
mRatBN7.22102,755,241 - 102,785,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2102,755,241 - 102,785,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2109,302,257 - 109,332,662 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02107,423,440 - 107,453,849 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02102,350,160 - 102,384,224 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02105,059,293 - 105,089,682 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2105,059,426 - 105,089,659 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02124,787,804 - 124,850,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42105,413,336 - 105,443,909 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12105,358,297 - 105,388,871 (-)NCBI
Celera298,123,613 - 98,155,223 (-)NCBICelera
Cytogenetic Map2q24NCBI
Cpb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,632,228 - 8,697,245 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,632,733 - 8,697,197 (-)NCBIChiLan1.0ChiLan1.0
CPB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22146,687,228 - 146,756,143 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13146,691,965 - 146,760,873 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03145,815,651 - 145,884,498 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13153,431,094 - 153,463,177 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3153,394,339 - 153,463,366 (+)Ensemblpanpan1.1panPan2
CPB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12343,679,901 - 43,714,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2343,679,361 - 43,748,213 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2343,544,341 - 43,578,459 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02344,307,489 - 44,341,627 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2344,276,898 - 44,375,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12343,889,898 - 43,924,027 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02343,943,078 - 43,978,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02344,198,385 - 44,232,509 (+)NCBIUU_Cfam_GSD_1.0
Cpb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560282,972,757 - 83,009,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365196,724,836 - 6,755,610 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365196,724,836 - 6,755,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1389,044,310 - 89,088,392 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11389,043,822 - 89,088,387 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21397,005,130 - 97,030,476 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CPB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,845,115 - 41,877,173 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1541,845,115 - 41,877,377 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604114,687,765 - 14,719,995 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473026,059,150 - 26,092,486 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473026,059,326 - 26,092,556 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpb1
2358 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:493
Count of miRNA genes:334
Interacting mature miRNAs:383
Transcripts:ENSMUST00000011607, ENSMUST00000125945, ENSMUST00000137855
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
12738410Lfibq2_mliver fibrosis QTL 2 (mouse)31206506020755242Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
12798540Scvg2_msubcutaneous vessel growth QTL 2 (mouse)3744981526249645Mouse
25671383Hrsq1_mhost response to SARS QTL 1, vascular cuffing (mouse)31844095426823641Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1828816852288168Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
1301256Skmw1_mskeletal muscle weight 1 (mouse)Not determined3125786432Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3452541938525519Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31163045345630591Mouse

Markers in Region
Cpb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3A2UniSTS
cM Map313.0UniSTS
AI504870  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38320,249,730 - 20,249,812UniSTSGRCm38
MGSCv37320,149,629 - 20,149,711UniSTSGRCm37
Celera320,238,929 - 20,239,011UniSTS
Cytogenetic Map3A2UniSTS
cM Map313.0UniSTS
Whitehead/MRC_RH3224.38UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000011607   ⟹   ENSMUSP00000011607
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl320,302,428 - 20,329,897 (-)Ensembl
GRCm38.p6 Ensembl320,248,264 - 20,275,733 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl320,303,790 - 20,306,486 (-)Ensembl
GRCm38.p6 Ensembl320,249,626 - 20,252,322 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137855
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl320,318,353 - 20,320,607 (-)Ensembl
GRCm38.p6 Ensembl320,264,189 - 20,266,443 (-)Ensembl
RefSeq Acc Id: NM_029706   ⟹   NP_083982
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39320,303,643 - 20,329,897 (-)NCBI
GRCm38320,249,479 - 20,275,733 (-)NCBI
MGSCv37320,149,383 - 20,174,651 (-)RGD
Celera320,238,683 - 20,264,826 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036163392   ⟹   XP_036019285
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39320,303,643 - 20,339,681 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_083982 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019285 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI38760 (Get FASTA)   NCBI Sequence Viewer  
  AAI38763 (Get FASTA)   NCBI Sequence Viewer  
  EDL34897 (Get FASTA)   NCBI Sequence Viewer  
  EDL34898 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000011607
  ENSMUSP00000011607.6
RefSeq Acc Id: NP_083982   ⟸   NM_029706
- Peptide Label: precursor
- UniProtKB: B2RS76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000011607   ⟸   ENSMUST00000011607
RefSeq Acc Id: XP_036019285   ⟸   XM_036163392
- Peptide Label: isoform X1
- UniProtKB: B2RS76 (UniProtKB/TrEMBL)
Protein Domains
Peptidase M14 carboxypeptidase A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RS76-F1-model_v2 AlphaFold B2RS76 1-415 view protein structure

Promoters
RGD ID:6880330
Promoter ID:EPDNEW_M3616
Type:initiation region
Name:Cpb1_1
Description:Mus musculus carboxypeptidase B1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38320,275,666 - 20,275,726EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923953 AgrOrtholog
Ensembl Genes ENSMUSG00000011463 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000011607 ENTREZGENE
  ENSMUST00000011607.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.340 UniProtKB/TrEMBL
  Zn peptidases UniProtKB/TrEMBL
InterPro CPB_M14_CPD UniProtKB/TrEMBL
  M14A-like_propep UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/TrEMBL
  Prot_inh_M14A UniProtKB/TrEMBL
KEGG Report mmu:76703 UniProtKB/TrEMBL
MGD MGI:1923953 ENTREZGENE
NCBI Gene 76703 ENTREZGENE
PANTHER CARBOXYPEPTIDASE B UniProtKB/TrEMBL
  PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B UniProtKB/TrEMBL
Pfam Peptidase_M14 UniProtKB/TrEMBL
  Propep_M14 UniProtKB/TrEMBL
PhenoGen Cpb1 PhenoGen
PRINTS CRBOXYPTASEA UniProtKB/TrEMBL
PROSITE CARBOXYPEPT_ZN_1 UniProtKB/TrEMBL
  CARBOXYPEPT_ZN_2 UniProtKB/TrEMBL
SMART Zn_pept UniProtKB/TrEMBL
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/TrEMBL
  Zn-dependent exopeptidases UniProtKB/TrEMBL
UniProt B2RS76 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-04 Cpb1  carboxypeptidase B1  Cpb1  carboxypeptidase B1 (tissue)  Symbol and/or name change 5135510 APPROVED