Cpb1 (carboxypeptidase B1 (tissue)) - Rat Genome Database

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Gene: Cpb1 (carboxypeptidase B1 (tissue)) Mus musculus
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Symbol: Cpb1
Name: carboxypeptidase B1 (tissue)
RGD ID: 734226
MGI Page MGI
Description: Predicted to have metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to extracellular space. Is expressed in alimentary system; brain; genitourinary system; thymus; and trachea. Orthologous to human CPB1 (carboxypeptidase B1); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0910001A18Rik; 1810063F02Rik; 2210008M23Rik; AI504870; carboxypeptidase B; pancreatic carboxypeptidase B1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39320,303,643 - 20,339,681 (-)NCBIGRCm39mm39
GRCm39 Ensembl320,302,428 - 20,329,897 (-)Ensembl
GRCm38320,249,479 - 20,275,733 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl320,248,264 - 20,275,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv37320,149,383 - 20,174,651 (-)NCBIGRCm37mm9NCBIm37
MGSCv36320,441,534 - 20,466,802 (-)NCBImm8
Celera320,238,683 - 20,264,826 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map36.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11707070   PMID:12226475   PMID:12466851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:19717511  
PMID:21677750   PMID:21873635   PMID:24194600   PMID:25063451   PMID:25186293   PMID:27626380  


Genomics

Comparative Map Data
Cpb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39320,303,643 - 20,339,681 (-)NCBIGRCm39mm39
GRCm39 Ensembl320,302,428 - 20,329,897 (-)Ensembl
GRCm38320,249,479 - 20,275,733 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl320,248,264 - 20,275,733 (-)EnsemblGRCm38mm10GRCm38
MGSCv37320,149,383 - 20,174,651 (-)NCBIGRCm37mm9NCBIm37
MGSCv36320,441,534 - 20,466,802 (-)NCBImm8
Celera320,238,683 - 20,264,826 (-)NCBICelera
Cytogenetic Map3A2NCBI
cM Map36.29NCBI
CPB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3148,791,102 - 148,860,187 (+)EnsemblGRCh38hg38GRCh38
GRCh383148,827,811 - 148,860,187 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373148,545,598 - 148,577,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363150,028,278 - 150,060,664 (+)NCBINCBI36hg18NCBI36
Build 343150,028,285 - 150,060,668NCBI
Celera3146,955,960 - 146,988,049 (+)NCBI
Cytogenetic Map3q24NCBI
HuRef3145,918,017 - 145,950,076 (+)NCBIHuRef
CHM1_13148,508,723 - 148,540,807 (+)NCBICHM1_1
Cpb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22102,755,241 - 102,785,628 (-)NCBI
Rnor_6.0 Ensembl2105,059,426 - 105,089,659 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02105,059,293 - 105,089,682 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02124,787,804 - 124,850,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42105,413,336 - 105,443,909 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12105,358,297 - 105,388,871 (-)NCBI
Celera298,123,613 - 98,155,223 (-)NCBICelera
Cytogenetic Map2q24NCBI
Cpb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554748,632,228 - 8,697,245 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554748,632,733 - 8,697,197 (-)NCBIChiLan1.0ChiLan1.0
CPB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13153,431,094 - 153,463,177 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3153,394,339 - 153,463,366 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03145,815,651 - 145,884,498 (+)NCBIMhudiblu_PPA_v0panPan3
CPB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12343,679,901 - 43,714,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2343,679,361 - 43,748,213 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2343,544,341 - 43,578,459 (+)NCBI
ROS_Cfam_1.02344,307,489 - 44,341,627 (+)NCBI
UMICH_Zoey_3.12343,889,898 - 43,924,027 (+)NCBI
UNSW_CanFamBas_1.02343,943,078 - 43,978,590 (+)NCBI
UU_Cfam_GSD_1.02344,198,385 - 44,232,509 (+)NCBI
Cpb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560282,972,757 - 83,009,199 (+)NCBI
SpeTri2.0NW_0049365196,724,836 - 6,755,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1389,044,298 - 89,088,214 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11389,043,822 - 89,088,387 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21397,005,130 - 97,030,476 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CPB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11541,845,115 - 41,877,173 (-)NCBI
ChlSab1.1 Ensembl1541,845,115 - 41,877,377 (-)Ensembl
Cpb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473026,059,326 - 26,092,556 (+)NCBI

Position Markers
Cpb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3A2UniSTS
cM Map313.0UniSTS
AI504870  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38320,249,730 - 20,249,812UniSTSGRCm38
MGSCv37320,149,629 - 20,149,711UniSTSGRCm37
Celera320,238,929 - 20,239,011UniSTS
Cytogenetic Map3A2UniSTS
cM Map313.0UniSTS
Whitehead/MRC_RH3224.38UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301256Skmw1_mskeletal muscle weight 1 (mouse)Not determined3125721372Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
1300559Thypr3_mthymocyte proliferative response 3 (mouse)Not determined3447125538471355Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3752111468809613Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1018416183277639Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31018416183277639Mouse
1357857Lvrq5_mliver weight QTL 5 (mouse)Not determined31018416183277639Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31018416183277639Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1018416183277639Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1018416183277639Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31018416183277639Mouse
1301358Eae20_mexperimental allergic encephalomyelitis 20 (mouse)Not determined31157630445576442Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
4142092Tgq13_mtriglyceride QTL 13 (mouse)Not determined1823401952234019Mouse
25671383Hrsq1_mhost response to SARS QTL 1, vascular cuffing (mouse)31838679026769492Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32012071354125954Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:493
Count of miRNA genes:334
Interacting mature miRNAs:383
Transcripts:ENSMUST00000011607, ENSMUST00000125945, ENSMUST00000137855
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000011607   ⟹   ENSMUSP00000011607
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl320,248,264 - 20,275,733 (-)Ensembl
RefSeq Acc Id: ENSMUST00000125945
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl320,249,626 - 20,252,322 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137855
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl320,264,189 - 20,266,443 (-)Ensembl
RefSeq Acc Id: NM_029706   ⟹   NP_083982
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39320,303,643 - 20,329,897 (-)NCBI
GRCm38320,249,479 - 20,275,733 (-)NCBI
MGSCv37320,149,383 - 20,174,651 (-)RGD
Celera320,238,683 - 20,264,826 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036163392   ⟹   XP_036019285
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39320,303,643 - 20,339,681 (-)NCBI
Protein Sequences
Protein RefSeqs NP_083982 (Get FASTA)   NCBI Sequence Viewer  
  XP_036019285 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI38760 (Get FASTA)   NCBI Sequence Viewer  
  AAI38763 (Get FASTA)   NCBI Sequence Viewer  
  EDL34897 (Get FASTA)   NCBI Sequence Viewer  
  EDL34898 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_083982   ⟸   NM_029706
- Peptide Label: precursor
- UniProtKB: B2RS76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000011607   ⟸   ENSMUST00000011607
RefSeq Acc Id: XP_036019285   ⟸   XM_036163392
- Peptide Label: isoform X1
Protein Domains
Peptidase_M14

Promoters
RGD ID:6880330
Promoter ID:EPDNEW_M3616
Type:initiation region
Name:Cpb1_1
Description:Mus musculus carboxypeptidase B1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38320,275,666 - 20,275,726EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923953 AgrOrtholog
Ensembl Genes ENSMUSG00000011463 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000011607 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000011607 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.340 UniProtKB/TrEMBL
InterPro CPB_M14_CPD UniProtKB/TrEMBL
  M14A-like_propep UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/TrEMBL
  Prot_inh_M14A UniProtKB/TrEMBL
KEGG Report mmu:76703 UniProtKB/TrEMBL
MGD MGI:1923953 ENTREZGENE
NCBI Gene 76703 ENTREZGENE
Pfam Peptidase_M14 UniProtKB/TrEMBL
  Propep_M14 UniProtKB/TrEMBL
PhenoGen Cpb1 PhenoGen
PRINTS CRBOXYPTASEA UniProtKB/TrEMBL
PROSITE CARBOXYPEPT_ZN_1 UniProtKB/TrEMBL
  CARBOXYPEPT_ZN_2 UniProtKB/TrEMBL
SMART Zn_pept UniProtKB/TrEMBL
UniProt B2RS76 ENTREZGENE, UniProtKB/TrEMBL